Harnessing multi-omics and artificial intelligence: revolutionizing prognosis and treatment in hepatocellular carcinoma by Zhen Wang, Zhen Wang, Zhen Wang, Gangchen Zhou, Gangchen Zhou, Rongchuan Cao, Rongchuan Cao, Guolin Zhang, Guolin Zhang, Yongxu Zhang, Yongxu Zhang, Mingyue Xiao, Longbi Liu, Longbi Liu, Xuesong Zhang

“…BackgroundHepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, characterized by elevated mortality rates and heterogeneity. …”
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Influence of BmNPV orf98 on DNA replication, transcription and virus package of Bombyx mori nucleopolyhedrovirus by Shi Lili, Jiang Caiying, Yu Wei, Chen Chen, Jiang Lei, Gong Chengjian, Tong Fudan

“…The BmNPV genome sequenced in 1999 was 128 413 nucleotides long with a G + C content of 40% and contained about 136 open reading frames (ORFs) encoding predicted proteins of over 60 amino acids.The gene of BmNPV orf98 is found in all Group Ⅰ and the most of Group Ⅱ genomes. It is not a highly conserved gene, as the deletion of this gene in BmNPV, it has no apparent effect on infectivity. …”
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Significance of platelets in the early warning of new-onset AKI in the ICU by using supervise learning: a retrospective analysis by Pan Pan, Yuhong Liu, Fei Xie, Zhimei Duan, Lina Li, Hongjun Gu, Lixin Xie, Xiangyun Lu, Longxiang Su

“…In the prediction of AKI 6, 9 and 12 h ahead, the importance of creatinine, platelets, and height was the most important based on SHapley.Conclusions The machine learning model described in this study can predict AKI 3–6–9–12 h before the new-onset of AKI in ICU. …”
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Acupuncture in the emergency department (ACUITY): Results from a BraveNet multi-center feasibility randomized controlled trial by Jeffery A. Dusek, Gene A. Kallenberg, Alan B. Storrow, Robert M. Hughes, Christopher J. Coyne, David R. Vago, Arya Nielsen, Alison Karasz, Ryung S. Kim, Jessica Surdam, Tracy Segall, Kiran A. Faryar, Natalie L. Dyer, Bruce A. Barton, M. Diane McKee

“…Prior studies of acupuncture in the ED reported pain reduction with minimal side effects, but most were small and single site. Methods: We conducted ACUITY, a prospectively designed multi-center feasibility RCT. …”
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A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growth by Huichun Liang, Fubing Li, Huan Fang, Wenlong Ren, Zhongmei Zhou, Jiecheng Wang, Jialing Liu, Yongjia Tang, Xue Liu, Yingying Wu, Jing Peng, Chuanyu Yang, Jiayi Chen, Yuting Fei, Yujie Shi, Dewei Jiang, Nu Zhang, Ceshi Chen

“…Abstract Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer that lacks reliable targets for diagnosis and therapy. …”
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Mapping the global burden of early-onset Parkinson’s disease: socioeconomic and regional inequalities from the Global Burden of Disease Study 2021 by Xinyu Li, Jingpei Zhou, Wanqing Peng, Renhui Zhao, Quan Sun, Zhijuan Liu, Yanning Liu, Ziyuan Li, Ziting Huang, Yihui Zhang, Shuqiao Zhang, Xubo Hong, Zhenhu Chen, Jun Lyu, Jun Lyu, Nanbu Wang

“…Regions with a middle SDI experience the most significant burden of disability and mortality, primarily driven by population growth. …”
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Two sets of bias-corrected regional UK Climate Projections 2018 (UKCP18) of temperature, precipitation and potential evapotranspiration for Great Britain by N. Reyniers, Q. Zha, N. Addor, N. Addor, T. J. Osborn, T. J. Osborn, N. Forstenhäusler, Y. He

