DFT-Based Elucidation and Evaluation of Selenium-Modified Tacrine Derivatives: Theoretical and Physicochemical Insights for Alzheimer’s Disease Therapy by Roberto Barbosa Morais, Manoela do Sacramento, Cecilia Scimmi, Darling de Andrade Lourenço, Frederico Schmitt Kremer, Lucielli Savegnago, Diego Alves

“…Compounds <b>12</b> and <b>13</b>, in particular, emerged as the most promising candidates due to their superior stability and binding affinity. …”
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Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies by Xibei Dang, Lars Guelen, David Lutje Hulsik, Grigori Ermakov, Edward J. Hsieh, Joost Kreijtz, Judith Stammen-Vogelzangs, Imke Lodewijks, Astrid Bertens, Arne Bramer, Marco Guadagnoli, Alexis Nazabal, Andrea van Elsas, Thierry Fischmann, Veronica Juan, Amy Beebe, Maribel Beaumont, Hans van Eenennaam

“…Our results suggest chemical cross-linking most accurately identifies the epitope as defined by crystallography.…”
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Clinical signs, diagnosis and treatment of trichophytosis in guinea pigs by V. O. Sablieva, K. V. Pashkov, O. E. Andriiash, M. V. Bilan, V. V. Zazharskyi

“…Dermatophytosis is one of the most common infectious diseases of the skin among animals. …”
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Results of Therapy Including Omalizumab in Adolescents With Recurrent Urticaria: Retrospective Cohort Study by Vera G. Kalugina, Elena A. Vishneva, Leyla S. Namazova-Baranova, Polina R. Grinchik

“…Addition of Omalizumab to the therapy in adolescents with uncontrolled recurrent urticaria let us reach remission of disease in most cases by 6 months of treatment.…”
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Perceived Behavioral Changes in Early Multiple Sclerosis by Fabiana Souza Lima, Samanta Simioni, Laure Bruggimann, Christiane Ruffieux, Jean Dudler, Christian Felley, Pierre Michetti, Jean-Marie Annoni, Myriam Schluep

“…The perceived behavioral changes (PBCs) most frequently reported in both groups were lack of stamina, lability/moodiness, anxiety, vulnerability to stress and irritability. …”
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A systematic review and meta-analysis on the prevalence and associated factors, bacterial profiles, and antibiotic susceptibility of subclinical mastitis in dairy cattle in Uganda by Reagan Muhwezi, Eilu Emmanuel, Vidya Sankarapandian, Rajendra Goud Neel, Ambrose Shabohurira, Danladi Makeri

“…Staphylococcus aureus was the most prevalent bacterial pathogen, accounting for 24 % of all isolates. …”
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Methodology for assessing the criterion of sustainability of the Investment potential of the Southern Federal District Regions, as a tool for managing their Potential by A. V. Alekseev, I. V. Kuznetsova

“…In this regard, one of the most urgent problems of managing sustainable socio-economic development of the studied Russian regions is the problem of assessing the sustainability of the investment potential of the regions of the analyzed macro-region. …”
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Multi-function of adipose-derived stem cells on gut disorder: from bench to bedside by Jiatong Zhao, Shuzi Xin, Xiaohui Liu, Weikai Shi, Boya Wang, Hongli Wang, Yi Wang, Rongxuan Hua, Yize Li, Lei Gao, Xin Lu, Jingdong Xu

“…ADSCs possess impressive capabilities in cell regeneration as well as differentiation, making them promising candidates for injury repair, tissue regeneration and alleviation of inflamed tissues. At present, most clinical studies on ADSCs focus on the treatment of wounds, multiple sclerosis, soft tissue trauma, aging, diabetes, Parkinson’s disease, bone and cartilage regeneration, stroke, and spinal cord injury, while its clinical applications in the gastrointestinal tract are relatively few. …”
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Magnetic resonance guided high intensity focused ultrasound (MR‐HIFU) effectively reduces fibroid‐related symptoms and improves quality of life—A prospective single‐centre 12‐month... by Saara Otonkoski, Antti Viitala, Gaber Komar, Teija Sainio, Anna Yanovskiy, Roberto Blanco Sequieros, Antti Perheentupa, Kirsi Joronen

“…Abstract Introduction Uterine fibroids are the most common benign tumors among women, and it is estimated that approximately 70% of women have one or multiple fibroids by the age of menopause. …”
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HISAPS: High-order smoothing spline with automatic parameter selection and shape constraints by Peter H. Broberg, Esben Lindgaard, Asbjørn M. Olesen, Simon M. Jensen, Niklas K.K. Stagsted, Rasmus L. Bjerg, Riccardo Grosselle, Iñigo Urcelay Oca, Brian L.V. Bak

