Evaluation of the Effectiveness and Safety Profile of First-Line Immune Checkpoint Inhibitors Combined with Chemotherapy in Pulmonary Sarcomatoid Carcinoma by Du H, Song X, Wu F

“…The median PFS was 13.3 months (95% CI, 10.2– 15.7) and median OS was not reached. The most common immune-related adverse events were pneumonitis, the incidence of which was 13.2%. …”
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Size‐Dependent Genetic Erosion due to Human Logging and Conservation Recommendation for an Endangered Yew (Taxus fuana) in Tibet, China by Xiao‐Lu Shen‐Tu, Yan Chen, Jun‐Yin Deng, Yao‐Bin Song, Ming Dong

“…Field surveys across six Gyirong sites indicated that trees with basal diameters of 6–30 cm experienced the most severe logging damage, particularly at Jilong (JL) and Langjiu (LJ). …”
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Evolutionary fuzzy learning for Chinese medicine liver syndrome differentiation by Jia-Yu Yan, Peng-Wei Zhang, Wei-Guo Sheng, Jun-Ping Shi, Wei Ni, Li Li, Yu-Jun Zheng

“…To effectively overcome the uncertainty and improve the interpretability, we proposed an evolutionary fuzzy learning method for syndrome differentiation of the TCM liver system, which used neuro-fuzzy inference systems to infer the severity of six typical syndromes (liver depression, liver blood deficiency, liver yin deficiency, liver-fire, liver-cold, and damp-heat liver-gallbladder) based on a wide set of symptoms as input features. To determine the most appropriate fuzzy membership functions of the fuzzy learning machines, an evolutionary algorithm was employed to optimize the types and parameters of the fuzzy functions simultaneously. …”
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Astroglia’s role in synchronized spontaneous neuronal activity: from physiology to pathology by Aswathy Ammothumkandy, Alisha Cayce, Mohammad Shariq, Michael A. Bonaguidi, Michael A. Bonaguidi, Michael A. Bonaguidi, Michael A. Bonaguidi, Michael A. Bonaguidi, Michael A. Bonaguidi

“…Aberrant neuronal hyperactivity is a pathological phenotype associated with several neurological disorders, with its most severe effects observed in epilepsy patients. …”
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Poor-tasting pediatric medicines: Part 1. A scoping review of their impact on patient acceptability, medication adherence, and treatment outcomes by Sejal R. Ranmal, Sejal R. Ranmal, Jennifer Walsh, Catherine Tuleu

“…The impact of poor-tasting medicines was observed across 77 diseases or indications, with 156 different unpalatable medicinal products identified. Outcomes were most frequently linked to reduced patient acceptability, with 64% of articles reporting rejection responses, the need for strategies to aid administration (from positive reinforcement to physical restraint and forced administration), and impacts on prescribing practices (e.g., use of non-first line alternative therapies). …”
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Insulin-like Growth Factor-1 and Myocardial Remodeling in Patients with Chronic Heart Failure of Ischemic Origin by A. N. Zakirova, N. E. Zakirova, D. F. Nizamova

“…Patients with class II CHF were hyperexpression of IGF-1, with class III CHF were registered low-normal level, with class IV CHF was established a deficiency of IGF-1. The most significant structural-geometric rearrangement of LV and significant deficit of IGF-1 recorded in patients with class IV CHF (95,6±7,02 ng/ml with class IV CHF versus 178,3±11,36 ng/ml and 124,3±9,14 ng/ml with class II and III CHF; р<0,05). …”
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Parcs agroforestiers sahéliens : de la conservation à l’aménagement by G. Smektala, R. Peltier, N. Sibelet, M. Leroy, R. Manlay, C. F. Njiti, M. Ntoupka, A. Njiemoun, O. Palou, Tapsou

“…Various types of wooded parklands have been created, depending on the composition of the original tree population, the ecological conditions, the know-how and requirements of the local populations and their socio-economic environment. The most well known are the faidherbia parklands (Faidherbia albida) and the shea parklands (Vitellaria paradoxa).Between 1950 and 1990, the forestry Department had a policy to protect trees located in fields and in indigenous forests, by prohibiting the cutting of trees. …”
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DiffViT-IBFD: A rolling bearing fault diagnosis approach based on diffusion model and vision transformer under data imbalance conditions by Zheru Dong, Wen Zhao, Di Zhu, Zixin Zhang, Yuheng Ren

“…Rolling Bearing fault data collected from industrial sites often exhibit class distribution imbalance, which significantly degrades the performance of deep learning-based intelligent bearing fault diagnosis models. Currently, most existing studies use the Generative Adversarial Network (GAN) to generate samples from the minority class, thereby improving the model's performance. …”
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Resilience of the Port Industry to Socioeconomic Challenges: The Role of Human Capital by Aly Assem, Mohamed Wahba, Eman El Haddad, Mohamed Ragheb