“…The change factor method was used as a benchmark for precipitation, and we show that it fails to capture changes in a range of variables, making it inadequate for most impact assessments. By comparing the differences between the two bias-correction methods and within the 12 ensemble members, we show that the uncertainty in future precipitation and temperature changes stemming from the climate model parameterization far outweighs the uncertainty introduced by selecting one of these two bias-correction methods. …”
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Uptake of fucosylated type I human milk oligosaccharide blocks by Bifidobacterium longum subsp. infantis by Morten Ejby Hansen, Mikiyasu Sakanaka, Mathias Jensen, Hiroka Sakanaka, Michael Jakob Pichler, Shingo Maeda, Julie Franck Høvring, Aruto Nakajima, Sonja Kunstmann, Tine Sofie Nielsen, Günther Herbert Johannes Peters, Dirk Jan Slotboom, Jens Preben Morth, Takane Katayama, Maher Abou Hachem

“…ABSTRACT Human milk oligosaccharides (HMOs) are uniquely rich in the type 1 building block disaccharide lacto-N-biose I (LNB; Galβ1,3GlcNAc), as compared to other mammals. Most HMOs are fucosylated, for example, α1,2 and α1,4 fucosylations on LNB blocks, resulting in H type 1 (H1) and Lewis a (Lea) epitopes, respectively. …”
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Принципи ергодизайнерського забезпечення проектування авіаційних систем та заходи з їх реалізації... by Anatoly Rubtsov, Vladimir Svirko, Ivan Otroumov

“…Ergodesign principles of the operator workplace as one of the most important components of UAS are developed. In common, it is determined that the modern format of aviation systems design in Ukraine, mainly unmanned aerial systems, requires a significant refreshment and updating of basic ergo design principles, approaches to their design, and operation. …”
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Strain promoted azide alkyne cycloaddition, an efficient surface functionalization strategy for microRNA magnetic separation by Djamila Kechkeche, Sirine El Mousli, Claire Poujouly, Emilie Secret, Vincent Dupuis, Isabelle Le Potier, Marie-Emmanuelle Goriot, Julien Siracusa, Sébastien Banzet, Jean Gamby, Jean-Michel Siaugue

“…The strain-promoted azide alkyne cycloaddition (SPAAC click chemistry) proved to be the most efficient functionalization strategy. Optimization of the complementary DNA grafting protocol, carried out by varying the ratios between the quantities of dibenzocyclooctyne groups and DNA and between the quantities of DNA and MNP, revealed on the one hand that the quantity of DNA grafted per nanoparticle could be finely controlled, and on the other hand that the grafting on the MNP’s surface of an excessive quantity of dibenzocyclooctyne groups led to a reduction in grafting yields. …”
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Factors Related to Knowledge, Perception, and Practices Towards COVID-19 Among Patients with Autoimmune Diseases: A Multicenter Online Survey by Alvina Widhani, Iris Rengganis, Agus Joko Susanto, Eko E Surachmanto, Anshari Saifuddin Hasibuan, Deasy Fetarayani, Deshinta Putri Mulya, Nova Kurniati, Evy Yunihastuti, Raveinal Masri, Teguh Harjono Karjadi, Sukamto Koesnoe, Zuhrial Zubir, Suriani Alimudin, Riwanti Estiasari, Ahmad Yanuar Safri, Suzy Maria

