Potentially inappropriate medication and its associated factors in older people living in nursing homes: a cross-sectional study by Ester Goutan-Roura, Geovanna O. Carneiro, Francisca S.M. Moreira, Montse Masó-Aguado, Pau Moreno-Martin, Eduard Minobes-Molina, Dawn A. Skelton, Javier Jerez-Roig

“…Polypharmacy (≥5 drugs) occurred in 69.1% (94), while extensive polypharmacy (≥10 drugs) occurred in 18.4% (25). The most prevalent PIMs were benzodiazepines (57.3%; 73), antipsychotics (48.5%; 66) and proton pump inhibitors (39.7%; 54). …”
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Resmetirom in the management of metabolic associated steatohepatitis (MASH): a review of efficacy and safety data from clinical trials by Ikponmwosa Jude Ogieuhi, Gbolahan Olatunji, Emmanuel Kokori, Olanrewaju Adeniran, Wuraola Awosan, Ifeoma Kwentoh, Owolabi Samuel, Oluwafemi Isaiah Ajimotokan, Okam Onyinyechi Victoria, Abdulrahmon Moradeyo, Deborah Aboyeji, Tejiri Napoleon, Chidinma Udojike, Chimezirim Ezeano, Yewande Abigail Adebayo, Reem Gamaleldin Hassan Mohamed, Nicholas Aderinto

“…It also reduced hepatic fat content in most studies, with the exception of one investigating a healthy subject. …”
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A reproducible ddRAD-seq protocol reveals novel genomic association signatures for fruit-related traits in peach by Najla Ksouri, Gerardo Sánchez, Carolina Font i Forcada, Bruno Contreras-Moreira, Yolanda Gogorcena

“…This approach produced 13,045 high-confidence SNPs and identified Blink as the most suitable model, effectively balancing false positive and negative associations. …”
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Genetically distinct Hajj and South American-related strains of serogroup W Neisseria meningitidis causing invasive meningococcal disease in Ontario, Canada, January 1, 2015 to Jun... by Courtney Meilleur, Julianne Kus, Christine Navarro, Vinita Dubey, Jay Lucidarme, Ray Borrow, Raymond S.W. Tsang

“…Results: The percentage of culture-confirmed IMD caused by MenW in Ontario increased from 10 % in 2015–40.9 % in the first half of 2024, consisting entirely of strains belonging to the ST-11 CC. cgMLST comparison of the Ontario invasive MenW isolates versus international MenW ST-11CC strains showed that the Ontario isolates were related to those found globally, with a recent cluster of eight cases from one city due to a strain highly related to international Umrah outbreak strains. Most MenW IMD cases (60 %) occurred in individuals older than 40 years of age and the majority (83.3 %) predicted to express antigens covered by the 4CMenB vaccine. …”
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Gender Difference in Frequency, Types, Risk Factors and Outcome in Stroke Patients by Naeemuddin SHAIKH, Teerth DAS, Deepa KUMARI, Heema MADHUMAL, Irfana ABBASI

“…Hemorrhagic stroke (55.6%) was more frequent than ischemic stroke (44.4%). The most prevalent modifiable risk factors were tobacco/paan/gutka use (56.3%), hypertension (41.7%), smoking (46.4%), and diabetes mellitus (28.5%). …”
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Half-thickness discretized format for simulating compressible delay interbed by Shangqi Han, Chuiyu Lu, Wen Lu, Qingyan Sun, Chu Wu

“…Abstract The simulation of compressible delay interbed is an important component of ground subsidence modeling. Currently, the most widely used groundwater simulation software, MODFLOW, has two modules: SUB and CSUB. …”
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The Fusion Gene <i>BPI-LY</i>, Encoding Human Bactericidal/Permeability-Increasing Protein Core Fragments and Lysozyme, Enhanced the Resistance of Transgenic Tomato Plants to Bacte... by Lei Ni, Yue Zhang, Yafei Qin, Mei Wang, Daodao Tang, Liantian Chen, Xing Ding, Yilin Zheng, Yu Pan, Jinhua Li, Xingguo Zhang

