The role of mutation testing in patients with chronic myeloid leukemia in chronic phase after imatinib failure and their outcomes after treatment modification: Single-institutional... by Puligundla Krishna Chaitanya, Karnam Ashok Kumar, Bala Stalin, Gundeti Sadashivudu, Maddali Lakshmi Srinivas

“…Introduction: BCR-ABL1 kinase domain mutations represent the most frequent mechanism of resistance to tyrosine kinase inhibitor (TKI) therapy, being detected in 40%–50% of imatinib-resistant patients with chronic myeloid leukemia in chronic phase (CML-CP). …”
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Spatial-temporal distribution characteristics, species selection, and influencing factors of cherry blossom scenic spots in China by Hongjun Peng, Ping Li, Xinyi Zhang, Yiwei Han, Rui Sun, Chunyan Zhang

“…The distribution has shifted from a discrete pattern to a clustering trend in high-density areas of North, East, and Central China, particularly Beijing, Shanghai, and Wuhan. (2) Main applications include parks, campuses, mountains, temples, and roadways, predominantly located in parks. (3) Variations in cherry blossom species and flowering periods are notable across regions, with diverse species in North, East, and Central China. (4) Economic status primarily influences distribution, alongside natural geographic and demographic factors, whose interactions enhance explanatory power. (5) The 10 most reviewed spots show positive visitor perceptions, with distinct emotional responses by region. (6) The layout and evolution of these spots result from both natural and socio-cultural influences. …”
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SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Interventio... by Piera Calamita, Annarita Miluzio, Arianna Russo, Elisa Pesce, Sara Ricciardi, Farhat Khanim, Cristina Cheroni, Roberta Alfieri, Marilena Mancino, Chiara Gorrini, Grazisa Rossetti, Ivana Peluso, Massimiliano Pagani, Diego L Medina, Johanna Rommens, Stefano Biffo

“…Shwachman-Diamond Bodian Syndrome (SDS) is an autosomal recessive disease caused, in most patients, by mutations of the SBDS gene. SBDS is a protein required for the maturation of 60S ribosomes. …”
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Impact of adapted physical education and para-athletics on mental skills and on pedagogical and school inclusion of teenagers with disabilities by Omar BEN RAKAA, Mustapha BASSIRI, Said LOTFI

“…The group that received the APE-Para-athletics combination exhibited the most notable outcomes (p<.05), displaying a pronounced enhancement in all competencies, including stress reaction (+84.39%) and concentration (+75.44%). …”
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Enhancing Periodontal Bone Loss Diagnosis Through Advanced AI Techniques by Nader Nabil Fouad Rezallah, George Sherif, Ahmed Z. Abdelkarim, Shereen Afifi

“…Based on our extensive research, we concluded that convolutional neural networks (CNNs) are the most effective type of neural network for addressing our problem. …”
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An Analytical Overview of the Rebirth of the Olympic Games and the Olympic Movement by Gheorghe BRANIȘTE

“…The centuries-old efforts of generations of prominent humanists, state and public figures, representatives of historical science, education, upbringing, physical culture and sports, which led to the formation in the most developed countries of an environment capable of perceiving, supporting and implementing the idea of reviving the Olympic Games. …”
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Predictive value of miR-637 for the occurrence of myocardial hypertrophy in patients with hypertension by Shenglan Zou, Xiaomin Li, Xueya Liu, Fei Sun

“…Abstract Background Hypertension is one of the cardiovascular diseases that seriously endangers human life and health, and myocardial hypertrophy is the most common secondary condition of hypertension. …”
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Optimal Reactive Power Generation for Radial Distribution Systems Using a Highly Effective Proposed Algorithm by Le Chi Kien, Thuan Thanh Nguyen, Bach Hoang Dinh, Thang Trung Nguyen

“…In this paper, a proposed modified stochastic fractal search algorithm (MSFS) is applied to find the most appropriate site and size of capacitor banks for distribution systems with 33, 69, and 85 buses. …”
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Psychiatric Symptoms in Patients with Immune-Related Mucocutaneous Lichen Planus by Narges Hejazi, Hossein Eslami, Ali Reza Shafiee-Kandjani, MohamadReza Ranjkesh, Behzad Shalchi, Fatemeh Eskandarpour

“…Background: Lichen planus (LP) is one of the most common chronic mucocutaneous diseases with an underlying immunological component. …”
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Economic Efficiency of Table Grape Production in Waterberg and Sekhukhune Districts, Limpopo Province, South Africa by Naume Maponya, Isaac Oluwatayo

“…Again, economic efficiency ranges from 0.56 to 1, with a mean of 0.73, an indication that most of the farmers were economically efficient. …”
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Impact of antenatal corticosteroid therapy on neonatal respiratory outcomes in late preterm births by Ahmet Kurt, Can Ozan Ulusoy, Dilara Sarikaya Kurt, Sadullah Özkan, Murat Levent Dereli, Aykut Kından, Özge Yücel Çelik, Safiye Elif Uzlu, Şevki Çelen

