c.7156C > T p.(Gln2386*) variant causes loss-of-function of the USP9X gene in a female-restricted X-linked syndromic intellectual disability: a case report by Talyta Alves da Silva Campos, Alex Honda Bernardes, Irene Plaza Pinto, Hiane Aparecida da Silva Teixeira, Juliana Ferreira da Silva, Victor Cortázio do Prado Santos, Raffael Zatarin, Aparecido Divino da Cruz

“…Despite the de novo nature of most loss-of-function variants, maternal testing is crucial for estimating recurrence risk. …”
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HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals by Baojun Wu, PhD, Mao Yang, MS, Donglei Hu, PhD, Ray Zhang, Bin Liu, PhD, MPH, Samantha Hochstadt, MS, David E. Lanfear, MD, MS, Jonathan Witonsky, MD, MAS, Rajesh Kumar, MD, MS, Jill A. Hollenbach, PhD, MPH, Esteban G. Burchard, MD, MPH, Elad Ziv, MD, L. Keoki Williams, MD, MPH, MBA

“…HLA-DRB1∗13:02 was the most significant allele associated with peanut allergy (adjusted odds ratio = 1.94 [95% CI = 1.28-2.93]), and HLA-DQA1∗01:02 was the top association with peanut-related anaphylaxis (aOR = 1.67 [95% CI = 1.14-2.44]). …”
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Identification of the Cinnamyl Alcohol Dehydrogenase Gene Family in <i>Brassica</i> U-Triangle Species and Its Potential Roles in Response to Abiotic Stress and Regulation of Seed... by Yiwei Liu, Ziwuyun Weng, Yuanyuan Liu, Mengjiao Tian, Yaping Yang, Nian Pan, Mengzhen Zhang, Huiyan Zhao, Hai Du, Nengwen Yin, Cunmin Qu, Huafang Wan

“…Based on phylogenetic analysis, these genes were categorized into four groups, designated as groups I to IV. Most of the <i>CAD</i> genes were implicated in mediating responses to abiotic stresses and phytohormones. …”
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Entinostat in combination with nivolumab for patients with advanced cholangiocarcinoma: a phase 2 clinical trial by Elsa Hallab, Jennifer N. Durham, Rosalind Walker, Leslie Cope, Soren Charmsaz, Nicole E. Gross, Dimitrios N. Sidiropoulos, Alexei Hernandez, James Leatherman, Sarah Mitchell, Mark Yarchoan, Won Jin Ho, Nilofer S. Azad, Marina Baretti

“…Grade ≥ 3 treatment-related AE (TRAEs) were encountered in 5 patients (38%). The most common grade ≥ 3 AEs were decreased cell counts. …”
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Dynamic Evaluation of Vinorelbine-Induced Phlebitis of Dorsalis Pedis Vein in a Rat Model by JIANG Meng, HAO Shulan, TONG Liguo, ZHONG Qiming, GAO Zhenfei, WANG Yonghui, WANG Xixing, JI Haijie

“…Phlebitis grading in the model group showed that 75.0% of rats were grade Ⅱ on day 1; grade Ⅲ and Ⅳ each accounted for 37.5% on day 3; from days 5 to 9, most rats exhibited cord-like veins, predominantly grade III. …”
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CHA2DS2‐VASc Score as a Predictor for Atrial Fibrillation Recurrence and Clinical Outcomes Following Pulmonary Vein Isolation by Mustafa Gabarin, Mahmoud Suleiman, Adi Elias, Ibrahim Marai, Roy Beinart, Eyal Nof, Yoav Michowitz, Michael Glikson, Yuval Konstantino, Moti Haim, David Luria, David Pereg, Avishag Laish‐Farkash, Alexander Omelchenko, the Israeli Working Group on Pacing Electrophysiology

“…ABSTRACT Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults, associated with serious cardiovascular complications such as ischemic stroke, heart failure, and myocardial infarction. …”
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Implementation and outcomes of an urban mobile adult extracorporeal life support programCentral MessagePerspective by Joseph Hadaya, MD, Yas Sanaiha, MD, Vadim Gudzenko, MD, Nida Qadir, MD, Sumit Singh, MD, Ali Nsair, MD, Nam Yong Cho, BS, Richard J. Shemin, MD, Peyman Benharash, MD, Ida Anderson, Stephanie Bland, David Boldt, Rene Cardiel, Wei Ting Chen, Jennie Chinchilla, Sara Crager, Kim De La Cruz, Ryan Dries, Jessica Fries, Joseph Meltzer, Jacquelyn Gates, Christopher Hernandez, Marisa Hernandez-Morgan, Wolf B. Kratzert, Nikoloz Kutateladze, Saba Lahar, George Lim, Ann McNeil, Katelyn Mears, Ashley Melendez, Curtis Murata, Christopher Ortiz, Anthony Pagel, Prachi Redkar, Daniel Salib, Jessica Samson, Nancy Satou, Lisa Toft, Savonna Warren, Michael Wolfe, Andrew Young

