OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles by Lucia Capodimonte, Fernando Teixeira Pinto Meireles, Guillermo Bahr, Robert A. Bonomo, Matteo Dal Peraro, Carolina López, Alejandro J. Vila

“…This contrasts with β-lactamases from other classes, which are predicted to be mostly soluble proteins. Almost all (>99%) putative lipidated OXAs are present in Acinetobacter spp. …”
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The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study. by Benjamin I Perry, Stephen Burgess, Hannah J Jones, Stan Zammit, Rachel Upthegrove, Amy M Mason, Felix R Day, Claudia Langenberg, Nicholas J Wareham, Peter B Jones, Golam M Khandaker

“…<h4>Methods and findings</h4>We used summary data from genome-wide association studies of mostly European adults from large consortia (Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) featuring up to 108,557 participants; Diabetes Genetics Replication And Meta-analysis (DIAGRAM) featuring up to 435,387 participants; Global Lipids Genetics Consortium (GLGC) featuring up to 173,082 participants; Genetic Investigation of Anthropometric Traits (GIANT) featuring up to 339,224 participants; Psychiatric Genomics Consortium (PGC) featuring up to 105,318 participants; and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium featuring up to 204,402 participants). …”
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Experimental murine non-alcoholic steatohepatitis is associated with behavioural, cognitive, and peripheral neuronal dysfunction by V. A. Prikhodko, D. A. Orlyakhina, V. D. Petrova, V. E. Karev, D. Yu. Ivkin, S. M. Napalkova, S. V. Okovityi

“…Mice with NASH exhibited markers of elevated anxiety in the OF, EPM, and LDB tests (p &lt; 0.05, p &lt; 0.01), which were mostly specific to the very onset of liver disease (1 mo) as well as its later stages (6 mo). …”
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Clima motivacional y niveles de ansiedad en futbolistas de categorías inferiores (Motivational climate and levels of anxiety in soccer players of lower divisions) by Manuel Castro-Sánchez, Félix Zurita-Ortega, Ramón Chacón-Cuberos, Antonio Miguel Lozano-Sánchez

“…In terms of motivational climate, the players mostly perceive a motivational climate of involvement in the task. …”
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Term breech presentation—Intended cesarean section versus intended vaginal delivery—A systematic review and meta‐analysis by Julia Wängberg Nordborg, Therese Svanberg, Annika Strandell, Ylva Carlsson

“…The certainty of evidence was moderate or low because the study designs were mostly retrospective cohort studies. The only randomized trial showed reduced risk of perinatal mortality for planned cesarean section, risk ratio (RR) 0.27 (95% confidence interval [CI] 0.08–0.97, 2078 women, low certainty of evidence), stillbirths excluded. …”
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Acute Liver Failure Triggered by Idiosyncratic Drug-Induced Liver Injury Associated with Ibuprofen Consumption. Case Report. by Luis R. Alvarez-Martín, Luis A. Esquivel-Pacheco, Alexis V. Hinostroza-Pezo, Karla J. Arroyo-García, Montserrat D. Moreno-Huesca, Adrian Z. Feria-Avendaño, Carlos A. Galván-Castro

“…Idiosyncratic reactions occur in susceptible individuals, are dose-independent, and mostly occur 5-90 days after drug intake. Ibuprofen is associated with a mixed pattern in this presentation. …”
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Successful treatment with refractory myasthenia gravis that developed after allogeneic hematopoietic stem cell transplantation: two case reports by Huili Zhang, Yi Wen, Yaotong Ou, Xi Chen, Yu Peng, Mingjun Lai, Wenjian Mo, Honghao Wang

“…Neostigmine and repetitive nerve stimulation tests were positive, the level of anti-AChR IgG antibodies and MuSK receptor antibodies were positive, leading to a diagnosis of type IVb MG. The symptoms were mostly relieved after rituximab treatment.DiscussionThis article reports two rare cases of MG after transplantation, including the first case of post-transplantation double-antibody-positive MG, and reviews the general clinical characteristics of MG cases after allo-HSCT reported in previous literature. …”
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Diversity of lakes and ponds in the forest-tundra ecozone: from limnicity to limnodiversity by Pedro Freitas, Gonçalo Vieira, Diana Martins, João Canário, Pedro Pina, Birgit Heim, Bennet Juhls, Raoul-Marie Couture, Warwick F. Vincent

