BIOLOGICAL ACTIVITY OF HYPERICUM PERFORATUM L. (HYPERICACEAE): A REVIEW by A. L. Budantsev, V. A. Prikhodko, I. V. Varganova, S. V. Okovityi

“…Unlike many other known medicinal plants, the pharmacological study of which is accompanied by the establishment of new (or rediscovered) structures of chemical compounds, the dynamics of the present study of H. perforatum is mostly associated with a detailed study of the mechanisms of its therapeutic effect and less with the search for new components.The aim of this work is to review and analyze the data on the biological activity of extracts and individual components of Hypericum perforatum L. …”
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Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. by Stéphane Cauchi, David Meyre, Emmanuelle Durand, Christine Proença, Michel Marre, Samy Hadjadj, Hélène Choquet, Franck De Graeve, Stefan Gaget, Frederic Allegaert, Jérôme Delplanque, Marshall Alan Permutt, Jon Wasson, Ilana Blech, Guillaume Charpentier, Beverley Balkau, Anne-Claire Vergnaud, Sébastien Czernichow, Wolfgang Patsch, Mohamed Chikri, Benjamin Glaser, Robert Sladek, Philippe Froguel

“…<h4>Conclusions/significance</h4>In addition to TCF7L2, SLC30A8 and HHEX, initially identified by the French GWA scan, CDKAL1, IGFBP2 and CDKN2A/2B strongly associate with T2D in French individuals, and mostly in populations of Central European descent but not in Moroccan subjects. …”
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A real-world study on the influence of unplanned reoperations on hospitalized patients using the diagnosis-related group by Rui Fan, Qifeng Chen, Shang Gao, Lili Wang, Shuqi Mao, Zhiyu Yan

“…Subgroup analyses indicated that the outcomes across the various subgroups were mostly uniform. In high-level surgery subgroups (levels 3–4) and in relation to complex diseases (relative weight ≥ 2), the increase in hospitalization costs and LOS was more pronounce after unplanned reoperations. …”
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Clinicopathological features and outcome for neuroendocrine neoplasms of gastroesophageal junction: A population‐based study by Panpan Zhang, Wei Wang, Ming Lu, Changqing Zeng, Jie Chen, Enxiao Li, Huangying Tan, Wei Wang, Xianjun Yu, Qiyun Tang, Jiemin Zhao, Lin Shen, Jie Li

“…Conclusion GEJ‐NENs were mostly poorly differentiated carcinomas, and all of Chinese patients were NEC/MANEC. …”
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Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C... by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“…In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results. The evaluation of neurological outcomes, predominantly as primary outcomes, using clinical scales (Glasgow Outcome Scale) has limitations that could explain these results. …”
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Countering the corporate tax avoidance in the Court of Justice of the European Union practice by К. A. Tasalov, S. G. Sokolova, D. M. Osina

“…The article contains the analysis of extensive CJEU practice regarding the issues of countering corporate tax avoidance, and legal framework, mostly the provisions of the Treaty on the Functioning of the European Union and Directives.The purpose of this paper is to conduct a comprehensive research of the issues of countering the corporate tax avoidance in the CJEU practice. …”
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Assessment of Tuberculosis Drugs and Diagnostics in Katsina Central, Katsina State, Nigeria by Adamu, S. U., Jamilu, M. Z., Adamu, M. B.

“… • It shows concern regarding the availability of drugs for Drug-Sensitive Tuberculosis, which are largely in stock, and those for Drug-Resistant Tuberculosis, which are mostly unavailable, compromising treatment regimens…”
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Differential use of multiple food sources at a bathyal benthic ecosystem in the central Sagami Bay revealed by amino acid nitrogen isotopic compositions by Hidetaka Nomaki, Yoshito Chikaraishi, Nanako O. Ogawa, Koh Maki, Motohiro Shimanaga, Hisami Suga, Masashi Tsuchiya, Toshi Nagata, Naohiko Ohkouchi

“…The trophic positions of organisms from the central Sagami Bay ranged mostly from 2.2 to 3.6, except hydrozoans (up to 4.3). …”
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Association of HLA-C*07:359 with HLA-A, -B, and -DRB1 alleles in Taiwanese by Kuo-Liang Yang, Py-Yu Lin

“…Since C*07:359 was found mostly in the Taiwanese indigenous population, we think the allele and its haplotypes we report here are important in population and anthropological studies.…”
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ROLE OF TNFα/TNF-R1-SIGNALING PATHWAY IN CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST GLIOBLASTOMA CELL LINES by T. V. Tyrinova, S. V. Mishinov, O. Yu. Leplina, A. A. Alshevskaya, Yu. D. Kurochkina, E. A. Oleynik, А. V. Kalinovskiy, Yu. A. Lopatnikova, S. V. Chernov, V. V. Stupak, S. V. Sennikov, A. A. Ostanin, E. R. Chernykh

“…Glioblastoma cell lines expressed both TNF-R1 and TNF-R2 receptors, but mostly – TNF-R1. However, rTNFα did not show cytotoxic activity towards glioblastoma cell lines. …”
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Combining immersive exergaming with physiotherapy in a specialized intensive Parkinson’s disease rehabilitation program: a randomized controlled trial by Daniela Pimenta Silva, Raquel Bouça-Machado, Filipa Pona-Ferreira, Teresa Lobo, Ricardo Cacho, Rebekka Anker, John W. Krakauer, Joaquim J. Ferreira

