Optimising asthma inhaler prescribing to improve health outcomes and lower greenhouse gas emissions by Ali Rajani, Monika Bhardva, Siva Mahendran, Lola Lowenthal, Natasha Nwosu, Sam Maisey

“…Results and discussion: 65 patients met the inclusion criteria, most of whom were female (61.5%). 30 patients (46.2%) were identified as having an asthma exacerbation, and the remainder with wheeze due to ‘other’ causes (eg, ‘LRTI with bronchospasm’).78.5% of patients were prescribed a salbutamol pMDI, 3.1% were prescribed a beclomethasone pMDI and 9.2% were prescribed a combination of both inhalers. 70.8% of patients were also prescribed oral prednisolone as a TTO.On average, there was a time delay of 11 h and 35 min between prescription and issue of inhalers at the on-site pharmacy.Only 9.2% of patients were offered respiratory follow-up. …”
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LncRNA A2ml2 inhibits fatty liver hemorrhage syndrome progression and function as ceRNA to target LPL by sponging miR-143-5p by Qingxing Xiao, Sibao Yang, Yuwei Yang, Hongyu Ni, Zongdi Li, Chengwen Wang, Wuyang Liu, Yuxin Han, Yumei Li, Yonghong Zhang

“…Fatty liver hemorrhage syndrome (FLHS) is the most common metabolic diseases in laying hens during the late-laying period, and it causes a significant economic burden on the poultry industry. …”
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The influence of workplace stressors on the risk of cardiovascular diseases among healthcare providers: a systematic review by Raghad Alhajaji, Raghad Alhajaji, Manal Z. Alfahmi, Saleh Ahmed Alshaikhi, Abdulmajeed Mohammed Fairaq, Salman Fudlaldeen Jan, Sultan Aljuaid, Mashael AlFaifi, Mashael AlFaifi, Mashael AlFaifi, Mashael S. Alaboud, Imad Mohammed Khojah, Imad Mohammed Khojah, Hadeel Alkofide, Hadeel Alkofide, Khalid Al Sulaiman, Khalid Al Sulaiman, Khalid Al Sulaiman, Khalid Al Sulaiman, Khalid Al Sulaiman

“…The key stressors identified were long working hours, night shifts, and high job strain. Most studies reported significant associations between these stressors and increased risks of hypertension, ischemic heart disease, and cardiometabolic disorders. …”
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Comparative effectiveness of Tuina therapy versus manual physical therapy for knee osteoarthritis: a randomized controlled trial by Peihong Ma, Luping Liu, Sina Li, Meiling Cai, Siyu Han, Zhiwen Weng, Qianji Chen, Yixuan Gao, Lingyun Zhang, Guiyun Wu, Xiaoming Yang, Yang Zhang, Duoduo Li, Changxin Liu, Ya’nan Sun, Shiyan Yan, Xiyou Wang, Changhe Yu

“…By week 8, Tuina showed significantly consistent improvement compared to mPT (between-group difference: −4.33, 95%CI: −8.34 to −0.31, P = 0.03, Bonferroni correction), whereas there were no statistically significant differences between groups at week 16 (between-group difference: 0.74, 95%CI: −3.67 to 5.15, P = 0.37, Bonferroni correction). Most secondary outcomes showed no significant between-group differences, except for the Timed Up and Go Test Time favoring mPT (0.94, 95%CI: 0.03 to 1.85, P = 0.04). …”
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Development of ZHPV16E7- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death by Xiaochun Tan, Xiaochun Tan, Jiani Yang, Jiani Yang, Yanheng Li, Kairong Wan, Sicong Feng, Xishang Jing, Zhenyun Xie, Lifang Zhang, Wenshu Li

“…IntroductionCervical cancer, predominantly caused by high-risk human papillomavirus (HPV), remains a major global health challenge. HPV16 is the most prevalent type, and its oncoprotein E7 promotes epithelial-mesenchymal transition (EMT), a critical step in metastasis. …”
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A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors by Paolo Romania, Loredana Cifaldi, Loredana Cifaldi, Paula Gragera, Valerio D’Alicandro, Matteo Caforio, Valentina Folgiero, Valeria Lucarini, Ombretta Melaiu, Ombretta Melaiu, Roberto Bei, Franco Locatelli, Franco Locatelli, Doriana Fruci

