Real-world data of cadonilimab in recurrent or metastatic cervical cancer in China: a multicentric study by Jian Chen, Haijuan Yu, Yingtao Lin, Dan Hu, Li Liu, Renliang Fan, Jianping Zou, Lele Zang, Yao Lin, Rong Lin, Dezhao Chen, Xiaoying Weng, Fenfang Shen, Shaoyu Wang, Wei Zeng, Qihua Tian, Yun Yi, Yuanfeng Chen, Jinjin Miao, Bo Zhang, Yinxia Zou, Fengming Gao, Fengming Gao, Rong Lian, Lin Yang, Yang Sun

“…The most prevalent genetic variant was PIK3CA, highlighting the importance of the PI3K-AKT pathway in the antitumor mechanism of cadonilimab.ConclusionsCadonilimab shows an encouraging tumor response rate, with a manageable safety profile in patients with R/M CC. …”
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Enfermedad renal diabética y polimorfismos de los genes ELMO1 y AGTR1: revisión sistemática by Yuliana Martínez-Nava, María Camila Ogaz-Escarpita, Sandra Alicia Reza-López, Irene Leal-Berumen

“…Results: The polymorphisms most frequently associated with a DKD higher risk were rs741301, rs1345365, and rs10951509 for the ELMO1 gene, whereas the rs5186 and rs388915 for the AGTR1 gene. …”
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Pomalidomide in relapsed and refractory multiple myeloma: multicenter retrospective study by V. G. Potapenko, E. V. Baumert, A. A. Bobrova, R. V. Vashchenkov, N. V. Dorofeeva, K. D. Kaplanov, E. V. Karyagina, A. N. Levanov, A. S. Luchinin, S. I. Moiseev, A. V. Novitskii, A. S. Nizamutdinova, О. V. Pirogova, S. A. Povzun, М. V. Platonov, V. V. Porunova, D. А. Ptashnikov, V. V. Ryabchikova, S. Ya. Simeniv, I. А. Skorokhod, Е. А. Ukrainchenko, D. А. Chaginskaya, T. V. Shelekhova, M. N. Shirokova, A. A. Shutylev, N. V. Medvedeva

“…Kidney impairment at the onset was in 10 (15 %) patients, the normal function was in 57 (85 %) patients and 4 patients had no data. Most patients (n = 68, 95.8 %) received pomalidomide in one therapy line, in 3 (4.2 %) patients - drug was given in two lines, totally 74 episodes of use. …”
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Modified Сomplex Treatment of the Cirhotic Patients with the Hepatopulmonary Syndrome of the Different Severity Degrees: Pathogenetic Reasoning and Efficiency by Abrahamovych M., Abrahamovych O., Tolopko S., Ferko M.

“…Engaging of the different organs and systems into the pathological process, including the organs of the respiratory system, interpretated as syntropic co­ and polymorbid lesions, including the most common ­ hepatopulmonary syndrome (HPS), in many cases determines the severity of the general condition of the cirrhotic patients, leads to a significant reduction of their life quality, disability, has a decisive prognostic value at all the stages of the treatment and is the leading cause of the death of the hepatological patients. …”
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Understanding patient pathways to Mother and Baby Units: a longitudinal retrospective service evaluation in the UK by Nikolina Jovanović, Žan Lep, Giles Berrisford, Aysegul Dirik, Julia Barber, Bukola Kelani, Olivia Protti

“…Here is what we found: Most patients were admitted to the Mother and Baby Unit after giving birth, and they were usually admitted in an emergency. …”
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Cirugía cardiovascular en España en el año 2023. Registro de intervenciones de la Sociedad Española de Cirugía Cardiovascular y Endovascular by Emilio Monguió Santín, Elio Martín Gutiérrez, Gregorio Cuerpo Caballero, Tomasa Centella Hernández, Luz Polo López, Rafael García Fuster, Encarnación Gutiérrez Carretero, Pilar Gascón García-Verdugo, Juan José Legarra Calderón

“…The proportion of interventions for major pathology groups remains stable compared to previous years, with isolated valve surgery once again being the most common group. In general, the observed mortality was below the mortality predicted by risk scales in most areas of the specialty.…”
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Safety and immunogenicity of primary vaccination with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: Two randomized, observer-blinded, placebo-c... by Gui-Ling Chen, Yuan-Zheng Qiu, Kai-Qi Wu, Ying Wu, Yuan-Hui Wang, Yu-Ying Zou, Cong-Gao Peng, Jie Zhao, Chang Su, Jun-Heng Ma, Shao-Nan Ni, Xing Wang, Ting-Han Jin, Qi Jiang, Tong Guo, Yan Xu, Chao-Chao Huang, Qing Zhang, Kai-Li Liu, Li Ji, Han-Yu Yang, Chun-Lei Li, Yu-Wen Su, Xiang Lu, Lan-Juan Li

“…The result showed that 7/15, 9/15 and 4/10 adult participants, and 9/15, 8/15 and 4/10 elderly participants reported at least one AE in the 20-µg, 30-µg and placebo groups, respectively. Most AEs were grade 1. Injection-site pain was the most common AE. …”
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Knowledge management in higher education: a meta-synthesis of success factors, challenges, and implementation strategies by Mohammad Hossein Zerafati, Reza Hosseinpour

