Exercise-induced lactate suppresses ccRCC via CNDP2-mediated depletion of intracellular amino acids by Rui Miao, Chunyan Liu, Yilong Wang, Hui Li, Cuihong Han, Chenchen Wang, Zhizhen Tian, Jiao Liu

“…Therefore, there is an urgent need to explore the molecular mechanisms underlying the antitumor effects of exercise to identify which types of cancers can benefit the most from physical exercise. Recent studies have shown that amino acids and exercise-induced lactate can be used by Carnosine Dipeptidase 2 (CNDP2) to synthesize lactoyl amino acids (Lac-AAs), which are then immediately secreted. …”
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Automatic Vessel Steering in a Storm by Zinchenko Serhii, Tovstokoryi Oleh, Mateichuk Vadym, Nosov Pavlo, Popovych Ihor, Gritsuk Igor

“…Vessel control in a storm is the most difficult stage in the vessel’s wiring, as it requires quick decisions to be made in difficult conditions. …”
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Prevalence of urinary symptoms among adolescents and young females in Eastern Uttar Pradesh by Sakshi Agarwal, Anuja Thakur, Lalit Kumar, Arun Das, Aruna Kumari, Tej Bali Singh

“…In addition, Hindus had the most frequent levels of LUTS, especially for urgency (60.7%) and nocturia (70.3%). …”
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Cortical thickness in brain imaging studies using FreeSurfer and CAT12: A matter of reproducibility by Maria de Fátima Machado Dias, Paulo Carvalho, Miguel Castelo-Branco, João Valente Duarte

“…However, neuroimaging studies often report divergent results, even for similar populations, thus it is important to determine whether this occurs as a result of different processing tools. Two of the most used tools are FreeSurfer and the Computational Anatomy Toolbox (CAT12). …”
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A disproportionality analysis of adverse events associated with ertapenem using the FAERS database from 2004 to 2024 by Fengjie Tang, Yue He, Wenting Ou, Na Yang, Xueling Bai

“…The two SOCs with the strongest signals were nervous system disorders and psychiatric disorders, with overall stronger signals in individuals aged ≥ 65 years. The most frequently reported AEs were confusional state (n = 265) and convulsions (n = 214). …”
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A metagenomics survey of viral diversity in mosquito vectors allows the first detection of Sindbis virus in Burkina Faso. by Didier P Alexandre Kaboré, Antoni Exbrayat, Floriant Charriat, Dieudonné Diloma Soma, Simon P Sawadogo, Georges Anicet Ouédraogo, Edouard Tuaillon, Philippe Van de Perre, Thierry Baldet, Côme Morel, Roch K Dabiré, Patricia Gil, Serafin Gutierrez

“…The analysis focused on two mosquito species, Aedes aegypti and Culex quinquefasciatus, considered to be among the most important vectors of arboviruses worldwide. …”
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An Engel–Kollat–Blackwell model application on restaurant clientele purchase decision-making processes in commercial eateries in Kakamega County, Kenya by Simon O. Were

“…To yield positive results, eatery managers will be required to adjust these predictor variables depending on the contribution of each on the outcome variables, given the predictor variables to be tested account for the most variance in the outcome variable.…”
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A Systematic Approach for Microscopic Models Based on Cellular Automata for Road Traffic by Eduardo Valente, Camelia Avram, Adina Astilean, José Machado

“…The transportation infrastructure is one of the most important resources for a country's economic and social well-being. …”
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MINDFULNESS BASED-ASSET IN ACCOUNTING: INTERDISCIPLINARY PERSPECTIVE by Driana leniwati, Endang Dwi Wahyuni

“…The mindfulness concept of asset is expected to change the mindset of most people that assets are accumulated not for want but need and blessing. …”
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Case Report: Ultrasound-guided interventional diagnosis and treatment of gastrosplenic fistula caused by lymphoma by Yahan Zhang, Yang Li, Manxi Li, Yu Song

“…Gastrosplenic fistula is a rare complication, most often secondary to gastric or splenic lymphoma. …”
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The Impact of Women’s Electronic Lifestyle on Advertising Acceptance and Intention to Purchase Online: A Structural Analysis by Sara Mohammadi, Eslam Fakher, Ali Mehrabi, Khadijeh Safikhani Nasimzadeh

“…It is imperative to comprehend the lifestyle and style of individuals in order to deliver the most suitable services to their respective departments. …”
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Mask-SL RCNN: Feature-Enhanced 3D Object Detection Network for Point Clouds by Yuanhong Zhong, Guangxia Yang, Dihang Deng, Panliang Tang, Fan Ren

