Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. by Evgeny V Berdyshev, Irina Gorshkova, Peter Usatyuk, Satish Kalari, Yutong Zhao, Nigel J Pyne, Susan Pyne, Roger A Sabbadini, Joe G N Garcia, Viswanathan Natarajan

“…Although S1P did not accumulate significantly in media under basal or S1PL knockdown conditions, addition of sodium vanadate increased S1P levels in the medium and inside the cells most likely by blocking phosphatases including lipid phosphate phosphatases (LPPs). …”
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The effects of acute and chronic Red Bull® consumption on cardiodynamics and oxidative stress in coronary effluent of trained rats by Pušica Irena, Đorđević Dušica, Bradić Jovana, Jeremić Jovana, Srejović Ivan, Živković Vladimir, Jakovljević Vladimir

“…Energy drinks (EDs) are widely used by athletes as ergogenic agents and Red Bull® is one of the most consumed EDs among them. The aim of this study was to determine the acute and chronic effects of Red Bull® on cardiodynamics and parameters of oxidative stress in physically trained rats. …”
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A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. by Thomas J Hoffmann, Bronya J Keats, Noriko Yoshikawa, Catherine Schaefer, Neil Risch, Lawrence R Lustig

“…Age-related hearing impairment (ARHI), one of the most common sensory disorders, can be mitigated, but not cured or eliminated. …”
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Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study. by Aiden Doherty, Dan Jackson, Nils Hammerla, Thomas Plötz, Patrick Olivier, Malcolm H Granat, Tom White, Vincent T van Hees, Michael I Trenell, Christoper G Owen, Stephen J Preece, Rob Gillions, Simon Sheard, Tim Peakman, Soren Brage, Nicholas J Wareham

“…The summary measure of overall physical activity is lower in older participants and age-related differences in activity are most prominent in the afternoon and evening. This work lays the foundation for studies of physical activity and its health consequences. …”
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COVID-19 Unmasked: trajectories, risk and protective factors for mental health outcomes in young Australian children during the first year of the COVID-19 pandemic by Mira Vasileva, Eva Alisic, Vanessa E. Cobham, Tahlia Gash, C. M. Hoeboer, Elisabeth Hoehn, Sonja March, Caroline Donovan, Christel M. Middeldorp, Rebecca Moore, Alexandra De Young

“…The overall means for depressive symptoms, anger/irritability, and sleep disturbance decreased while anxiety increased over time. For most outcomes, two individual trajectories were identified: moderate/high-decreasing (26–29%) andlow-increasing. …”
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Biophysical characterization of human serum albumin interaction with dapagliflozin: multi-spectroscopic and molecular docking study by Tuvshinjargal Duurenjargal, Tuguldur Badamkhatan, Khurelbaatar Luvsanbat, Mishig-Ochir Tsogbadrakh, Urnukhsaikhan Enerelt

“…Human serum albumin (HSA) is the most abundant protein in human blood plasma and plays a crucial role in drug transport and pharmacokinetics. …”
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Filth Flies As Carriers of Intestinal Parasites And Fungi in a Tertiary Institution in Ghana by Seth Offei Addo1, 2*, Jennifer Oppong1, Elisha Monikey Achawe1, Barbara Baah Nketia1, Prince Boateng Agyei1, John Asiedu Larbi1*

“…Results: Pathogens were mostly isolated from the body surfaces of the flies. …”
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Stabilization interventions in the treatment of traumatized refugees: A scoping review by Irja Rzepka-Marot, Nadja Gebhardt, Jonathan Nowak, Bastian Bruns, Hans-Christoph Friederich, Christoph Nikendei

“…This scoping review aims to provide a comprehensive overview of stabilizing, non exposure-based interventions for traumatized refugees A systematic search identified 31 relevant studies featuring diverse interventions, settings, and outcomes. Most studies showed a significant reduction in PTSD symptoms compared to waitlist (six studies), treatment as usual (three studies) and pre-post analyses (nine studies), though nine studies found no difference between intervention and comparison group. …”
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Key regulatory challenges in developing modified new chemical drugs in China: a national survey study by Lixia Fu, Lixia Fu, Guoshu Jia, Guoshu Jia, Guoshu Jia, Minji Wei, Minji Wei, Yimin Cui, Yimin Cui, Yimin Cui, Yimin Cui

“…Half of the respondents had over 10 years of work experience, 66% held intermediate or higher professional titles, and over 90% were experienced in R&D or regulatory submissions. Most respondents identified clinical advantage evaluation as the primary regulatory hurdle, with the lack of clear guidance and case references cited as significant impediments in the R&D and marketing application of MNCDs. …”
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Clinical-epidemiological analysis of HIV positive patients hospitalized in a Burn Therapy Unit by Murilo Sgarbi Secanho, Balduino Ferreira de Menezes, Ana Beatriz Pedroso Maciel de Oliveira, Merimar Maria Chequim, Laisa Brandão Carvalho, Weber Ribolli Moragas, Cristiane Rocha, Aristides Augusto Palhares

