Pooling umbilical cord-mesenchymal stromal cells derived from selected multiple donors reduces donor-dependent variability and improves their immunomodulatory properties by Miryam Mebarki, Coralie Moine-Picard, Romain Enjaume-Rauch, Antoine Laurent-Puig, Annaelle Suissa, Valentine Feyants, Jérôme Larghero, Audrey Cras

“…Preparation of pools containing UC-MSCs derived from each profile in a 1:1:1 ratio reduced the donor-dependent variability and, most importantly, improved the lowest immunomodulatory functions. …”
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Analysis of skeletal pain, general symptoms and patient-reported outcome measures and their value in detecting symptomatic progression – An interdisciplinary prospective study in p... by Carlotta Pietsch, Monika Engelhardt, Gabriele Ihorst, Laura Wystrach, Johannes Jung, Hagen Schmal, Andreas Frodl, Ralph Wäsch, Evangelos Terpos, Georg W. Herget

“…At ID, 74% reported bone pain, mostly in the spine. General symptoms, particularly fatigue, were present in 89% of the patients. 88/455 (19%) of the follow-up patients experienced PD. …”
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Knee phenotypes distribution according to CPAK classification in Turkish population by Vahit Emre Özden, Göksel Dikmen, Kayahan Karaytuğ, Arda Mavi, Yılmaz Onat Köylüoğlu, İsmail Remzi Tözün

“…Conclusion: CPAK type IV and CPAK type I were the most common subgroups in the nonarthritic and arthritic groups. …”
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A gelable polymer loaded with curcumin and apatinib absorbed in gelatin sponge delays postoperative residual tumor growth by Zhuo-Nan Meng, Jian-Yuan Chen, Chong Yu, Ai-hong Zheng, O. Sreekanth Reddy, Kai-Yan Liu, Yong-Rui Su, Shi-Tai Zhang, Yin-Shuang Wang, Hang-Yu Gu, Fu-Wei Wang, Song-Cheng Xu, Li-Tao Sun, Bing-Chen Chen, Wing-Fu Lai, Guo-Qing Wu, Da-Hong Zhang

“…Abstract Surgical resection of the tumor remains the preferred treatment for most solid tumors at an early stage, however, residual tumor cells after surgical resection poses a considerable obstacle in cancer treatment. …”
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Characteristics of the course of inflammatory bowel diseases among the residents of the Kabardino-Balkarian Republic by R.  Kh. Kazhaeva, P. S. Akhmedova, R. M. Aramisova, Z. A. Kambachokova, D. Kh. Kushkhova, Z. M. Nartokova, D. E. Osmanova, S. A. Teppeeva, A. Yu. Toguzaeva, K. A. Thazaplizhev, A. A. Gukova, I. A. Kalmykov

“…GEBDs were more often used in the treatment of CD, with Infliximab being the most frequently used drug. The results of the study indicate that over the 3 years of the study, the treatment of patients became more consistent with the recommended approaches.Conclusion. …”
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O terramoto de Lisboa de 1755: tremores e temores by María José Ferro TAVARES, Filomena AMADOR, Manuel Serrrano PINTO

“…</p><p>ABSTRACT: Before the great Lisbon earthquake of 1755 the continental part of Portugal had already experienced strong, catastrophic tremors; present day seismotectonic maps show that indeed the metropolitan area of the capital city, as well as the south-western and southern coastal areas of the country are the most risky ones. Earthquakes have always been a matter of great concern among the communities living there, causing fears and phobias that have been transmitted from generation to generation. …”
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Recent advances of photolithography patterning of quantum dots for micro-display applications by Xuemin Kong, Xiaotong Fan, Yuhui Wang, Yunshu Luo, Yihang Chen, Tingzhu Wu, Zhong Chen, Yue Lin, Shuli Wang

“…Lastly, we summarize the most recent developments in this field and outline future prospects.…”
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Ten-year survival in early-stage breast cancer patients in a comprehensive breast cancer care program in India by Priyansh Nathani, Priyansh Nathani, Parth Tailor, Prashant Bhandarkar, Priti Patil, Pratima Pimpalkar, Niranjna Swaminathan, Riya Sawhney, Riya Sawhney, Nobhojit Roy, Nobhojit Roy, Anita Gadgil, Anita Gadgil

“…The clinical stage at diagnosis is the most important prognostic factor. Increased cancer awareness, early diagnosis, and affordable and accessible treatment facilities have been recommended for clinical downstaging and improved survival in low- and middle-income countries including India. …”
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Immunity Against <i>Mycobacterium avium</i> Induced by DAR-901 and BCG by Getahun Abate, Krystal A. Meza, Chase G. Colbert, Octavio Ramos-Espinosa, Nancy J. Phillips, Christopher S. Eickhoff

“…<b>Background:</b> The prevalence of pulmonary nontuberculous mycobacteria (NTM) is increasing in Europe and North America. Most pulmonary NTM cases are caused by <i>Mycobacterium avium</i> complex (MAC). …”
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RBM20 nucleotide sequence variant in a family with a dilated phenotype of left ventricular non-compaction by O. V. Kulikova, R. P. Myasnikov, A. N. Meshkov, E. A. Mershina, A. V. Kiseleva, E. A. Sotnikova, M. M. Kudryavtseva, M. S. Kharlap, M. G. Divashuk, A. A. Zharikova, R. K. Angarsky, S. N. Koretsky, D. А. Filatova, V. E. Sinitsyn, O. M. Drapkina