“…Adverse events (n = 309) were mostly mild (55%). Overall, 20 participants (67%) adhered to the study protocol, with the COM being more compliant than the SEQ group. …”
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&#x03F5;-Confidence Approximately Correct (&#x03F5;-CoAC) Learnability and Hyperparameter Selection in Linear Regression Modeling by Soosan Beheshti, Mahdi Shamsi

“…These issues have been addressed mostly by alternating modeling cost functions or by utilizing cross-validation methods. …”
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Green Synthesis and Characterization of Silver Nanoparticles from <i>Minthostachys acris</i> Schmidt Lebuhn (Muña) and Its Evaluation as a Bactericidal Agent Against <i>Escherichia... by Fabián Ccahuana Ayma, Ana María Osorio Anaya, Gabrielle Caroline Peiter, Silvia Jaerger, Ricardo Schneider

“…Dynamic light scattering (DLS) shows the hydrodynamic size of the colloidal nanoparticles between 11 and 200 nm, and scanning electron microscopy (SEM) reveals monodisperse AgNPs of different morphologies, mostly nanospheres, while Laser-Induced Breakdown Spectroscopy (LIBS) demonstrates the presence of Ag in the colloidal solution. …”
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Chronic Limb Threatening Ischemia masquerading as Vitamin D deficiency; A case report by Sarah Afzal Kothari, Hadia Iftikhar, Iqra Anis

“…Introduction: Limb Ischemia is an uncommon but high risk emergency. It mostly presents as a painful limb in patients with peripheral arterial disease with risk factors such as hypertension, diabetes, smoking and chronic kidney disease. …”
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Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer by Anna Dieper, Stephan Scheidegger, Rudolf M. Füchslin, Paraskevi D. Veltsista, Ulrike Stein, Mathias Weyland, Dominik Gerster, Marcus Beck, Olof Bengtsson, Daniel Zips, Pirus Ghadjar

“…These effects span from mitotic arrest and growth inhibition to cancer cell death in the form of autophagy and apoptosis and appear to be mostly exclusive to cancer cells. Several cellular mechanisms were identified through which RF-EMF radiation potentially imposes its anti-cancer effects. …”
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The Effects of Low- vs. High-Glycemic Index Mediterranean-Style Eating Patterns on Subjective Well-Being and Sleep in Adults at Risk for Type 2 Diabetes: The MEDGICarb-Intervention... by Anna Hjort, Robert E. Bergia, Marilena Vitale, Rosalba Giacco, Gabriele Riccardi, Wayne W. Campbell, Rikard Landberg

“…Low- vs. high-GI MED-HEP resulted in differential changes between the groups in domains of well-being, driven mostly by improvements in the low-GI group, of which role physical (5.6 AU vs. −2.5 AU, <i>p</i> = 0.022) and vitality (6.9 AU vs. −0.3 AU, <i>p</i> = 0.008) were significant (ANOVA with group, site and sex as fixed factors and age and BMI as covariates). …”
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Lithologically constrained velocity–density relationships and vertical stress gradients in the North Alpine Foreland Basin, SE Germany by P. Obermeier, F. Duschl, M. C. Drews

“…The up to 5 km thick Cenozoic basin fill comprises mostly shales, marls, sandstones, carbonates, and coarse-grained clastics; in particular, Oligocene–Miocene age sediments display significant lateral lithological variability due to two marine transgressions. …”
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Diagenetic facies of the Fengcheng Formation tight reservoir in the alkaline lake sedimentary environment, the southern margin of Mahu Sag, Junggar Basin, China by Zongbin Zhang, Jun Qin, Zhongchen Ba, Wenbiao Huang, Mengyun Han, Yuhui Gao, Dong Wu

“…The outer front of the fan delta is mostly associated with solution-cementation facies, resulting in an average porosity of the reservoir of about 3.1%. …”
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Screening for primary aldosteronism in 1,181 Swedish primary care patients with hypertension by Nikita Makhnov, Nikita Makhnov, Nikita Makhnov, Jakob Skov, Jakob Skov, Tobias Åkerström, Tobias Åkerström, Fredrik Axling, Daniel Andernord, Mikael Bergenheim, Mikael Bergenheim, Mauritz Waldén, Per Hellman, Per Hellman

“…Treatment results were assessed after a minimum of 6 months.ResultsA total of 53 discovered cases of (mostly mild) PA corresponded to its prevalence of 4.5%. …”
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Psychosocial problems in women attending French, German and Spanish genetics clinics before and after targeted or multigene testing results: an observational prospective study by Peter Devilee, Antoine de Pauw, Dominique Stoppa-Lyonnet, Anne Brédart, Jean-Luc Kop, Julia Dick, Alejandra Cano, Amélie Anota, Rita Schmutzler, Sylvie Dolbeault

“…Other PAHC scales (ie, emotions, familial cancer, personal cancer and children-related issues) were not affected by genetic testing.Conclusions In women tested for breast or ovarian cancer genetic risk in European genetics clinics, psychosocial problems were mostly unaffected by genetic testing. Apart from women receiving a VUS result, those with another test result presented unchanged needs in counselling in particular about hereditary predisposition and familial/social issues.…”
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