“…At present, with the original point cloud as input, most of the object detectors use Pointnet++ to extract features of the point cloud based on the Farthest Point Sampling (FPS). …”
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Targeting of voltage-gated calcium channel α2δ-1 subunit to lipid rafts is independent from a GPI-anchoring motif. by Philip Robinson, Sarah Etheridge, Lele Song, Riddhi Shah, Elizabeth M Fitzgerald, Owen T Jones

“…Taken together, these data are most consistent with a model where α(2)δ-1 retains its type I transmembrane topology and its targeting to lipid rafts is governed by sequences upstream of the putative GPI anchor, that promote protein-protein, rather than lipid-lipid interactions.…”
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Effects of exogenous sucrose on root nitrogen uptake in apple at sub-low root-zone temperature by Xiaoping Zhao, Hanyu Liu, Lijie Li, Deguo Lyu

“…In addition, exogenous sucrose alleviated the inhibition of N uptake by low temperature, increased the NO3 −-N content, and increased the activities of enzymes related to N metabolism (NR, GS, NADH-GOGAT, GPT, and GOT) in roots. Most of the genes associated with C and N metabolism (MdBMY3, MdSS3, MdPFK6, MdCS2, MdNPF4.4, MdGS and MdGDH1) were upregulated under sucrose treatment, as confirmed by transcriptomic data. …”
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Analysis of ChatGPT-generated texts on Taiwan’s disputed status by Aleksandr Yu. Petukhov, Dmitriy I. Kaminchenko

“…The purpose of this research is to identify the features of the presentation of texts generated by one of the most popular online services, neural network ChatGPT, for key text queries associated with two approaches to the issue of the political status of Taiwan: considering Taiwan as part of the Chinese People’s Republic or as an independent and sovereign territorial entity. …”
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Economic evaluation of serplulimab plus chemotherapy as the first-line treatment of oesophageal squamous cell carcinoma in China by Fang Chen, Yunchun Long, Jiayong Yang, Kailong Zhong, Bili Liu

“…Sensitivity analysis was performed to assess the effect of parameter uncertainty on the model.Outcome measures Total costs, incremental costs, life years, quality-adjusted life years (QALYs), incremental QALYs and incremental cost-effectiveness ratio (ICER).Results The base case analysis showed that the cost of serplulimab plus chemotherapy (US$69 356) was US$41 607 higher than that of chemotherapy (US$27 749), but it also gained 0.38 QALYs more (1.38 vs 1 QALYs), with an ICER of US$110 744.36/QALY, which was higher than the willingness to pay. The factors that most influenced the ICER were the price of serplulimab, weight and utility value of the progression-free survival stage. …”
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Oral mucosal lesions in Polish patients with acute myeloid leukemia after allogeneic hematopoietic cell transplantation by Aleksandra Wysocka-Słowik, Zuzanna Ślebioda, Barbara Dorocka-Bobkowska, Marzena Liliana Wyganowska

“…The dental team investigated the oral mucosa in all patients thrice during the treatment. The most common oral pathological lesion in the study group was mucositis, which developed in a significantly higher percentage of patients who underwent myeloablation therapy compared to reduced intensity conditioning (p = 0.0335). …”
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Beyond Instructional Development: An Exploration of Using Formal Pedagogy Training to Benefit Perceived Quality of Life and Sense of Community in Graduate Students by Ashley Hooper, Brian Sato, Daniel Mann, Matthew Mahavongtrakul

“…Using a mixed methods approach, we demonstrate that participants in our introductory quarter-long Developing Teaching Excellence course increased their pedagogical knowledge, and participants in both our introductory course and our advanced year-long Pedagogical Fellows Program reported having improved quality of life and sense of belonging. Most commonly, participants framed these pedagogical programs/courses as providing a safe and inclusive space to explore teaching in an interdisciplinary manner; a network of like-minded and supportive peers; and an opportunity to develop greater confidence in teaching, mentorship, and other aspects of graduate life such as conducting research and entering the academic job market. …”
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Optimal sizing of a grid-connected DC microgrid for agricultural applications with water-energy management system considering battery cycle life by Mohammad Hossein Mokhtare, Ozan Keysan

“…Comparative simulations with alternative topologies show that the PV-BESS-Grid microgrid with solar water pumping is the most techno-economically efficient topology. The target farm, while supplied only from the grid, has a levelized cost of energy (LCOE) equal to 401 $/MWh. …”
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Effect of bacteria on the wound healing behavior of oral epithelial cells. by Rupa Bhattacharya, Fanxing Xu, Guangyu Dong, Shuai Li, Chen Tian, Bhaskar Ponugoti, Dana T Graves

“…P. gingivalis and F. nucleatum adversely affected cell proliferation and the effect also had a spatial component being most striking at the edge. The impact of the bacteria was long lasting even when exposure was brief. …”
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