Dynamic shift of malaria cases in northwest Ethiopia: a 10-year retrospective cohort data analysis from 2012 to 2021 by Aberham Abere, Solomon Ayalew, Bealemlay Wondale, Fentahun Tigabu, Nigus Gizachew, Takele Tesfaye, Getnet Ayalew, Banchamlak Tegegne, Mulat Yimer Melaku, Yibeltal Aschale, Adane Tilahun, Mebratu Tamir, Fentahun Megabiaw, Tegegne Eshetu, Adane Derso

“…BackgroundDespite the WHO’s extensive efforts to eliminate malaria from sub-Saharan Africa, including Ethiopia, it remains the most serious public health issue, with seasonal variations and high mortality. …”
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Unraveling relevant cross-waves pattern drifts in patient-hospital risk factors among hospitalized COVID-19 patients using explainable machine learning methods by Fernanda Cristina Barbosa Lana, Carolina Coimbra Marinho, Bruno Barbosa Miranda de Paiva, Lucas Rocha Valle, Guilherme Fonseca do Nascimento, Leonardo Chaves Dutra da Rocha, Marcelo Carneiro, Joanna d‘Arc Lyra Batista, Fernando Anschau, Pedro Gibson Paraiso, Frederico Bartolazzi, Christiane Corrêa Rodrigues Cimini, Alexandre Vargas Schwarzbold, Danyelle Romana Alves Rios, Marcos André Gonçalves, Milena Soriano Marcolino

“…Thrombocytopenia was the most important feature in wave 2 (ICU); overall, values below 143,000 × 109/L were more related to death. …”
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Clinical and Genetic Profile of Pediatric and Adult Wilson's Disease in India by Anand V. Kulkarni, Govardhan Bale, Ravikanth Vishnubotla, Anuhya Rambhatla, Mithun Sharma, Swapnali Sabhapandit, Archana Chintam, Manasa Alla, Shantan Venishetty, Sowmya Iyengar, Ravi Babu Komalla, Sumana Kolar Ramachandran, Balachandran Menon, Rakesh Kalapala, Rajesh Gupta, Padaki Nagaraj Rao, Duvvur Nageshwar Reddy, Michael L. Schilsky, K.Rajender Reddy

“…Seventy percent of patients underwent genetic evaluation for ATP7B mutations and 54.1% (59 of 109) were homozygous or compound heterozygous for a combination of either pathogenic variant and/or variants of uncertain significance. The most common pathogenic ATP7B variants were p.Gly977Glu, p.Cys271Ter, and p.Asn1186Ser. …”
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The Sloan Digital Sky Survey Reverberation Mapping Project: Insights on Maximizing Efficiency in Lag Measurements and Black Hole Masses by Y. Homayouni, Yuanzhe Jiang, W. N. Brandt, C. J. Grier, Jonathan R. Trump, Yue Shen, Keith Horne, Patrick B. Hall, Scott F. Anderson, Luis C. Ho, D. P. Schneider

“…Analyzing 172 high-confidence (“gold”) lag measurements from SDSS-RM for the H β , Mg ii , and C iv emission lines, we find that the Durbin–Watson statistic (a statistical test for residual correlation) is the most significant predictor of light curves suitable for lag detection. …”
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Global, regional, and national burdens of eating disorders from 1990 to 2021 and projection to 2035 by Xiangrong Liu, Xiangrong Liu, Lu Liu, Hang Yu, Xueyan Yang, Zhao Liu, Zhimeng Yu, Xin Qin, Yinghua Liu

“…This study offered the most current and comprehensive global assessment of the burden of eating disorders, providing critical and updated evidence for healthcare professionals, public health practitioners, and policymakers worldwide. …”
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Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device by Asako Otomo, Asako Otomo, Keiko Nishijima, Yuta Murakami, Mitsuru Ishikawa, Mitsuru Ishikawa, Haruka Yudahira, Kento Shimakura, Hideyuki Okano, Hideyuki Okano, Masashi Aoki, Hiroshi Kimura, Hiroshi Kimura, Shinji Hadano, Shinji Hadano

“…Mutations in the FUS/TLS gene have been reported as the second most common mutation in Japanese patients with familial ALS. …”
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Carbothioamides as anticancer agents: synthesis, in-vitro activity, structure-activity relationship evaluations and molecular docking by Basharat Ali, Muhammad Riaz, Ajmal Khan, Nadir Rasheed, Muhammad Masood, Ali Iftikhar, Amir Faisal, Sobia Ahsan Halim, Jalal Uddin, Afnan Jan, Ahmed Al-Harrasi

