Improving nutritional quality and aflatoxin detoxification of peanut meal by co-fermentation with Weizmannia coagulans, Bacillus subtilis, and supplemented enzymes by Youwei Chen, Hao Huang, Dan Li, Limei Zou, Wendi Yu, Weiwei Dong, Xiang Yu, Yanli Feng, Jun Liu, Shumiao Zhao, Yunxiang Liang, Yuanliang Hu, Nan Peng

“…Microbial fermentation is one of the most effective methods to reduce anti-nutritional factors and enhance the nutritional value of peanut meal. …”
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Ten-Year Evaluation of Ventilator-Associated Pneumonia (VAP) According to Initial Empiric Treatment: A Retrospective Analysis Using Real-World Data by Alejandro Rodríguez, Julen Berrueta, Carolina Páez, Ronny Huertas, Marco Marotta, Laura Claverias, Josep Gómez, Sandra Trefler, Frederic F. Gómez Bertomeu, María Dolores Guerrero-Torres, Sergio Pardo-Granell, Ester Picó-Plana, Alicia Selles-Sánchez, Francisco Javier Candel, Ignacio Martín-Loeches, María Bodí

“…<b>Results</b>: A total of 220 patients were included in the study (P1 = 47, P2 = 96, and P3 = 77 patients). The most prevalent microorganisms identified were <i>P. aeruginosa</i>, <i>Klebsiella</i> spp., and <i>S. aureus</i>. …”
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Prevalence of cardiovascular diseases and risk factor assessment in breast cancer survivors exposed to cardiotoxic therapy by Marina V. Vitsenya, Irina V. Barinova, Nana V. Pogosova, Tatevik A. Terteryan, David T. Kuchiev, Yulia V. Khrushcheva, Anna A. Gerasimova, Anastasiya Y. Filatova, Nursiyat M. Ibragimova, Olga O. Frolkova, Fail T. Ageev

“…Conclusion: There is a high prevalence of cardiovascular risk factors in the patients who underwent cardiotoxic antitumor treatment for BC. The most frequent CVD was heart failure; two thirds of the patients had a high cardiovascular risk. …”
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A decade of Benzodiazepine and Z-drug use in Hong Kong: a longitudinal studyResearch in context by Kyung Jin Lee, Yue Wei, Shek-Ming Leung, Caige Huang, Hei Hang Edmund Yiu, Eunice Kehui Deng, David J. Castle, Simon S.Y. Lui, Vincent K.C. Wong, Ian C.K. Wong, Esther W. Chan

“…Depression and dementia were the most common psychiatric diagnoses within 180 days before and after treatment initiation. …”
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Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma by Xiaoxuan Tang, Shanxing Dang, Jie Qiu, Ruilan Zhou, Jing Ling, Limei Zhang, Xiaopeng Peng, Qingyun Li, Jin Liu, Wei Liao, Qingxiu Mei, Miao Xie, Yehong Sun, Jianmei Huang, Xuelian Du, Wencong Song

“…BackgroundUterine corpus endometrial carcinoma (UCEC) is one of the most common cancers in women, yet lacks specific and sensitive tumor markers for diagnosis, as traditional markers like CA125 show limited specificity. …”
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Climate science for 2050 by Guy Brasseur, Guy Brasseur, Detlef Stammer, Pierre Friedlingstein, Pierre Friedlingstein, Gabriele Hegerl, Tiffany Shaw, Kevin Trenberth, Kevin Trenberth, Jadwiga Richter, Carolina Vera, André Berger, Helen Cleugh, Steve Easterbrook, Paul Edwards, Daniela Jacob, Michael Mann, Valérie Masson-Delmotte, Gavin Schmidt, Mary Scholes, Thomas Stocker, Martin Visbeck, Guoxiong Wu

“…The development of a skillful climate information system, based on the most advanced Earth system science, will be required to inform decision-makers and the public around the world about the local and remote impacts of climate change, and guide them in optimizing their adaptation and mitigation agendas. …”
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Anticancer, antioxidant, and antibacterial activities of low molecular weight bioactive subfractions isolated from cultures of wood degrading fungus Cerrena unicolor. by Anna Matuszewska, Magdalena Jaszek, Dawid Stefaniuk, Tomasz Ciszewski, Łukasz Matuszewski

“…The low molecular weight subfraction III was the most effective and additionally showed the highest free radical 1,1-diphenyl-2-picryl-hydrazyl scavenging activity (IC50 20.39 μg/mL) followed by the low molecular weight subfraction I (IC50 64.14 μg/mL) and II (IC50 49.22 μg/mL). …”
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STING regulates NETs formation by activating GSDMD in influenza viral pneumonia by Rongrong Huang, Rongrong Huang, Rongrong Huang, Ranran Chen, Ranran Chen, Ranran Chen, Lijuan Xing, Lijuan Xing, Lijuan Xing, Lianhao Wu, Lianhao Wu, Lianhao Wu, Wenwen Zhu, Junsong Jing, Junsong Jing, Junsong Jing, Ting Zhou, Yueguo Wu, Sheng Zhang, Zhenqiang You, Zhenqiang You, Zhenqiang You

