Dual-loaded niosome-dendrimer nanoplatform enhances Tirapazamine delivery to hypoxic breast cancer cells by Masoumeh Kaveh Zenjanab, Aysan Salemi, Abolfazl Doustmihan, Sajjad Alimohammadvand, Rana Jahanban Esfahlan

“…Abstract Breast cancer (BC) is one of the most common cancers in women, requiring comprehensive treatment strategies to reduce disease burden and costs. …”
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Unveiling the Anti-Inflammatory Effects of Antidepressants: A Systematic Review of Human Studies over the Last Decade by Layla Bleibel, Paulina Sokołowska, Gabriela Henrykowska, Jacek Owczarek, Anna Wiktorowska-Owczarek

“…<b>Background/Objectives</b>: Depression ranks among the most prevalent mental health conditions globally, marked by a variety of symptoms that frequently cause significant emotional distress and impairment in individuals, alongside a high recurrence rate. …”
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Early Triassic super-greenhouse climate driven by vegetation collapse by Zhen Xu, Jianxin Yu, Hongfu Yin, Andrew S. Merdith, Jason Hilton, Bethany J. Allen, Khushboo Gurung, Paul B. Wignall, Alexander M. Dunhill, Jun Shen, David Schwartzman, Yves Goddéris, Yannick Donnadieu, Yuxuan Wang, Yinggang Zhang, Simon W. Poulton, Benjamin J. W. Mills

“…Abstract The Permian–Triassic Mass Extinction (PTME), the most severe crisis of the Phanerozoic, has been attributed to intense global warming triggered by Siberian Traps volcanism. …”
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ASSESSMENT OF AWARENESS LEVEL OF OWN DISEASE IN PATIENTS WITH STABLE ARTERIAL HYPERTENSION by G. F. Andreeva, V. M. Gorbunov, S. Y. Martsevich

“…Arterial hypertension (AH) is the most frequent risk factor of cardiovascular diseases and related mortality in all developed countries. …”
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Spectrum of epilepsy &amp;ndash; prevalence, impact, and treatment gap: an epidemiological study from Al-Quseir, Egypt by El tallawy H, Farghaly W, Rageh T, Shehata G, Metwally N, Badry R, Sayed M, Abdelwarith A, Kandil M, Ibrahim MAAEH, Mohamed K, Tohamy A

“…Localization-related epilepsy is the most frequently encountered type (58.8%). The treatment gap of epilepsy in Al-Quseir is 83.8%.Conclusion: The lifetime prevalence of epilepsy in Al-Quseir city, Red Sea Governorate, was 5.5/1000. …”
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Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction by Ruidong Xiang, Chief Ben-Eghan, Yang Liu, David Roberts, Scott Ritchie, Samuel A. Lambert, Yu Xu, Fumihiko Takeuchi, Michael Inouye

“…Variance polygenic scores (vPGSs) were constructed to stratify individuals in the INTERVAL cohort (N ~ 40,466), where the genetically most variable individuals had increased conventional PGS accuracy (by ~19%) relative to the genetically least variable individuals. …”
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Comparative Study on Chemical Constituents of Ginseng Flowers with Four Consecutive Cultivation Age by Lian-Yun Du, Hui-E. Zhang, Ye Zhang, Yan-Yan Han, Ping Ye, Xiang-Ru Meng, Yan-Long Shen, Chang-Bao Chen, Mei-Ling Fan, En-Peng Wang

“…According to the peak intensity of determined VOCs, the contents of most differential compounds arranged in an order from high to low are GF3, GF4, GF5, and GF6, such as the compounds 2–15, 17–19, 22, and 25–26, therefore, they can be inferred that they are important markers to identify the age of GFs. 461 common differential compounds were gained and 26 common volatile organic compounds were identified with RSI >800 and RI and RIx no more than 30, including alcohols (such as 11, 12, and 15), sesquiterpenes (such as 2, 3, and 4), esters (such as 1 and 26), naphthalene and naphthol (such as 7 and 20), which had potential effects on curing Alzheimer’s disease, inflammatory diseases, and prostate cancer based on network pharmacology analysis. …”
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Association Between Human Embryo Culture Conditions, Cryopreservation, and the Potential Risk of Birth Defects in Children Conceived Through Assisted Reproduction Technology by Romualdo Sciorio, Luca Tramontano, Giuseppe Gullo, Steven Fleming

“…Since the first successful ART birth in 1978, over 10 million babies have been conceived through these techniques. Although most of these children are healthy, concerns exist about potential birth defects or changes linked to the handling of gametes and embryos. …”
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Comparison of maintaining of body balance in combat sports between experts and non-experts by Artur Litwiniuk, Zbigniew Bujak, Andrzej Mastalerz, Paweł Różański, Oscar Romero Ramos, Tomasz Niźnikowski