“…PLAC1 and DSG2 expression in healthy tissues and NK cells was obtained from the HPA database and a GEO dataset.ResultsWe identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. The most promising candidates were functionally validated through single-target gene silencing and overexpression. …”
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Investigating the role of stable flies (Stomoxys calcitrans) and biting midges of the genus Culicoides as potential mechanical vectors of African swine fever virus in Lithuania, Po... by Sofie Dhollander, Oana-Maria Balmoș, Eleonora Cattaneo, José Abrahantes Cortiñas, Anette Ella Boklund, Anna Szczotka-Bochniarz, Andrei Daniel Mihalca, Lina Mur, Maciej Frant, Anna Gal-Cisoń, Malgorzata Kwasnik, Wojciech Rozek, Alvydas Malakauskas, Marius Masiulis, Jurga Turcinaviciene, Theodora Chesnoiu, Krzysztof Jazdzewski, Jerzy Rola, Florica Barbuceanu, Miguel Ángel Miranda, Jan Arend Stegeman

“…Positive pools were predominantly observed in Culicoides punctatus, C. newsteadi, and the Obsoletus complex, with most detections occurring in August. However, ASFV isolation was unsuccessful. …”
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V_o2peak, Ve/V_CO2, and Cardiac Remodeling Correlate with Long-Term Cardiovascular Outcome in Heart Failure Patients by Antonio Pagliaro, Luna Cavigli, Roberta Molle, Elisabetta Iardino, Francesca Anselmi, Francesca Righini, Luca Martini, Valerio Zacà, Giulia Elena Mandoli, Maria Concetta Pastore, Marta Focardi, Matteo Cameli, Sonia Bernazzali, Massimo Maccherini, Marco Chiostri, Flavio D’Ascenzi, Serafina Valente

“…LV ejection fraction (LVEF) is the most used parameter in clinical practice. This study aimed to analyze CPET and echocardiographic data in patients under evaluation for heart transplantation (HTx) to identify the parameter that best correlates with cardiac events. …”
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The Impact of Sports Training on the Spinal Cord Injury Individual’s Balance by Cristina Chieffo, Giorgia Chini, Tiwana Varrecchia, Irene Gennarelli, Alessio Silvetti, Vincenzo Molinaro, Ida Poni, Andrea Mariotti, Simone Tiberti, Annamaria Tamburro, Ilaria Calabrese, Sara Felici, Marco Bartoli, Loredana Gigli, Roberto Minella, Barbara Lucia, Aldo Toscano, Alberto Ranavolo

“…Sports and physical activities have become one of the most popular rehabilitation methods for people with SCI. …”
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HYPERTENSIVE HEART DISEASE IN COVERT ARTERIAL HYPERTENSION OF A LARGE FACTORY EMPLOYEE by A. N. Britov, E. M. Platonova, M. I. Smirnova, V. M. Gorbunov, V. P. Shapovalova, V. M. Ryzhov, S. V. Olishevko, N. A. Eliseeva, T. V. Ryzhova, Ya. N. Koshelyavskaya, A. D. Deev

“…In CAH comparing to normotonics there is an increase of E/A equation by increase of the A (p<0,0001). The most prevalent in CAH and CTI AH was concentric LVH — in 60% and 78,1 cases, respectively, and concentric remodeling — in 15% cases in both groups, that is comparable to the patients with St. …”
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Adaptation strategies to manage summer forage shortages improve animal performance and better maintain milk and cheese quality in grass- versus corn-based dairy systems by M. Bouchon, B. Martin, C. Bord, A. Ferlay, J.M.G. Bloor, M. Eugène, A. Delacroix-Buchet, C. Cebo, M.C. Michalski, B. Graulet, I. Verdier-Metz, C. Delbès

“…Cheese from cows fed with more grazed grass were the yellowest and had the most pronounced flavors, as well as higher counts of heterofermentative lactobacilli and lactic acid bacteria. …”
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Second primary malignancies following CAR T-cell therapy in patients with hematologic malignancies by Elvira Umyarova, Charles Pei, William Pellegrino, Qiuhong Zhao, Nidhi Sharma, Don Benson, Francesca Cottini, Evandro Bezerra, Jonathan Brammer, Naresh Bumma, Hannah Choe, Nathan Denlinger, Srinivas Devarakonda, Abdullah Khan, Sam Penza, Ashley Rosko, Sumithira Vasu, Sarah Wall, Lapo Alinari, Robert Baiocchi, David A. Bond, Beth Christian, Walter Hanel, Kami Maddocks, John Reneau, Yazeed Sawalha, Alma Habib, Audrey Sigmund, Timothy J. Voorhees, Marcos de Lima, Narendranath Epperla

