Identification of OqxB Efflux Pump and Tigecycline Resistance Gene Cluster tmexC3D2-toprJ3 in Multidrug-Resistant Pseudomonas Stutzeri Isolate G3 by Amande TJ, Kaszyk V, Brown F

“…ARGs were identified using the Comprehensive Antibiotic Resistance Database (CARD).Results: P. stutzeri isolate G3 demonstrated resistance to most antibiotics tested, including meropenem (10 μg), ciprofloxacin (5 μg), gentamicin (10 μg), and tetracycline (30 μg). …”
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Phylogenetic analysis and genetic evolution of porcine respiratory coronavirus in Guangxi province, Southern China from 2022 to 2024 by Yuwen Shi, Yuwen Shi, Kaichuang Shi, Kaichuang Shi, Yanwen Yin, Shuping Feng, Feng Long, Wenjun Lu, Sujie Qu, Yan Ma, Jiakang He

“…The strains obtained from Guangxi province distributed in group I, and formed an independent clade. They were most closely related to PRCV 137 isolate 86/135308 strain from the United Kingdom basing on the S, M, and N gene sequences. …”
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Guest Editorial-SOLUTIONS OF CHILDHOOD OBESITY-AND-MALNUTRITION by Syed Arif Kamal

“…The prime challenges are (a) weight management according to the height, computed from Growth-and-Obesity Roadmaps, within the next half-a-year, so that the youngster does not become wasted based on recommendations according to the most-recently-measured height and (b) absence of a proper definition of obesity in children. …”
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A New View of the Spiral Structure of the Northern Outer Milky Way in Carbon Monoxide by Yan Sun, Ji Yang, Shaobo Zhang, Qing-Zeng Yan, Yang Su, Xuepeng Chen, Xin Zhou, Ye Xu, Hongchi Wang, Min Wang, Zhibo Jiang, Ji-Xian Sun, Deng-Rong Lu, Bing-Gang Ju, Xu-Guo Zhang, Min Wang

“…The Perseus and Outer arms stand out prominently, appearing as quasi-continuous structures along most of their length. At the Galactic outskirts, about 1306 clouds connect the two segments of the new spiral arm discovered by T. …”
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Association of serum potassium time in target range with cardiovascular outcomes in patients with HFpEF by Yu Liu, Jianping Bin, Yating Tang, Yanmei Chen, Wenlong Xu, Yuegang Wang, Zhiwen Xiao, Yingxuan Li, Xingqiao Chen, Fengling He, Haoxiang Huang, Chuling Li, Jiajun Zhou

“…The sK TTR predicted a lower risk of CV events, even after adjusting for traditional CV risk factors, mean sK and sK variability.Conclusion Maintaining sK levels within the range of 4.3–4.9 mmol/L most of the time in patients with HFpEF is associated with a lower risk of CV events or all-cause mortality.Trial registration number NCT00094302.…”
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Co-design and prototype development of MedManageSCI: a medication self-management toolkit for adults with spinal cord injury/dysfunction by Lauren Cadel, Rasha El-Kotob, Sander L. Hitzig, Lisa M. McCarthy, Shoshana Hahn-Goldberg, Tanya L. Packer, Tejal Patel, Stephanie R. Cimino, Aisha K. Lofters, Chester H. Ho, Maliha Asif, Sara J.T. Guilcher

“…Abstract Background Medications are among the most common health interventions, with certain populations, such as individuals with spinal cord injury/dysfunction (SCI/D), commonly prescribed multiple medications. …”
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Antimicrobial resistance and molecular characteristics of bovine mastitis-associated methicillin-resistant Staphylococcus aureus: potential for cross-species transmission of ST59-M... by Wen Sun, Jiayi Liu, Shuangshuang Li, Xiaoman Zhu, Xiangyun Wu, Baojing Dou, Xiaomin Pang, Keke Tian, Peipei Wang, Haihong Hao, Yulian Wang

