Chromene flavanones from Dalea boliviana as xanthine oxidase inhibitors: in vitro biological evaluation and molecular docking studies by Einy Nallybe Bedoya Aguirre, Einy Nallybe Bedoya Aguirre, María Daniela Santi, Melisa Fabiana Negro, Melisa Fabiana Negro, Javier Echeverría, Margot Paulino Zunini, Mariana Andrea Peralta, Mariana Andrea Peralta, María Gabriela Ortega, María Gabriela Ortega

“…Moreover, molecular docking studies were performed to propose the binding modes of the most active natural compounds.Results and discussionCompounds 1 and 2 exhibited potent inhibition, with IC50 values in the nanomolar range (0.5 ± 0.01 nM and 1.7 ± 0.46 nM, respectively), demonstrating significantly higher activity than allopurinol (AL), the reference inhibitor (IC50 = 247 ± 4 nM). …”
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Clinical features, treatment and prognosis analysis of distant metastatic esophageal cancer by Shuang Li, Yanwei Lu, Ruiqi Liu, Luanluan Huang, Ding Nan, Xiaoyan Chen, Wenjie Xia, Xiaodong Liang, Haibo Zhang

“…Abstract Esophageal cancer (EC) is one of the most common malignant tumors in China. EC is characterized by a poor clinical prognosis, with many patients being diagnosed at advanced stages. …”
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Groundwater ammonia-oxidizing bacteria distribution and the correlations between the distribution and environmental factors around livestock lagoons by REN Juan, ZHANG Lei, ZENG Lingzao, WU Laosheng, SHI Jiachun

“…The correlations among environmental factors, AOB abundance and relative abundance of AOB were analyzed by Pearson correlation coefficient.The results indicated that NH₄⁺-N concentration was ranged from 0.35 - 18.98 mg/L, most of which was much higher than 0.5 mg/L in groundwater quality standard (GB/T 14848-93). …”
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Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fe... by Wilson Santos Molari, Mohamed Amine Jmel, Mohamed Amine Jmel, Josiane Betim Assis, Alan Frazão-Silva, Júlia Moura Bernardi, Gretta Huamanrayme, José María Medina, Eliane Esteves, Solange Cristina Antão, Gabriel Cerqueira Alves Costa, Aparecida Sadae Tanaka, Aparecida Sadae Tanaka, Andréa Cristina Fogaça, Andréa Cristina Fogaça, Zdenek Franta, Lucas Tirloni, Michalis Kotsyfakis, Michalis Kotsyfakis, Anderson Sá-Nunes, Anderson Sá-Nunes

“…Thus, this study aims to describe and characterize the most expressed member of the cystatin family identified in Amblyomma sculptum salivary transcriptome, named Amblyostatin-1. …”
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Brain functional connectivity associated with cognitive deficits in younger patients at first episode of schizophrenia by Na Liu, Lihua Xu, Xiaofeng Guan, Ansi Qi, Fei Liu, Chengqing Yang, Xiangyun Long, Junjuan Zhu, Nan Huang, Jie Zhang, Yi Xu, Jing Chen, Huan Huang, Jijun Wang, Zheng Lu

“…Results: Significant cognitive differences were observed between the four groups (H = 13.447, p = 0.004, Rank ε2 = 0.259). The most prominent differences were found between the FES_young and HC_young groups (Holm-adjusted p = 0.012). …”
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Peculiarities of morphological indicators of quail spleen (Coturnix japonica Temminck et Schlegel, 1849) when using protein-vitamin mineral supplements by O. F. Dunaievska, I. M. Sokulskiy, L. P. Horalskyi, M. L. Radzikhovskyi, B. V. Gutyj

“…In most countries of the world, poultry farming is one of the main branches of agriculture, which provides the population with high-quality food products. …”
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Distribution of HLA-A, -B, and -C Alleles and HLA/KIR Combinations in Han Population in China by Yunsong Shen, Danfeng Cao, Yalin Li, J. K. Kulski, Lei Shi, Hongjun Jiang, Qianli Ma, Jiankun Yu, Jingxian Zhou, Yufeng Yao, Li Shi

