Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico stu... by Mohammed S. Taghour, Hazem Elkady, Wagdy M. Eldehna, Nehal M. El-Deeb, Ahmed M. Kenawy, Eslam B. Elkaeed, Aisha A. Alsfouk, Mohamed S. Alesawy, Ahmed M. Metwaly, Ibrahim. H. Eissa

“…Compound 12a was found to be the most potent candidate against the investigated cell lines with IC50 values of 2, 10, and 40 µM, respectively. …”
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Teucrium polium induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia by Zarić Milan, Živković-Zarić Radica, Mitrović Marina, Nikolić Ivana, Čanović Petar, Milosavljević Zoran, Jovanović Danijela, Zelen Ivanka

“…The activation of apoptosis is one of the main molecular mechanisms responsible for anti-cancer activities of most of the currently studied potential anti-cancer agents, including natural compounds. …”
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ANALYSIS OF MICROBIOCENOSIS OF ORAL FLUID IN PATIENTS WITH DEFECTS OF DENTITION, ZAKARPATTIA REGION RESIDENTS by A.S. Chobey, O.V. Klytinska, O.Ye. Kostenko, R.O. Dunets

“… Dental diseases are among the most frequent diseases of the human body. The microflora of the oral cavity is specific, unlike the microflora of other cavities both in composition, quantity, and functions. …”
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Research coordinators’ perspectives on recruitment of minoritized people with cystic fibrosis into clinical trials by Tijana Milinic, Nora Burdis, Eliana Gill, Patricia Burks, Mary Elizabeth Jarosz, Amy J. Hoffman, Siddhartha G. Kapnadak, Kathleen J. Ramos, Christopher H. Goss

“…Respondents who had a moderate or great deal of experience (n = 20, 91%) identified that having a trusted clinical team member first introduce the study to PwCF as the most common strategy for recruitment. Experienced respondents also identified the importance of having team members who speak the same language or are the same culture as the minoritized PwCF (n = 17, 35%). …”
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Predicting the compressive strength of concrete incorporating waste powders exposed to elevated temperatures utilizing machine learning by Islam N. Fathy, Hany A. Dahish, Mohammed K. Alkharisi, Alaa A. Mahmoud, Hala Emad Elden Fouad

“…The SHAP analysis, Individual Conditional Expectation (ICE), and Partial Dependence Plots (PDP) revealed that GWP and MWP positively influence the compressive strength, while the temperature exerts the most negative influence on predicting the compressive strength. …”
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Neuromuscular Blocking Agents and Reversal Agents Usage, and Neuromuscular Blockade Monitoring in the Intensive Care Unit – Review Article by Szewczyk M, Bieniecka A, Sobolewski K, Banasiak Ł, Grabarczyk Ł

“…Peripheral nerve stimulation (PNS) and train-of-four (TOF) monitoring are qualitative methods, whereas quantitative techniques, which provide objective measurements, are increasingly recommended for managing neuromuscular blockade. Most guidelines currently focus on perioperative monitoring, and there is a lack of detailed recommendations for using these methods in the ICU. …”
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PREVALENCE OF MULTIDRUG-RESISTANT ORGANISMS IN HOSPITAL-ACQUIRED PNEUMONIA AMONG ICU PATIENTS AND ITS CLINICAL OUTCOMES: A PROSPECTIVE OBSERVATIONAL STUDY. by Dr. Chintapalli Suryamani, Dr. Vennela Gangaram, Dr. R.B. Swathi, Dr. Vepuri Pavitra Sonica

“…The majority of patients had comorbidities such as diabetes mellitus (45%), chronic obstructive pulmonary disease (33%), and hypertension (30%). The most common MDROs identified were Klebsiella pneumoniae (24%), Pseudomonas aeruginosa (21%), and Acinetobacter baumannii (19%). …”
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Mg-Li-Cu alloy anode for highly reversible lithium metal batteries by Xinbin Li, Shuai Liu, Fangya Li, Kaiwen Ma, Hao Xu, Zhiang Li, Fan Ding, Zhenhua Yan, Runhua Fan, Hongzhi Cui

“…Lithium metal is considered as the most promising anode material for the next generation of secondary batteries due to its high theoretical specific capacity and low potential. …”
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Evaluation in Our New Normal Environment: Navigating the Challenges with Data Collection by Nadini Persaud, Ruby Dagher