“…A total of 20 STs were identified, with ST59 being the most prevalent among MRSA isolates (35.7%). All MRSA isolates possessed various Staphylococcal cassette chromosome mec (SCCmec) types, including XII (n = 5), IV.a (n = 4), IV.c (n = 2), IV.g (n = 2), and V (n = 1). …”
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Generation of neutralizing and non-neutralizing monoclonal antibodies against H7N9 influenza virus by Fan Yang, Yixin Xiao, Rufeng Lu, Bin Chen, Fumin Liu, Liyan Wang, Hangping Yao, Nanping Wu, Haibo Wu

“…Two of these mAbs, 1H10 and 2D1, have been identified to have therapeutic and prophylactic efficacy against the HP strain in mouse passive transfer-viral challenge experiments. The mAb 1H10 was most efficacious, even if the treatment-time was as late as 72 h post-infection, or the therapeutic dose was as low as 1 mg/kg; and it was confirmed to have haemagglutination inhibition and neutralizing activity on both LP-and HP-H7N9 strains. …”
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Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa: An individual participant data meta-analysis of 18 HIV prevention studies. by Elizabeth A Torrone, Charles S Morrison, Pai-Lien Chen, Cynthia Kwok, Suzanna C Francis, Richard J Hayes, Katharine J Looker, Sheena McCormack, Nuala McGrath, Janneke H H M van de Wijgert, Deborah Watson-Jones, Nicola Low, Sami L Gottlieb, STIMA Working Group

“…Among clinic/community-based populations, prevalence was generally greater in South Africa than in Southern/Eastern Africa for most STIs; for gonorrhea, prevalence among 15-24-year-olds was 4.6% (95% CI: 3.3%, 6.4%; I2 = 82.8%) in South Africa and was 1.7% (95% CI: 1.2%, 2.6%; I2 = 55.2%) in Southern/Eastern Africa. …”
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A single-nucleotide mutation of G301A in GaIAA14 confers leaf curling in Gossypium arboreum by Pengfei Miao, Pengfei Miao, Huan Zhang, Huan Zhang, Yifan Xu, Yifan Xu, Ruowen Zhang, Ruowen Zhang, Yunfei Hao, Yunfei Hao, Guoli Song, Guoli Song, Ji Liu, Ji Liu

“…Comparative transcriptomic RNA-Seq analysis revealed significant changes in the expression levels of most auxin-related genes, suggesting that the mutation disrupts auxin signaling transduction. …”
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Longitudinal insights into maternal body composition across trimesters of pregnancy by Mugdha Deshpande, Neha Kajale, Nikhil Shah, Ketan Gondhalekar, Vivek Patwardhan, Anagha Pai Raiturker, Sanjay Gupte, Leena Patankar, Anuradha Khadilkar

“…Conclusion Distinct BMI categories exhibited varying trends of change in fat percentage where women belonging to the underweight BMI category gained the highest fat% and lost most of it during childbirth as compared to those in the overweight/obese BMI category. …”
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Estimating mineral-associated organic carbon saturation and sequestration potential using MIR spectral based local quantile regression by Longnan Shi, Karen Daly, Sharon O’Rourke

“…Based on measured MAOC from physical carbon fractionation, the model with a medium RMSE (R2 = 0.86, RMSE = 4.41 g C kg−1) among 41 randomizations was identified as the most generalized and was selected to predict MAOC values from a large regional-scale spectral library. …”
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Identification of glycolysis-related molecular subtypes and prognostic model in intrahepatic cholangiocarcinoma by Yue Wang, Pengxiang Wang, Hui Liu, Haokang Feng, Muzi Cao, Zefan Zhang, Keqiang Rao, Jia Fan, Xiutao Fu, Yunfan Sun

“…Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver tumor, notable for its high heterogeneity. …”
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A novel ubiquitin-related genes-based signature demonstrated values in prognostic prediction, immune landscape sculpture and therapeutic options in laryngeal cancer by Lu Liu, Lu Liu, Lu Liu, Lu Liu, Bing Wang, Xiaoya Ma, Xiaoya Ma, Lei Tan, Lei Tan, Lei Tan, Xudong Wei, Xudong Wei