“…Tomato bacterial wilt, caused by <i>Ralstonia solanacearum</i> (G⁻), is one of the most devastating plant diseases. Developing effective resistance against this pathogen remains a major challenge in plant disease management. …”
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Terpenoids and phenolic compounds as biologically active compounds of medicinal plants with diuretic effect by V. A. Kurkin, O. E. Pravdivtseva, E. N. Zaitseva, A. V. Dubishchev, A. S. Tsibina, A. V. Kurkina, S. V. Pervushkin, A. V. Zhdanova

“…It was determined that the diuretic activity of most of the medicinal plants used, is due to such groups of biologically active compounds as terpenoids (essential oils and saponins), simple phenols, flavonoids and anthracene derivatives related to the secondary metabolites. …”
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A simple, low-cost, and highly efficient protocol for rapid isolation of pathogenic bacteria from human blood by Fatma S. Coskun, Joshua Quick, Erdal Toprak, Erdal Toprak

“…Bacteremia is a serious clinical condition in which pathogenic bacteria enter the bloodstream, putting patients at risk of septic shock and necessitating aggressive antibiotic treatment. Choosing the most effective antibiotic is crucial not only for resolving the infection but also for minimizing side effects, such as dysbiosis in the healthy microbiome and mitigating the evolution of antibiotic resistance. …”
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Diffusivity alterations related to cognitive performance and phenylalanine levels in early-treated adults with phenylketonuria by Jèssica Pardo, Clara Capdevila-Lacasa, Bàrbara Segura, Adriana Pané, Pedro J. Moreno, Glòria Garrabou, Josep M. Grau-Junyent, Carme Junqué, Consortium PKU.cat

“…Results Patients exhibited a widespread white matter tract involvement, with lower MD and higher FA values compared to controls. The most affected tracts were the inferior longitudinal fasciculus and inferior fronto-occipital fasciculus for MD, and the anterior corona radiata, uncinate fasciculus and forceps minor for FA. …”
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Genetic Diversity and Virulence Factors of S. aureus Isolated from Food, Humans, and Animals by Roberto Adame-Gómez, Natividad Castro-Alarcón, Amalia Vences-Velázquez, Jeiry Toribio-Jiménez, Abigail Pérez-Valdespino, Marco- Antonio Leyva-Vázquez, Arturo Ramírez-Peralta

“…Profile 4 (490 bp, 300 bp) was the most frequent, containing a higher number of strains with a higher number of virulence factors and antimicrobial resistance, which is associated with greater adaptation to different environments. …”
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Applicability of Virtual Commissioning Concepts in Industrial Robotics as a Solution for Compatibility Issues Between Virtual Simulation and Logic Control Software by Alexandru Andrei, Florin-Adrian Nicolescu, Cristina Pupăză, Cezara-Georgia Coman, Ionuț Gabriel Ghionea

“…The TIA Portal is recognized by robotics application integrators as the most efficient work environment for VC. However, there is currently no direct compatibility between the ABB RobotStudio (RS) platform and Siemens TIA Portal. …”
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Increased lipoprotein (a) as an additional factor in the failure to achieve target blood pressure levels and lipid spectrum optimal parameters in patients with arterial hypertensio... by S. S. Vedenskaya, O. G. Smolenskaya

“…In both groups, the majority of patients were on a free combination of antihypertensive drugs, only a third of patients used a fixed combination. In most cases, patients of both groups did not reach the target blood pressure levels (63.9% — group 1, 55.3% — group 2), despite the fact that the average blood pressure figures were relatively low (132;83 mmHg in each group). …”
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Arterial Destiffening Starts Early after Renal Artery Denervation by Andrius Berukstis, Rokas Navickas, Gintarė Neverauskaite-Piliponiene, Ligita Ryliskyte, Jonas Misiura, Donatas Vajauskas, Nerijus Misonis, Aleksandras Laucevicius

