The Results of a Three-Year Pneumococcal Vaccination of Children in Russia by Nikolay I. Briko, Vladimir A. Korshunov, Leyla S. Namazova-Baranova, Juriy V. Lobzin, Alexander A. Baranov, Natalia A. Kostenko, Marina V. Fedoseenko, Elena V. Kajtukova, Elena V. Vishneva, Natalia E. Tkachenko, Tatiana A. Kaljuzhnaya, Firuza Ch. Shakhtakhtinskaya, Marika I. Broeva, Elena L. Semikina, Nikolay A. Mayanskiy

“…By questioning parents (n = 352) who applied to the Federal State Autonomous Institution of the Russian Federation Ministry of Health ‘National Medical Research Centre for Children’s Health, the timeliness of pneumococcal vaccination for infants was established. Results. In most regions, a high level of pneumococcal vaccination coverage was reached (87% of children). …”
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Increased reflux secondary bile acids are associated with changes to the microbiome and transcriptome in Barrett’s esophagus by Ceylan Tanes, Yun Li, Gary W. Falk, Gregory G. Ginsberg, Kenneth K. Wang, Prasad G. Iyer, Charles J. Lightdale, Armando Del Portillo, Stephen M. Lagana, Timothy C. Wang, Anil K. Rustgi, Michael Quante, Zhezhen Jin, Gary D. Wu, Elliot S. Friedman, Kyle Bittinger, Hongzhe Li, Julian A. Abrams

“…Streptococcus correlated with upregulation of IL6, FGF2, and HGF, and decreased Actinomyces showed the most associations with gene expression, including the oxidative phosphorylation pathway. …”
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Rubidium Abundances in Cool Giants from High-resolution H-band Spectra: A New Diagnostic for Galactic Chemical Evolution by Nils Ryde, Jess Kocher, Govind Nandakumar, Henrik Hartman, Marta Molero, Henrik Jönsson, Gregory Mace, Erica Sawczynec, Kyle F. Kaplan

“…We analyze high-resolution ( R = 45,000) Immersion GRating INfrared Spectrograph (or IGRINS) near-IR spectra of 40 M giants in the solar neighborhood, most observed with Gemini South. We perform spectral synthesis of the Rb i line at 15289.48 Å, using new ${\mathrm{log}}\,gf$ values and including an astrophysical calibration of the blending Fe i lines. …”
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Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study by Ana Lucía Guzmán, Isabella Villamil, Sofía Martínez-Betancur, Oriana Arias-Valderrama, Jacobo Triviño-Arias, Jessica Largo, Viviana Lotero, Alexis Franco, Ximena Castro, Pamela Rodríguez, Luz Angela Urcuqui, Diego Medina, Manuela Olaya

“…In the follow-up, the most significant reduction among all ages was for IgA and was related to infections and death. …”
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Effectiveness and Mechanisms of a Digital Mindfulness–Based Intervention for Subthreshold to Clinical Insomnia Symptoms in Pregnant Women: Randomized Controlled Trial by Juan Wang, Qiuhong Yang, Naixue Cui, Liuliu Wu, Xuan Zhang, Yaoyao Sun, Yongqi Huang, Fenglin Cao

“…The intervention group had a significantly increased likelihood of achieving insomnia remission or reliable change at the third trimester; however, we did not observe significant between-group differences in the changes in most secondary outcomes. The changes in adverse cognitive and behavioral processes (mainly sleep-specific worry and presleep arousal) significantly mediated the dMBI-PI’s effect on prenatal insomnia symptoms. …”
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Rates and Determinants of Depression and Anxiety Among Acute Leukemia Patients by Tran Thi Ha An, Nguyen Thao Van, Duong Minh Tam, Nguyen The Tai, Pham Thi Thu Hien, Pham Lien Huong, Vu Thi Lan, Phan Thi Minh Ngoc

“…Results: Participants had a mean age of 43.4 years (SD = 14.0), with 53.7% male and 69.5% residing in rural areas. Most were married (82.9%) and had completed high school (45.1%). …”
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Physiological plasticity in zebra finch color varieties mitigates DNA damage under oxidative stress by Cristiana I. Marques, Sol Rodríguez-Martínez, Pedro Miguel Araújo, Sandra Afonso, Mohammed Zougagh, Ángel Ríos, Miguel Carneiro, Ismael Galván

