Incidence of SARS-CoV-2 Infection Among European Healthcare Workers and Effectiveness of the First Booster COVID-19 Vaccine, VEBIS HCW Observational Cohort Study, May 2021–May 2023... by Camelia Savulescu, Albert Prats-Uribe, Kim Brolin, Zvjezdana Lovrić Makarić, Anneli Uusküla, Georgios Panagiotakopoulos, Colm Bergin, Catherine Fleming, Antonella Agodi, Paolo Bonfanti, Rita Murri, Viesturs Zvirbulis, Dace Zavadska, Konstanty Szuldrzynski, Ausenda Machado, Corneliu Petru Popescu, Mihai Craiu, Maria Cisneros, Miriam Latorre-Millán, Goranka Petrović, Liis Lohur, Kyriaki Tryfinopoulou, Jonathan McGrath, Lauren Ferguson, Martina Barchitta, Anna Spolti, Katleen de Gaetano Donati, Ilze Abolina, Dagne Gravele, Vânia Gaio, Simin Aysel Florescu, Mihaela Lazar, Pilar Subirats, Laura Clusa Cuesta, Gordan Sarajlić, Marina Amerali, Jacklyn Sui, Claire Kenny, Venerando Rapisarda, Marianna Rossi, Silvia Lamonica, Dainis Krievins, Elza Anna Barzdina, Ana Palmira Amaral, Alma Gabriela Kosa, Victor Daniel Miron, Carmen Muñoz-Almagro, Ana María Milagro, Sabrina Bacci, Piotr Kramarz, Anthony Nardone, the VEBIS HCW VE Study Group

“…<b>Results:</b> We included a total of 3015 HCWs. Participants were mostly female (2306; 79%), with a clinical role (2047; 68%), and had a median age of 44 years. …”
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The clinical value of screening for acetaminophen in all patients with intentional overdose or altered mental status suspected to be secondary to overdose by Bader Alyahya, Abdulaziz Alalshaikh, Mohammed Almohawes, Mosaed Alnowiser, Omar Alsuliman, Rand Alrefaei, Sarah Alaidarous, Maha Alnahdi, Shadi Tamur, Musa Alfaifi, Mohammed Al Deeb, Zohair A. Al Aseri, Zohair A. Al Aseri, Zohair A. Al Aseri

“…However, ordering unnecessary test is not cost-effective specially if it is mostly negative, and empirical therapy is associated with significant cost and possible adverse effects.MethodsThis single-center retrospective study was conducted at King Saud University Medical City (KSUMC) in Riyadh, Saudi Arabia. …”
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Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia by Rosa Rodríguez-Rodríguez, Mads Hornum, Ana Elena Rodríguez Rodríguez, Sebastjan Bevc, Francesco Trevisani, Gema Fernández, Radovan Hojs, Beatriz Fernández-Fernández, Clara María Cases Corona, Josep María Cruzado, María Quero, Maruja Navarro Díaz, Arianna Bettiga, Francisco Moreso, Clara García Carro, Khaled Khazim, Fedaa Ghanem, Meritxell Ibernón, Ivo Laranjinhia, Luís Mendonça, Miguel Bigotte Vieira, Bo Feldt-Rasmussen, Alberto Ortiz, Per Bagi, Cristian Acosta Sorensen, Enrique Morales, Esteban Porrini, Radovan Hojs, Sebastjan Bevc, Gema Fernández, Clara María Cases Corona, María Quero, Laia Pujol, Sergi Beato Montserrat Gomà, Josep Cruzado, Meritxell Ibernon, Francisco Moreso, Marina López-Martínez; Mads Hornum, Bo Feldt-Rasmussen; Alberto Ortíz, Beatriz Fernández-Fernandez, Elena Gomá-Garces, Teresa Stock da Cunha, Ana B. Sanz, María Garranzo, Carmen Gonzalez-Enguita, Ana María Autrán-Gómez; Pablo Cannata, Khalid Khazim, Fedaa Ghanem, Esteban Porrini, Rosa Rodríguez-Rodríguez, Natalia Negrín Mena, Tomás Concepción; Ivo Laranjinhia, Luís Mendonça; Miguel Bigotte Vieira, Trevisani Francesco, Arianna Bettiga, Federico Di Marco, Andrea Salonia, Francesco Montorsi, Dell'Antonia Giacomo, Enrique Morales, Manuel Praga