“…Results: Of 110 patients transported to our institution on ECLS, 65.5% required venovenous, 30.9% peripheral venoarterial, and 3.6% central venoarterial support. The most common indications for mobile ECLS were acute respiratory failure (46.4%), COVID–19-associated respiratory failure (19.1%), cardiogenic shock (18.2%) and postcardiotomy syndrome (11.8%). …”
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Gestational Diabetes Management and Outcomes in South Jordan: Metformin Alone vs. Metformin-Insulin Therapy, A Retrospective Cohort Study by Ahlam M. Al-Kharabsheh, Seham M. Abufraijeh, Ashwaq K. Al-Tarawneh, Hana K. Al-Masarwah, Omar H. Abu Azzam

“…Treatment modalities included metformin alone (25.3%) and combined metformin-insulin therapy (65.3%). LGA was the most prevalent antenatal complication (30.6%). After controlling for gestational age at diagnosis, no statistically significant differences were found between treatment groups for LGA, polyhydramnios, and pregnancy-induced hypertension (MH p values: 0.505, 0.971, and 0.737, respectively). …”
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Retrospective OCT Analysis of Sphingosine-1-Phosphate Modulator Fingolimod in Multiple Sclerosis by Wilson X. Wang, MD, MPhil, Helen Rossmiller, BS, Henok Getahun, BS, Aditya Santoki, BS, Dana C. Perantie, MPH, Robert T. Naismith, MD, Rajendra S. Apte, MD, PhD

“…Methods: Eligible participants were those with baseline and follow-up OCT images conducted at or prior to S1P initiation and at the most recent visit. The peripapillary retinal nerve fiber layer (pRNFL), ganglion cell layer (GCL), central subfield thickness (CST), macular volume (MV), RPE, and photoreceptor thickness were determined through OCT segmentation. …”
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Proteomic analysis reveals a potential anticancer mechanism for a novel effervescent curcumin-ascorbic acid-polysaccharide-β-cyclodextrin inclusion complex towards colorectal cance... by Atthapan Morchang, Keerakarn Somsuan, Artitaya Rongjumnong, Churat Weeraphan, Sasivimon Pramual, Theetat Ruangjaroon, Daranee Chokchaichamnankit, Wuttichai Jaidee, Phateep Hankittichai, Chanatip Pramvichai, Rawiwan Charoensup, Arunothai Wanta, Chantragan Srisomsap, Jisnuson Svasti, Siripat Aluksanasuwan

“…CUR-A-Poly-β-CD was non-toxic to normal colon cells (CCD-841 CoN) but significantly reduced the viability of CRC cell lines HT-29, SW-48, and SW-480, with SW-480 cells being the most responsive. CUR-A-Poly-β-CD induced apoptosis and inhibited proliferation, clonogenicity, and migration of SW-480 cells. …”
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Orthodontic treatment improves gingival morphological symmetry parameters: a retrospective study by Yibo Wang, Siyi Wang, Yu Chen, Kaijin Lin, Guanglin Gao, Shanshan Wu, Wei Zhao, Minqian Zheng, Jianbin Guo

“…Comparisons between the postorthodontic group and the control group revealed no significant differences in most gingival contour symmetry parameters. Additionally, there were no statistically significant differences in the mean changes of MDD and RMS across different tooth positions before and after orthodontic treatment. …”
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Comprehensive preventive treatments for episodic migraine: a systematic review of randomized clinical trials by María-Karina Vélez-Jiménez, Adriana Patricia Martínez-Mayorga, Adriana Patricia Martínez-Mayorga, Ildefonso Rodriguez-Leyva, Ildefonso Rodriguez-Leyva, Marisol Jannet Figueroa-Medina, Maria Teresa Reyes-Alvarez, Juan Carlos Pérez-García, Rubén Darío Vargas-García, Daniel San-Juan, Mauricio Pierdant-Perez, Emilio García Gómez, Miguel Angel Morales Morales, Carlos Trenado, Marco Antonio Martínez-Gurrola, Marco Antonio Martínez-Gurrola

“…Anti-CGRP monoclonal antibodies and gepants demonstrated the most consistent reduction in MMD (−3.2 to −4.4 days) with favorable tolerability. …”
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Reliable unmanned aerial vehicle-based thermal infrared target detection method for monitoring Procapra przewalskii in Qinghai by Guoqing Zhang, Wei Luo, Yongxiang Zhao, Quanqin Shao, Lin Li, Keyu Mei, Guohong Li