“…RBM20 gene variants can lead to disruption of splicing at several points and, as a result, to cardiomyopathy progression. Most known pathogenic RBM20 variants are associated with dilated cardiomyopathy; however, a number of studies have found RBM20 gene variants in patients with LVNC. …”
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Single cell RNA sequencing analysis of mice hindlimb muscles identifies transcriptional heterogeneity in aging and physical frailty by Minwen Jie, Tong Feng, Fengjuan Hu, Xuelian Sun, Shuli Jia, Yanrong Lu, Birong Dong, Hao Jiang

“…B cells and satellite cells in both the AIF and AAF groups showed the most down-regulated and up-regulated differentially expressed genes, respectively. …”
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Temporal dynamics and relationship between negative air ions and environmental factors in subtropical forests, China by Changshun Li, Chen Zong, Bo Chen, Xiaoyan Yang, Man Huang, Yu Hong, Kaijin Kuang, Habib Ali, Guofang Zhang

“…The concentration of NAIs in the Yunzhong Mountain forest is highest between 7:00 and 8:00 AM during July and August in the summer, making it the most suitable time for outdoor activities. Meteorological factors, air quality, and radiation factors all influence the NAIs in Yunzhong Mountain. …”
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DEVELOPMENT AND CHARACTERISATION OF 3D SOLID TUMOUR CELL MODELS FOR INDIVIDUALIZED CANCER TREATMENT by A. B. Danilova, T. L. Nekhaeva, N. A. Efremova, M. A. Maydin, E. I. Fedoros, I. A. Baldueva

“…They are an interesting tool for genetic, epigenetic, biomedical and pharmacological studies aiming to determine the most effective individual therapeutic approaches, since they allow modeling the dynamic evolution of a tumor disease from early stages to metastatic spread through interaction with the microenvironment.The purpose of the study was to compare characteristic features of formation and spatial organization of spheroids, obtained from solid malignant tumors cells with various histogenesis: melanomas, soft tissue sarcomas and osteosarcomas, epithelial tumors.Material and Methods. …”
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Prevalence and contributing factors of depression among women with infertility in low-resource settings: a systematic review and meta-analysis by Shimelis Tadesse, Henok Kumsa, Gemeda Wakgari Kitil, Alex Ayenew Chereka, Getnet Gedefaw, Fiker Chane, Esuyawkal Mislu

“…BackgroundDepressive symptoms are the most common manifestations of psychiatric disorders among women with infertility. …”
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Vision-Threatening Diabetic Macular Ischemia Based on Inferred Progression Pathways in OCT Angiography by Miyo Yoshida, MD, Tomoaki Murakami, MD, PhD, Keiichi Nishikawa, MD, Kenji Ishihara, MD, PhD, Yuki Mori, MD, PhD, Akitaka Tsujikawa, MD, PhD

“…Main Outcome Measures: Inference of DMI progression pathways. Results: In most cases, NPS counts increased in both the superficial and deep layers. …”
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Spironolactone and metformin combination therapy as a potential non-hormonal treatment for management of hyperandrogenic symptoms of polycystic ovarian syndrome by Irene Karderinis, Yangxinrui Ma, Telma Viveiros, Neha Deshpande, Bassel Watter, Vikram Talaulikar

“…Introduction: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinological conditions in women of child-bearing age.1 It is characterised by symptoms of oligo- or anovulation, hyperandrogenism and polycystic ovarian morphology.2 Current mainstay treatment for PCOS involves off-label use of combined oral hormonal contraception (COC).3 However, use of COC carries several contraindications and cautions. …”
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The response to anti-seizure medications and the development of pharmacoresistant epilepsy in malformations of cortical development by Pu Miao, Meiping Ying, Ruotong Chen, Yuyu Yang, Yao Ding, Junming Zhu, Jianhua Feng, Jin Wang, Thandar Aung, Shuang Wang, Bo Jin

“…Sodium channel blockers (SCBs) were the most prescribed initial ASMs and demonstrated a higher response rate than other ASMs. …”
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Advancing the selection of implementation science theories, models, and frameworks: a scoping review and the development of the SELECT-IT meta-framework by Guillaume Fontaine, Meagan Mooney, Joshua Porat-Dahlerbruch, Katherine Cahir, Moriah Ellen, Anne Spinewine, Natalie Taylor, Rachael Laritz, Ève Bourbeau-Allard, Jeremy M. Grimshaw

“…Results Of 9,276 records, 43 articles (2005–2024) were included. Most articles reported TMF purposes (41 articles), followed by attributes (30) and practical considerations (13). …”
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Lipidomic Landscapes of Cryopreserved Sperm from Alpine and Spanish–Creole Bucks by Mustafa Bodu, Mustafa Hitit, Selamawit Woldesenbet, Muhammet Raşit Uğur, Zeynep Erdoğan, Olivia Chika Greenwood, Raheem Davian Murray, Andres Pech Cervantes, Erdoğan Memili

“…Network and pathway analyses revealed that 16:0, 18:1 (cis-9), and 18:2 contributed to the most central nodes of the lipidomic network, which may support membrane stability and cryotolerance. …”
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S100A9 as a promising therapeutic target for diabetic foot ulcers by Renhui Wan, Shuo Fang, Xingxing Zhang, Weiyi Zhou, Xiaoyan Bi, Le Yuan, Qian Lv, Yan Song, Wei Tang, Yongquan Shi, Tuo Li, Sihan Zhou, Xiuyuan Hao

“…The overlapping of the most significant DEGs and node genes led to the identification of S100A9 as a target gene. …”
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