“…Employees aged 36-50 and those with 6-15 years of experience showed the most significant performance improvements, with mid-career personnel driving the reduction in idle time. …”
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Mortality of trauma patients in conflict-affected region: a retrospective observational study of ICU admissions and surgical management by Jacques Fadhili Bake, Phalek Kambere Mukama, Mumbere Kigayi Jean-Pierre, Kabuyaya Kakule Medard, Munyantwari Akomu Eugene

“…Traumatic brain injury was the most common diagnosis (39.5%), and only 39.5% of patients underwent surgery. …”
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Role of hydrometeorological factors and solar activity in interannual variability of ice extent in the East Siberian Sea by L. A. Timokhov, V. E. Borodachev, I. V. Borodachev, N. A. Vyazigina, E. U. Mironov, M. Janout

“…These equations were used to calculate contribution of each factor to the general dispersion of fluctuations of the ice coverage. The most important factors influencing the ice cover of the Sea in August and September are: the air temperature; the atmospheric circulation, presented by the Arctic Oscillation at the end of winter; and Atlantic waters which are characterized by AMO with a time lag of eight years. …”
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Study of the Dynamics of Diflunisal Release from a Polymer Matrix by P. A. Mihajlova, A. A. Adamova, Yu. E. Generalova, P. P. Snetkov, S. N. Morozkina

“…The release rate for all samples exceeded 90 % after 3 hours after the start of the experiment, with most of the active substance released within an hour.Conclusion. …”
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Injury Related to Fall and Its Predictors among Medically Diagnosed Adults with Visual Impairment in Ethiopia: An Observational Cross-Sectional Study by Moges Gashaw, Biruk Adie Admass

“…Soft tissue injuries were the most common fall-related injuries reported by the study participants. …”
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Optimization of local dry underwater laser welding process for stainless steel based on orthogonal experiment by Xingshuai LI, Qinghua ZHANG, Yongqing ZHAO, Yingjie CHEN, Qingjie SUN, Yibo LIU, Yifeng TIAN

“…To investigate the effects of various parameters on the melt width, melt depth, and porosity of the welds, and to explore the influence of the most significant parameters on the mechanical properties of the joints, an underwater welding platform was independently built to conduct underwater partial dry laser welding on 304 stainless steel. …”
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Impact of mobile learning operating room principles and communication skills on nursing college students: a quasi-experimental study by Sajjad Ranjbar Kouchaksaraei, AmirHossian Yousefinya, Bagher Khoram, Camellia Torabizadeh, Fatemeh Vizeshfar

“…Since medical students experience most of their learning in clinical settings, attention should be given to developing software and applications in the clinical domain. …”
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Identification of SURF4 and RALGAPA1 as promising therapeutic targets in glioblastoma and pan-cancer through integrative multi-omics, CRISPR-Cas9 screening and prognostic meta-anal... by Fei Wang, Yuxuan Chen, Run Huang, Dengfeng Lu, Juyi Zhang, Yanbo Yang, Hanhan Dang, Meirong Liu, Zhouqing Chen, Xiaoou Sun, Zhong Wang

“…Abstract Glioblastoma (GBM) is the most aggressive and malignant type of primary brain tumor, with a median survival time of less than two years and a uniformly poor prognosis, despite multimodal therapeutic approaches, which highlights an urgent need for novel therapeutic targets. …”
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Association between socioeconomic factors and cancer risk: a population cohort study in Scotland (1991-2006). by Katharine H Sharpe, Alex D McMahon, Gillian M Raab, David H Brewster, David I Conway

“…Occupational social class associations were most pronounced and elevated for UADT risk. No car access (versus ownership) was associated with increased risk (excluding all cancer risk, males). …”
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The myoblast methylome: multiple types of associations with chromatin and transcription by Sagnik Sen, Michelle Lacey, Carl Baribault, V. K. Chaithanya Ponnaluri, Pierre Olivier Esteve, Kenneth C. Ehrlich, Mia Meletta, Sriharsa Pradhan, Melanie Ehrlich

“…In contrast, brain-specific OLIG2 was in repressed chromatin and silent in most cell types but linked to hypermethylated DMRs specifically in myoblasts. …”
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INSTITUTIONALIZING UKRAINE’S POST-WAR RECONSTRUCTION by Glib Aleksin

“…The paper concludes that institutionalizing recovery is Ukraine’s most strategic path toward rebuilding not only what has been destroyed, but also what was previously weak or dysfunctional. …”
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ASSOCIATION OF MATRIX METALLOPROTEINASES GENE POLYMORPHISM WITH CLINICAL MANIFESTATIONS OF BRONCHIAL ASTHMA IN CHILDREN by A. A. Lebedenko, T. P. Shkurat, E. V. Mashkina, O. E. Semernik, T. K. Dreyzina, E. B. Tyurina

“…Homozygous C/C variant of the polymorphic ММР20 gene, 320A>C heterozygous variant of the ММР20 Val275Ala polymorphism, and heterozygous locus of -8202A>G ММР9 gene were found to be most frequent among the children with asthma. Generally, we have observed that the frequencies of the studied alleles and genotypes did not significantly differ berween the asthma patients and children from the control group (p < 0.05). …”
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