A Formulation–Process–Product Integrated Design Method for Accelerating Pharmaceutical Tablet Development via the High-Shear Wet Granulation and Tableting Route by Zichen Liang, Xuefang Tang, Liping Chen, Yifei Liu, Shuying Zhao, Xiao Ma, Gan Luo, Bing Xu

“…<b>Background/Objectives</b>: Tablet is the most popular oral solid dosage form, and high-shear wet granulation and tableting (HSWGT) is a versatile technique for manufacturing tablets. …”
Get full text

Time required to implement a computerized patient decision aid for lupus in outpatient visits by Nathan W. Carroll, Aizhan Karabukayeva, Larry R. Hearld, Diane Kamen, Alfred H. J. Kim, Sonali Narain, Narender Annapureddy, Zineb Aouhab, Maureen McMahon, Vikas Majithia, Cathy Lee Ching, Winn Chatham, Jasvinder A. Singh

“…Identifying patients eligible for the decision aid was a weekly or bi-weekly process for most clinics and took an average of 41.43 min. Conclusion The time required for a rheumatology clinic to implement the decision aid for patients with lupus is low. …”
Get full text

The wear resistance research of the rail contact surface depending on the grinding process by Pavlo Protsenko, Yurii Borodii, Mykola Bobyr, Eckart Uhlmann, Janis Thalau, Pavlo Lypovka

“…The nature of the influence of grinding process parameters (rail temperature, depth of cut, grinding wheel speed) on the wear resistance of the rail surface is established. The most optimal values of the process parameters that provide greater wear resistance of the rail surface are depth of cut - 0.007 mm, grinding wheel speed - 30 m/s, rail temperature - 20°C (it is better to conduct the processing of rails in the warm season). …”
Get full text

Compulsive Sighing: Very Common but Unknown to Many and Often Misdiagnosed as Asthma or Anxiety Disorder by Mahavir Satishchand Bagrecha, Shailesh Bhanudas Meshram, Lekshmi Rajendran Surabhy

“…Conclusion: Compulsive sighing is a common diagnosis, but most cases remain undiagnosed or misdiagnosed as asthma or anxiety. …”
Get full text

Optimizing intelligent reflecting surface assisted visible light communication networks under blockage and practical constraints using TLBO for IoT applications by Vipul Dixit, Ajit Kumar, Nishant Sharan, Shikha Pandey, Atul Kumar, Ram Sewak Singh

“…Additionally, detailed convergence analysis demonstrates that TLBO performs better than Genetic Algorithm (GA) and Particle Swarm Optimization (PSO) in terms of convergence speed, higher fitness value and lower sensitivity to initial conditions, making it most suitable for real-time IRS-VLC based IoT applications.…”
Get full text

Complete chloroplast genomes of three Pleurozia species and comparative analyses with P. purpurea: codon usage bias and phylogeny by Sheng Bi, Sheng Bi, Qin Liu, Jie-Wei Hao, Xiang-Zhe Cai, De Gao, Li-Na Zhang, Li-Na Zhang

“…The IR regions also displayed significantly lower sequence divergence compared to the single-copy regions. Most protein-coding genes were subject to purifying selection, whereas ycf66 and ndhD showed signs of positive selection. …”
Get full text

Determining the Traction Characteristic of a Tractor in Operating Conditions by A. G. Arzhenovskiy, D. S. Kozlov, N. A. Petrishchev

“…One of the most important aspects in terms of increasing the efficiency of agricultural production is the improvement of the methods and tools of determining the main operating indicators of tractors as they influence the productivity, efficiency and ecological safety of machine­tractor units. …”
Get full text

Rating of perceived exertion as a tool for managing exercise intensity during pregnancy: a scoping review by Christina Gjestvang, Lene A H Haakstad, Malin Landro Olsen, Emilie Mass Dalhaug

“…However, the determination and monitoring of exercise intensity seem to be a particular source of confusion, and the most effective method to monitor exercise intensity remains uncertain. …”
Get full text

Comparative Evaluation of Dynamic Maceration and Ultrasonic Assisted Extraction of Fucoidan from Four Arctic Brown Algae on Its Antioxidant and Anticancer Properties by Ekaterina D. Obluchinskaya, Olga N. Pozharitskaya, Irina M. Lapina, Anna A. Kulminskaya, Elena V. Zhurishkina, Alexander N. Shikov

“…The treatment of HeLa G-63 cells with all studied fucoidans for 48 h increased concentration-dependently the number of dead cells. The most promising were Fv and Fs fucoidans with high phlorotannins, low sulfates, and uronic acid extracted by DM. …”
Get full text

Signs of connective tissue dysplasia in women with genital prolapse by A. S. Ustyuzhina, M. A. Solodilova, A. V. Polonikov, S. P. Pakhomov, U. G. Shokirova

“…The number of studies pinpointing the cause of the disease in connective tissue dysplasia (CTD) has been increasing annually.Aim: to conduct a systematic analysis and determine most common signs of CTD in women with genital prolapse.Materials and methods. …”
Get full text

A radiomics-based interpretable model integrating delayed-phase CT and clinical features for predicting the pathological grade of appendiceal pseudomyxoma peritonei by Dong Bai, Guanjun Shi, Yuanzi Liang, Fang Li, Zhuozhao Zheng, Zhiqun Wang

