Multifaceted analysis of noncoding and coding de novo variants implicates NOTCH signaling pathway in tetralogy of Fallot in Chinese population by Qiongfen Lin, Detao Zhang, Peter J. Gruber, Paul Kwong-hang Tam, Vincent Chi-hang Lui, Zhongluan Wu, Haifa Hong, Kenneth R. Chien, Pak Chung Sham, Clara Sze-man Tang

“…Summary: Tetralogy of Fallot (TOF) is the most common cyanotic heart defect in neonates. While there is compelling evidence of genetic contribution to the etiology of TOF, the contribution of noncoding variants to the development of the defect remains unexplored. …”
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Distribution, types, metallogenic regularity and exploration potential analysis of zirconium deposit in China by Qiong-wen Liang, Yong-shen Li, Ying-cai Sun, De-gao Zhai, Hai-rui Sun, Shi-xu Zhou, Bang-lu Zhang, Xin Lü, Jin-chi Xu, Xue-feng Li, Yi-lun Du

“…However, economic extraction of endogenetic deposits remains constrained by rare earth element (REE) associations and radioactive complexities. Currently, China's most economically significant reserves derive from clastic sedimentary systems, particularly coastal placer deposits. …”
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Distribution characteristics and value range of numerical simulation mechanical parameters in coal seam mining by Nan WANG, Yang LI, Gustavo André PANEIRO, Xinghai LEI, Xiaoming SHI, Yihang LI, Yutong CUI, Haotian LIU, Jinlong CAO, Tieji WANG

“…Statistical analysis of different lithologies shows that siltstone and fine sandstone are the most common in research, with noticeable differences in their mechanical properties. …”
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Evolving Antimicrobial Susceptibility Patterns in Salmonella spp. Isolated from Blood Specimens, Over 10 Years: A Retrospective Observational Analysis by Dinesh Kumar Perumal, Priyadarshini Shanmugam, R Alice Peace Selvabai, Perumal Jayaraman

“…Results: Among the 304 isolates, S. Typhi was the most frequently identified species (225, 74%), followed by Salmonella Paratyphi A (66 isolates, 21.7%), Salmonella Paratyphi B (7 isolates, 2.3%) and Salmonella Typhimurium (6 isolates, 2%). …”
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From Colors to Spectra and Back Again: First Near-IR Spectroscopic Survey of Neptunian Trojans by Larissa Markwardt, Hsing Wen Lin, Bryan J. Holler, David W. Gerdes, Fred C. Adams, Renu Malhotra, Kevin J. Napier

“…A principal component analysis comparing these spectra with those of trans-Neptunian objects (TNOs) and Centaurs reveals that most NTs belong to the “bowl-type” spectral group, while 2013 VX _30 is categorized as “cliff-type” in the N. …”
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Antimalarial Drug Repurposing of Epirubicin and Pelitinib in Combination with Artemether and Lumefantrine by Douglas O. Ochora, Reagan M. Mogire, Bernard M. Murithi, Farid Abdi, Erick N. Ondari, Rael J. Masai, Edwin Mwakio, Agnes Cheruyiot, Abiy Yenesew, Hoseah M. Akala

“…The combination of LU and EPI against the 3D7 strain demonstrated the highest efficacy with a synergism FIC₅₀ value of 0.18. Most combinations of PEL with ART and LU showed antagonism (FIC₅₀ > 1) when tested against strains of <i>P. falciparum</i> and clinical isolates. …”
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Mechanisms of improved nitrogen utilization and root architecture in cotton under reduced fertilization: a comparative study of individual and group planting systems by Sijia Wang, Sijia Wang, Jinghua Zhao, Jinghua Zhao, Chunxia Wang, Tingrui Yang, Tingrui Yang

“…Nitrogen application was identified as the primary contributor to soil total nitrogen accumulation in all soil layers within the limited-area study; however, in the open-field experiment, it was observed to contribute most significantly (27.4%) to soil total nitrogen accumulation specifically in the 0-40 cm soil layer.DiscussionThis study provides theoretical and technical support for optimizing cotton production, enhancing water-nitrogen use efficiency, and promoting environmental sustainability in Xinjiang’s arid farming systems.…”
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Induction of Apoptosis by Ethanol, Methanol, and Ethyl Acetate Extracts from Cyperus Rotundus' Leaf on In Vitro Human Ovarian, Cervix, and Breast Cancer Cell Lines by Mahdi Moradi Kooshkmeydani, Arezoo Khoradmehr, Ali Dehghani Firoozabadi, Alireza Tavassoli, Farzad Mohammad Rezazadeh, Gholamhossein Mohebbi, Asset A Kaliyev, Nadiar Mussin, Mojtaba Farjam, Kulyash R.Zhilisbayeva, Amin Tamadon

“…The HeLa treatment group with 6.25 μg/ml of ethyl acetate extract, MCF-7, and OVCAR-3 cells with 3.125 μg/ ml of methanol extract treatment group exhibited the most significant growth inhibition in the MTT assay. …”
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<i>Passiflora Incarnata L. Herba</i> in the Treatment of Anxiety Symptoms and Insomnia in Children and Adolescents with Feeding and Eating Disorders by Angela La Tempa, Giulia Ferraiuolo, Beatrice Pranzetti, Jacopo Pruccoli, Antonia Parmeggiani

“…Results: this study includes 94 patients, with most diagnosed with anorexia nervosa (71.3%). <i>Passiflora incarnata L. …”
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Development and validation of a novel prediction model for new-onset atrial fibrillation after lung resection by Yasha Chen, Yangxi Hu, Jiamei Wang, Jianmin Sun, Bowen Hu, Kun Huang, Zhiqing He, Chun Liang, Yunling Lin

