Status of temozolomide use without insurance coverage in patients with aggressive pituitary neuroendocrine tumors by Atsushi Ishida, Naoko Inoshita, Noriaki Tanabe, Koji Takano, Hideki Shiramizu, Haruko Yoshimoto, Masataka Kato, Go Matsuoka, Shozo Yamada

“…Furthermore, one case of a lactotroph tumor, which achieved remission with CAPTEM but was discontinued after three years for financial reasons, remains in remission on imaging and maintained normal PRL levels for 15 months after discontinuation. The most significant issue is off-label use. Concern exists that financial constraints may prevent future patients from using TMZ.…”
Get full text

A Multi-Goal Particle Swarm Optimizer for Test Case Prioritization by Muhammad Nazir, Arif Mehmood, Waqar Aslam, Yongwan Park, Gyu Sang Choi, Imran Ashraf

“…This study proposes an approach based on MOPSO that focuses on maximum fault coverage, most circumstance insurance, and minimal execution time. …”
Get full text

Investigating bidirectional causal relationships between gut microbiota and insomnia by Fuquan Zhang, Ancha Baranova, Hongbao Cao, Shangyun Shi, Dongming Liu

“…Cochrane’s Q test indicated no significant heterogeneity between most single-nucleotide polymorphisms. In addition, no significant level of pleiotropy was found according to MR-Egger and MR-PRESSO.Conclusions Our study highlighted the reciprocal relationships between gut microbiota and insomnia, which may provide new insights into the treatment and prevention of insomnia.…”
Get full text

Safety-specific transformational leadership and safety outcomes at workplaces: a scoping review study by Fakhradin Ghasemi, Mohsen Mahdinia, Amin Doosti-Irani

“…Results Coined in 2002, SSTL is a distinct construct from general transformational leadership with a greater influence on safety outcomes. Most studies are conducted in Canada and among construction workers. …”
Get full text

Dose-dependent impact of tixagevimab–cilgavimab as primary prevention against SARS-CoV-2 in immunocompromised individuals by Daniela Dluzynski, Paddy Ssentongo, Cory M. Hale, Shareef K. Shaheen, Natella Maglakelidze, Jeffrey M. Sivik, Maria Paula Henao, Vernon M. Chinchilli, Catharine I. Paules

“…There was a trend towards protection with increasing dose from 150 (HR 0.83, CI 0.50–1.38) to 600 mg (HR 0.48, CI 0.06–3.63) when truncating data on November 1st, 2022, which was also seen in HSCT or CAR-T cell therapy recipients, 150 mg (HR 0.71, CI 0.31–1.65) to 600 mg (HR 0.26, CI 0.01–7.47). This was most evident in immunocompromised individuals when variants neutralized by tixagevimab–cilgavimab in vitro were circulating; effectiveness 74%. …”
Get full text

Impact of Chemotherapy Alone and in Combination with Immunotherapy on Oral Microbiota in Cancer Patients—A Pilot Study by Adriana Padure, Ioana Cristina Talpos-Niculescu, Paula Diana Ciordas, Mirabela Romanescu, Aimee Rodica Chis, Laura-Cristina Rusu, Ioan Ovidiu Sirbu

“…The oral cavity harbors a highly intricate and dynamic microbial ecosystem of multiple microhabitats supporting diverse microbial populations. As the second most complex microbiome in the human body, surpassed only by the gut, the oral microbiome comprises over 1000 species. …”
Get full text

Similarity measure for intuitionistic fuzzy sets and its applications in pattern recognition and multimodal medical image fusion by Anjali Patel, Deepa Gupta, E. A. Gopalakrishnan, Divya Sasidharan, V. Sowmya, Mohammed Zakariah, Abdulaziz S. Almazyad

“…Experimental results reveal that the proposed IFSM and fusion approach achieve superior performance compared to most existing methods.…”
Get full text

Selection for Growth Performance in <i>Oreochromis niloticus</i> Across Different Aquatic Environments Using Growth Hormone Gene Polymorphisms by Fawzia S. Ali, Simone T. Awad, Mohamed Ismail, Shabaan A. Hemeda, Abeer F. El Nahas, Eman M. Abbas, Ahmed Mamoon, Hani Nazmi, Ehab El-Haroun

“…Furthermore, their progenies documented the most promising gene expression patterns of all tested genes. …”
Get full text

Provider experiences with and attitudes about an embedded pragmatic clinical trial by Sarah M. Leatherman, Britte Beaudette-Zlatanova, Gregory Robben, Peter A. Glassman, Patricia Woods, Ryan E. Ferguson, William C. Cushman, Areef Ishani

“…Results There were 180 completed surveys. Of those, most found the trial question of interest (91%) and found the time required to participate in the trial was reasonable (67%). …”
Get full text