“…DCA confirmed greater clinical utility across most threshold probabilities, with favorable Brier scores (training:0.124; testing:0.142) indicating excellent calibration. …”
Get full text

Magnitude and associated factors of disrespect and abusive care among laboring mothers at public health facilities in Borena District, South Wollo, Ethiopia. by Mulusew Maldie, Gudina Egata, Muluken Genetu Chanie, Amare Muche, Reta Dewau, Nigusu Worku, Mamo Dereje Alemu, Gojjam Eshetie Ewunetie, Tesfaye Birhane, Elsabeth Addisu, Wolde Melese Ayele, Metadel Adane

“…<h4>Result</h4>Almost four out of five (79.4%) women experienced at least one type of disrespect and abuse during facility-based childbirth. The most frequently reported type of disrespect and abuse was non-consented care 63.7%. …”
Get full text

One Axis, Two Faces: The Shared Biology of PMS and Migraine by Michalina Makieła, Weronika Koziak, Marta Makieła, Aleksandra Bętkowska, AGATA KORNACKA, Aleksandra Zając, Kamila Szostak, Rafał Tomaka, Daniel Worobiej, Stanisław Dudek

“…Both disorders are characterized by cyclical patterns tied to hormonal fluctuations—most notably the abrupt withdrawal of estrogen and changes in progesterone levels during the luteal phase. …”
Get full text

In-frame germline TP53 variant impairs p53 oligomerization and predisposes to cancer by Lucie Vanikova, Eva Machackova, Barbora Nemcova, Jana Soukupova, Silvia Petrezselyova, Klara Novakova, Marcela Zenatova, Sarka Pavlova, Petra Kleiblova, Zdenek Kleibl, Lenka Foretova, Libor Macurek

“…Abstract Germline loss-of-function variants in TP53 cause Li–Fraumeni syndrome (LFS) characterized by an early onset of various cancer types including sarcomas, adrenocortical carcinoma, and breast cancer. The most common are mutations in the DNA binding domain of p53, but alterations in the oligomerization domain also cause LFS with variable level of penetrance. …”
Get full text

Measurement report: Per- and polyfluoroalkyl substances (PFAS) in particulate matter (PM₁₀) from activated sludge aeration by J. P. Kizhakkethil, Z. Shi, A. Bogush, I. Kourtchev

“…The total PFAS concentrations in PM<span class="inline-formula">₁₀</span> were 15.49 and 4.25 pg m<span class="inline-formula">⁻³</span> during autumn and spring campaigns, respectively. PFBA was the most abundant of the PFAS, suggesting a shift towards short-chain PFAS use. …”
Get full text

Assessment of hydrological response to soil and water conservation measures in the Loess Plateau based on a novel modeling framework by Xixi Wu, Xuehua Zhao, Xuerui Gao, Bowen Zhu, Xueping Zhu, Xining Zhao, Pan Chen, Xiaoqi Guo, Marie Rose IRIBAGIZA

“…Compared to other measures, the berm measure was most effective in reducing surface runoff, with its runoff component was mainly in the form of interflow, accounting for 94.2 %. …”
Get full text

Integrating socio-ecosystemic factors in One Health approaches: a scoping review in zoonotic disease research by Anthony Giacomini, Agnès Waret-Szkuta, Tephanie Sieng, Didier Raboisson, Guillaume Lhermie, Marisa Peyre, Hélène Guis

“…The social factor “hunting, poaching and wildlife trafficking” was the most referenced, with 24 citations. Only 15 % of the studies were considered truly “interdisciplinary” because they integrated all three dimensions of the socio-ecosystem, and their publication dates show that the issue has only recently been taken up. …”
Get full text

Single‐center study to determine the safety and efficacy of CT‐707 in Chinese patients with advanced anaplastic lymphoma kinase‐rearranged non‐small‐cell lung cancer by Peng Song, Xiaotong Zhang, Dongliang Yang, Hanping Wang, Xiaoyan Si, Li Zhang

“…After treatment, grade 3 diarrhea (600 mg once a day) was found as dose‐limiting toxicity (DLT).The most common adverse events included diarrhea (92%), elevated aspartate aminotransferase (61%), elevated alanine aminotransferase (54%), hair loss (38%), and vomiting (31%). …”
Get full text

The Effect of Wheat Mixtures on the Powdery Mildew Disease and Some Yield Components by Ning LI, Shao-feng JIA, Xiu-na WANG, Xia-yu DUAN, Yi-lin ZHOU, Zong-hua WANG, Guo-dong LU

“…The cultivar combinations tested in 2007 showed increase of grain yield, while most of the combinations tested in 2010 did not show the increase. …”
Get full text

11 Using human-centered design to improve cervical cancer screening for people experiencing homelessness by Natalia Rodriguez, Lara Balian, Abigail Higgins, Rebecca Ziolkowski, Kalesia Smith, Bridget Hawryluk, Andrea Kiser, Sarah Wiehe

“…Despite common misconceptions regarding indifference toward preventive healthcare among homeless populations, most (87%) wanted to be screened and believed it is important for their health. …”
Get full text