“…IC50 determination of these four compounds revealed 1-benzoyl-4-(2-bromophenyl) thiosemicarbazide (11) as the most potent compound with IC50 values of 21.61 ± 4.77 μM, 18.34 ± 3.53 μM and 17.87 ± 12.02 μM in the breast cancer (MCF-7) cell line, human colorectal carcinoma (HCT116) cell line and MD Anderson-metastatic breast (MDA-MB-453) cell lines respectively. …”
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Characterization of Hospital Admissions During Immune Checkpoint Inhibitor Therapy: Insights From the ICOG Study by Jonas Paul Wiegmann, Tabea Fröhlich, Nora Möhn, Laura Duzzi, Emily Narten, Johanna Aurich, Janin Thomas, Lea Grote‐Levi, Susann Mahjoub, Dominik Berliner, Thomas Wirth, Heiko Golpon, Benjamin‐Alexander Bollmann, Imke Von Wasilewski, Ralf Gutzmer, Florian H. Heidel, Thomas Skripuletz, Gernot Beutel, Philipp Ivanyi, ICOG‐CCCH (Immune Cooperative Oncology Group, Comprehensive Cancer Center Hannover)

“…Results During the observation period, 30/237 patients were hospitalized (HA(+)). Most common underlying tumor entities were malignant melanoma (59.5%), renal cell carcinoma (13.1%), and nonsmall‐cell lung carcinoma (12.7%). …”
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Purification and Functional Characterization of a New Endoglucanase from <i>Pleurotus djamor</i> PLO13 Produced by Solid-State Fermentation of Agro-Industrial Waste by Monizy da Costa Silva, Ricardo Bezerra Costa, Marta Maria Oliveira dos Santos Gomes, Josiel Santos do Nascimento, Andreza Heloiza da Silva Gonçalves, Jéssica Alves Nunes, Marta Angelo dos Santos, Francis Soares Gomes, José Maria Rodrigues da Luz, Luciano Aparecido Meireles Grillo, Hugo Juarez Vieira Pereira

“…Solid-state fermentation (SSF) was found to be highly efficient for enzyme synthesis, with wheat bran emerging as the most effective substrate, yielding an enzyme production of 7.19 U after 120 h of cultivation. …”
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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference by Yinlei Lei, Min Li, Han Zhang, Yu Deng, Xinyu Dong, Pengyu Chen, Ye Li, Suhua Zhang, Chengtao Li, Shouyu Wang, Ruiyang Tao

“…Cutibacterium was the most abundant bacterium in palmar samples from Shanghai and Kunming, Psychrobacter in Chifeng samples, and Psychrobacillus in Urumqi samples. …”
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Chemical Composition and Biological Activities of <i>Psilocybe</i> Mushrooms: Gaps and Perspectives by Mateus A. Luz, Hellen V. S. Guedes, Antônio B. M. Bisneto, Raquel A. de Jesus, Taynah P. Galdino, Lucas C. Oliveira, Victor Ignacio Afonso, Marcus Vinícius L. Fook, Antônio G. B. Lima, Suedina M. de L. Silva, Maria C. M. Torres

“…Therefore, it is evident that species of this genus remain underexplored in terms of chemical diversity; only compounds classified as alkaloids, terpenoids and phenolic compounds were found, and, in total, only 36 compounds in a study range time of 67 years. Furthermore, most studies focused primarily on evaluating the tryptamine alkaloids responsible for the psychoactivity of the mushrooms, without any study focusing on demonstrating the biological activity of isolated compounds against any pathological factor, except for studies relating the whole extract to larvicidal, antimicrobial and antioxidant potential. …”
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Vibrio cholerae O47 associated with a cholera-like diarrheal outbreak concurrent with seasonal cholera in Bangladesh by Mohammad Tarequl Islam, Jarin Tasnim, Rabeya Basri, Mohammad Nazmus Sakib, Wali Ullah, Kazi Sumaita Nahar, Abdus Sadique, Marzia Sultana, Eiji Arakawa, Masatomo Morita, Haruo Watanabe, Yann F. Boucher, Anwar Huq, Rita R. Colwell, Munirul Alam

“…Results of the study suggest that V. cholerae O47 could represent an emerging Vibrio pathogen with the potential to spread virulence and antimicrobial resistance traits impacting the management of cholera-like diseases.IMPORTANCEDespite the global insurgence of human diseases caused by Vibrios in recent years, most research focuses only on the O1 serogroup of V. cholerae, leaving a significant gap concerning the environmental and human-associated aspects of other serogroups found in nature. …”
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Preliminary study on the cooling effect of geothermal exchange at the superficial layer on greenhouse in South Jiangsu in summer by WANG Jiawei, WANG Zhao, YANG Junwei, ZHAO Hailiang, ZOU Zhirong

