Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis by Dennis W Lendrem, John D Isaacs, Ann W Morgan, Amy E Anderson, Arthur G Pratt, Philip M Brown, Najib Naamane

“…Methotrexate (MTX) remains the first-line disease modifying therapy, however there are no biomarkers with which to identify those most likely to achieve remission. To address this unmet need we explored metabolic pathways involved in MTX mechanism of action within circulating CD4+T cells in a cohort of treatment naive patients with early RA.Methods Purified CD4+T cells were isolated from peripheral blood of 68 patients with early RA commencing MTX. …”
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Perception of Space in the Traditional and Virtual Classroom by T. G. Nikitina

“…The paper presents the study of the educational context and its characteristics to achieve the most effective learning process.The aim of the research is to examine the perception of physical space in the traditional classroom and virtual space in online learning. …”
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Seedling growth of primed seed under drought stress in sorghum by Mohammad Omar Shihab, Jalal Hameed Hamza, William Serson, Andre Amakobo Diatta, Martin Battaglia, Maythem Al-Amery, Hail Z Rihan

“…The interaction between priming treatments and irrigation intervals was significant for most of the studied traits. It can be concluded that priming has improved seed performance's ability to tolerate drought stress compared to unprimed seed. …”
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The Physiology Constant Database of Teen-Agers in Beijing by Wei Wei-Qi, Zhu Guang-Jin, Xu Cheng-Li, Han Shao-Mei, Qi Bao-Shen, Chen Li, Zu Shu-Yu, Zhou Xiao-Mei, Hu Wen-Feng, Zhang Zheng-Guo

“…Until recently, physiology constants were not available in China and therefore most physiologists, physicians, and nutritionists had to use data from abroad for reference. …”
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Determination of S-genotypes of 13 Chinese pear cultivars based on sequence analysis by ZHANG Lin, TAN Xiao-feng, YUAN De-yi, LI Xiu-gen, LIANG Wen-jie

“…S₁₉ was found to be the most frequent S-allele in Chinese pears. Based on restriction sites analysis, a rapid and economical method was developed for the identification of S₁₉ without going to the effort of sequencing but using the digestion with S₁₉-specific restriction endonuclease Afl Ⅱ. …”
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Species turnover within cystic fibrosis lung microbiota is indicative of acute pulmonary exacerbation onset by Leah Cuthbertson, Lauren Hatfield, Helen Gavillet, Michelle Hardman, Ryan Marsh, Damian W. Rivett, Christopher van der Gast

“…Abstract Background Acute pulmonary exacerbations (PEx) are associated with increased morbidity and earlier mortality for people living with cystic fibrosis (pwCF). The most common causes of PEx in CF are by bacterial infection and concomitant inflammation leading to progressive airway damage. …”
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Comprehensive analysis of chromosome 8 abnormalities and its prognostic value in patients with uveal melanoma by V. A. Yarovaya, A. A. Yarovoy, L. V. Chudakova, I. A. Levashov, A. R. Zaretskiy

“…The genetic ones are considered to be the most significant. The role of disorders of the short arm of chromosome 8 (8p), as well as a combination of changes in 8p and the long arm of this chromosome (8q) in the development of metastatic lesions in this pathology remains insufficiently studied.The study objective – to evaluate the prognostic value of chromosome 8 abnormalities in patients with uveal melanoma.Materials and methods. …”
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The h4 coil surface region of human papillomavirus type 58 L1 virus-like particle serves as a potential location for presenting the RG1 epitope peptide by Zhirong Wang, Ting Zhang, Xuemei Xu

“…To our knowledge, there have been no reports on the construction and immunogenicity research of chimeric L1-L2 proteins based on HPV58 L1VLP, the third most prevalent high-risk type in Asia. Here, we inserted the RG1 epitope peptides at two sites of the highly expressed HPV58 L1 – the h4 coil region or the DE loop (with linkers) – to construct seven chimeras. …”
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Usefulness of a double immunofluorescence technique for detection of intestinal tTG-IgA deposits in diabetic and non-diabetic children with celiac disease by Raghav Lal, Ranjeet Bhardwaj, Ranjana Walker Minz, Kaushal Kishore Prasad, Sadhna Lal, Devi Dayal, Yashwant Kumar

“…Results: Histologically, villous atrophy was most severe in CD, followed by T1D with CD, while all control biopsies except 1 were normal. …”
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Comparative Analysis of Dalargin Pharmaceutical Substance Identification Methods by M. G. Shulzhenko, I. A. Vasilenko, B. I. Ugrak, I. E. Shohin, Yu. V. Medvedev, E. A. Malashenko

“…When assessing the quality of substances and drugs, the most important indicators are authenticity, the content of the main substance and impurities. …”
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Combination Therapy for Cryptosporidiosis in Immunocompromised Patients by Wiwien Sugih Utami, M.S. Irham Rozaq, Laksmi Indreswari, Cholis Abrori, Bagus Hermansyah