“…Regarding gender, nine (64.3%) were male, and five (35.7%) were female. The most common mechanism was direct flame in 11 (78.7%) cases. …”
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Finding women in fishing communities around Lake Victoria: "Feasibility and acceptability of using phones and tracking devices". by Gertrude Nanyonjo, Zachary Kwena, Sarah Nakamanya, Elialilia Okello, Bertha Oketch, Ubaldo M Bahemuka, Ali Ssetaala, Brenda Okech, Matt A Price, Saidi Kapiga, Pat Fast, Elizabeth Bukusi, Janet Seeley, LVCHR study team

“…Twenty-four (24) participants were given a study phone; 24 were asked to use their own phones and 16 were provided with a portable GPS device to understand what is most preferred. Women were interviewed about their experiences and recommendations on carrying GPS devices or phones. …”
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Investigation of the histoarchitecture of bovine pericardium as the primary material used in reconstructive surgery and bioprosthesis by A. I. Zvyagina, K. V. Pyatina, V. V. Minaiychev, M. I. Kobyakova, Ya. V. Lomovskaya, A. S. Senotov, A. Yu. Teterina, I. S. Fadeeva

“…The BP-CT group had the lowest cellular density and, consequently, DNA content (369.75 ± 23.12 ng/mg), in addition to having the most homogeneous, predominantly collagenous (95.6 ± 2.9%) matrix composition with minimal lipid (2.6 ± 1.5%), glycosaminoglycan (0.68 ± 0.7%) and elastin (3 ± 2.4%) content. …”
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Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay by Yazun Jarrar, Mansour Almansour, Mansour Al-Sayed Ahmad, Belal O. Al-Najjar, Amin A. Al-Doaiss, Sireen Abdul Rahim Shilbayeh, Su-Jun Lee

“…Conclusions Simvastatin effectively inhibits the formation of 20-HETE most probably through interaction with CYP4A11, CYP4F2, and CYP4F3B, suggesting its potential as a therapeutic agent for managing conditions associated with elevated 20-HETE levels. …”
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CLINICAL AND DIAGNOSTIC VALUE OF YKL-40 AND NGAL IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE by Valeriy Kuznetsov, Yana Kozlova, Alexey Sobolev, Ekaterina Frolova, Alexandra Uchevatkina, Olga Secretareva, Natalya Vasilieva

“…Chronic obstructive pulmonary disease (COPD) is one of the most common diseases of the bronchopulmonary system. …”
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CEREBRAL ARTERY FENESTRATIONS: INCIDENCE, ASSOCIATION WITH CEREBRAL ARTERIAL ANEURYSMS AND OTHER VASCULAR DISEASES ACCORDING TO THE DATA OF MULTISLICE SPIRAL COMPUTED TOMOGRAPHY AN... by M. Yu. Kalmykov

“…Fenestrations were located most frequently in the area of ACA and less frequently in the area of BA and middle cerebral artery. …”
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Patient preferences for stroke prevention treatments in atrial fibrillation in Asia: A discrete choice experiment by Rosa Wang, Hui Lu, Gabriela Fernandez, Nicolas Krucien, Dong Huang, Hiroshi Higashiyama, Juan Du, Xin Ye, Tommi Tervonen, Matthew Quaife

“…Participants preferred treatments with improved clinical outcomes, with reduced risk of death being their most important attribute. They valued a 1 % reduction in severe disability risk the same as a 0.36 % death risk reduction, a 1 % reduction in mild or moderate disability risk the same as a 0.25 % death risk reduction, and a 1 % reduction in non-disabling event risk the same as a 0.18 % death risk reduction. …”
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Autism-like phenotype across the lifespan of Shank3B-mutant mice of both sexes by Jakub Szabó, Johan Filo, Rebeka Démuthová, Emese Renczés, Veronika Borbélyová, Daniela Ostatníková, Peter Celec

“…As ASD is commonly diagnosed in early childhood, most of the research is focused on children, yet animal research predominantly uses adult-aged animals. …”
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Bariatric surgery decision-making of adults with obesity: a grounded theory study by Yihong Xu, Wen Li, Liping Zhu, Yunxia Li, Jianan Wang, Xiaoxiao Zhang, Shanni Ding, Mizhi Wu, Hongying Pan, Weihua Yu, Jionghuang Chen

“…The study identified five key stages in the decision-making process: Initial Attention, Proactive Information-Seeking, Decision-Making Process, Definitive Surgical Decision, Preparation Phase, and Abandonment, with the Decision-Making Process being the most critical. The study examined the influence of External Environment on Cognitive Decision-Making, focusing on social pressure, social support, and peer support. …”
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Diagnosis and treatment of 23 cases of acute nephritis syndrome with lung injury by 张媛媛, 袁发焕

“…The syndrome is hard to detect and progress quickly, in most cases pulmonary pathological changes may be improved through immunosuppression therapy, and the overall prognosis is poor. …”
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A novel cardiomyopathy phenotype linked to a CHD7 missense variant by In Young Park, Chih-Wei Hsu, Karim Bouazoune, Christina E. Espindola, Madeline Hannah McLaughlin Armond, Cristian Coarfa, Sandra L. Grimm, James F. Martin, Donna M. Martin, Cheryl Lyn Walker

“…However, establishing genotype-phenotype correlations has been challenging, as most CHD7 inactivating mutations are null alleles. …”
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