“…Results: there were 685 respondents. Most of them were female and had systemic lupus erythematosus with median age of 37 years old. …”
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The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima. by Ariel D Chipman, David E K Ferrier, Carlo Brena, Jiaxin Qu, Daniel S T Hughes, Reinhard Schröder, Montserrat Torres-Oliva, Nadia Znassi, Huaiyang Jiang, Francisca C Almeida, Claudio R Alonso, Zivkos Apostolou, Peshtewani Aqrawi, Wallace Arthur, Jennifer C J Barna, Kerstin P Blankenburg, Daniela Brites, Salvador Capella-Gutiérrez, Marcus Coyle, Peter K Dearden, Louis Du Pasquier, Elizabeth J Duncan, Dieter Ebert, Cornelius Eibner, Galina Erikson, Peter D Evans, Cassandra G Extavour, Liezl Francisco, Toni Gabaldón, William J Gillis, Elizabeth A Goodwin-Horn, Jack E Green, Sam Griffiths-Jones, Cornelis J P Grimmelikhuijzen, Sai Gubbala, Roderic Guigó, Yi Han, Frank Hauser, Paul Havlak, Luke Hayden, Sophie Helbing, Michael Holder, Jerome H L Hui, Julia P Hunn, Vera S Hunnekuhl, LaRonda Jackson, Mehwish Javaid, Shalini N Jhangiani, Francis M Jiggins, Tamsin E Jones, Tobias S Kaiser, Divya Kalra, Nathan J Kenny, Viktoriya Korchina, Christie L Kovar, F Bernhard Kraus, François Lapraz, Sandra L Lee, Jie Lv, Christigale Mandapat, Gerard Manning, Marco Mariotti, Robert Mata, Tittu Mathew, Tobias Neumann, Irene Newsham, Dinh N Ngo, Maria Ninova, Geoffrey Okwuonu, Fiona Ongeri, William J Palmer, Shobha Patil, Pedro Patraquim, Christopher Pham, Ling-Ling Pu, Nicholas H Putman, Catherine Rabouille, Olivia Mendivil Ramos, Adelaide C Rhodes, Helen E Robertson, Hugh M Robertson, Matthew Ronshaugen, Julio Rozas, Nehad Saada, Alejandro Sánchez-Gracia, Steven E Scherer, Andrew M Schurko, Kenneth W Siggens, DeNard Simmons, Anna Stief, Eckart Stolle, Maximilian J Telford, Kristin Tessmar-Raible, Rebecca Thornton, Maurijn van der Zee, Arndt von Haeseler, James M Williams, Judith H Willis, Yuanqing Wu, Xiaoyan Zou, Daniel Lawson, Donna M Muzny, Kim C Worley, Richard A Gibbs, Michael Akam, Stephen Richards

“…For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. …”
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Inter-cluster and intra-cluster flow distribution and proppant allocation in deep coalbed methane orientation fracturing by Ruiyue YANG, Yiwen LIU, Yu LI, Mengmeng ZHOU, Yanjin GONG, Zhongwei HUANG

“…Field applications in the eastern margin of the Ordos Basin for deep CBM have shown that orientation perforating yields higher gas production than conventional spiral perforating, with the “fan shape down + horizontal direction (240° pattern)” orientation perforating showing the most significant increasing in gas production. It is recommended that deep CBM reservoir stimulation be designed based on the position of the well trajectory within the coal seam (especially its relative position to bright coal), implementing a “one-cluster one-policy” perforating design to induce directional fracture initiation, targeted communication with the “geological-engineering” sweet spots, and achieve the stimulation objectives of “directed guidance, taper design, uniform proppant placement and effective support”. …”
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PECULIARITIES OF DENTAL CARIES PREVENTION IN CHILDREN WITH OLIGOPHRENIA by N.L. Chukhray, Е.V. Bezvushko, G.Z. Dutko, U.O. Stadnyk, Kh.H. Musiy-Sementsiv

“… Nowadays dental caries and periodontal diseases are among the most pressing problems in Paediatric Dentistry. Young patients with psychoneurological disorders are a special category among children with somatic pathology. …”
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Transformation of Gender Dominance in Russian TV Content in 2000s and 2010s: Based on Detective Series / Трансформация гендерной доминанты в российском телеконтенте 2000-х–2010-х г... by Ilchenko Sergei N. / Ильченко С.Н.

“…The work focuses on the series that tend toward the most mass and popular forms of solving aesthetic problems—melodrama, comedy, and detective. …”
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THE PSYCHOMETRIC PROPERTIES OF A RUSSIAN VERSION OF THE DISEASE-SPECIFIC LUPUSQOL QUESTIONNAIRE ASSESSING THE HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEM... by E. A. Aseeva, L. D. Vorobyeva, S. K. Solovyev, V. N. Amirdzhanova, S. I. Glukhova, G. M. Koilubaeva, M. V. Letunovich