Importance of early transfer to higher levels of in-patient care – an experience from a lower-middle-income country by Huzefa Jibril, Syed Ahsan Ali, Safia Awan, Muhammed Tariq

“…There were 310(50.2%) females and 307(49.8%) males with mean age 52.2±18.8 years. The most common comorbidity was hypertension 288(46.7%). …”
Get full text

Applications of beta-carotene in food technology by E. V. Lisovaya, T. I. Ugryumova, T. A. Shakhrai, E. P. Viktorova, A. A. Skhalyakhov

“…It has been shown that the most promising system for delivering beta-carotene to food systems is the encapsulation system in the form of micro emulsions, which allows increasing its stability and bioavailability, ensuring the preservation of the high bioactive potential of beta-carotene.…”
Get full text

Beta-Catenin Mutations Can Impact on the Interplay Between Tumor and Immune Cells and Hepatic Microbiota in Hepatocellular Cancer by Ota Y, Driscoll J, Hill AR, Yan IK, Patel T

“…Alterations in β-catenin are among the most frequently observed oncogenic drivers of hepatocarcinogenesis and are associated with T-cell exclusion. …”
Get full text

Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood–brain barrier permeability by Suyi Liu, Xingyue Jin, Yuanyuan Ge, Junlin Dong, Xinyue Liu, Xiao Pei, Ping Wang, Bing Wang, Yanxu Chang, Xie-an Yu

“…Abstract The blood–brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). …”
Get full text

An attachment‐based program for parents of youth with clinically significant mental health problems: Scaling up and drilling down to mechanisms of change by Marlene M. Moretti, Sebastian P. Dys, Stephanie G. Craig, Carlos A. Sierra Hernandez, Natalie Goulter, Katherine O’Donnell, Dave S. Pasalich

“…Such interventions are most likely to succeed in meeting population needs if they are scalable, sustainable, and effective. …”
Get full text

Predictive factors of waste disposal behaviours among university undergraduates: implications for public health and the realization of sustainable development goals (SDGs) by Abidemi Kafayat Adegbore, Moruf Ayobami Lawal, Aderemi Temitayo Olabode, Sabitu Aishat Ayodeji, Faridah Abidemi Mustapha

“…Papers/cardboard (21.4%) constituted most of the waste generated. The respondents had a good knowledge of waste disposal (71%); positive attitudinal disposition (89%) towards waste disposal; and good waste disposal practice (84.3%). …”
Get full text

Quasars Can Signpost Supermassive Black Hole Binaries by J. Andrew Casey-Clyde, Chiara M. F. Mingarelli, Jenny E. Greene, Andy D. Goulding, Siyuan Chen, Jonathan R. Trump

“…We find at 95% confidence that quasars are at most 5 times as likely to host an SMBHB as a random galaxy. …”
Get full text

Phenolic Extracts of Zizyphus lotus L. (Rhamnaceae) and Ruta chalepensis L. (Rutaceae) as Alternatives to Antibiotics and their Antimicrobial Effects on Clinical Multidrug-Resist... by Nour El Houda Bekkar, Boumediene Meddah, Yavuz Selim Çakmak, Bahadır Keskin, Pascal Sonnet

“…Important antimicrobial activity was observed against all the clinical pathogen strains. The most potent effect was estimated against MDR Salmonella enterica sp. arizonae with 20±0.1mm of growth inhibition zone diameter using RCMeOH.E, while a diameter of 35.03±0.06 mm was measured using ZLMeOH.E. …”
Get full text

Evaluación nutricional y su repercusión en la capacidad funcional en pacientes urémicos terminales con diálisis by Judith Rodriguez Tamargo, Leonardo Almaguer Arena, Reynaldo Labrada Pupo, Maigre Gallo González, Annia Kirenia Pérez Reverón

“…The group of the normal weight was the most representative (67 cases, representing 71.2%). …”
Get full text

The Development of a Kinetic Model for Biochar Gasification with CO₂: Comparison Between a Thermogravimetric Analyzer and a Fluidized Bed Reactor by Luis Reyes, Michael Jabbour, Lokmane Abdelouahed, Bechara Taouk

“…In the TGA, the PLM provided the best fit to experimental data, with standard deviations of 2.6–9%, while in the FBR, the SCM was most accurate, yielding an average deviation of 1.5%. …”
Get full text

Differences in Imaging and Histology Between Sinonasal Inverted Papilloma with and Without Squamous Cell Carcinoma by Niina Kuusisto, Jaana Hagström, Goran Kurdo, Aaro Haapaniemi, Antti Markkola, Antti Mäkitie, Markus Lilja

“…<b>Results:</b> The nasal cavity and ethmoid and maxillary sinuses were the most common sites for both tumor types. The SNIP tumors were mostly unilateral, and the SNIP-SCC tumors were both unilateral and bilateral. …”
Get full text