“…Supportive organizational culture emerged as the most crucial factor, emphasizing the need for trust, transparency, and continuous learning values.2. …”
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A discourse analysis of six stories based on the thematic progression factor: Halliday and Matthiessen's functional grammar approach (2014) by seyed abbas navabi sohi, ferdous aghagolzade, ahmad mohseni

“…However, the above studies are mostly structure-based rather than discourse-based. …”
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Critical discourse analysis of “Rostam and Esfandiyar” story of Ferdowsi’s Shahnameh based on Van Dijk’s (2006) ideological square by Abbas Ali Ahangar, Saeid Oveisi Kahkha

“…There are many approaches in this field, one of the most important being Van Dijk's (2006) socio-cognitive model. …”
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Clinical characteristics, treatment patterns, and survival outcomes of 1031 patients with peripheral T cell lymphoma in china: a multicenter, real-world study by Ling Huang, Yong Yang, Zhenyu Zhao, Shengsheng Zhou, Jingsong Wu, Ning Wang, Fen Zhang, Keqian Shi, ChengPing Li, Xiaolei Wei, Hongyu Zhang, Yun Lin, Guowei Li, Hui Zhou, Hanguo Guo, Xinmiao Jiang, Xiaojuan Wei, Feili Chen, Sichu Liu, Caidi Lin, Zhanli Liang, Yilan Huang, Lu Pan, Hui Yang, Yirong Jiang, Yudan Wu, Shuqin Cheng, Huifang Yang, Xiaoqiang Zheng, Xinggui Chen, Xiaoliang Li, GuiNian Huang, Jihao Zhou, Zhigang Peng, Li-e Lin, Tingbo Liu, Wenyu Li

“…The median age was 52 years, most patients had stage III-IV, and fewer patients had infiltrated bone marrow. …”
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Identifying factors affecting the competence of heads of units and centers of Islamic Azad University in accordance with the statement of the second step of the Islamic Revolution... by Seyed samad Emadi vahdi, mohammadreza mardani, Nader Bohlouli, Mojtaba Ramazani

“…Among these 14 factors, the appointment of appropriate managers at Islamic Azad University holds the most significant influence. The scientific and professional development of managers, the revolutionary and Islamic competencies of managers, the components of jihadi management, and the cognitive competence of managers are the five most significant factors, respectively.…”
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Benefits of aldosterone receptor antagonism in chronic kidney disease: the BARACK-D RCT by F D Richard Hobbs, Richard McManus, Clare Taylor, Nicholas Jones, Joy Rahman, Jane Wolstenholme, Louise Jones, Jennifer Hirst, Sam Mort, Ly-Mee Yu

“…These increased events result in CKD having high cost to healthcare systems, with the dialysis required in ESRF benchmarked as at the maximum acceptable cost-effectiveness threshold for an intervention by most healthcare systems. However, the most important component of CKD in terms of mortality and morbidity is cardiovascular disease (CVD). …”
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Use of ICT to Confront COVID-19 by Yousry Saber El Gamal

“…A hospital at Wuhan was being staffed entirely by robots. Most of the devices are IoT enabled and services are carried out by robots. …”
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Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET by Janine Wesslowski, Sadia Safi, Michelle Rottmann, Melanie Rothley, Gary Davidson

“…Co-receptors play a pivotal role in guiding the specificity of Wnt signaling, most notably between β-catenin-dependent and -independent pathways, where co-receptors such as LRP5/6 and ROR1/2/PTK7 play major roles, respectively. …”
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A review on the recent mechanisms investigation of PFAS electrochemical oxidation degradation: mechanisms, DFT calculation, and pathways by Gengyang Li, Mason Peng, Qingguo Huang, Ching-Hua Huang, Yongsheng Chen, Gary Hawkins, Ke Li

“…Electrochemical oxidation (EO) has shown great promise for the destructive treatment of PFAS with direct electron transfer and hydroxyl radical (⋅OH)-mediated indirect reactions. One of the most popular electrodes is Magnéli phase titanium suboxides. …”
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Sex-based estimation of biological variation in plasma-free amino acid concentrations among healthy adults by Müjgan Ercan, Emiş Deniz Akbulut, Ayşen Caniklioğlu, Esra Fırat Oğuz, Yakup Dülgeroğlu, Esin Avcı, Şerif Ercan

“…The estimated CVI values for essential amino acids were significantly lower than those for non-essential amino acids (P = 0.03). For most plasma FAAs, no significant differences in CVI (except for alanine, arginine, glutamic acid, and threonine) or CVG were observed between sexes. …”
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Global phylogeography and microdiversity of the marine diazotrophic photoautotrophs Trichodesmium and UCYN-A by Angie Nguyen, Lucas J. Ustick, Alyse A. Larkin, Adam C. Martiny

“…In contrast, UCYN-A was most frequently observed in regions experiencing iron stress. …”
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The Relationship of Youth Family Values with Hedonism and Eudemonia by I. V. Anoshkin, O. A. Sychev

“…A notable trend in modern society is the transformation of family institution, which has long been considered the most important social and personal value. The change of attitudes of young people towards marriage in Russia is slower than in Europe; however, this process is becoming more obvious today and there is an urgent need to study it. …”
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