Assessment of neurological symptoms and associated factors in patients with Wilson’s disease in Southwest China by Lu Zhang, Jieru Peng, Yao Dong, Qiwen Zhang, Wencheng Long, Yueshan Wang, Zhong Li, Lu Long, Yaxin Li, Qiaoling Jin, Lin Deng, Lin Cai, Dailan Yang, Juan Liao, Chunxia Yang

“…Multiple linear regression analysis was performed to assess the association between patient characteristics and UWDRS Part I scores. Results The most prevalent neurological symptoms of patients with Wilson’s disease were impaired rapid alternating movements of hands (76.2–81.0%), impaired finger tapping (75.0%), dysarthria (70.2%), salivation (66.7%), impaired handwriting (61.9%), impaired legs agility (60.7–61.9%), impaired gait (leg dystonia, 59.5%; ataxia, 58.3%), and dystonia of arms and hands (54.8–56.0%). …”
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Overuse of Computed Tomography Pulmonary Angiography in the Diagnosis of Pulmonary Thromboembolism “Real-Life Data” by Aksu EA, Uzun O, Işıksungur İ, GÜndoĞdu BA, Kökten FC, Özbek B, Elmali M

“…Plain Language Summary: Pulmonary thromboembolism (PTE) is a common cause of cardiovascular mortality with an increasing incidence rate. CTPA is the most effective method for the diagnosis of PTE. The diagnostic algorithm includes clinical probability scoring prior to CTPA. …”
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Global burden and trends of high BMI-attributable chronic kidney disease: a comprehensive analysis from 1990 to 2021 and projections to 2035 by Huifang Tan, Zhifu Liu, Yongjie Zhang, Kehao Yang, Yiming Zeng, Guoli Li, Zheng Xiao, Yuanwei Li, Yinyin Chen

“…Regionally, low- and low-middle SDI areas exhibited the most rapid burden escalation, while some high-income countries achieved burden reduction. …”
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Alternative methods for analyzing cross-sectional studies of common outcomes: A guide for healthcare professionals by Mohammad H. Aljawadi, BPharm, PharmD, MSc, PhD

“…The objective was to identify the most reliable method and reduce misinterpretation when outcome prevalence is high. …”
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Leflunomide monotherapy in patients with early rheumatoid arthritis: Results of the Russian national Arava mono study by Rimma Mikhailovna Balabanova, Yu A Olyunin

“…The choice of these drugs is very limited and leflunomide (LEF) is one of the most promising agents. The present study assessed the results of using the standard LEF regimen for patients with early RA in the everyday clinical practice of Russian health care facilities. …”
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High healthcare utilization and associated costs in the year prior to both primary reverse and anatomic shoulder arthroplasty: a study of 2393 patients from a private insurance dat... by Jason Corban, MD, Krishna Mandalia, BS, Darren Nin, PhD, Ya-Wen Chen, MD, MPH, Yutung Lan, MD, MPH, Ruijia Niu, MPH, David Chang, PhD, MPH, MBA, Eric Smith, MD, Kaley Beall, MPH, Sarav Shah, MD

“…Conclusion: There is high health care utilization and associated cost of nonoperative procedures in the year prior to rTSA and aTSA. rTSA patients had significantly higher preoperative utilization and costs, mainly due to PT and magnetic resonance imaging. Most notably, for those waiting more than 10 months for rTSA, nearly 30% of the spending occurred in the last 3 months preceding surgery. …”
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Cumulative environmental exposures and metabolic syndrome: A study of heavy metals and volatile organic compounds by Brooke Scardino, Destyn Dicharry, Akshat Agrawal, Diensn Xing, Md. Mostafizur Rahman Bhuiyan, Md. Shenuarin Bhuiyan, Oren Rom, Steven A. Conrad, John A. Vanchiere, A. Wayne Orr, Christopher G. Kevil, Mohammad Alfrad Nobel Bhuiyan

“…Younger adults (18–50 years), men, Hispanics and non-Hispanic whites, and those with a monthly poverty index > 1.3 (higher socioeconomic status) emerged as the most vulnerable groups. Conclusion: These findings emphasize an urgent need to address and tackle the cumulative impact of environmental toxins through a shift in public health efforts to go beyond investigating isolated exposures to address real-world chemical exposures. …”
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Screening of acetolactate synthase inhibitors against Sclerotinia sclerotiorum for the purpose of controlling rapeseed Sclerotinia disease by WEN Xuewei, CHEN Yangyang, WU Bin, HU Dongwei, LIANG Wusheng