“…Background-suppressed images can effectively minimize most background pixels, while regions with high vector values in optical flow–processed images indicate object positions. …”
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Microbiome gut community structure and functionality are associated with symptom severity in non-responsive celiac disease patients undergoing a gluten-free diet by Laura Judith Marcos-Zambrano, Blanca Lacruz-Pleguezuelos, Elena Aguilar-Aguilar, Helena Marcos-Pasero, Alberto Valdés, Viviana Loria-Kohen, Alejandro Cifuentes, Ana Ramirez de Molina, Alberto Diaz-Ruiz, Vera Pancaldi, Enrique Carrillo de Santa Pau

“…There is currently no cure for CD, and the most effective treatment is maintaining a strict, lifelong gluten-free diet (GFD). …”
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Reproductive qualities and the manifestation of different forms of heterosis in sows of English origin of different breeding directions during purebred breeding, crossing, and hybr... by M. I. Kremez, M. H. Povod, B. V. Gutyj, M. B. Shpetnyi, O. H. Mykhalko, V. M. Nechmilov, S. V. Zhyzhka, I. S. Moisei, S. V. Tsap, O. S. Orishchuk

“…When hybridizing crossbred sows of the Large White breed and Landrace breeds of accessions (♀WB×♂L) and (♀L×♂WB) with boars of the synthetic terminal line RIS-337, higher values of hypothetical heterosis and specific heterosis were established for most signs of reproductive performance. In contrast, the proper and general form of heterosis with this breeding method was manifested less frequently and was less pronounced.…”
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Heterogeneous treatment effects of stress ulcer prophylaxis among ICU patients at risk for gastrointestinal bleeding by Yongpeng Xie, Yao Yan, Qixiang Hong, Hui Zheng, Lijuan Cao, Xiaoming Li, Songqiao Liu, Hui Chen

“…Results A total of 25,475 patients were included, of whom 6199 (24.3%) received SUP, with famotidine being the most commonly prescribed (53.7%). Baseline characteristics were well-balanced between treatment groups after weighting. …”
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A Massive Yellow Supergiant in the Far Outer Disk of M31: Evidence for in Situ Massive Star Formation beyond the Optical Radius by Pinjian Chen, Bingqiu Chen, Haibo Yuan, Xuan Fang, Xiaodian Chen, Chao-Wei Tsai, Kai Zhang, Xiaowei Liu

“…Here, we present the discovery of LAMOST J0048+4154, a massive yellow supergiant situated at a deprojected galactocentric distance of ∼34 kpc in M31, making it the most distant massive star confirmed in this galaxy. …”
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Features of the welded seam material crystalliza-tion in Ti-TiB alloy under electron-beam welding conditions by Petro Loboda, Volodymyr Zvorykin, Constantine Zvorykin, Eduard Vrzhyzhevskyi, Tatjana Taranova, Valery Kostin, Leonid Zvorykin

“…The purpose of this study is the determination of formation mechanism of boride microfibers originated in the welded seam material. Two most probable variants of the formation mechanism are analyzed, which involve eutectic decomposition during crystallization from a liquid melt or eutectoid decomposition from a metastable crystallized alloy. …”
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Reliability Analysis of Hybrid Laser INS Under Multi-Mode Failure Conditions by Bo Zhang, Changhua Hu, Xinhe Wang, Jianqing Wang, Jianxun Zhang, Qing Dong, Xuan Liu, Feng Zhang

“…The uncertainties in the inner frame thickness, inner frame material strength, and outer frame thickness have the most significant impact on the probability of functional failure in the hybrid INS, with sensitivity indices of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mi>δ</mi><mn>6</mn><mrow><mi>P</mi><mo>{</mo><mi>F</mi><mo>}</mo></mrow></msubsup></mrow></semantics></math></inline-formula> = 0.01657, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mi>δ</mi><mn>2</mn><mrow><mi>P</mi><mo>{</mo><mi>F</mi><mo>}</mo></mrow></msubsup></mrow></semantics></math></inline-formula> = 0.00873, and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mi>δ</mi><mn>4</mn><mrow><mi>P</mi><mo>{</mo><mi>F</mi><mo>}</mo></mrow></msubsup></mrow></semantics></math></inline-formula> = 0.00818, respectively. …”
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Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in China by Kongkong Cui, Kongkong Cui, Peng Hong, Peng Hong, Jie Lin, Jie Lin, Zaihong Hu, Zaihong Hu, Zhiqiang Gao, Zhiqiang Gao, XiaoMao Tian, XiaoMao Tian, Tao Lin, Tao Lin, Qinlin Shi, Qinlin Shi, Guanghui Wei, Guanghui Wei

“…BackgroundWilms tumor (WT), which represents about 90% of kidney tumors in children, is the most prevalent type of renal tumor among children. …”
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