“…Introduction: The pathogenesis of renal disease in obesity and metabolic syndrome (MS) is mostly unknown. This is in part because of the limited information about renal morphological changes in these conditions. …”
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Burst steroid therapy and quality of life in patients with acute heart failure: Insights from the CORTAHF trial by Matteo Pagnesi, Gad Cotter, Beth A. Davison, Yonathan Freund, Adriaan A. Voors, Christopher Edwards, Maria Novosadova, Koji Takagi, Hamlet Hayrapetyan, Andranik Mshetsyan, Mayranush Drambyan, Alain Cohen‐Solal, Jozine M. terMaaten, Jan Biegus, Piotr Ponikowski, Gerasimos Filippatos, Ovidiu Chioncel, Malha Sadoune, Tabassome Simon, Douglas L. Mann, Alexandre Mebazaa, Marco Metra

“…Conclusions In patients with AHF and high hsCRP levels, 7 day burst steroid therapy improved QoL mostly by affecting the mobility and usual activities domains. …”
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Habitat Stability Modulates Temporal β‐Diversity Patterns of Seagrass‐Associated Amphipods Across a Temperate–Subtropical Transition Zone by Sandra Navarro‐Mayoral, Francisco Otero‐Ferrer, Victoria Fernandez‐Gonzalez, Néstor E. Bosch, Yolanda Fernández‐Torquemada, Fiona Tomás, Jorge Terrados, Luis Miguel Ferrero Vicente, Yoana delPilar‐Ruso, Fernando Espino, Fernando Tuya

“…Insights from terrestrial and marine studies on temporal β‐diversity has mostly considered environmental drivers, while the role of biotic mechanisms has been largely ignored. …”
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Novel composite health assessment risk model for older allogeneic transplant recipients: BMT-CTN 1704 by Mohamed L. Sorror, Wael Saber, Brent Logan, Nancy Geller, Anna Bellach, Jianqun Kou, William Wood, John M. McCarty, Thomas G. Knight, Lyndsey Runaas, Laura Johnston, Jeremy Walston, Ryotaro Nakamura, Lori Jarrett, Asmita Mishra, Joseph Uberti, Parastoo B. Dahi, Jennifer N. Saultz, Shannon R. McCurdy, Lawrence E. Morris, Philip H. Imus, William J. Hogan, Kalyan Nadiminti, Vijaya Raj Bhatt, Rebecca Olin, Joseph Maakaron, Ronald Sobecks, Sarah A. Wall, Deborah Mattila, Bailey Protz, Steven M. Devine, Mary M. Horowitz, Andrew S. Artz

“…Comparing primary-CHARM with HCT-comorbidity index and 2 ML-CHARM models, calibration, Brier score, and DCA analysis favored primary-CHARM. Primary-CHARM, with mostly simple and readily available parameters, risk stratifies older adults for allo-HCT. …”
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Estimating Dengue Outbreak Thresholds in West Africa: A Comprehensive Analysis of Climatic Influences in Burkina Faso, 2018–2024 by John Otokoye Otshudiema, Watton R. Diao, Sonia Marie Wend-Kuuni Ouedraogo, Alain Ngoy Kapete, Laurent Moyenga, Emmanuel Chanda, Tieble Traore, Otim Patrick Ramadan, Alimuddin Zumla

“…Principal Findings: The incidence of probable dengue cases remained stable, mostly below 5 cases per 100,000 people, except for a sharp surge in week 40 of 2023, peaking at 38 cases per 100,000. …”
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Predicting Urinary Function Outcomes Following Low-dose-rate Brachytherapy for Prostate Cancer by Gianni Rüedi, Manolis Pratsinis, Hans-Peter Schmid, Sabine Güsewell, Paul M. Putora, Ludwig Plasswilm, Christoph Schwab, Orlando Burkhardt, Armin Thoeni, Werner Hochreiter, Ladislav Prikler, Stefan Suter, Patrick Stucki, Michael Müntener, Nadja Blick, Hans Schiefer, Gautier Müllhaupt, Daniel S. Engeler

“…The primary outcome was poor urinary function after LDR-BT, defined as an IPSS-Quality of Life score >3 (“mostly dissatisfied” or worse) at 3 yr or the occurrence of TURP during follow-up. …”
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Characteristics and in‐hospital outcomes of elderly patients with cancer in a top‐ranked hospital in China, 2016–2020: Real‐world study by Lei Huang, Yan Shi, Lei Wang, Lan Rong, Yan Ren, Chenying Xu, Junwei Wu, Mingmin Zhang, Lifeng Zhu, Junjie Zhang, Xiaofeng Xu, Weiguo Hu, Jun Zhang