“…Rapeseed is an oil crop with quite large growing areas in China, and also one of the main oil crops in the world. As one of the most serious diseases in rapeseed, Sclerotinia disease, caused by the fungal pathogen Sclerotinia sclerotiorum, can result in significant yield loss. …”
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Pemodelan Simulasi Sistem Dinamik untuk Meningkatkan Jumlah Pendapatan Unit Rawat Inap Rumah Sakit Islam Surabaya A.Yani by Anwar Romadhon, Erma Suryani

“…Limiting the number of visits is not possible considering that most patients come from BPJS Health participants. …”
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Predicting suicidality in people living with HIV in Uganda: a machine learning approach by Anthony B. Mutema, Anthony B. Mutema, Anthony B. Mutema, Lillian Linda, Lillian Linda, Daudi Jjingo, Segun Fatumo, Segun Fatumo, Eugene Kinyanda, Allan Kalungi, Allan Kalungi, Allan Kalungi

“…A positive MDD diagnosis and high stress contributed the most to predicting suicidality risk.ConclusionA cost-sensitive AdaBoost model developed using the sociodemographic, psychosocial, and clinical data of PLWH in Uganda can predict suicidality risk, albeit with modest PPV. …”
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Belantamab Mafodotin Monotherapy for Multiply‐Relapsed Myeloma: A Retrospective Study From the United Kingdom and the Republic of Ireland by Edmund C. R. Watson, Faouzi Djebbari, Fotios Panitsas, Grant Vallance, Samir Asher, Malahat Saeed, Mairi Walker, Matthew Powell, Alexandros Rampotas, Heather Leary, Akhil Khera, Angharad Atkinson, Ni Ni Aung, Gillian Brearton, Joseph Froggatt, Ezzat El Hassadi, Ellen Gokkel, Sarah Lawless, Beena Salhan, Salim Shafeek, Anand Lokare, Carol Stirling, Udo Oppermann, Richard Soutar, Rakesh Popat, Charalampia Kyriakou, Karthik Ramasamy

“…Eye‐related adverse events were the most common, affecting 66% (56/85), leading to dose reduction or delay in 41% (35/85) and discontinuation in 6% (5/85). …”
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CYP1B1 knockout enhanced IFN-γ production is required but not sufficient for protection of cigarette smoke-exposed mice against lethal influenza virus infection by Wenxin Wu, Jeremy S. Alexander, J. Leland Booth, Magdalena Chlebicz, Craig A. Miller, Chao Xu, Susan Kovats, Susan Kovats, Jordan P. Metcalf, Jordan P. Metcalf, Jordan P. Metcalf

“…To determine whether CYP1B1 knockout (CYP KO) improves mortality and reduces lung injury in CS-exposed mice, we compared the survival rates, host immune responses, and lung-to-body weight ratio of CYP KO mice with the wild-type (WT) mice following challenge with IAV with or without CS exposure.ResultsCYP1B1 is one of the most highly upregulated genes in human lung epithelia derived from cigarette smokers. …”
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Two Ultralow-mass-ratio Binary Systems at Critical Evolutionary Stages by Di-Fu Guo, Kai Li, Fen Liu, Li-heng Wang, Huai-Zhen Li, Xu Chen, Xiang Gao

“…Notably, J175200 represents the most extreme mass ratio observed in contact binaries to date. …”
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Global Trends of Early, Middle, and Late‐Onset Lung Cancer From 1990 to 2021: Results From the Global Burden of Disease Study 2021 by Zongyuan Li, Cheng Yu, Jianqi Hao, Nanzhi Luo, Haoning Peng, Jian Zhang, Qiang Pu, Lunxu Liu

“…In the current study, we aimed to systematically evaluate the most update temporal trends in incidence, mortality and DALYs of early, middle, and late‐onset lung cancer (EOLC, MOLC, and LOLC) from 1990 to 2021, with stratifications of gender, location, and socio‐demographic development. …”
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USE OF QUANTUM-CHEMICAL PARAMETERS FOR FORECASTING ANTIRADICAL (HO·) ACTIVITY OF RELATED STRUCTURES CONTAINING A CINNAMIC MOLD FRAGMENT. III. CHALCONES, FLAVANONES AND FLAVONES WIT... by E. T. Oganesyan, S. S. Shatokhin

