Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development by Michael Swingler, Martina Donadoni, Ellen M. Unterwald, Sanjay B. Maggirwar, Ilker K. Sariyer

“…Opioids, while highly effective for pain management, are among the most addictive substances, contributing significantly to the global opioid crisis. …”
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Numerical Investigation and Optimization of Transpiration Cooling Plate Structures with Combined Particle Diameter by Dan Wang, Yaxin Liu, Xiang Zhang, Mingliang Kong, Hanchao Liu

“…The results suggest that porosity (<i>ε</i>) and <i>d_p</i> are the most crucial parameters affecting <i>η</i>_ave and <i>p</i> of CPD−PS. …”
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Application of Digital Simulation for Training Purposes Through Virtual Reality in The Workplace by Ari Prayogo Pribadi, Vena Jaladara, Chris Dwina Anggiana Br Silalahi, Yusuf Mukasyafah Rizqi Rahman

“…Conclusion: Several studies have shown that virtual reality is one of the most effective training methods at present. It is believed that the application of VR technology could be used to investigate human behavior in dangerous settings; Additionally, VR can be used to improve HSE employers' understanding of unsafe behavior. …”
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Renewable energy as an auxiliary to heat pumps: Performance evaluation of hybrid solar-geothermal-systems by Rabih Murr, Jalal Faraj, Hicham El Hage, Mahmoud Khaled

“…In addition, results revealed that the most efficient system is the (HP-G-S-D) for all simulated conditions and assumptions with a gain in COP that can reach up to 191 % in comparison to the baseline heat pump system.…”
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Reassessment of the Taxonomic Borders Within <i>Pipistrellus</i> (Chiroptera, Vespertilionidae, Pipistrellini) by Svetlana S. Zhukova, Alexander P. Yuzefovich, Vladimir S. Lebedev, Sergei V. Kruskop

“…In the “eastern” clade, the most basal position was occupied, contrary to expectations, not by the morphologically divergent <i>P. stenopterus</i>, but by <i>P. abramus</i>. …”
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Clinical Indication‐Based Pediatric Diagnostic Reference Level Values for Abdominal Computed Tomography: A Descriptive Cross‐Sectional Study by Tebello Pitso, Ida‐Keshia Sebelego, Henra Muller

“…At the time of the study, nephroblastoma was the most prevalent clinical indication for abdominal CT examinations in pediatric patients. …”
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Building the 8-star doctor: a modified Delphi study to define, teach, and assess health professions education for undergraduate medical students by Sara Jamil Khan, Rahila Yasmeen, Shazia Imran

“…Objective Structured Teaching Exercises (OSTE) emerged as the most endorsed assessment approach. Response rates for the three Delphi rounds were 93%, 96%, and 90%, respectively. …”
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Myotendinous junction: a microenvironment favorable for short-term adaptations to resistance training following gastrocnemius muscle atrophy by Lara Caetano Rocha-Braga, Jurandyr Pimentel Neto, Isabella Gomes, Adriano Polican Ciena

“…Conversely, the IT groups demonstrated a progressive increase in muscle mass, with significant improvements from 7 days (p &lt; 0.01) to 14 days (p &lt; 0.0001). The most pronounced adaptations in sarcoplasmic projections were observed in the IT14 group, which exhibited: a significant increase in the length of sarcoplasmic invaginations (p &lt; 0.05); a marked increase in sarcoplasmic evaginations (p &lt; 0.001); a substantial enlargement of the belly sarcomere (p &lt; 0.0001) and proximal sarcomere (p &lt; 0.0001); and a notable expansion of the collagen XXII perimeter (p &lt; 0.001). …”
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Particle and Particle-Surfactant Mixtures at Fluid Interfaces: Assembly, Morphology, and Rheological Description by Armando Maestro, Eva Santini, Dominika Zabiegaj, Sara Llamas, Francesca Ravera, Libero Liggieri, Francisco Ortega, Ramón G. Rubio, Eduardo Guzman

“…The different mechanisms of interfacial assembly are also addressed, being the adsorption and spreading the most widely used processes leading to the well-known adsorbed and spread layers, respectively. …”
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A comprehensive review of bibliometric and methodological approaches in flood mitigation studies: Current trends and future directions by Funmilayo Ebun Rotimi, Roohollah Kalatehjari, Taofeeq Durojaye Moshood, George Dokyi

“…The study reveals the predominance of modeling and simulation approaches, geographic information systems (GIS) remote sensing approaches, and statistical and data-driven approaches as the most widely employed methodologies. Furthermore, it highlights the growing diversity of approaches, with increasing interest in machine learning algorithms and combined methods. …”
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The Effectiveness of Laboratory Methods for the Early Differential Diagnosis of Ophthalmohlamidiosis and Conjunctival Lymphoma (Clinical Cases) by G. I. Krichevskaya, E. S. Vakhova, S. V. Saakyan, E. B. Myakoshina, A. E. Andryushin, A. M. Maybogin, O. V. Proskurina, A. V. Trukhina