“…Renal artery denervation (RDN) is a new widely discussed method in treatment of hypertension. Most of the RDN studies assessed BP and arterial changes 3 and 6 months after the procedure, but there is a lack of trials that investigated early changes after RDN. …”
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Risks of using digital technologies in the activities of local government bodies by M. A. Lipchanskaya, S. E. Channov, A. Yu. Churikova

“…The choice of the research object is conditioned by the fact that currently most acts in the field of digitalization of public authority affect the federal or regional level, meanwhile, the digital transformation of local self-government has its own specificity, due to the peculiarities of this level of social management, which should be taken into account in the legal regulation.The purpose of the study: identify the risks that have a negative impact on the process of digital transformation of local governance, and propose measures to minimize or eliminate the identified risks by legal means.Methodology. …”
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Tadalafil Once a Day for Men with Erectile Dysfunction: Is It Superior than On-Demand Administration? by Dimas Tri Prasetyo, Putu Angga Risky Raharja, Ben Julian Mantiri, David Ralph Lienhardt Ringoringo, Irham Arif Rahman, Jody Felizio, Made Parulian Tambunan, Syifa Fauziah Fadhly, Harrina Erlianti Rahardjo

“…Based on our judgements, the study by Kang et al. was the most applicable in our clinical setting. This study showed that subjects who received tadalafil OAD had statistically significant higher increases of mean IIEF-EF (6.5 (SD 4.5) vs 4.9 (SD 4.2), p=0.032), proportion of “yes” responses to SEP-2 (81.8% vs 64.7%, p=0.025), and proportion of “yes” responses to SEP-3 (77.3% vs 60.3%, p=0.034). …”
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Recruitment Strategies for Lung Cancer Screening: An Umbrella Review Protocol [version 1; peer review: 2 approved] by Tytti Sarkeala, Patrick Redmond, Bethany Cushing, Benjamin Jacob, XinYi Low, Ildiko Horvath, Sam McGlynn, Martina Vranka

“…This umbrella review will synthesise evidence from systematic reviews to identify the most effective recruitment strategies for improving LCS participation. …”
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Differential Analysis of Hemogram Parameters and Cellular Ratios in Severe Asthma Exacerbations: A Comparative Study of Eosinophilic and Non-Eosinophilic Phenotypes by Nicolae Demenciuc, Corina Eugenia Budin, Corina Ureche, Mircea Stoian, Teodora Nicola-Varo, Dragos-Florin Baba, Dariana-Elena Pătrîntașu, Diana Deleanu

“…ROC analysis highlighted the ELR as the most specific indicator of the eosinophilic phenotype (specificity 100%, AUC 0.938, cut-off 0.003), whereas the NLR and TLR showed stronger associations with the non-eosinophilic group (AUC 0.733 and 0.676). …”
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Menstrual management using hormonal medications in adolescents and young adults with developmental disability: a systematic review and a meta-analysis by Dehlia Moussaoui, Judith Laqua, Victoria L Crofts, Camille M Nemitz-Piguet, Anne-Chantal Héritier-Barras, Arnaud Merglen, Michal Yaron

“…Breakthrough bleeding was the most common side effect and the primary reason for ceasing or switching medication. …”
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Social, Psychological and Pedagogical Problems of Digital Education in Subject’s Development by Olga Nekrasova, Anastasia Demchuk, Andrey Merezhnikov, Mariam Arpentieva

“…Consideration of the problems of digital education (that is, education organized through digital technologies, including artificial intelligence technologies) is necessarily connected with the analysis of not only pedagogical, but also social, psychological processes and effects of digital education, its influence on the formation and development of students and teachers as subjects. Most of these types of transformations should and can be considered within the framework of social and psychological transformations of human relationships and the values and ideas that govern these relationships. …”
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