Evaluation of the effectiveness of allogeneic tendon graft sterilization with supercritical carbon dioxide by A. A. Budaev, N. V. Borovkova, A. M. Fayn, A. Yu. Nikolaev, M. S. Makarov, M. V. Storozheva, K. I. Skuratovskaya, A. Yu. Vaza, I. V. Fomicheva, T. V. Chernen'kaya, A. А. Kanibolotskiy

“…For supercritical carbon dioxide sterilization of tendon grafts the most optimal processing time is 1 hour.…”
Get full text

Metabolic syndrome and its associations with socio-demographic and behavioral risk factors in the Russian population aged 25-64 years by Yu. A. Balanova, A. E. Imaeva, V. A. Kutsenko, A. V. Kapustina, G. A. Muromtseva, S. E. Evstifeeva, S. A. Maksimov, N. S. Karamnova, E. B. Yarovaya, S. A. Shalnova, O. M. Drapkina

“…The risk of lipid metabolism disorders was higher among women with secondary education. Most of these associations were confirmed by multivariate analysis.Conclusion. …”
Get full text

Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial by Paul Little, Alastair D Hay, Lucy Yardley, G Ardine de Wit, Nicolaas P A Zuithoff, Sibyl Anthierens, Roderick P Venekamp, Anne G M Schilder, Roger A M J Damoiseaux, Elisabeth A M Sanders, Saskia Hullegie, Joline L H de Sévaux

“…Introduction Ear pain is the most prominent symptom of childhood acute otitis media (AOM). …”
Get full text

Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers by Maria Teresa De Angelis, Antonia Rizzuto, Angela Amaddeo, Carlo Sagnelli, Niccolò Vono, Michela Reda, Valentina Lise, Luca Parrillo, Carmela De Marco, Donatella Malanga, Gianluca Santamaria, Giuseppe Viglietto

“…Importantly, analysis of predicted non-canonical driver genes identified ACVR1B, LTBP4, SETD1A as CC-specific drivers and C4BPA, EHD1 as RC-specific drivers, underscoring divergent oncogenic mechanisms. However, the most substantial divergence was observed in transcriptomic profiling, with 56% and 33% of DEGs (in CC and RC, respectively) that were tumor-type specific. …”
Get full text

Non-invasive breath testing to detect colorectal cancer: protocol for a multicentre, case–control development and validation study (COBRA2 study) by Michael G. Fadel, James Murray, Georgia Woodfield, Ilaria Belluomo, Ivan Laponogov, Aaron Parker, Valerio Converso, James K. Ellis, Pete Wheatstone, Julie Hepburn, Chris Groves, Kevin Monahan, Brian P. Saunders, Patrik Španěl, Kirill Veselkov, Amanda J. Cross, Christos Kontovounisios, Linda D. Sharples, George B. Hanna, COBRA2 Collaborators

“…Abstract Background Colorectal cancer (CRC) is the fourth most common cancer in the United Kingdom. The five-year survival rate from CRC is only 10% when discovered at a late stage, but can exceed 90% if diagnosed early. …”
Get full text

Comparative Efficacy of 20-Degree versus 30-Degree Angled Wedges on Inferior Vena Cava Diameter and Haemodynamic Stability during Spinal Anaesthesia for Caesarean Section: A Random... by Janani Rajamannar, Mahesh Vakamudi, Gayathri Sakthivel, V Rajesh Kumar Kodali, Aruna Parameswari

“…Spinal anaesthesia also provides adequate pain relief for parturient. The most common condition that occurs during the pregnancy is supine hypotension syndrome, which gets aggravated after spinal anaesthesia. …”
Get full text

Evaluating the impact of DREAMS on HIV incidence among adolescent girls and young women: A population-based cohort study in Kenya and South Africa. by Isolde Birdthistle, Daniel Kwaro, Maryam Shahmanesh, Kathy Baisley, Sammy Khagayi, Natsayi Chimbindi, Vivienne Kamire, Nondumiso Mthiyane, Annabelle Gourlay, Jaco Dreyer, Penelope Phillips-Howard, Judith Glynn, Sian Floyd

“…<h4>Conclusions</h4>Substantial declines in HIV incidence among AGYW were observed, but most began before DREAMS introduction and did not accelerate in the first 3 years of DREAMS implementation. …”
Get full text