“…Abstract Background Cancer is mostly a disease of aging, and older patients with cancer are generally frailer. …”
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Resistant and refractory migraine – two different entities with different comorbidities? Results from the REFINE study by C. Rosignoli, R. Ornello, V. Caponnetto, A. Onofri, S. Avaltroni, M. Braschinsky, O. Šved, R. Gil-Gouveia, C. Lampl, J. Paungarttner, P Martelletti, W. D. Wells-Gatnik, I. P. Martins, D. Mitsikostas, L. Apostolakopoulou, G. Nabaei, A. Ozge, D. B. Narin, P. Pozo-Rosich, A. Muñoz-Vendrell, M. P. Prudenzano, M. Gentile, K. Ryliskiene, J. Vainauskiene, M. Sanchez del Rio, F. Vernieri, G. Iaccarino, M. Waliszewska-Prosol, S. Budrewicz, M. Carnovali, Z. Katsarava, S. Sacco

“…Several comorbidities, mostly psychiatric conditions, have been linked to migraine worsening; however, there is little knowledge of the comorbidity profile of individuals with resistant and refractory migraine. …”
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Improved in-situ direct shear test of rock mass structural plane and its application to stability analysis of bedding slope by Zhiming Wang, Changguang Qi, Zhichao Zhang, Rufa Huang, Chaoxu Guo, Lijin Dong, Rongyue Zheng

“…Previous tests of shear strength parameters for rock mass structural planes have mostly focused on laboratory experiments, which inevitably suffer from sample disturbance, boundary effects, size effects, and grading scale error. …”
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Bullous pemphigoid and mucous membrane pemphigoid humoral responses differ in reactivity towards BP180 midportion and BP230 by Feliciana Mariotti, Anna Pira, Naomi De Luca, Anna Rita Giampetruzzi, Filomena Russo, Amilcare Cerri, Giulia Gasparini, Giulia Gasparini, Emanuele Cozzani, Emanuele Cozzani, Angelo V. Marzano, Angelo V. Marzano, Emiliano Antiga, Marzia Caproni, Pietro Quaglino, Marco Carrozzo, Biagio Didona, Giovanni Di Zenzo

“…In addition, negative results obtained by commercially available enzyme-linked immunosorbent assays (ELISAs) with BP and MMP sera, especially from patients with ocular involvement, often delay diagnosis and treatment, leading to a greater risk of poor outcomes.ObjectivesOur aim was to find potentially different reactivity profiles in BP and MMP and improve available approaches for diagnosis with focus on ocular MMP.MethodsTwo cohorts of 90 BP and 90 MMP, recruited from different Italian clinical centers, were characterized also employing a novel ELISA based on the BP180 extracellular domain (ECD-BP180).ResultsImmunoglobulin G (IgG) reactivity to BP180 and BP230 in MMP sera was significantly reduced in comparison with BP, mostly affecting BP230 and E-1080 (53% and 36% in BP vs. 11% and 3% in MMP, respectively, p &lt; 0.0001). …”
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The seed transcriptome of Rafflesia reveals horizontal gene transfer and convergent evolution: Implications for conserving the world's largest flower by Jeanmaire Molina, Adhityo Wicaksono, Todd P. Michael, Su‐Hwan Kwak, Ronniel D. Pedales, Zoé Joly‐Lopez, Semar Petrus, Allen Mamerto, Brian Tomek, Sumaya Ahmed, Venkatasivasankar Maddu, Kristina Yakubova, Danilo Tandang, Joseph W. Morin, So‐Yon Park, Hyun‐Oh Lee, William McLaughlin, Kyle Wallick, James Adams, Ari Novy, Susan Pell, Michael D. Purugganan

“…To date, ex situ propagation of Rafflesia by seed has been mostly unsuccessful. Our research is a bold step forward in understanding the fundamentals of Rafflesia seed biology that will inform the continued propagation and seed‐banking efforts concerning this recalcitrant plant. …”
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Inflammatory markers and calcification of coronary arteries, aorta and cardiac valves: Findings from the atherosclerosis risk in communities study by Vennela Avula, Yejin Mok, Kentaro Ejiri, Jeremy Van't Hof, Seamus P. Whelton, Ron C. Hoogeveen, Christie M. Ballantyne, Matthew J Budoff, Michael J Blaha, Kunihiro Matsushita

