Accuracy of clinical symptoms and nuclear imaging in the diagnosis of infection in revision shoulder arthroplasty by Cristina Bassi, MD, FRCSC, Diane Nam, MSc, MD, FRCSC, Elham Sabri, MSc, Darren Drosdowech, MD, FRCSC, J.W. Pollock, MSc, MD, FRCSC, Dominique Rouleau, MD, FRCSC, Taryn Hodgdon, MD, FRCPC, Katie McIlquham, HBScHK, Jonathan Doyon, MD, FRCSC, Peter Lapner, MD, FRCSC

“…Background: Prosthetic shoulder infection is the most common reason for revision arthroplasty within 2 years of the index procedure. …”
Get full text

Utilitarian diversity and options for the sustainable use of the bush banana Uvaria chamae P. Beauv. in Benin (West Africa) by Emilienne Houévo Daï, Rodrigue Idohou, Sèwanoudé Scholastique Mireille Toyi, Juliano Sènanmi Hermann Houndonougbo, Fortuné Akomian Azihou, Amadé Ouédraogo, Stefan Hotes, Achille Ephrem Assogbadjo

“…The main use categories, summarized from all the respondents, were medicinal (97%), food (84.10%), magico-religious (52.92%), firewood (25.52%), and material for handicrafts (7.30%). The most valued plant parts were roots, fruits, leaves, and branches. …”
Get full text

Characterization of Post-Production Waste from Winemaking of Selected <i>Vitis vinifera</i> L. Varieties Grown in Temperate Climates and Their Energy Valorization by Magdalena Kapłan, Grzegorz Maj, Kamila E. Klimek, Kamil Buczyński, Anna Borkowska, Radek Sotolář, Richard Danko, Mojmir Baroň

“…Merlot clusters were characterized by the highest mass of clusters and the largest peduncles. Riesling had the most berries in the cluster, the heaviest peduncles, and the highest share of peduncles in the cluster mass (8.99%). …”
Get full text

A rare deleterious missense mutation in the AXIN2 gene in Chinese women with polycystic ovary syndrome by Ying Zhang, Yu Chen, Fa-Ying Liu, Jing-Wen Fu, Xian-Xian Liu, Jun Tan, Ou-Ping Huang, Yang Zou

“…Previous genome-wide association study (GWAS) showed that Wing-less-related integration site (Wnt) signaling is the most affected pathway among PCOS-related risk genes, and genetic mutations in the Wnt/β-catenin signaling may lead to abnormal development of PCOS.Objective To explore the possibility of axis inhibitor-2 (AXIN2) variants in Chinese women with PCOS and assess their pathogenicities.Methods A total of 365 Chinese women with PCOS and 905 women without PCOS as control were recruited from Jiangxi Provincial Maternal and Child Health Hospital, All of the 11 exons and flanking regions of the AXIN2 gene were amplified by polymerase chain reaction (PCR), the potential variants were analyzed by Sanger sequencing. …”
Get full text

Traditional Chinese medicine diagnostic prediction model for holistic syndrome differentiation based on deep learning by Zhe Chen, Dong Zhang, Chunxiang Liu, Hui Wang, Xinyao Jin, Fengwen Yang, Junhua Zhang

“…Results: The TCM-BERT-CNN model had a higher precision (0.926), recall (0.9238), and F1 score (0.9247) than the BERT, TextCNN, Long Short-Term Memory (LSTM) of Recurrent Neural Network (RNN), and attention mechanism-based LSTM (LSTM-attention) models and achieved superior results in model performance and predictive classification of most TCM syndromes. Symptom feature visualization demonstrated that the TCM-BERT-CNN model can effectively identify the correlation and characteristics of symptoms in different syndromes with a strong correlation, which conforms to the diagnostic characteristics of TCM syndromes. …”
Get full text

Pien-Tze-Huang alleviates lithocholic acid-induced cholestasis in mice by shaping bile acid-submetabolome by Yan Cao, Yanhong Zhai, Qihong Deng, Shufen Song, Wei Li, Youran Li, Yifan Lu, Jun Li, Zheng Cao, Yuelin Song

“…Abstract Background Cholestasis is one of the most common and devastating manifestations of liver diseases. …”
Get full text

Evaluating chain-of-thought prompting in a GPT chatbot for BCID2 interpretation and stewardship: how does AI compare to human experts? by Daniel M. Tassone, Matthew M. Hitchcock, Connor J. Rossier, Douglas Fletcher, Julia Ye, Ian Langford, Julie Boatman, J. Daniel Markley

“…Results: The chatbot had a significantly higher rate of harmful or inadequate recommendations (13%) compared to ASP (4%, p = 0.047). The most significant discrepancy was observed in the domain of antibiotic therapy, where harmful recommendations occurred in up to 10% (p <0.05) of chatbot evaluations. …”
Get full text

