Bayesian Integration of Bronchoalveolar Lavage miRNAs and KL-6 in Progressive Pulmonary Fibrosis Diagnosis by Piera Soccio, Valerio Longo, Corrado Mencar, Pasquale Tondo, Fabiola Murgolo, Giulia Scioscia, Donato Lacedonia

“…<b>Background/Objectives</b>: Progressive pulmonary fibrosis (PPF) represents one of the most severe and complex challenges in respiratory medicine, characterized by a rapid decline in lung function and often poor prognosis, making it a priority in research on interstitial lung diseases (ILDs). …”
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Translation, adaptation, and validation of Person-Centered Primary Care Measures for patients in family doctor contract services within mainland China by Yang Wang, Dehua Yu, Hua Jin

“…Results The study led to the development of the PCPCM-Simplified Chinese version tailored for patients receiving family doctor contract services (PCPCM-SC-FDCS), specifically designed to address the needs of populations most closely aligned with the concept of “primary care patients” in mainland China. …”
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Molecular investigation of methicillin-resistant staphylococcus aureus isolates from blood: USA600 emerges as the major type by Mehdi Goudarzi, Fattaneh Sabzehali, Mohsen Heidary, Hadi Azimi, Hossein Goudarzi

“…Results: All the isolates were resistant to methicillin. The most prevalent resistance gene was mecA gene (100%) followed by tetM (57.1%), aac (6΄)-Ie/aph (2˝) (53.6%), ant (4΄)-Ia (46.4%), ermA (45.2%), msrA (35.7%), msrB (33.3%), aph (3΄)-IIIa (33.3%), ermB (31%), ermC (16.7%), and mupA (14.3%) genes. …”
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Delirium screening and alerting systems for older hospital inpatients by Lakeshia Benn, Nirav Shah, Amy McKinney, Lillian Min, Ilyas Aleem, Matthew Luzum, Phillip E. Vlisides

“…Among surveyed nurses, 32/41 (78%) expressed that the alerting system provided at least “moderate” motivation to screen for delirium, and 35/41 (85%) voiced that it provided at least “moderate” motivation to record positive screens. Most respondents (23/42, 55%) reported recurrent educational sessions as “very helpful.” …”
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Estimating the impact of the Russian invasion on the displacement of graduating high school students in Ukraine by Tetiana Zakharchenko, Andrew Bell, Nazarii Drushchak, Oleksandra Konopatska, Falaah Arif Khan, Julia Stoyanovich

“…We found that, among the graduating Ukrainian high school students in 2022, approximately 36,500 (16%) were displaced, with 64% of them moving abroad, primarily to Poland, Germany, and Czechia. Most displaced students originated from the front-line war regions, and either moved abroad or migrated towards the central and western parts of Ukraine. …”
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Genetic Differentiation of Ornamental and Fruit-Bearing <i>Prunus laurocerasus</i> Revealed by SSR and <i>S</i>-Locus Markers by Attila Hegedűs, Péter Honfi, Sezai Ercisli, Gulce Ilhan, Endre György Tóth, Júlia Halász

“…A dendrogram and principal coordinate analysis revealed three distinct groups. Group 1 included most Hungarian and some European cultivars. Groups 2 (Western European cultivars) and 3 (Turkish selections) exhibited higher average allele numbers, suggesting greater genetic diversity in these groups. …”
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Circulating tumor cells: overcoming challenges of detecting a needle in a haystack by Zhuldyz Myrkhiyeva, Kuanysh Seitkamal, Zhannat Ashikbayeva, Assiya Taizhanova, Daniele Tosi, Aliya Bekmurzayeva

“…Circulating tumor cells (CTCs) are cancer cells that are detached from the primary and metastatic tumor site and invade the bloodstream. Most importantly, CTCs are the key players in the development of metastasis. …”
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Intersection of Cardio‐Oncology: An Overview of Radiation‐Induced Heart Disease in the Context of Tumors by Chunan Zhao, Shuai Xu, Yanru Yang, Xing Shen, Jingjing Wang, Shuang Xing, Zuyin Yu

“…Radiation‐induced heart disease (RIHD) is a prevalent cardiovascular complication of radiation therapy, with coronary heart disease being the most common manifestation. Clinical presentations of RIHD vary and may include conduction abnormalities, ischemic heart disease, cardiomyopathy, heart failure, and valvular damage. …”
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β-Amyrin and Metformin, Alone and in Combination, Protect NRK-52E Cell Lines from High Glucose-Induced Nephrotoxicity by Attenuating Oxidative Stress, Apoptosis, Endoplasmic Reticu... by Tamsheel Fatima Roohi, K. L. Krishna

“…Moreover, the test compounds effectively inhibited high glucose-induced ROS production, with the combination treatment displaying the most significant reduction. Gene expression studies demonstrated a downregulation of ER stress, apoptotic markers, and inflammatory markers, with the combination treatment consistently yielding the greatest reductions. …”
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Exploring Nonresponse to Botulinum Toxin in Aesthetics: Narrative Review of Key Trigger Factors and Effective Management Strategies by George Kroumpouzos, Fernando Silikovich