“…The COVID-19 pandemic has highlighted the plight of the most vulnerable and evidence-based data is the only means to assist this group. …”
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A study of histopathological spectrum and expression of Ki-67, TP53 in primary brain tumors of pediatric age group by Subhalakshmi Sengupta, Uttara Chatterjee, Uma Banerjee, Samarendranath Ghosh, Sandip Chatterjee, Ashit k Ghosh

“…Objectives: The primary brain tumors are the second most common cause of death due to malignancies in children. …”
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The relationship between sports performance, physical activity and e-cigarette use among Australian adolescents: A qualitative study by Amelia Yazidjoglou, Christina Watts, Grace Joshy, Emily Banks, Becky Freeman

“…Sport participation and athletic performance were perceived as key drivers of protective adolescent e-cigarette use behaviors including abstinence, cessation and ‘responsible use’. Most current and former users reported experiencing health harms attributed to e-cigarettes – predominantly shortness of breath – during dayto- day physical activity such as walking or climbing the stairs and during sporting activities. …”
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A comparative analysis of non-invasive respiratory support modalities in the treatment of acute hypercapnic respiratory failure: a network meta-analysis by Liyu Yan, Guishen Wu

“…Additionally, the rank probabilities were presented, demonstrating the likelihood of each non-invasive respiratory support method being the most effective across various measured outcomes.ResultsNineteen studies (2,022 participants) were included. …”
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Computer-based music production: Specifics of professional training by A. A. Konovalov, N. I. Butorina

“…The process of professional training in most economic sectors is now thoroughly developed and regulated by global science. …”
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Social-demographic factors of providing regional economic security (by the data of Omsk oblast) by E. A. Kapoguzov, R. I. Chupin, M. S. Kharlamova, A. S. Tsaturyan

“…As a result of the study, we propose estimations of the probability of social development scenarios of the region, where the considered demographic problems have shown high relevance, since all scenarios have chances significantly different from zero, while the most likely is the movement in the direction of “society of universal risk” (35%).Scientific novelty: given the variety of approaches to the definition and assessment of economic security, only a limited list of techniques is institutionalized, which does not always contribute to the timely prevention of threats. …”
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Tumor-specific delivery of KRAS siRNA with iRGD-exosomes efficiently inhibits tumor growth by Yu Zhou, Yuan Yuan, Minghui Liu, Xiuting Hu, Yiming Quan, Xi Chen

“…Mutant KRAS is a feature of 15–50% of lung cancer cases and represents one of the most prevalent oncogenic drivers in this disease. …”
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Evaluation of serum electrolytes and kidney function among untreated malaria (Plasmodium falciparum) patients in health centers, Konso zone, South Ethiopia by Bachaw Basire, Belayhun Kibret, Kibru Kifle, Freshet Assefa

“…Plasmodium falciparum (P. falciparum) is the species that is most commonly associated with the severe and complicated forms of malaria, especially in tropical and subtropical areas, including Ethiopia. …”
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Spatial Distribution and Monitoring of Land Subsidence Using Sentinel-1 SAR Data in Java, Indonesia by Teguh P. Sidiq, Irwan Gumilar, Hasanuddin Z. Abidin, Irwan Meilano, Ayu Purwarianti, Rahayu Lestari

“…However, past studies have mostly focused on one particular important area, while the big picture of LS on the whole island is often overlooked. …”
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Trends in HPV-positive cervical cancer prevalence: a retrospective study from 2013 to 2020 by Xiaohui Yang, Shiyuan Qi, Liyan Dai, Qingjian Ye, Xiaomao Li

“…Abstract Background Cervical cancer ranks as the fourth most common cancer among women globally, mainly linked to persistent high-risk HPV infection. …”
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Machine Learning- and Deep Learning-Based Multi-Model System for Hate Speech Detection on Facebook by Amna Naseeb, Muhammad Zain, Nisar Hussain, Amna Qasim, Fiaz Ahmad, Grigori Sidorov, Alexander Gelbukh

“…This study seeks to minimize this problem by developing an Arabic script-based tool for automatically detecting hate speech in Roman Urdu, an informal script used most commonly for South Asian digital communications. …”
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Role of Deep Fluid Injection in Induced Seismicity in the Delaware Basin, West Texas and Southeast New Mexico by K. M. Smye, J. Ge, A. Calle, A. Morris, E. A. Horne, R. L. Eastwood, R. Darvari, J. P. Nicot, P. Hennings

“…These results serve as a critical step in understanding the stress changes that induce earthquakes in one of the most seismically active and geologically complex basins in the US.…”
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