“…The results of KIR/HLA-C combination analysis showed that all individuals had at least one inhibitory or activating KIR/HLA-C pair, and one KIR/HLA-C pair was the most frequent (157/239), followed by two pairs (46/239), three pairs (33/239), and no pairs (3/239). …”
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Interactions Between Bacterivorous Nematodes and Bacteria Reduce N2O Emissions by Xu Xu, Xinling Wang, Ting Sun, Shanshan Liu, Menghui Dong, Yang Yue, Yi Min, Alexandre Jousset, Xian Xiao, Shuwei Liu, Stefan Geisen, Valentyna Krashevska, Qirong Shen, Stefan Scheu, Rong Li

“…Removal of nematodes by defaunation resulted in increased N2O emissions, with the removal of Protorhabditis contributing most to this increase. Further, inoculation with Protorhabditis altered bacterial community composition and increased the relative abundance of Bacillus, and the abundance of the nosZ gene in soil. …”
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Análisis de la elección de la especialidad de Medicina Familiar y Comunitaria entre los candidatos MIR en el periodo 2020 a 2024: Índice de preferencia competitiva by Yoseba Cánovas Zaldúa, Remedios Martín Álvarez, Aina Mas Tena, Jorge Lema Bartolomé, Ermengol Coma, Núria Nadal Braqué

“…Site and participants: The MIR squares of the 5 most populated Spanish cities were chosen. Interventions and Main measurements: The construction of the CPI is based on the comparison of MFyC with each specialty, taking into account the equal opportunity to choose MFyC or another specialty, and takes into account the percentage of choice of MFyC at the time in which the choice has been finalized of that other specialty. …”
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Pulp fiber-based composites with plasticized starch via high-shear mixing by A Eliasson, V Polisetti, M Hedenqvist, A Larsson, T Geiger, G. Nyström, E. Malmström

“…The glycerol-containing samples processed at 200°C exhibited significantly lower strength and stiffness than samples prepared at 150°C, likely due to evaporation of glycerol and phase separation. The most favorable results showed a more than sixfold increase in stiffness and strength compared to pure Kraft pulp.Structural weaknesses in the composites were primarily observed at interfaces where starch agglomerates lacked fiber reinforcement. …”
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Isolation, Identification and Biological Characteristics of Grape Anthracnose Pathogen in Zhejiang Province by Shendan YU, Ziqi LU, Rongyao CHAI, Jun WU, Jing WANG, Haiping QIU, Yanli WANG, Guocang SUN, Jiaoyu WANG

“…【Objective】Grape anthracnose is one of the most serious and common grape diseases in China. …”
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Factors Affecting Attitudes towards Cohabitation among Iranian Youth by Reyhane Ghasemi Neyasar, Rasoul Sadeghi, Fatemeh Torabi

“…The demographic characteristics of the sample were as follows: the average age of respondents was approximately 27 years. Most participants (about 53%) were unemployed. In terms of religion, the majority of the sample population (89%) identified as Shia Muslims and 74% of respondents resided in urban areas. …”
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Predictive value of liver enzymes in long-term prognosis of hepatic Wilson disease: results from the Wilson AEEH registry by Marina Berenguer, Luis García-Villarreal, Antonio Olveira, Esther Mollina Pérez, José María Moreno Planas, Marta Romero-Gutiérrez, José María Pinazo Bandera, Helena Masnou Ridaura, Paula Iruzubieta, María Luisa González Diéguez, Javier Ampuero, José Ramón Fernández Ramos, Carolina Muñoz, Ana Arencibia Almeida, Sara Lorente, Manuel Delgado Blanco, Diego Burgos Santamaría, Mònica Pons Delgado, Alba Cachero, Manuel Hernández Guerra, Judith Gómez Camarero, Sergio Gil Rojas, María Lázaro Ríos, Isabel Carmona Soria, Gemma Carrión, Ariadna Bono, Anna Miralpeix, Pablo Alonso Castellano, Zoe Mariño, Registro Wilson-AEEH

“…Results Of 162 patients, 81.5% had mild disease at diagnosis. Most received chelators as first-line therapy, achieving an 81.4% one-year biochemical response. …”
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Optimization of composition and technology for tablets containing aspen bark extract by O. I. Onуshkiv