“…BackgroundViral pneumonia is the most common and lethal pandemic disease, but there are no broad-spectrum antiviral drugs with high genetic barriers to resistance. …”
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Identification and characterization of the powdery mildew resistance in cultivated emmer wheat accession Lxd-682 via bulked segregant RNA sequencing by Jiatong Li, Ningning Yu, Nina Sun, Lige Geng, Yanmin Qie, Dongfeng Zhai, Yuxiang Wang, Linzhi Li, Xueqing Liu, Xusheng Sun, Jiangchun Wang, Ruishan Liu, Guantong Pan, Shengmao Zou, Guohao Han, Yuli Jin, Pengtao Ma

“…Utilizing and identifying resistance genes and elucidating the molecular mechanisms underlying this resistance are the most effective and sustainable ways to fight this disease. …”
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Target product profiles for digital health technologies including those with artificial intelligence: a systematic review by Trystan B. Macdonald, Trystan B. Macdonald, Trystan B. Macdonald, H. D. Jeffry Hogg, H. D. Jeffry Hogg, Jacqueline Dinnes, Jacqueline Dinnes, Lucy Verrinder, Gregory Maniatopoulos, Sian Taylor-Phillips, Bethany Shinkins, J. Kevin Dunbar, Ameenat Lola Solebo, Ameenat Lola Solebo, Hannah Sutton, John Attwood, Michael Pogose, Rosalind Given-Wilson, Felix Greaves, Felix Greaves, Carl Macrae, Carl Macrae, Russell Pearson, Adnan Tufail, Adnan Tufail, Xiaoxuan Liu, Xiaoxuan Liu, Xiaoxuan Liu, Alastair K. Denniston, Alastair K. Denniston, Alastair K. Denniston, Alastair K. Denniston

“…A total of 14 TPPs were identified, most targeted at low- and middle-income settings and communicable diseases. …”
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Caracterización preliminar de la susceptibilidad sísmica en el entorno de la localidad de Sampacho, Córdoba, Argentina by Romina Daga, Grosso Virginia, Sagripanti Guillermo, Villegas Monica, Villalba Diego

“…It is worth mentioning that it was epicenter of two historical earthquakes (year 1934), considerated two of the most destructive ones within of the zone of reduced seismicity.…”
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Hydroxyl Lines and Moonlight: A High Spectral Resolution Investigation of Near-infrared Skylines from Maunakea to Guide Near-infrared Spectroscopic Surveys by Frederick Dauphin, Andreea Petric, Étienne Artigau, Andrew W. Stephens, Neil James Cook, Steven Businger, Nicolas Flagey, Jennifer Marshall, Michelle Ntampaka, Swara Ravindranath, Laurie Rousseau-Nepton

“…In addition, we used Lomb–Scargle periodograms and Gaussian process regression to estimate that most OH lines vary on similar timescales, which provides a valuable input for IR spectroscopic survey strategies. …”
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Integrated multi-omics analysis and machine learning identify G protein-coupled receptor-related signatures for diagnosis and clinical benefits in soft tissue sarcoma by Duo Wang, Duo Wang, Duo Wang, Jihao Tu, Jihao Tu, Jianfeng Liu, Jianfeng Liu, Yuting Piao, Yuting Piao, Yiming Zhao, Yiming Zhao, Ying Xiong, Ying Xiong, Jianing Wang, Jianing Wang, Xiaotian Zheng, Xiaotian Zheng, Bin Liu, Bin Liu

“…Building up a GPR-TME classifier, low GPR combined with high TME exhibited the most favorable prognosis and immunotherapeutic efficacy, which was further performed for immune infiltration, functional enrichment, somatic mutation, immunotherapy response prediction, and scRNA-seq analyses.ConclusionsOur study constructed a GPRS that can serve as a promising tool for diagnosis and prognosis prediction, targeted prevention, and personalized medicine in STS.…”
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Assessing rehabilitation potential of the masticatory musculature in patients with temporomandibular myofascial pain syndrome: A randomized prospective controlled study by E. N. Iarygina, V. V. Shkarin, Yu. A. Makedonova, S. V. Dyachenko