“…After 12 months of standard therapy, 128 patients included in the assessment of questionnaire sensitivity showed a significant improvement in HRQOL for all questionnaire domains. The most significant positive changes were achieved on the domains of pain (p = 0.002), intimate relationships (IR; p=0.01), body image (p=0.0003), and fatigue (p=0.006).Validity was assessed in 328 patients with SLE. …”
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Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus... by Mattia Moratti, Mattia Moratti, Gioacchino Schifino, Francesco Baccelli, Francesco Baccelli, Simona Ferrari, Elisabetta Magrini, Mirna Bassi, Aldo Guerrieri, Maurizio Zompatori, Marcello Lanari, Marcello Lanari, Francesca Conti, Francesca Conti

“…BackgroundCommon variable immune deficiency (CVID) is the most prevalent inborn error of immunity (IEI), marked by diverse clinical-immunological phenotypes and significant immune-dysregulation, including granulomatous lymphocytic interstitial lung disease (GLILD). …”
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Multidimensional insights into the biodiversity of Streptomyces in soils of China: a pilot study by Ziguang Deng, Wei Yang, Tongtong Lin, Yaohai Wang, Xiaojing Hua, Xiaoyu Jiang, Junhao Chen, Dan Liu, Zhiqiang Ye, Yu Zhang, Michael Lynch, Hongan Long, Jiao Pan

“…Amplicon analysis showed that Actinobacteria were among the most abundant bacteria, with 0.3% of amplicon sequence variants (ASVs) belonging to Streptomyces. …”
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Fever in travelers returning from tropical and subtropical areas: a hospital-based study of factors affecting investigations and diagnoses in children and adults by Klara Sondén, Donya Satarvandi, Helena Hildenwall, Sara Falck-Jones, Victor Yman, Niclas Johansson, Katja Wyss, Elin Folkesson, Hilmir Asgeirsson, Irene Nordling, Anna Löwhagen Welander, Anna Färnert

“…An etiological diagnosis was confirmed in 63.3 % (n = 1546) of patients; with malaria (5.6 %, n = 138), dengue (4.0 %, n = 98) and typhoid fever (0.9 %, n = 22) being the most common tropical infections. Patients with fever >38 °C (aOR 1.48, 95 % CI 1.20–1.84) or hospitalization (aOR 4.68, 95 % CI 3.23–6.80) had higher odds of etiological diagnosis. …”
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CRYPTO-RESISTANT METHODS AND RANDOM NUMBER GENERATORS IN INTERNET OF THINGS (IOT) DEVICES by Petro Klimushyn, Tetiana Solianyk, Oleksandr Mozhaiev, Yurii Gnusov, Oleksandr Manzhai, Vitaliy Svitlychny

“…The analysis of technologies and circuit solutions allowed to draw the following conclusions: protection of IoT solutions includes: security of IoT network nodes and their connection to the cloud using secure protocols, ensuring confidentiality, authenticity and integrity of IoT data by cryptographic methods, attack analysis and network cryptographic stability; the initial basis for the protection of IoT solutions is the true randomness of the formed RNG sequences and used in algorithms for cryptographic transformation of information to protect it; feature of IoT devices is their heterogeneity and geographical distribution, limited computing resources and power supply, small size; The most effective (reduce power consumption and increase the generation rate) for use in IoT devices are RNG exclusively on a digital basis, which implements a three-stage process: the initial digital circuit, normalizer and random number flow generator; Autonomous Boolean networks (ABN) allow to create RNG with unique characteristics: the received numbers are really random, high speed – the number can be received in one measure, the minimum power consumption, miniature, high (up to 3 GHz) throughput of Boolean chaos; a promising area of ABN development is the use of optical logic valves for the construction of optical ABN with a bandwidth of up to 14 GHz; the classification of known classes of RNG attacks includes: direct cryptanalytic attacks, attacks based on input data, attacks based on the disclosure of the internal state of RNG, correlation attacks and special attacks; statistical test packages to evaluate RNG sequences have some limitations or shortcomings and do not replace cryptanalysis; Comparison of cryptoaccelerators with cryptographic transformation software shows their significant advantages: for AES block encryption algorithm, speeds increase by 10-20 times in 8/16-bit cryptoaccelerators and 150 times in 32-bit, growth hashing of SHA-256 in 32-bit cryptoaccelerators more than 100 times, and for the NMAS algorithm - up to 500 times. …”
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