“…Sustained pheomelanin synthesis may thus reduce cysteine availability for antioxidant defenses, resulting in a trade-off most relevant in stressful environments. Here, we investigated how pheomelanin may influence birds’ response to oxidative stress. …”
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Clinical case of COVID-19 in a patient with Hodgkin's lymphoma by D. A. Malashenko, Zh. B. Ponezheva, A. N. Turapova, E. P. Rodionov, A. A. Ploskireva, M. A. Magomedov, N. G. Burda, I. I. Tsvetaev, T. A. Trubina

“…At present, infection caused by the SARS-CoV-2 virus is one of the most urgent problems of infectious pathology. The total number of cases of a new coronavirus infection in the Russian Federation exceeded 22 million, of which more than 398 thousand cases were fatal.All resources of the healthcare organizations around the world were thrown into the fight against the coronavirus pandemic, which affected the quality of medical care for patients with other diseases. …”
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Five advanced chatbots solving European Diploma in Radiology (EDiR) text-based questions: differences in performance and consistency by Jakub Pristoupil, Laura Oleaga, Vanesa Junquero, Cristina Merino, Suha Sureyya Ozbek, Lukas Lambert, European Society of Radiology (ESR)

“…Chatbots were prompted to evaluate each answer as correct or incorrect and grade its confidence level on a scale of 0 (not confident at all) to 10 (most confident). Scores per question were calculated using a weighted formula that accounted for correct and incorrect answers (range 0.0–1.0). …”
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Geo-mapping of government healthcare facilities providing diagnostic laboratory services in Delhi, India: a pilot study by Garima Jain, Usha Agrawal, Ankit Singh, Kshitij Misra, Sandeep Agrawal, Ashish Dutt Upadhyay, Surya Durbha

“…Background Despite significant advances, the Indian public diagnostic healthcare system faces serious challenges, particularly in availability and accessibility, often affecting those most in need. There is a wide urban–rural disparity, necessitating long travel distances for patients. …”
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Vision Performance of a 3-Zone Progressive™ Design Kalifilcon A Silicone Hydrogel Multifocal Contact Lens is Not Influenced by Pupil Size: Findings from a Multicenter Cli... by Phatak NR, Reindel W, Rah MJ, Proskin H, Giedd K, Pucker AD

“…VA was assessed at 1- and 3-weeks’ follow-up for distance, intermediate, and near vision, and participants rated vision performance using a 0– 100 scale (100=most favorable) at both these follow-ups. Responses with score ≥ 50 were considered favorable. …”
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Harnessing single-cell and multi-omics insights: STING pathway-based predictive signature for immunotherapy response in lung adenocarcinoma by Yang Ding, Dingli Wang, Dali Yan, Jun Fan, Zongli Ding, Lei Xue

“…BackgroundLung adenocarcinoma is the most prevalent type of small-cell carcinoma, with a poor prognosis. …”
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Sources of dissolved organic matter in initial rainwater and its photochemical activity by Yanting Xi, Sihan Fan, Yixin Liu, Danni Cui, Zhicheng Liao, Ziwei Guo, Chaochao Lai, Haodong Zhang, Zhe Zhang, Fengxia Han, Huan He, Bin Huang, Xuejun Pan

“…Among them, only SDOM that had undergone freeze-thaw cycles exhibited a promotive effect on the photodegradation of BPA, with the most significant effect observed at −20°C. Illumination (ultraviolet light (UV) and natural light (NL)) consumed the chromophoric groups of SDOM, disrupted its intricate electron transfer structure, and reduced the production of •OH and Triplet-state dissolved organic matter (3DOM∗). …”
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Modern Approaches to the Management of Children with Hypophosphatasia by Aleksander A. Baranov, Tatiana T. Batysheva, Olga V. Bykova, Nato D. Vashakmadze, Elena V. Vislobokova, Alisa V. Vitebskaya, Elena A. Vishneva, Victoria Yu. Voynova, Natalia V. Zhurkova, Ekaterina Yu. Zakharova, Larisa P. Kisel'nikova, Mikhail M. Kostik, Sergey I. Kutsev, Tea V. Margieva, Leyla S. Namazova-Baranova, Svetlana V. Mikhaylova, Sergey V. Moiseev, Tatyana S. Nagornaya, Liliia R. Selimzyanova, Alla N. Semyachkina, Olga Ya. Smirnova, Marina V. Fedoseenko, Svetlana V. Pishchal'nikova