“…Verification of gene expression was conducted with Western blot, qRT-PCR and ELISA, ultimately.ResultsPPARG, LCK and LHX1 were identified and employed to construct the UbRGs-based prognostic signature, showing a strong ability to discriminate LC patients with distinct OS in TCGA-LC and GSE65858, and excellent applicability in most clinical conditions. The nomogram showed higher predictive value and net clinical benefit than traditional indicators. …”
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Feasibility, safety and tolerability of the CREB-binding protein/β-catenin inhibitor OP-724 in patients with advanced primary biliary cholangitis: an investigator-initiated, open-l... by Eiichi Ogawa, Atsushi Tanaka, Kenichi Harada, Hiroshi Yatsuhashi, Kazumoto Murata, Masamichi Kimura, Jun Imamura, Masanao Saio, Yoshihiro Ikura, Kouichi Miura, Ichiro Ieiri, Kiminori Kimura

“…SAEs did not occur. The most common AEs were abdominal discomfort (29%) and abnormal hepatic function (43%). …”
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Application of supervised machine learning and unsupervised data compression models for pore pressure prediction employing drilling, petrophysical, and well log data by Abu Bakker Siddique, Tanveer Alam Munshi, Nazmul Islam Rakin, Mahamudul Hashan, Sushmita Sarker Chnapa, Labiba Nusrat Jahan

“…The results suggest that the stacking model, which integrates CatBoost and Random Forest (RF) as base models and Polynomial Regression (PR) as the meta-model, achieves an R2 of 0.9846, an adjusted R2 of 0.9842, MAE of 11.20 and an RMSE of 22.747 on the testing dataset. This makes it the most accurate model for pore pressure prediction, followed closely by CatBoost. …”
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Finnish University Students’ Retrospective Reflections on Transitioning from Upper Secondary Education: Traits of Career Learning by Kicki Häggblom, Jessica Aspfors, Pia Nyman-Kurkiala

“…Finland has been acknowledged as having one of the most professionalized school-based career education systems, with a long tradition of guidance counseling taught in class as a school subject in addition to support provided individually or in groups. …”
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Preexisting statin therapy is not associated with reduced acute kidney injury following cardiac surgery: a retrospective analysis by Jia Wang, Chuzhu Huang, Yan Chen, Yilin Huang, Zhuomin Wu

“…BackgroundCardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most prevalent forms of acute kidney injury (AKI) encountered in clinical practice, and its occurrence is significantly correlated with increased mortality and poor prognosis in patients. …”
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Epidemiology of Vancomycin-Resistant Enterococci in Various Medical Wards by A. V. Liubimova, N. A. Shalyapina, V. V. Kolodzhieva, S. A. Riachovskich, O. V. Dmitrieva, T. V. Brodina, A. A. Shishmakov

“…Neonatal and haemato-oncology departments were identified as high risk hospital units. The most common mode of transmission of VRE is contact transmission via hands of health care workers in neonatal units and via environmental objects in haemato-oncology. …”
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Aqueous extract of Cissus quadrangularis L. alleviates heavy metal toxicity in Saccharomyces cerevisiae by limiting metal uptake and enhancing detoxification mechanisms by Tossapol Limcharoensuk, Wisuta Chumsawat, Unays Siraj, Sucheewin Krobthong, Pureeya Pitchayawat, Assanee Hamkrasri, Kittikhun Kerdsomboon, Choowong Auesukaree

“…In this study, we screened 24 Thai herbal extracts for their detoxification efficacy against toxic metals and identified the aqueous extract of Cissus quadrangularis (ACQ) as the most effective in alleviating the toxicities of cadmium (Cd), cobalt (Co), and nickel (Ni) in Saccharomyces cerevisiae. …”
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