“…Flavonoids with the phloroglucinic type of ring “A” are the most common in nature, which is due to the peculiarities of biogenetic formation with the participation of malonyl and acetyl fragments.The aim of the article is to determine the effect of the hydroxy group in position 6' of chalcones and in position 5 of flavanones and flavones on bond numbers (Nµ), free valence indices (Fµ), Mulliken charges (a.e), electron density, unsaturation indices (IUA) of the carbon atoms C-1 → C-6 → C-7 → C-8.Materials and methods. …”
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Análisis cuantitativo de las competencias de comunicación y seguridad del paciente incluidas en un programa de simulación clínica del grado de Medicina by María Martínez-García, Griselda Gonzalez-Caminal, Carmen Gomar-Sancho

“…Patient safety competencies are scarce, the most frequent being medication related. Competencies are distributed throughout the degree years but are concentrated in the last three clinical years. …”
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CircSPINT2 confers sensitivity to osimertinib via hsa-miR-1296-3p/RBP1 axis and inhibits NSCLC progression by Nalini Devi Verusingam, Aliaksandr A. Yarmishyn, Min-Long Tsai, Ping-Hsing Tsai, Yi-Chen Chen, Chih-Ling Yeh, Soon-Keng Cheong, Po-Kuei Hsu, Shih-Hwa Chiou, Alan Han-Kiat Ong, Mong-Lien Wang

“…Lung adenocarcinoma (LUAD) is the most common type of lung cancer. Prolonged treatment of LUAD with 1st/2nd generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) promotes the emergence of secondary EGFR T790M mutation conferring resistance to these drugs. …”
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Probe amplifications in the Xpert MTB/RIF Ultra assay for non-tuberculous mycobacteria identified from diabetes mellitus and chronic kidney disease patients in Ethiopia by Ayinalem Alemu, Getu Diriba, Getachew Seid, Amanuel Wondimu, Bedo Buta, Mengistu Tadesse, Biniyam Dagne, Daniel Melese, Solomon H Mariam, Nega Berhe, Balako Gumi

“…Of them, 88.5% and 78.2% had probe amplification in the Xpert Ultra assay and Xpert MTB/RIF assay, respectively. The most often amplified probe was rpoB2 (77, 88.5%), followed by rpoB4 (10, 11.5%) in the Xpert Ultra, and Probe C (64, 73.6%), followed by Probe A (7, 8.0%) in the Xpert MTB/RIF. …”
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Time-Driven Activity-Based Costing for Cervical Myelopathy Surgery: A Step Towards Total Episode Costs by Keppetipola KM, Leibold A, Trivedi J, Kabani AS, Sarikonda A, Self DM, Isch EL, Glener S, Prasad S, Jallo J, Heller JE, Harrop J, Vaccaro AR, Sivaganesan A

“…Kavantissa M Keppetipola,1 Adam Leibold,1 Jay Trivedi,1 Ashmal Sami Kabani,1 Advith Sarikonda,1 D Mitchell Self,1 Emily L Isch,2 Steven Glener,1 Srinivas Prasad,1 Jack Jallo,1 Joshua E Heller,1 James Harrop,1 Alexander R Vaccaro,3 Ahilan Sivaganesan4 1Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA, USA; 2Department of General Surgery, Thomas Jefferson University, Philadelphia, PA, USA; 3Rothman Orthopedic Institute, Philadelphia, PA, USA; 4Department of Spine Surgery, Hospital for Special Surgery, Naples Comprehensive Health, Naples, FL, USACorrespondence: D Mitchell Self, Department of Neurosurgery, Thomas Jefferson University, 909 Walnut Street, Philadelphia, PA, 19107, USA, Email dwightmitchell.self@jefferson.eduIntroduction: Time-driven activity-based costing (TDABC) is a highly accurate method for determining the true cost of delivering a healthcare service. However, TDABC is most often applied to a singular phase of care such as an outpatient visit or a surgical event. …”
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Parametric study of the decomposition of methane for COx-free H2 and high valued carbon using Ni-based catalyst via machine-learning simulation by Dinghao Xue, Pingyang Zhang, Yuanyuan Lin, Wenshuo Wang, Jiachang Shi, Qiang Hu, Gartzen Lopez, Cristina Moliner, Jin Sun, Tao Wang, Xinyan Zhang, Yingping Pang, Xiqiang Zhao, Yanpeng Mao, Zhanlong Song, Ziliang Wang, Wenlong Wang

“…Copper doping significantly affects carbon yield and its quality, and there is a strong bond between Ni and Al2O3, contributing the most to the reaction. This work would provide a guidance for the efficient catalyst design and effective hydrogen production.…”
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