“…Background Postoperative atrial fibrillation (POAF) is the most prevalent and potentially life-threatening arrhythmia following thoracic surgery. …”
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IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC by Yanan Cui, Tianyu Qiu, Jiale Wang, Xinyu Liu, Libo Luo, Jizhong Yin, Xinxin Zhi, Wanying Wang, Gaohua Feng, Chunyan Wu, Zhikai Zhao, Hua Zhang, Fei Li, Fengying Wu, Shengxiang Ren

“…Abstract Background Most small cell lung cancer (SCLC) patients exhibit resistance to immune checkpoint inhibitors (ICIs) and demonstrate downregulation of major histocompatibility complex class I (MHC-I) molecules. …”
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Healthcare under fire: quantifying the impact of violence on medical services in facilities supported by International Medical Corps in three prefectures of Central African Republi... by Natalya Kostandova, Jennifer OKeeffe, Audrey Mahieu, Blaise Bienvenu Ali, Christian Mulamba, Pierre Somsé, Odilon Guesset Bingou IV, Sebastien Dackpa, Gerard Mbonimpa, Thierry Fikiri, Larissa Fast, Leonard Rubenstein

“…Results A total of 127 individual attacks were identified over five years, primarily from IMC security reports. The most common incidents were asset removal or attempted removal (27%), threat (18%), and pillage (17%). …”
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Synergic action of MicroRNAs and Wnts delivered by motor neuron EVs in promoting AChR clustering by Rachele Agostini, Paola Ceccaroli, Emanuela Polidori, Manuela Ferracin, Ilaria Pace, Serena Maggio, Andrea Cioccoloni, Michela Battistelli, Giulia Matacchione, Matilde Sbriscia, Fabiola Olivieri, Fabrizia Cesca, Vilberto Stocchi, Michele Guescini

“…Results NGS analysis of small RNAs carried by NSC-34-derived EVs identified a total of 245 EV specific miRNAs, most of which are up-regulated in NSC-34 cells and EVs during neurite stretching. …”
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Prevalence of Ectoparasites in Tilapia (Oreochromis niloticus) in Sidoarjo, Indonesia by Aulia Puspita Sari, Setiawan Koesdarto, Tita Damayanti Lestari, Poedji Hastutiek, Muchammad Yunus, Eduardus Bimo Aksono Herupradoto, Aswin Rafif Khairullah, Siti Rani Ayuti, Abdullah Hasib, Suhita Aryaloka, Ikechukwu Benjamin Moses

“…The problem most often encountered in fish farming is disease which can cause a decrease in fish production levels. …”
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Thermally Triggered Double Emulsion‐Integrated Hydrogel Microparticles for Multiplexed Molecular Diagnostics by Eui Ju Jeon, Seungwon Jung, Yoon‐ha Jang, Seoyoung Lee, Song‐Ee Choi, So Young Jeon, Lankyeong Yoon, Bong Kyun Kim, Tae Jong Kim, Kuenyoul Park, Seok Chung, Yong Shin, Sung‐Han Kim, Heungsup Sung, Sang Kyung Kim

“…Abstract During the COVID‐19 pandemic, reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) has been recognized as the most reliable diagnostic tool. However, there is a need to develop multiplexed assays capable of analyzing multiple genes simultaneously to expand its application. …”
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Klasifikasi Aktivitas Manusia Menggunakan Algoritme Computed Input Weight Extreme Learning Machine dengan Reduksi Dimensi Principal Component Analysis by M. Sofyan Irwanto, Fitra A. Bachtiar, Novanto Yudistira

“…Abstract   One of the most important research area is automatic human activity recognition due to its potential application in various other fields such as surveillance, smart environment, and healthcare. …”
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The Effectiveness of Economic Sanctions Implementation Against the Apartheid Regime in South Africa by GRIGORYAN Gevorg Rafikovich

“…Effectiveness of the implemented economic sanctions in most cases was dubious, since the desired results were not achieved or at least deviated from the initial purpose. …”
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Artificial Intelligence in Pediatric Orthopedics: A Comprehensive Review by Andrea Vescio, Gianluca Testa, Marco Sapienza, Filippo Familiari, Michele Mercurio, Giorgio Gasparini, Sergio de Salvatore, Fabrizio Donati, Federico Canavese, Vito Pavone

“…Bone age estimation using DL models often matched or outperformed traditional methods. However, most studies lacked external validation, and many relied on small or single-institution datasets. …”
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Preface by Editor-in-Chief by Ingrida Baranauskienė

“…Without going into polemic about how much Immanuel Kant’s philosophy influenced John Rawls’ theory of social justice, I will quote the principles of justice defined by him: “a) each person is to have an equal right to the most extensive scheme of equal basic liberties compatible with a similar scheme of liberties for others; and in this scheme the equal political liberties, and only those liberties, are to be guaranteed their fair value. b) Social and economic inequalities are to be arranged so that they are both: (a) to the greatest benefit of the least advantaged, consistent with the just savings principle, and (b) attached to offices and positions open to all under conditions of fair equality of opportunity” (Rawls, 2002, p. 61[5]). …”
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Lemierre's syndrome secondary to fusobacterium necrophorum in an immunocompetent patient: A rare case by Saad Bouchlarhem, Mohammed Amine Rabhi, Amine Salek, Achraf Amine Sbai, Drissia Benfadil, Azeddine Lachkar, Fahd El Ayoubi El Idrissi

“…Lemierre syndrome is a rare and life-threatening condition that typically arises secondary to an oropharyngeal infection, progressing to thrombosis of the internal jugular vein and dissemination of septic emboli, most commonly to the lungs. Diagnosis is confirmed via contrast-enhanced cervicothoracic CT imaging, which identifies the presence of internal jugular vein thrombosis. …”
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