“…In bedrock outcrops, large water bodies were mostly associated with glacially carved depressions (higher limnicity). …”
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Global Rice Paddy Inventory (GRPI): A High‐Resolution Inventory of Methane Emissions From Rice Agriculture Based on Landsat Satellite Inundation Data by Zichong Chen, Haipeng Lin, Nicholas Balasus, Andy Hardy, James D. East, Yuzhong Zhang, Benjamin R. K. Runkle, Sarah E. Hancock, Charles A. Taylor, Xinming Du, Bjoern Ole Sander, Daniel J. Jacob

“…Abstract Rice agriculture is a major source of atmospheric methane, but current emission inventories are highly uncertain, mostly due to poor rice‐specific inundation data. …”
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Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and... by Michael E. Herce, Caitlin Cassidy, Alexandra Munson, Jessie K. Edwards, Sarah E. Rutstein, Mitch Matoga, Chimwemwe Kumwenda, Katherine R. Simon, Joep J. van Oosterhout, Carrie M. Cox, Funny Kamanga, Wiza Kumwenda, Sam Phiri, Ethel Rambiki, Agness Thawani, Jacqueline Huwa, Bridget Malewezi, Tisu Mvalo, Agatha Bula, Lameck Chinula, Irving Hoffman, Madeleine A. Squibb, Rose K. Nyirenda, Friday Saidi, Mina C. Hosseinipour, Maganizo B. Chagomerana

“…In Malawi, the current standard of care (SOC) involves mostly passive approaches to pediatric HIV diagnosis, relying on mothers presenting to health facilities with their infants. …”
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Typology of out-of-home eaters: a description of sociodemographic, lifestyle, nutritional and environmental characteristics in the NutriNet-Santé cohort by Emma Meyer, Benjamin Allès, Justine Berlivet, Sandrine Péneau, Alice Bellicha, Mathilde Touvier, Brigitte Langevin, Philippe Pointereau, Denis Lairon, Serge Hercberg, Emmanuelle Kesse-Guyot, Julia Baudry

“…Frequent weekday and weekend eaters, with the highest OOH consumption, had the lowest dietary quality and the highest diet-related environmental impacts and consisted mostly of younger women with higher socioeconomic status. …”
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Perioperative the BTLA inhibitor (tifcemalimab) combined with toripalimab and chemotherapy for resectable locally advanced thoracic esophageal squamous cell carcinoma trial (BT-NIC... by Chengzhi Ding, Yahao Zhang, Tian Xia, Jiwei Li, Wenjian Yao, Quan Zhang, Zhijun Han, Jianjun Wang, Zhikun Cao, Jinlong Hu, Li Wei

“…BackgroundThe treatment of cancer has brought about a paradigm shift with the introduction of immune checkpoint blockade (ICB) therapy, which is mostly dependent on inhibiting PD-1/PD-L1 and CTLA-4. …”
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Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI by Omar Baritello, Simon H. Sündermann, Kristian Espinosa‐Garnica, Jörg Kempfert, Markus Jähnert, Nick L. Beetz, Dominik Geisel, Jasmin Gaugel, Julia Rominger, Ursula Müller‐Werdan, Catrin Herpich, Kristina Norman, Alexandra Chadt, Hadi Al‐Hasani, Heinz Völler, Annett Salzwedel, Heike Vogel

“…ABSTRACT Background Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). …”
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Assessing patients’ experience of care in four referral hospitals: a cross-sectional survey of outpatients in two South African rural provinces by Wezile W. Chitha, Onke R. Mnyaka, Akhona Ncinitwa, Olona Giwu, Teboho Mashao, Kuhle Mabophe, Sibusiso C. Nomatshila, Itumeleng Funani, Vivien Essel, Xolelwa Ntlongweni, Kedibone Maake, Nomfuneko Sithole, Ntiyiso Khosa, Maphoko Masemola, Ziyanda Ngcobo, Murendeni Mulamu, Bongiwe Mkabela, Siyabonga Sibulawa, Buyiswa Swartbooi, Godfrey Mokobane, Sikhumbuzo A. Mabunda