“…Cesarean delivery was associated with a nearly fourfold increase in pulmonary complications compared to vaginal delivery (adjusted OR: 3.775; 95% CI: 1.859–7.666; p < 0.001). ACT showed the most significant protective effect in earlier gestational weeks and among cesarean deliveries. …”
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Antibiotic-loaded cement spacer for treatment of Klebsiella infected total hip and knee arthroplasty by Barjaktarović Radoslav, Radoičić Dragan, Mitković Milorad

“…According to our experience with multidrug-resistant Klebsiella TKA/THA infections, two-stage approach, in some cases with double articulating cement spacer exchange prior to definitive reimplantation, is the most effective treatment option.…”
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Predictive Factors for Procedure Time for Closure of Mucosal Defect Following Colorectal Endoscopic Submucosal Dissection by Hideaki Kazumori, Rurika Masatsugu, Kousuke Fukuda, Koji Onishi, Yasuhiko Ohno

“…Background To prevent complications following a colorectal endoscopic submucosal dissection (ESD) procedure, closure of the resultant mucosal defect is considered to be most effective. However, closure after colorectal ESD is challenging, and technical difficulties can lead to a longer procedure time. …”
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Industrial 300 mm wafer processed spin qubits in natural silicon/silicon-germanium by Thomas Koch, Clement Godfrin, Viktor Adam, Julian Ferrero, Daniel Schroller, Noah Glaeser, Stefan Kubicek, Ruoyu Li, Roger Loo, Shana Massar, George Simion, Danny Wan, Kristiaan De Greve, Wolfgang Wernsdorfer

“…The possibility of using existing industrial semiconductor fabrication techniques and infrastructure for up-scaling and reproducibility makes silicon based spin qubits one of the most promising platforms to achieve this goal. The implementation of the up to now largest semiconductor based quantum processor was realised in a silicon/silicon-germanium heterostructure known for its low charge noise, long qubit coherence times and fast driving speeds, but the high structural complexity creates challenges for industrial implementations. …”
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Doubling diversity: a cautionary tale of previously unsuspected mammalian diversity on a tropical oceanic island by Lawrence Richard Heaney, Danilo S. Balete, Mariano Roy M. Duya, Melizar V. Duya, Sharon A. Jansa, Scott J. Steppan, Eric A. Rickart

“…To test the assumption that mammalian diversity on tropical oceanic islands is well documented, we conducted a 12-year intensive survey of the native mammal fauna on Luzon Island, a large (ca. 103,000 km²), mostly volcanic island in the Philippines, which was thought to be well known. …”
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Phytosociological study of herbaceous communities under Vachellia tortilis subsp. raddiana (Savi) Kyal. & Boatwr in eastern Niger by Ismael Bio, Mamadou Boubacar Moussa, Idrissa Soumana, Ali Mahamane

“…The analysis of the floristic composition shows that the Poaceae family (41.08%) is the most important, followed by the Mimosaceae (14.82%). …”
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Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure by E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov

“…The aryl hydrocarbon receptor (AhR), a ligand- activated transcription factor, participates in a wide range of critical cellular events in response to endogenous signals or xenobiotic chemicals. 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is one of the AhR ligands with a very high binding affinity for the AhR. TCDD is the most toxic among the dioxin xenobiotics and induces a broad spectrum of biological responses, including immunotoxicity and cancer. …”
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Proteomics of colorectal tumors identifies the role of CAVIN1 in tumor relapse by Ana Martinez-Val, Leander Van der Hoeven, Dorte B Bekker-Jensen, Margarita Melnikova Jørgensen, Jesper Nors, Giulia Franciosa, Claus L Andersen, Jesper B Bramsen, Jesper V Olsen

“…As the mesenchymal-rich tumors are known to represent the most invasive and metastatic phenotype, we focused on the protein signature defining this subtype to evaluate their potential as relapse risk markers. …”
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Berberine hydrochloride inhibits the proliferation and metastasis of p53 mutant gallbladder Cancer cells by regulating the IL6/STAT3 pathway by Huan Zhang, Guoning Li, Lanxin Ni, Rui Wang, Lijun Peng, Lanlan Zang, Chunlei Lu, Zhi Wang, Jinghua Liu

“…Abstract Gallbladder cancer (GBC) is one of the most common biliary malignancies. Berberine hydrochloride, an compound extracted from the traditional Chinese medicinal plant Coptis chinensis, has potential therapeutic effects on various tumor cells. …”
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Relationship between level of serum VIT D and insulin resistance in patients with MAFLD by Alshymaa A. Hassnine, Amr M. Elsayed, Samar K. Abdelaziez, Mahmoud M. Higazi, Nagwa I. Okaily, Wael Soliman

“…Abstract Background Non-alcoholic fatty liver disease has been recognized as the most common metabolic liver disease in Western countries, and its prevalence is increasing all over the world. …”
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