“…Conjunctival lymphomas are predominantly extranodal B-cell non-Hodgkin’s lymphomas (NHL), most of them are MALT-lymphomas originating from the mucosa-associated lymphoid tissue. …”
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Epidemiological Situation on Rickettsial Diseases and Q Fever in the Russian Federation over the Period of 2010–2023, Forecast for 2024 by S. V. Shtrek, N. V. Rudakov, S. N. Shpynov, A. I. Blokh, D. V. Trankvilevsky, N. A. Pen’evskaya, L. V. Kumpan, A. V. Sannikov

“…In 2023, the rates of registered incidence of rickettsial infections and Q fever in Russia as a whole decreased relative to the long-term average level of 2010–2019, and there is a significant downward trend in most regions. The exception is the Far Eastern Federal District, where the incidence rate of STT in 2023 increased by 1.5 times as compared to the period of 2010–2019, and the city of Sevastopol, where an increase in the incidence of Marseilles fever was detected. …”
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Shafranov-shift destabilization of ballooning-type micro-instabilities by X. Jian, V. Chan, Z. Qiu, S. Ding, C. Holland, E. Bass, A. Garofalo, X. Liu

“…Contrary to common wisdom, we argue that the Shafranov shift is destabilizing for the ambient ballooning-type instabilities, which account for most of the transport flux in tokamak core plasmas. …”
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3SqAir Project: A Living Lab Towards Sustainable Smart Strategy for Indoor Climate Quality Assurance in Classrooms by James Ogundiran, Jean-Paul Kapuya Bulaba Nyembwe, John Omomoluwa Ogundiran, Ruben Alexandre de Souto Santos, Luísa Dias Pereira, Manuel Gameiro da Silva

“…The results showed inadequate thermal conditions in both classrooms, particularly during the heating season. Most weekly mean CO₂ concentrations were within acceptable limits, while ACH were below standard recommendations in four CO₂ decay phases. …”
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Antifungal activity of a maleimide derivative: disruption of cell membranes and interference with iron ion homoeostasis by Chaoqun Chen, Zhiyu Xie, Liu Cong, Shanshan Mao, Liying Wang, Yalun Wu, Yu Zhang, Qing Zhou, Aijaz Ahmad, Wenqiang Chang, Zuobin Zhu, Ying Li

“…The maleimide compound 5 (MPD) with the most potent activity demonstrated fungicidal action at a concentration that was twice as potent as the minimal inhibitory concentration and effectively prevented the formation of biofilms. …”
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Global trends in the value of simulation as a pedagogical tool in oncology: a bibliometric analysis from 2010 to 2024 by Ouissam Al Jarroudi, Ahmed Rhassane El Adib, Hind Chibani, Said Afqir, Mohammed Mouhaoui

“…The articles were published in the fields of surgical oncology (165, 38.6%), medical oncology (130, 30.4%), and radiation oncology (77, 18.0%). Additionally, most of the publications were covered by the PubMed and Web of Science core collections. …”
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Antipredator Response in Domestic Japanese Quail and Game-Farmed Quail by Pedro González-Redondo, Natalia Diego-Fuentes, Carlos Romero

“…Game-farmed quails that are currently raised in captivity and released in hunting preserves are not attractive for many hunters because of their low antipredator instinct, which is due to the fact that in most cases, these farm-reared quails are hybrids between European common (<i>Coturnix coturnix</i>) and Japanese (<i>Coturnix japonica</i>) quails, with the latter having been selectively bred for docility. …”
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STUDY OF PHARMACEUTICAL SPECIALISTS’ INFORMATION AWARENESS ON THE MATTERS OF DRUG ABUSE by N. Yu. Porseva, A. V. Soloninina, O. N. Dvorskaya

“…Prevention of non-medical use of drugs is the most important task of the state anti-drug policy of the Russian Federation, the effectiveness of which can largely be due to the professional awareness of pharmaceutical specialists, their compliance with the established regulations for the dispensing of drugs, and proper pharmaceutical advice.The aim. …”
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The olfactory bulb - gateway for SARS-Cov-2? by Jovanović Aleksandar, Niković Jelena, Boban Nikola, Pejin Radoslav, Samardžić Filip

“…Anosmia and ageusia are one of the most common and characteristic symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection, with a frequency of almost 50% in patients in Western countries. …”
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Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis by Qingzhou Song, Xuanlin Wu, Firooz Ahmad Taheri, Linghou Meng, Wentao Wang, Xianwei Mo

“…Subgroup analyses showed no significant interactions between RDW and most subgroups. Conclusion Elevated RDW is independently associated with increased short- and long-term all-cause mortality in patients with AP and sepsis.…”
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