“…In recent years, as an emerging technology of environmental management inside the greenhouse, ground source heat pump (GSHP) is sufficiently emphasized by many scholars. While most of them only focus on heating effect of greenhouse rather than its cooling effect, due to some severe crop problems induced by relatively high temperature in South Jiangsu during summer. …”
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Intimate partner violence during pregnancy against 601,534 women aged 15 to 49 years in 57 LMICs: prevalence, disparities, trends and associated factors using Demographic and Healt... by David Jean Simon, Vénunyé Claude Kondo Tokpovi, Adama Ouedraogo, Kassoum Dianou, Ann Kiragu, Comfort Z. Olorunsaiye, Bénédique Paul

“…Further, prevalence varied greatly across countries, ranging from 1.1% (95% CI 0.6–1.5) in South Africa to 17.6% (95% CI 15.3–20.0) in Papua New Guinea. Examining AARC, most countries (23/31) experienced a decreasing trend in IPVDP, however, seven countries showed increasing trends, with the largest of 8.3% (95% CI 6.8–9.9) in Gambia and the smallest of 0.6% (95% CI –0.7 to 1.8) in the Democratic Republic of Congo. …”
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Perceptions about chronic health conditions, multimorbidity and self-management practices in rural northeast South Africa: findings from a qualitative study by Edward Fottrell, Stephen Tollman, F Xavier Gómez-Olivé, Rochelle Burgess, Alisha N Wade, Audry Dube, Nicola Joan Christofides, Belinda J Njiro, Chodziwadziwa Whiteson Kabudula

“…An inclusive thematic approach was used for analysis.Results Participants identified most chronic health conditions and their progression. …”
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XBB.1.5 monovalent vaccine induces lasting cross-reactive responses to SARS-CoV-2 variants such as HV.1 and JN.1, as well as SARS-CoV-1, but elicits limited XBB.1.5 specific antibo... by Juan Manuel Carreño, Brian Lerman, Gagandeep Singh, Anass Abbad, Temima Yellin, Jordan Ehrenhaus, Miriam Fried, Jessica R. Nardulli, Hyun Min Kang, Lubbertus C. F. Mulder, Charles Gleason, Komal Srivastava, Viviana Simon, Florian Krammer

“…However, antibody depletion experiments showed that most of the response was cross-reactive to the ancestral spike, and only low levels of XBB.1.5-specific antibodies to the spike or the receptor-binding domain were detected. …”
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INDEXED ASSESSMENT OF PERIODONTAL TISSUE IN PATIENTS WITH EARLY FORMS OF GENERALIZED PERIODONTITIS ON A BACKGROUND OF DIABETES TYPE I DIABETIC CARDIOMYOPATHY by R. Shkrebnyuk

“…The smallest subgroup - 10.52% men and 11.49% women were persons with diabetes duration of the course of 1 year, and most numerous subgroup was represented 44.73% 45.97% men and women who have diabetes duration of the course was over 10 years . …”
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Optimized selection of clean nitrogen fertilizers for high-sediment water pressure-compensating drip irrigation systems based on system failure perspective by Changjian Ma, Bowen Li, Lining Liu, Enkai Cao, Qichao Zhang, Zeqiang Sun, Peng Hou, Yan Li

“…Urea resulted in the least structural and performance degradation, while calcium nitrate induced the most severe impacts. Structural equation modeling indicated that emitter performance decline was primarily driven by clogging material accumulation (standardized path coefficient β = –0.83) and diaphragm mechanical deterioration (β = 0.59). …”
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Efficacy and safety of intermittent intravenous doxercalciferol in the treatment of secondary hyperparathyroidism in Chinese patients on maintenance hemodialysis: a phase II, open-... by Guang Yang, Yaoyu Huang, Yifei Ge, Xiangbao Yu, Li Liu, Li Xiang, Bin Liu, Chaoqing Gao, Changhua Liu, Yong Xu, Wenwen Li, Donghua Lou, Tongqiang Liu, Huijuan Mao

“…All three groups showed a decrease in serum alkaline phosphatase (ALP) levels, with the Severe Group experiencing a statistically significant reduction (P = 0.001). The most common adverse event was hypercalcemia, occurring in 33.3% of patients (15 cases), with only 8.9% (4 cases) experiencing severe hypercalcemia (serum calcium &gt;2.8 mmol/L). …”
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Comparative analysis of virulence-associated genes in ESBL-producing Escherichia coli isolates from bloodstream and urinary tract infections by Mayuko Tanaka, Tomoko Hanawa, Tomoya Suda, Yasunori Tanji, Le Nhat Minh, Kohei Kondo, Kohei Kondo, Aa Haeruman Azam, Kotaro Kiga, Shota Yonetani, Ryu Yashiro, Takuya Ohmori, Takeaki Matsuda, Takeaki Matsuda

“…Therefore, in the present study, we analyzed the genotypes and virulence-associated genes of ESBL-producing strains isolated from the blood of patients with UTIs to determine the characteristics of ESBL-producing UPEC strains associated with severe infections. Most of the clinical isolates belonged to phylogroup B2, with the exception of three strains from phylogroup D. …”
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