Development and validation of an integrative 54 biomarker-based risk identification model for multi-cancer in 42,666 individuals: a population-based prospective study to guide adva... by Renjia Zhao, Huangbo Yuan, Yanfeng Jiang, Zhenqiu Liu, Ruilin Chen, Shuo Wang, Linyao Lu, Ziyu Yuan, Zhixi Su, Qiye He, Kelin Xu, Tiejun Zhang, Li Jin, Ming Lu, Weimin Ye, Rui Liu, Chen Suo, Xingdong Chen

“…Employing five supervised machine learning approaches, we used a LASSO-based feature selection strategy to identify the most informative predictors. The model was trained and internally validated in the discovery cohort, externally applied in the validation cohort, and further evaluated through a prospective clinical follow-up to assess cancer events via clinical examinations. …”
Get full text

Climate Change and Its Impacts on the Planting Regionalization of Potato in Gansu Province, China by Yulan Lu, Junying Han, Guang Li, Zhengang Yan, Lixia Dong, Zhigang Nie, Qiang Liu

“…The accumulated temperature above 10 °C showed a spatial pattern of high accumulated temperatures in the northwestern and southeastern regions and low accumulated temperatures in the remaining regions, while its tendency rate showed a decreasing trend from west to east and from north to south. (4) The impacts of climate change on potato planting in Gansu Province were mainly manifested as a decrease of 0.30 × 10⁶ hm² in the cultivated land area in the most suitable region for potato planting post-1998, while the suitable area diminished by 0.96 × 10⁶ hm², the sub-suitable area expanded by 0.47 × 10⁶ hm², and the plantable area increased by 0.79 × 10⁶ hm². …”
Get full text

Evaluation of additional resources and stories within therapist-assisted internet-delivered cognitive behaviour therapy for alcohol misuse by H.D. Hadjistavropoulos, V. Peynenburg, R.P. Sapkota, E. Valli, M. Nugent, M.T. Keough, C. Sundström, M.P. Schaub, N. Titov, B.F. Dear

“…Large effects were also observed for depression and cravings, with high treatment satisfaction. 63 % of patients accessed at least one resource (M = 2.27 resources), with anger (35 %), cognitive coping (35 %), sleep (34 %) and worry (30 %) being the most used. When accessed, patients found resources informative and/or helpful to varying degrees (25–67 %). …”
Get full text

Spatiotemporal analysis of Anopheles gambiae larval sites and malaria transmission in Djilakh, Central Senegal by Assane Ndiaye, Camille Morlighem, Aminata Niang Diène, Moussa Kane, Abdoulaye Diallo, Fassiatou Tairou, Mohamed Abderemane Nourdine, Pape Cheikh Sarr, Lassana Konaté, Ousmane Faye, Oumar Gaye, El Hadji Amadou Niang, Catherine Linard, Ousmane Sy

“…The incidence of malaria cases was significantly higher (82.4%; 103/125; P < 0.011; OR = 27.006) in hamlets closer to the breeding sites (less than 500 m), declining gradually with distance with 17.6% (22/125) of the cases recorded in hamlets located between 500 and 1000 m apart from the larval habitats and, no cases in the most remote hamlets (> 1000 m). Conclusions These findings represent a preliminary step towards a better understanding of how the environmental factors influence the persistence of malaria transmission in the studied hotspot villages in Senegal. …”
Get full text

The miR-302 cluster-IRFs-IRF1AS axis regulates influenza A virus replication in a species-specific manner by Lingcai Zhao, Chenglin Hou, Xifeng Hu, Chenfeng Jiang, Shengmin Li, Jun Xia, Jihui Ping

“…Our findings indicate that the miR-302 cluster-IRFs axis facilitates the transcription of key hub genes and hub lncRNAs, most of which significantly inhibit influenza virus replication. …”
Get full text

Multidimensional analysis suggests that ZNF433 is a promising biomarker for the diagnosis and prognosis of human cancers by Lingyu Xie, Lingyu Xie, Xin Zeng, Xin Zeng, Hui Luo, Hui Luo, Bin Xie, Xuefeng Wang, Nan Wu, Junrong Zou, Junrong Zou, Junrong Zou, Guoxi Zhang, Guoxi Zhang, Guoxi Zhang, Xiaofeng Zou, Xiaofeng Zou, Xiaofeng Zou, Hui Xu, Hui Xu, Hui Xu