“…Secondary nonresponse (SNR) occurs when BoNT-A is initially effective before failure commences at a later point. Most reported cases involve SNR in aesthetics. Several aspects of this complication remain elusive or controversial. …”
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Small-sized type A thymoma with pulmonary metastasis: a case report by Sachi Kawagishi, Tomohiro Maniwa, Hirokazu Watari, Ryuhei Sakata, Akiisa Omura, Ryo Tanaka, Toru Kimura, Keiichiro Honma, Jiro Okami

“…They may be accompanied by few non-neoplastic lymphocytes. Most type A thymomas are detected in the earlier Masaoka stages. …”
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Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker by Karzan Ghafur Khidhir, Baban Ahmad, Dana Khdr Sabir

“…The GENT2 revealed that HLA-B27 expression levels vary across different tumor types, most notably in heart tissue. The gene-gene interaction network revealed that KIR3DL1, KIR3DS1, LILRB1, B2M and LILRA1 were the leading genes showing the highest correlations with the HLA-B27. …”
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Non-adherence and predictors in patients with schizophrenia on second generation antipsychotics at Amanuel Mental Specialized Hospital, Ethiopia. by Melak Gedamu Beyene, Solomon Teferra, Teferi Gedif Fenta

“…Univariate and multivariate binary logistic regression analyses were conducted.<h4>Results</h4>Most participants were male, (90.0%), and aged 26-40 years, (53.5%). …”
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Implementing value-based healthcare: a scoping review of key elements, outcomes, and challenges for sustainable healthcare systems by Hanan Khalil, Mary Ameen, Charles Davies, Chaojie Liu

“…Key findings highlight that Value-Based Purchasing and Time-Driven Activity-Based Costing models were the most frequently reported funding models. Traditional in-hospital care remains the dominant delivery model, with increasing interest in telemedicine. …”
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Radio Spectrum Sensing Framework for Large-Scale, High-Density IoT Sensor Networks by Partemie-Marian Mutescu, Alexandru Lavric, Adrian-Ioan Petrariu, Alin-Mihai Cailean, Valentin Popa

“…This paper presents an Artificial Intelligence (AI) based spectrum sensing framework designed to detect and classify various IoT communication technologies and generate advanced communication channel analytics, such as the technology in use, central frequency and the bandwidth of the radio channel, time-on-air parameter, channel usage patterns, and radio spectrum occupancy degree. In contrast to most existing other methods, the proposed framework follows an end-to-end approach that integrates dataset design, AI model training, and inference evaluation using IoT sensors controlled by a traffic orchestrator that emulates a large-scale, high-density WSN architecture. …”
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Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol by Xin Zhou, Miesje M. van der Stoel, Shreyas Kaptan, Haoran Li, Shiqian Li, Maarit Hölttä, Helena Vihinen, Eija Jokitalo, Christoph Thiele, Olli Pietiläinen, Shin Morioka, Junko Sasaki, Takehiko Sasaki, Ilpo Vattulainen, Elina Ikonen

“…Here, we employ acute auxin-inducible Sac1 degradation to identify its immediate downstream effectors in human cells. Most of Sac1 is degraded in ~1 h, paralleled by increased PI(4)P and decreased cholesterol in the trans-Golgi network (TGN) during the following hour, and superseded by Golgi fragmentation, impaired glycosylation, and selective degradation of TGN proteins by ~4 h. …”
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Facilitation of the Understanding of Novels by Senior Pupils as a Problem of Psycholinguistics by Наталія Михальчук, Наталія Хупавцева

“…Personality-reflexive dialogism which is the most meaningful in terms of understanding of the partner in the process of quasi-communication. …”
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ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma by Marjon A Smit, Gianluca Maddalo, Kylie Greig, Linsey M Raaijmakers, Patricia A Possik, Bas van Breukelen, Salvatore Cappadona, Albert JR Heck, AF Maarten Altelaar, Daniel S Peeper

“…Abstract Treatment of BRAF mutant melanomas with specific BRAF inhibitors leads to tumor remission. However, most patients eventually relapse due to drug resistance. …”
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The distribution of optimism across sociodemographic groups in 22 countries by Ying Chen, Laura D. Kubzansky, Eric S. Kim, Hayami Koga, Koichiro Shiba, R. Noah Padgett, Renae Wilkinson, Byron R. Johnson, Tyler J. VanderWeele

“…Optimism also varies significantly across most of the sociodemographic factors included in our analyses. …”
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Landscape of cancer associated EpCAM mutations: molecular modeling, predictive insights and impact on patient survival by Priyanka S. Dhotare, Audrey C. Bochi-Layec, Timothy P. Fleming, William E. Gillanders, Ross M. Bremner, Kailas D. Sonawane, Narendra V. Sankpal

“…Of these, seven mutations most frequently associated with lung cancer were further validated through molecular dynamics simulations, evaluation of ERK signaling activity, and assessment of sensitivity to the MEK inhibitor Trametinib. …”
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