“…Conclusions Whilst hospitals have been implementing various quality measures to improve patient’s experience of care, there are a few concerns such as non-availability of drinking water, lack of knowledge of complaints processes and waiting times that were mostly reported to be unacceptable. Efforts should be made to address the highlighted areas that affect patient experiences to continue improving patient care. …”
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Statin-induced risk of diabetes does not reduce cardiovascular benefits in primary prevention: a 6-year propensity-score matched study in a large population by Maria Lembo, Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Stanislovas S. Jankauskas, Paola Gallo, Roberto Piccinocchi, Carmine Morisco, Gaetano Piccinocchi, Luca Bardi, Stefano Cristiano, Giovanni Esposito, Giuseppe Giugliano, Fahimeh Varzideh, Maria Virginia Manzi, Bruno Trimarco, Gaetano Santulli

“…Abstract Background The long-term risk of cardiovascular (CV) events in individuals who develop new-onset type 2 diabetes (T2D) after having received statin therapy in primary prevention is mostly unknown. Methods We designed a population-based cohort study in individuals without T2D and atherosclerotic CV disease (ASCVD), divided in two groups according to the presence of statin therapy. …”
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Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous mycobacteria by Céline Boidin-Wichlacz, Marc Maresca, Isabelle Correia, Olivier Lequin, Vanessa Point, Magali Casanova, Alexis Reinbold, Olga Iranzo, Sharon A. Huws, Priscille Brodin, Linda B. Oyama, Aurélie Tasiemski, Stéphane Canaan, Jean-François Cavalier

“…Membrane permeabilization and monolayer lipid insertion assays suggested that these peptides mostly act by insertion into the mycobacterial membrane resulting in a rapid membranolytic effect. …”
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Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its Fren... by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…In contrast, SRP strains were detected in 98 of the samples, mostly from the southern part of the river, at population densities that did not exceed 3 ´ 104 bacteria L-1. …”
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Analysis of detection of repeat blood donors with unqualified alanine aminotransferase by ZENG Zijian, LIAO Fenfang, XIE Junmou, WAN Zhiting, DU Rongsong, LI Zhongping, LIANG Haojian, LI Shijie, JI Yanli, LIANG Huaqin, WANG Hao

“…[Conclusion] The ALT unqualified rates of repeat blood donors were mostly non-specific elevation without TTD. Repeat blood donors with multiple ALT disqualifications tend to have continuous high ALT. …”
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Adjunctive IgM-enriched immunoglobulin therapy with a personalised dose based on serum IgM-titres versus standard dose in the treatment of septic shock: a randomised controlled tri... by Giacomo Grasselli, Patrizia Murino, Emanuela Biagioni, Martina Tosi, Giorgio Berlot, Giacomo Castiglione, Alberto Corona, Maria Giovanna De Cristofaro, Abele Donati, Paolo Feltracco, Francesco Forfori, Fiorentino Fragranza, Ornella Piazza, Livio Tullo

“…Immunoglobulin preparations enriched with the IgM component have largely been used in sepsis, mostly at standard dosages (250 mg/kg per day), regardless of clinical severity and without any dose adjustment based on immunoglobulin serum titres or other biomarkers. …”
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A worldwide event-based debris flow barrier dam dataset from 1800 to 2023 by H. Cheng, H. Cheng, K. Hu, K. Hu, S. Liu, S. Liu, X. Zhang, X. Zhang, H. Li, H. Li, Q. Zhang, Q. Zhang, L. Ning, L. Ning, M. R. Gouli, M. R. Gouli, P. Li, P. Li, A. Yang, A. Yang, P. Zhao, P. Zhao, J. Liu, J. Liu, L. Wei, L. Wei

“…The understanding of debris flow barrier dams (DFBDs) is poor, mostly due to existing studies focusing on individual events and a lack of summarization of multiple DFBD events. …”
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