“…One solution is to use smoothing splines. However, most conventional and readily available smoothing spline software implementations are cubic with a penalty on the 2nd order derivative, which results in poor and sometimes noisy derivatives. …”
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Impact of Antibiotics on the Efficacy of Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma by Do Gyeong Lim, Ho Yeon Lee, Ho Seok Chung, Eu Chang Hwang, Seung Il Jung, Dong Deuk Kwon

“…The ATB-use group had shorter progression-free survival (median three vs. six months, log-rank p=0.045) and shorter overall survival (median three vs. 14 months, log-rank p=0.023) than the no-ATB-use group. The most commonly used antibiotics were fluoroquinolones (46.7%), cephalosporins (40.0%), non-cephalosporin beta-lactams (6.7%), and nitrofurantoin (6.7%). …”
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A case report of insulinoma presenting with seizures and localized on endoscopic ultrasound by Waseem Umer, Ahmed Salah Mohammed, Adeel Ahmad Khan, Muhammad Umar Saddique, Muhammad Zahid

“…Up to 10% of insulinomas are associated with multiple endocrine neoplasia 1 (MEN1). Most of the tumors present with symptomatic hypoglycemia. …”
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Soybean domestication and lead stress on plant–herbivore–parasitoid interactions by Yating Liu, Luhan Li, Shangyang Li, Jiahao Xu, Zhaoyi Feng, Zhe Wang, Liya Zeng, Xiaohong Li

“…The wild genotype was affected the most, followed by the landrace and cultivated genotypes, which negatively affected S. litura and M. pulchricornis. …”
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Immunological Remission as a Basis for Dose Reduction of Immunosuppressors in Autoimmune Hepatitis: Results of Monocenter Surveillance Study by A. O. Bueverov, S. V. Koblov, P. O. Bogomolov

“…To confirm the diagnosis, a liver biopsy was performed in 17 patients, a histological picture of AIH was detected in all of them. The most used combination was prednisolone and azathioprine — in 25 patients (53.2 %), as well as methylprednisolone and azathioprine — in 8 patients (17 %).Results. …”
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PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. by Megan Stiles, Gennadiy P Moiseyev, Madeline L Budda, Annette Linens, Richard S Brush, Hui Qi, Gary L White, Roman F Wolf, Jian-Xing Ma, Robert Floyd, Robert E Anderson, Nawajes A Mandal

“…Eye drops of 5% 4-CH3-PBN were most effective, inhibiting the regeneration of bleachable rhodopsin significantly (60% compared to vehicle control). …”
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Functional Modification and Applications of Rice Starch Emulsion Systems Based on Interfacial Engineering by Pingyuan Ge, Ye Tian, Heng Yan, Qingqing Li, Tianle Yao, Jie Yao, Liuyu Xiao, Meng Zhu, Yu Han

“…Rice starch, as one of the most abundant and renewable polysaccharide resources in nature, holds great potential for applications in the food, pharmaceutical, and industrial fields due to its wide availability, low cost, and biodegradability. …”
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Refugees and host communities’ vulnerability to climate and disaster risks in Rwanda by Nfamara K. Dampha, Nfamara K. Dampha, Colette Salemi, Stephen Polasky, Stephen Polasky, Amare Gebre Egziabher, Wendy Rappeport

“…The findings reveal spatial variability in hazard exposure across camps, with Mahama and Mugombwa refugee camps experiencing the highest flood risks, while Gihembe, Kiziba, and Kigeme camps are most susceptible to landslides. Between 2013 and 2021, landslides resulted in the damage of 324 hectares of cropland in Gihembe district and caused 110 fatalities in Kiziba’s district in 2016 alone. …”
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Prevalence and Associated Factors of Work-Related Spinal Pain Among Bank Workers in Harar, Eastern Ethiopia: A Cross-Sectional Study by Murad Umer MPH, Aboma Motuma PhD, Nesredin Ahmed MSc, Shiferaw Letta PhD

“…Results The study found that lower back pain (45.4%), neck pain (37.14%), and upper back pain (34.92%) were the most frequently reported spinal complaints among bank employees in the past 12 months. …”
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Application of modern computer-aided technologies in the production of individual bone graft: A case report by Mirković Siniša, Budak Igor, Puškar Tatjana, Tadić Ana, Šokac Mario, Santoši Željko, Đurđević-Mirković Tatjana

“…Application of 3D CBCT images, computer-aided systems and software in manufacturing custom bone grafts represents the most recent method of guided bone regeneration. This method substantially reduces time of recovery and carries minimum risk of postoperative complications, yet the results fully satisfy the requirements of both the patient and the therapist.…”
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Comparative effectiveness of root canal machining with modern ni-ti tools by L. Yu. Orekhova, V. Yu. Vashneva, T. V. Porkhun, Yu. A. Zaitseva

“…The quality of endodontic treatment largely depends on the mechanical cleaning of the root canal, which is carried out in most cases by machine nickel-titanium instruments. …”
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