“…With a median follow-up of 38 months (range 11–66), 21 patients (8.5%) developed a second primary malignancy (SPM), with non-melanoma skin cancer being the most common (52%), followed by hematologic malignancies (33%) and non-skin solid tumors (14%). …”
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Integrating immune library probing with structure-based computational design to develop potent neutralizing nanobodies against emerging SARS-CoV-2 variants by Lidia Cerdán, Katixa Silva, Daniel Rodríguez-Martín, Patricia Pérez, María A. Noriega, Ana Esteban Martín, Alfonso Gutiérrez-Adán, Yago Margolles, Juan A. Corbera, Miguel A. Martín-Acebes, Juan García-Arriaza, Juan Fernández-Recio, Luis A. Fernández, José M. Casasnovas

“…The Nb4 VHH domain grasped the RBD and covered most of its outer face, including the core and the receptor-binding motif (RBM), which was consistent with hcAb4 blocking RBD binding to the SARS-CoV-2 receptor. …”
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Effectiveness of Minimally Invasive Hepatectomy in Patients with Early or Intermediate-Stage Hepatocellular Carcinoma: A Multi-Institutional Cohort Study in an Asian Population by Chen HK, Chang KC, Shao SC, Soong RS, Chen YC, Wu CF, Wu TH, Chou TS, Chan SC, Lai ECC

“…We found consistent results from a series of subgroup analyses (eg, age groups, BCLC stages and hospital levels) and sensitivity analyses (eg, study period restricted to the most recent 5 years (2015– 2019)). The control analysis (OH group vs RFA group) confirmed the robustness of main analyses.Conclusion: Our study suggested that MIH had better survival outcomes for patients with early or resectable intermediate-stage HCC, compared to RFA or OH.Keywords: hepatocellular carcinoma, minimally invasive hepatectomy, open hepatectomy, radiofrequency ablation, long-term survival…”
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Incorporation of tritium by pepper and eggplant cultures with short-term exposure to tritium oxide by E. N. Polivkina, E. S. Sysoyeva, E. V. Romanenko, L. F. Subbotina, A. V. Panitskiy, F. F. Zhamaldinov, L. B. Kenzhina

“…For organically bound tritium, no distinct regularity in the distribution of plant parts was established, which is most likely due to the short period of exposure. …”
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Delineating the source of resistance to bean common mosaic virus (BCMV) and bean common mosaic necrosis virus (BCMNV) in common bean (Phaseolus vulgaris) cultivars of Jammu and Kas... by Dasari Meghanath, Sumiah Wani, Sabiya Bashir, Shahjahan Rashid, Andleeb Javaid, Zahoor Ahmad Dar, Shabir Hussain Wani, Parvaze A. Sofi, Gowhar Ali, Aflaq Hamid

“…Bean common mosaic virus (BCMV) and bean common mosaic necrosis virus (BCMNV) are among the most challenging constraints for common bean production in Northern states of India due to their easy transmission through aphids and seeds. …”
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Hodgkin’s Lymphoma: Analysis Results of Volgograd Regional Registry by KD Kaplanov, NP Volkov, TYu Klitochenko, IV Matveeva, AL Shipaeva, MN Shirokova, NV Davydova, EG Gemdzhian

“…The significance of some laboratory IPS risk factors can be reviewed; most obvious is increasing importance of PET for predicting the need for salvage therapy.…”
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Neurodegenrative changes in retina of rats with streptozotocin diabetes under different conditions of experimental treatment by N. V. Kresyun

“…At the same time the investigated index was reduced by 34,4% in comparison with the such one registered in intact animals (P<0,05).Conclusions. 1.The development of STZ-induced diabetes is connected with neurodegenerative changes in retina, which is most pronounced in the outer nuclear layer. 2. …”
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Epidemiological Assessment of the First Results of the National Program of Immunization of Young Children against Pneumococcal Infection in Russia by N. I. Brico, N. N. Tsapkova, V. A. Sukhova, A. N. Gerasimov, R. V. Polybin, I. E. Turina, P. I. Dryagileva, N. V. Kholodnova, Yu. Yu. Khetagurov, I. V. Feldblum, A. V. Polushkina, L. N. Titova, K. A. Thapa, G. V. Sharuho, O. A. Rychkova, O. P. Markova, Yu. A. Kazyanov

“…Pneumococcal infections are among the most common infections are an important cause of morbidity and mortality worldwide, including Russia. …”
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Rural-urban disparities in breast cancer survival in the context of the national breast cancer screening program for rural women in China by Xing Xing, Qing Wang, Xiaoyun Liu, Fuzhong Xue, Qingyue Meng, He Zhu

“…Background: Breast cancer is the most diagnosed cancer and is the second leading cause of cancer death among women in China. …”
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