“…The standard treatment was established to be most effective within the short-term period (up to 14 days from the start of treatment), while the suggested regimen activates the compensatory mechanisms of the body. …”
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Effect of prior and first-line immunotherapy on baseline immune biomarkers and modulation of the tumor microenvironment in response to nivolumab and relatlimab combination therapy... by James Larkin, Evan J Lipson, Charlie Garnett-Benson, Ignacio Melero, Reinhard Dummer, Paolo A Ascierto, Vanna Chiarion-Sileni, Marta Nyakas, Hao Tang, Inge Marie Svane, Margaret Callahan, Eva Muñoz-Couselo, Jean Jacques Grob, Katriina Peltola, Sonia Dolfi, Carlos Alberto Gomez-Roca, Patrick Djidel, Deepti Warad, Diane Reusser-Wolf

“…Further research is needed to identify patients who will most benefit from anti-LAG-3/PD-(L)1 agents, and to elucidate the mechanisms of action of, and resistance to, this combination therapy in patients with advanced melanoma.Trial registration number NCT01968109.…”
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Chloroquine and hydroxychloroquine-related ocular adverse events in SLE treatment: a real-world disproportionality analysis based on FDA adverse event reporting system (FAERS) by Xiang Li, Xiang Li, Xiang Li, Xiang Li, Xiang Li, Xiang Li, Xiang Li, Xiang Li, Si-Qi Zhang, Ke-Rui Wang, Ke-Rui Wang, Shi-Nan Wu, Shi-Nan Wu, Meng-Yuan Wang, Meng-Yuan Wang, Cui-Ting Chen, Cui-Ting Chen, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong, Nuo Dong

“…Sensitivity analyses were performed to validate these signals, and the time to onset for each Preferred Term (PT) was assessed.ResultsBetween 2004 and 2024, a total of 2,575 adverse event reports related to HCQ or CQ use in patients with SLE were identified in the FAERS database, of which 437 involved ocular adverse events. The most frequently reported ocular conditions were cataract, macular degeneration, and glaucoma. …”
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FEATURES OF LOCAL IMMUNITY IN PATIENTS WITH OROPHARYNGEAL CANCER by O. I. Keith, M. N. Tilliashaihov, P. V. Svetitsky, E. Yu. Zlatnik, G. I. Zakora, A. A. Ganiev, G. P. Nistratov

“…Oropharyngeal cancer is the second most frequent cancer among patients with head and neck tumors in the Russian Federation. …”
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Cost‐Effective DNA Storage System with DNA Movable Type by Chenyang Wang, Di Wei, Zheng Wei, Dongxin Yang, Jing Xing, Yunze Wang, Xiaotong Wang, Pei Wang, Guannan Ma, Xinru Zhang, Haolan Li, Chuan Tang, Pengfei Hou, Jie Wang, Renjun Gao, Guiqiu Xie, Cuidan Li, Yingjiao Ju, Peihan Wang, Liya Yue, Yongliang Zhao, Yongjie Sheng, Jingfa Xiao, Haitao Niu, Sihong Xu, Huaiyi Yang, Di Liu, Bo Duan, Dongbo Bu, Guangming Tan, Fei Chen

“…Abstract In the face of exponential data growth, DNA‐based storage offers a promising solution for preserving big data. However, most existing DNA storage methods, akin to traditional block printing, require costly chemical synthesis for each individual data file, adopting a sequential, one‐time‐use synthesis approach. …”
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Assessment of regional variation in the management of heart failure with a preserved ejection fraction between the Russian Federation and the European Union: the results of the int... by Nathan Mewton, Clara Saldarriaga, Irina Dyachuk, Han Naung Tun, Ilya Giverts, Anastasia Shchendrygina, Natalia Cherkasova, Aleksandr Suvorov, Irina Komarova, Nadezhda Mukhina, Violetta Sitnikova, Elena Kuzheleva, Soloveva Anzhela, Nikolay Novitsky, Andrey Baglikov, Alina Bibarsova, Anastasia Rogova, Viktoria Lezhneva, Ekaterina Stepanenko, Sydney Goldfeder de Gracia, Vergun Marija, Yu V Mareev, Galib Imanov

“…The responders were comparable across the groups in most of the baseline characteristics, except that RF specialists were less likely to be heart failure specialists (RF: 2% vs EU: 26%) and less often worked in academic environments (RF: 17% vs EU: 61%). …”
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Prevalence, determinants, and complications of adolescent pregnancy: an umbrella review of systematic reviews and meta-analysesAJOG Global Reports at a Glance by Biruk Beletew Abate, Ashenafi Kibret Sendekie, MSc, Addis Wondimagegn Alamaw, MSc, Kindie Mekuria Tegegne, MSc, Tegene Atamenta Kitaw, MSc, Molla Azmeraw Bizuayehu, MSc, Amare Kassaw, MSc, Gizachew Yilak, MSc, Alemu Birara Zemariam, MSc, Befkad Derese Tilahun, MSc

“…To reduce the burden of adolescent pregnancy, collaborative efforts are required from global, regional, and local stakeholders, such as policymakers and reproductive health program planners, through health education and training that focus on the most vulnerable populations.…”
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