“…This study aimed to determine the most effective combination therapy for cryptosporidiosis in immunocompromised patients. …”
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A Rare Case of Contralateral Diaphragm Paralysis following Birth Injury with Brachial Plexus Palsy: A Case Report and Review of the Literature by Audra J. Reiter, Yazan K. Rizeq, Benjamin T. Many, Jonathan C. Vacek, Fizan Abdullah, Seth D. Goldstein

“…According to Fitting and Grassino, though most cases of phrenic nerve injuries are ipsilateral to shoulder dystocia brachial plexus palsy, contralateral occurrence is possible and should be considered. …”
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Hyposensitizing effect of high altitude and immunogenetic law by R. S. Galiev, A. V. Droblenkov

“…One may conventionally consider that the first protective barrier against antigens is the most evolutionarily ancient structure, i.e., skin and mucous membrane; the second represents factors of nonspecific defense (phagocytosis, lysozyme, interferon, etc.); the third barrier is presented by cellular immunity (T effector cells, etc.), with humoral immunity serving as the fourth barrier. …”
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Sustainable shelf-life extension of Musa acuminata using starch-based coatings infused with pomelo peel essential oil by Sumia Rahman Sweet, B. M. Khaled, Md Abdullah Al Naeem, Md. Suman Rana, Adda Ann Sina, Asif Shahriar, Tamanna Naznin Shetu, Md. Momin Khan, Md. Entaduzzaman Jony, Mushfikur Rahman, Md. Mozaffor Hossain, Mahamudul Hasan

“…The findings indicated that the coating effectively lowered the weight loss (15.65%) and microbial load (10% spoilage) for T-III (5 % essential oil), the most effective treatment. The expected lifespan of coated fruit was prolonged by 12 days in comparison to the untreated control, which ripened in seven days and became unmarketable after Day 6. …”
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Simvastatin suppresses spinal cord metastasis of medulloblastoma at clinically significant doses by Charley Comer, Kian Cotton, Christopher Edwards, Xiaoyang Dai, Sara Badodi, Roberto Buccafusca, Chris Bennett, Andrew Peet, Alice Williams, David Michod, Elena Bochukova, Maria Victoria Niklison-Chirou

“…Abstract Medulloblastomas (MBs) are aggressive brain cancers and represent the most common primary malignant tumour in children. …”
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Evaluation of therapeutic effects of Crocin in patients with polycystic ovary syndrome: A randomized Double-Blind clinical trial by Fatemeh Saghafi, Atiyeh Javaheri, Farhad Mohammadi, Nooshin Hatamizadeh, Fatemeh Khanizadeh, Mahdieh Safakish, Adeleh Sahebnasagh

“…Abstract Background Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder in women of reproductive age. …”
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Drivers of Insect Diversity and Community Turnover in Protected Tropical Deciduous Forests of Mexico by Pilar Benites, Antonio García‐Bautista, Natalia Bautista‐Briseño, Flavio E. Zárate‐Hernández, Ek del‐Val, Antonio Hernández‐López, Enrique Ramírez‐García, Diana P. Zavala‐de la Rosa, Alfried P. Vogler, Alejandro Zaldívar‐Riverón

“…ABSTRACT Tropical deciduous forests (TDFs) are among the world's most biodiverse yet endangered ecosystems. In the Neotropics, TDFs have experienced substantial range reductions due to land use changes, with profound implications for their insect diversity, much of which remains unknown. …”
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Breast cancer incidence in Indonesia: a sex-disaggregated analysis using WHO health equity assessment toolkit data by Augustus Osborne, Qorinah Estiningtyas Sakilah Adnani, Bright Opoku Ahinkorah

“…Abstract Introduction Breast cancer is the most common cancer among women globally, with notable disparities in incidence between sexes, particularly in low and middle-income countries. …”
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Treatment with Apocynin Limits the Development of Acute Graft-versus-Host Disease in Mice by Barbara Maximino Rezende, Priscila T. T. Bernardes, William Antonio Gonçalves, Carolina Braga de Resende, Rayssa Maciel Athayde, Thiago Vinicius Ávila, Débora Gonzaga Martins, Marina G. M. Castor, Mauro M. Teixeira, Vanessa Pinho

“…Graft-versus-host disease (GVHD) is the most serious complication limiting the clinical utility of allogeneic hematopoietic stem cell transplantation (HSCT), in which lymphocytes of donors (graft) are activated in response to the host antigen. …”
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The human STING agonist E7766 induces immunogenic tumor clearance, independent of tumor-intrinsic STING expression in the KRASG12D/+ Trp53−/− murine model of sarcoma by Karys M. Hildebrand, Kurt N. Hildebrand, Carolina Salazar Arcila, Kayla Marritt, Jahanara Rajwani, Golpira Elmi Assadzadeh, Antoine Dufour, Frank R. Jirik, Michael J. Monument

“…Soft tissue sarcomas (STS) are aggressive high-fatality cancers that affect children and adults. Most STS subtypes harbor an immunosuppressive tumor microenvironment (TME) and respond poorly to immunotherapy. …”
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