“…This quick test can be easily administered in most settings and may be helpful in guiding training. …”
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Underwater fiber laser removal of synthetically cultured Caulobacter crescentus biofilms on aluminium using response surface methodology by Hawa Ringkai, Khairul Fikri Tamrin, Ngieng Ngui Sing, Abdullah Yassin, Awang Ahmad Sallehin Awang Husaini, Jamil Musel

“…Results revealed that the number of repetition loops was the most significant factor, as multiple repetition loops compensated for energy losses caused by water absorption and the high thermal conductivity of aluminium. …”
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Gas discharge visualization as a promising tool for meat analysis during its storage by A. U. Shkabrou, I. M. Chernukha, V. D. Raznichenka, L. U. Lazovikava, I. I. Andreeva, S. N. Baitava

“…Using the software ImageJ to analyze the gas-discharge glow of meat, its main parameters were obtained, such as an area, average radius of glow and color characteristics. The most significant characteristics of the gas-discharge glow were determined, among which the glow area, shape factor, uncertainty and dispersion were focused on. …”
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Ischemic stroke in children: a study of the associated alterations Acidente vascular cerebral isquêmico na infância: estudo das alterações associadas by Josiane Ranzan, Newra Tellechea Rotta

“…Focal seizures and hemiparesis were the most frequent symptoms; 40% of the patients presented prior pathologies. …”
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Advancing antimicrobial susceptibility testing in body fluid-associated infections: a focus on direct testing for timely and targeted therapeutic interventions by Nisha Goyal, Vikas Saini, Nimisha Jain, Bandi Shravana, Shukla Das, Narendra Pal Singh, Meenakshi Goswami

“…Results: D-AST showed high concordance with R-AST for most antibiotics (p>0.05), with a significant reduction in turnaround time (D-AST: 24-36 hours; R-AST: 48-72 hours). …”
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Unraveling Racial Disparities in Papillary Thyroid Cancer: A Comparative Bulk RNA-Sequencing Gene Expression Analysis by Luiza Barseghyan, Samuel Chan, Celina R. Yamauchi, Andrea Shields, Mia C. Perez, Alfred A. Simental, Salma Khan

“…Papillary thyroid cancer (PTC) is the most common thyroid malignancy, with significant racial/ethnic disparities in incidence and survival. …”
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Symptoms of herpesvirus infection in reproductive disorders in married couples by E. K. Shushakova, V. S. Markina, S. V. Nikolaeva, T. A. Ruzhencova

“…Complaints, anamnesis and examination data should be taken into account to confirm or exclude significant infection with herpes simplex virus. The most informative are the culture method, as well as serological with the detection of IgA class antibodies among the laboratory methods for assessing the significance of infection associated with HSV-1, 2. …”
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Profile of inborn errors of metabolism among the neonates admitted in special newborn care unit of a tertiary care hospital by Kushal Mandal, Sushama Sahoo, Sarbani Misra, Bharat Lal Kisku

“…Twenty-three newborns were diagnosed with IEM. The most common IEM noted is G6PD deficiency with an overall incidence of 34%, followed by amino acid disorder. …”
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Health literacy, multimorbidity and its effect on mental health in South African adults: a repeated cross-sectional nationally representative panel study by A. Craig, K. Mabetha, O. Gafari, O. Gafari, S. A. Norris, S. A. Norris

“…Using repeated cross-sectional nationally representative data, this study examined the relationship between health literacy and multimorbidity, with a specific focus on mental health among South African adults (18 years and older).ResultsMost respondents had minimal depression risk, with 21.7% showing probable depression, lower than the 25.7 and 26.2% in Panels 1 (2021) and 2 (2022) respectively. …”
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Effect of Dermanyssus gallinae on zootechnical and productive indicators of farming chicken by V. Yevstafieva, А. Petrunenko

“…Dermanyssus gallinae ticks are among the most dangerous blood-sucking ectoparasites, in addition, they are carriers of dangerous bird infections pathogens. …”
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Cranioplasties: surgical reconstruction strategies by Pablo Maricevich, André Mansur, Acrysio Peixoto, Julia Amando, Eduardo Pantoja, André Braune, José Augusto Nasser, Ricardo Lopes da Cruz

“…Twelve patients underwent reconstruction with a parietal graft, two with custom prosthesis, one with fracture reduction and fixation, and one with reconstruction of soft parts . Most of the defects were located in the fronto-orbital region. …”
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Mechanistic basis of atypical TERT promoter mutations by Kerryn Elliott, Vinod Kumar Singh, Alan Bäckerholm, Linnea Ögren, Markus Lindberg, Katarzyna M. Soczek, Emily Hoberg, Tom Luijts, Jimmy Van den Eynden, Maria Falkenberg, Jennifer Doudna, Anders Ståhlberg, Erik Larsson

“…Abstract Non-coding mutations in the TERT promoter (TERTp), typically at one of two bases −124 and −146 bp upstream of the start codon, are among the most prevalent driver mutations in human cancer. …”
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