“…Without timely treatment the prognosis of the disease is unfavorable in most cases. Such patients require follow-up by multidisciplinary team of physicians. …”
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Oral health status, oral hygiene behaviors, and caries risk assessment of individuals with special needs: a comparative study of Pakistan and Saudi Arabia by Osama Khattak, Farooq Ahmad Chaudhary, Shahzad Ahmad, Muhammad Amber Fareed, Shazia Iqbal, Asma Shakoor, Mohammed Nadeem Baig, Haifa Ali Almutairi, Rakhi Issrani, Azhar Iqbal

“…Tooth brushing frequency showed a significant difference between the two groups (p = 0.005). Most participants (76% in Pakistan, 62% in Saudi Arabia) were classified as high caries risk. …”
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Incidence, prevalence, and mortality of sarcoidosis in England: a population-based studyResearch in context by Katie Bechman, Mark D. Russell, Kathryn Biddle, Mark Gibson, Maryam Adas, Zijing Yang, Samir Patel, Alex Dregan, Sarah Walsh, Peter Brex, Amit Patel, Katherine J. Myall, Sam Norton, Surinder S. Birring, James Galloway

“…The age- and sex-standardised incidence per 100,000 person-years increased from 6.65 in 2003 to 7.73 in 2023, with the most pronounced rise occurring between 2010 and 2016. …”
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Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury by Bin Zou, Juan Du, Qiwen Xuan, Yajing Wang, Zixiao Wang, Wen Zhang, Lianghua Wang, Wei Gu

“…There are many factors inducing NLBP, among which the damage and atrophy of multifidus (MF) are most closely related to NLBP. Scraping therapy can have significant treatment effects on NLBP with fewer adverse reactions and less medical fund input than other modalities or medications. …”
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Food additive mixtures and type 2 diabetes incidence: Results from the NutriNet-Santé prospective cohort. by Marie Payen de la Garanderie, Anaïs Hasenbohler, Nicolas Dechamp, Guillaume Javaux, Fabien Szabo de Edelenyi, Cédric Agaësse, Alexandre De Sa, Laurent Bourhis, Raphaël Porcher, Fabrice Pierre, Xavier Coumoul, Emmanuelle Kesse-Guyot, Benjamin Allès, Léopold K Fezeu, Emmanuel Cosson, Sopio Tatulashvili, Inge Huybrechts, Serge Hercberg, Mélanie Deschasaux-Tanguy, Benoit Chassaing, Héloïse Rytter, Bernard Srour, Mathilde Touvier

“…Our objective was to identify most common food additive mixtures, and investigate their associations with type 2 diabetes incidence in a large prospective cohort.…”
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Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects by Tomoaki Hara, Sikun Meng, Yuuya Kasahara, Takashi Osawa, Daisuke Motooka, Hiromichi Sato, Yasuko Arao, Yoshiko Saito, Kana Inoue, Yumiko Hamano, Yuichiro Doki, Hidetoshi Eguchi, Satoshi Obika, Hideshi Ishii

“…The antisense oligonucleotide candidates were finally narrowed down to eight sequences, and when they were examined for their inhibitory effect on NNMT expression in cancer cells, all of the sequences showed inhibitory effects. The most effective one was conjugated with a small molecule compound that targets the stroma of cancer tissues. …”
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Loading-related injuries of mechanically loaded broilers under field conditions by Julia Unterholzner, Elke Rauch, Alexandra Blaeske, Michael Erhard, Anne Werner, Paul Schmidt, Martin Gotthart, Helen Louton

“…Hematomas on the wing (6.55%) were the most common type of injury followed by hematomas on the wing tip (6.17%), abrasions on the body (4.92%), abrasions on the wing tip (4.25%), severe wing injuries (1.13%), and hematomas on the wing proximal to the wing tip (0.38%). …”
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