“…Functional enrichment and protein interaction network analyses were also performed to explore its potential involvement in cancer-related pathways.ResultsOur findings revealed that ZNF433 is significantly downregulated in most cancer types, with stage-dependent expression patterns observed in KIRC and KIRP. …”
Get full text

Clinical experience with the interleukin-1β blocker canakinumab in patients with chronic tophaceous gout: abolishment of arthritis and prevention of exacerbations when allopurinol... by M. S. Eliseev, O. V. Zhelyabina, M. V. Mukagova, E. L. Nasonov

“…The administration of high-dose allopurinol causes a target reduction in serum UA levels in most patents.…”
Get full text

Cyclic alternating pattern in normal children aged 12 to 24 months Padrão alternante cíclico em crianças normais de 12 a 24 meses by Gabriela Rodrigues Alves, Agostinho Rosa, Magneide Brito, Marcia Pradella-Hallinan, Sergio Tufik

“…CONCLUSION: Our study provides normative data on CAP in a group of young children (12 to 24 months). The most salient result of this study is the strong correlation of CAP rate of 2% per month in this age group.…”
Get full text

Analysis of 19.9 million publications from the PubMed/MEDLINE database using artificial intelligence methods: approaches to the generalizations of accumulated data and the phenomen... by I. Yu. Torshin, O. A. Gromova, L. V. Stakhovskaya, N. P. Vanchakova, A. N. Galustyan, Zh. D. Kobalava, T. R. Grishina, A. N. Gromov, I. A. Ilovaiskaya, V. M. Kodentsova, A. G. Kalacheva, O. A. Limanova, V. A. Maksimov, S. I. Malyavskaya, E. V. Mozgovaya, N. I. Tapilskaya, K. V. Rudakov, V. A. Semenov

“…., the positive dynamics of sentiment quality of the texts of publications) for 27,090 of the studied headings. The most intense positive dynamics was found for research in genetics, physiology, pharmacology, and gerontology. 249 headings with sharply negative dynamics of sentiment quality and with a pronounced increase in the manipulative sentiments characteristic of the tabloid press were highlighted. …”
Get full text

Peculiarities of the macro- and micromorphology of the liver of fish of the carp family (Cyprinidae) in a comparative aspect by L. P. Goralskyi, N. V. Demus, I. M. Sokulskyi, B. V. Gutyj, N. L. Kolesnik, O. V. Pavliuchenko

“…It was established that the most significant volume of cytoplasm and karyoplasm was found in silver crucian carp, where it was 12.982 ± 1.420 μm³ and 0.398 ± 0.021 μm³, respectively. …”
Get full text

Alterations in the intestinal fungal microbiome of patients with severe fever with thrombocytopenia syndrome by Meng-Yu Liu, Sheng-Fu He, Yu-Yao Li, Jiao-Jiao Shen, Jia-Jia Li, Ya-Sheng Li, Yan-Yan Liu, Ting Wu, Jia-Bin Li, Li-Fen Hu

“…In SFTS patients with IPA, A. subversicolor, A. flavus and A. penicillioides were the three most common fungal species. Longitudinal dynamic detection revealed that patients who experienced significant fluctuations in their intestinal mycobiome tended to have more severe illness. …”
Get full text

Structural Characterization and Hypolipidemic Activity of Highland Barley Polysaccharide-Polyphenol Complexes by Zibin GUO, Yang YANG, Bei FAN, Litao TONG, Yatao HUANG, Lili WANG, Ting ZHANG, Liya LIU, Peipei SUN, Jing SUN, Fengzhong WANG

“…Additionally, HVP exhibited a dose-dependent effect on the reduction of triglyceride (TG) and total cholesterol (TC) levels in hyperlipidemic zebrafish, with the most pronounced effects observed at high doses (P<0.001). …”
Get full text

Cuantificación de especies químicas y propiedades termodinámicas de los gases para el cálculo de su temperatura en el interior de la cámara de combustión en MCI. // Chemical specie... by F. Soto Pau, J. A. Silva, A. M. dos Santos, A. G. Sanches

“…We are in presence of an application of a phenomenalistic model that consists<br />in the union of several sub models created by different authors in order to arrive to temperatures values inside the combustion chamber in<br />the most realistic possible way.</p><p><br />Key words: Combustion chamber, molecular dissociation, ethanol, gasoline.…”
Get full text