“…These associations were mostly attenuated after adjusting for potential confounders, but the associations with ascending aorta and right coronary artery calcifications remained significant (adjusted odds ratio [aOR] 1.45 [95 % CI 1.02–2.07]) and 1.55 [1.12–2.16]) for the highest vs. lowest quartiles, respectively. …”
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Is rotavirus aetiology in young children with acute diarrhoea associated with sociodemographic and clinical factors, including rotavirus vaccination status? A secondary cross-secti... by Jie Liu, Christopher R Sudfeld, Per Ashorn, Queen Dube, Tahmeed Ahmed, Pratibha Dhingra, Usha Dhingra, Arup Dutta, Sunil Sazawal, Karim Manji, Rodrick Kisenge, Mohamed Bakari, Rajiv Bahl, Jonathon L Simon, Naor Bar-Zeev, Christopher Duggan, Ayesha De Costa, Nigel Cunliffe, Sadia Shakoor, Mohammod Jobayer Chisti, Farah Naz Qamar, Desiree Witte, Patricia B Pavlinac, Doreen Rwigi, Judd L Walson, Samba O Sow, Shahida Qureshi, Eric Houpt, James Platts-mills, Chifundo Ndamala, Sarah Somji, Abraham Samma, Fadima Cheick Haidara, Karen L Kotloff, Emily L Deichsel, Benson Singa, Mohammad Tahir Yousafzai, Muhammad Waliur Rahman, Irin Parvin, Anil Kumar Sharma, Vijay Kumar Jaiswal, Churchil Nyabinda, Christine McGrath, Maurine Anyango, Kevin Mwangi Kariuki, Stephanie N Tornberg-Belanger, Flanon Coulibaly, Jasnehta Permala-Booth, Dramane Malle, Latif Ndeketa, Rozina Thobani, Jan Mohammed, Cecylia Msemwa, Md Farhad Kabir

“…Introduction One of the leading causes of global child mortality continues to be diarrhoea where rotavirus contributed to about 24% of deaths among all diarrhoeal deaths, mostly in low-income and middle-income countries. …”
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Association Between Diabetes and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis of Observational Studies by Ana Paula Pagano, Bruna Ramos da Silva, Flávio Teixeira Vieira, Luiz Fernando Meira Filho, Sarah A. Purcell, John D. Lewis, Michelle L. Mackenzie, Paula J. Robson, Jennifer E. Vena, Flávia Moraes Silva, Carla M. Prado

“…High heterogeneity may partially explain discrepancy in findings and was mostly associated with study design, method used for PC diagnosis, and risk measures. …”

Reconstruction of Holocene and Last Interglacial vegetation dynamics and wildfire activity in southern Siberia by J. Margerum, J. Homann, S. Umbo, G. Nehrke, T. Hoffmann, A. Vaks, A. Kononov, A. Kononov, A. Osintsev, A. Giesche, A. Mason, F. A. Lechleitner, G. M. Henderson, O. Kwiecien, S. F. M. Breitenbach

“…While our understanding of the drivers behind wildfires and their environmental impact is growing, it is mostly limited to the observational period. Here we focus on the boreal forests of southern Siberia and exploit a U–Th-dated stalagmite from Botovskaya Cave, located in the upper Lena region of southern Siberia, to document wildfire activity and vegetation dynamics during parts of two warm periods: the Last Interglacial (LIG; specifically part of the Last Interglacial maximum between 124.1 and 118.8 ka) and the Holocene (10–0 ka). …”
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Enrichment mechanisms and accumulation models of deep tight sandstone reservoirs in Junggar Basin: A case study of Moxizhuang and Yongjin areas by MA Ji, WANG Jinduo, ZHANG Kuihua, ZHANG Guanlong, ZENG Zhiping, HU Haiyan, GONG Yajun, ZHANG Yi

“…However， the faults with small sizes and short movement distances are mostly closed. The pore sizes of the tight reservoirs are small， mainly in the range of 163.8-207.7 μm， and the throats are 0.5-8.1 μm. …”
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Second‐line treatment options in advanced thymic carcinoma after failure of platinum‐based chemotherapy: A multicenter retrospective study by Yang Wang, Xuanye Zhang, Dan Tian, Sen Han, Jie Zhang, Jun Nie, Ling Dai, Weiheng Hu, Xiaoling Chen, Xiangjuan Ma, Guangming Tian, Di Wu, Ziran Zhang, Jieran Long, Jian Fang

“…Multivariate analysis showed that second‐line treatment was independent factor for both PFS (p = 0.035) and OS (p = 0.037). Grade 3–4 AEs were mostly detected in patients receiving multidrug chemotherapy and were primarily hematologic. …”
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Deep learning of the particulate and mineral-associated organic carbon fractions using a compositional transform and mid-infrared spectroscopy by Mingxi Zhang, Zefang Shen, Lewis Walden, Farid Sepanta, Zhongkui Luo, Lei Gao, Oscar Serrano, Raphael A. Viscarra Rossel

“…Previous spectroscopic modelling has mostly ignored the compositional nature of the SOC fractions (i.e. …”
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