“…Using mathematical planning of the experiment gives the possibility to reduce the number of experiments and to obtain the most detailed results of researches about effects of excipients on the basic parameters of tablet quality. …”
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Plasma cytokines in patients with COVID-19 during acute phase of the disease and following complete recovery by N. A. Arsentieva, N. E. Liubimova, O. K. Batsunov, Z. R. Korobova, O. V. Stanevich, A. A. Lebedeva, E. A. Vorobyov, S. V. Vorobyova, A. N. Kulikov, D. A. Lioznov, M. A. Sharapova, D. E. Pevtcov, A. A. Totolian

“…We revealed a significant decrease of most plasma cytokines upon recovery as compared to acute phase. …”
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Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021) by Le HHL, Thuc LC, Ta TB, Tran TV, Hung DV, Kien HT, Le MN, Luong VH, Nguyen VTH, Pham HQ, Le HV, Viet NH, Hoang LH, Nguyen TT, Latsavong M, Le TD, Trong Tuan D, An NV

“…Gram-negative bacteria predominated (591/892; 66.3%), with Escherichia coli being the most prevalent (336/892; 37.7%). Enterococcus spp. (152/892; 17.0%) was the leading Gram-positive pathogen. …”
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HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer by Qing Wang, Maha Ayyoub, Olivia Le Saux, Paola Bonaventura, Isabelle Treilleux, Nicolas Chopin, Clarisse Dubois, Virginie Mutez, Nicolas Chuvin, Yann Estornes, Jenny Valladeau-Guilemond, Stephane Depil, Nicolas Gadot, Marie Michelas, Audrey Page, Olivier Tabone, Marie Delles, Sarah Moran, Thibault Richard, Marjorie Lacourrège, Dina M Tawfik, Ema Etchegaray, Adrian Valente, Rasha E Boulos, Gabriel Jimenez Dominguez

“…Background Ovarian cancer represents the most lethal gynecological cancer with poor response to checkpoint inhibitors. …”
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Pediatric autoimmune diseases in the light of COVID-19 pandemic, A retrospective observational big data study by Rim Kasem Ali Sliman, Hilla Cohen, Shereen Shehadeh, Reut Batcir, Yigal Elenberg Alter, Keren Cohen, Ilana Koren, Inbal Halabi, Hussein Sliman, Mohamad Hamad Saied

“…Rheumatic diseases (Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, Henoch Schoenlein Purpura (HSP)) showed consistent increases, with HSP demonstrating the most pronounced trend. Endocrine disorders exhibited diverse patterns, with autoimmune thyroid diseases and Type 1 diabetes showing overall increases, while diabetic ketoacidosis exhibited an initial spike followed by a decline. …”
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Extrinsic and intrinsic drivers of prevalence and abundance of hard-bodied ticks (Acari: Ixodidae) in one-humped camel (Camelus dromedarius) by Rachid Chaibi, Nora Mimoune, Farouk Benaceur, Latifa Stambouli, Lamine Hamida, Rabah Khedim, Radhwane Saidi, Mohammed Hocine Benaissa, Hicham Gouzi, Souad Neffar, Haroun Chenchouni

“…Results: A total of 980 ticks were collected, with Hyalomma dromedarii Koch, 1844 being the most abundant species (553 specimens), followed by Hyalomma impeltatum Schulze & Schlottke, 1930 (393 specimens), and Hyalomma excavatum Koch, 1844 (34 specimens). …”
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Genetic testing and evidence of a founder mutation in a hotspot for hereditary transthyretin amyloidosis by Marc Ventayol-Guirado, Eugenia Cisneros-Barroso, Maria Antonia Ribot-Sanso, Juan Gonzalez-Moreno, Ines Losada, Tomas Ripoll-Vera, Jaume Pons, Elena Fortuny, Teresa Bosch, Antonio Figuerola, Cristina Descals, Joan Carles Montala, Jorge Alvarez-Rubio, Jessica Hernandez-Rodriguez, Jose Lustre-Rodriguez, Maria Victoria Llull-Alberti, Juan Antonio Jimenez-Barcelo, Victor Jose Asensio-Landa, Laura Torres-Juan, Iciar Martinez-Lopez, Juan Buades-Reines, Damian Heine-Suñer

“…The Balearic Islands are a known endemic focus for the NP_000362.1:p.Val50Met (V30M) variant, one of the most prevalent pathogenic mutations. We analysed 23 years of genetic testing data from the Balearic Islands’ public health system to determine the prevalence and distribution of ATTR pathogenic variants, with a focus on V30M. …”
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