The Influence of Fracture Defect Size on Treatment Outcomes in Distal Femur Fractures: A Comparative Study Between Lateral Locking Plate and Double Plate Fixation by Meng Li, Taoguang Wu, Zicheng Zhang, Xiaomeng Ren, Mengmeng Hu, Dong Zhang, Wei Zhang

“…This observation underscores the pivotal role of the scope of metaphysical damage in determining the most suitable internal fixation techniques for DFFs.…”
Get full text

Antimicrobial Susceptibility Testing to Erythromycin and Azithromycin of Clinical Isolates of Bordetella pertussis Circulating in Russia by A. S. Pimenova, N. T. Gadua, I. Yu. Andrievskaya, O. Yu. Borisova, M. S. Petrova, A. B. Borisova, S. S. Afanas'ev, I. V. Podoprigora, M. S. Afanas'ev, T. I. Moskvina, G. V. Vorob'eva, I. M. Degtyareva, O. V. Timirkina, S. A. Luk'yanceva, T. N. Trigorlova

“…The large-scale and unjustified use of antimicrobials to treat these infections has led to the emergence of resistance in most pathogens. The aim. To study antimicrobial susceptibility testing to erythromycin and azithromycin of strains of B. pertussis isolated in Russia. …”
Get full text

Adubação nitrogenada para o milho cultivado em sistema plantio direto, no Estado de Alagoas Nitrogen fertilization for corn cultivated under a no-tillage system in the State of Ala... by Simério C. S. Cruz, Francisco R. da S. Pereira, José R. Santos, Abel. W. de Albuquerque, Rodrigo G. Pereira

“…For yield, it was observed that the hybrids DOW-8550 and AG-9010 were the most promising. It may be concluded that the economic return of the N fertilization can be reached with a 120 kg ha-1 dose. …”
Get full text

Phytochemical Characterization, Bioactivities, and Nanoparticle-Based Topical Gel Formulation Development from Four <i>Mitragyna speciosa</i> Varieties by Pimporn Anantaworasakul, Weeraya Preedalikit, Phunsuk Anantaworasakul, Sudarshan Singh, Aekkhaluck Intharuksa, Warunya Arunotayanun, Mingkwan Na Takuathung, Songwut Yotsawimonwat, Chuda Chittasupho

“…In summary, KG and KY cultivars emerged as the most promising cosmeceutical candidates due to their superior phytochemical content, antioxidant capacity, enzyme-inhibitory activities, and formulation performance. …”
Get full text

Combining inhibition of galectin-3 with and before a therapeutic vaccination is critical for the prostate-tumor-free outcome by Carolina Tiraboschi, Lucas Gentilini, Carla Velazquez, Enrique Corapi, Felipe Martín Jaworski, José Daniel Garcia Garcia, Yorfer Rondón, Anne Chauchereau, Diego José Laderach, Daniel Compagno

“…In the case of immunotherapy, tumors develop robust immune escape mechanisms that abolish any protective response, and to date why prostate cancer is one of the most resistant diseases remains unresolved.Methods By using a combination of clinical data to study the transcriptome of metastasis samples from patients with castration-refractory prostate cancer, and state of the art cellular and molecular biology assays in samples from tumor-bearing mice that have been submitted to surgical resection of the tumor before receiving a vaccination, we answered several essential questions in the field of immunotherapy for prostate cancer. …”
Get full text

Cytokine profile of surgical patients with infective endocarditis by E. O. Kotova, A. S. Pisaryuk, A. V. Lokhonina, A. Y. Moiseeva, E. A. Domonova, T. A. Gusarova, J. I. Babukhina, P. V. Kakhktsyan, T. K. Fatkhudinov, Z. D. Kobalava

“…The level of cytokine gene expression by tissue macrophages, depending on the presence of embolic events, etiological affiliation to S. aureus, as well as hospital mortality and the combined endpoint (death from all causes or recurrence of IE in 6 months after surgery) did not differ between IE patients with or without events. IL-1β had the most favorable characteristics for assessing the activity of IE (IL-1β AUC 0.816 (p = 0.02)).   …”
Get full text

Geographic patterns in wildland fire exposures and county-level lung cancer mortality in the United States by Richard V. Remigio, Ian D. Buller, Michael S. Bogle, Maria E. Kamenetsky, Samantha Ammons, Jesse E. Bell, Jared A. Fisher, Neal D. Freedman, Rena R. Jones

“…There were positive (high WF exposures and high LCM rate) clusters for males and females in counties within the mid-Appalachian region and Florida, and modest differences across WF metrics in the cluster patterns were observed across the Western US and Central regions. The most positive clusters were seen between WF density by area and LCM rates among women (n = 82 counties) and a similar geographic pattern among men (n = 75 counties). …”
Get full text

Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…The primary reason for first‐line osimertinib discontinuation was toxicity in 32 (60.4%, 17 patients with pneumonitis) and disease progression in 20 (37.7%) patients. The most common rechallenge EGFR‐TKI was afatinib (n = 24, 45.3%), followed by gefitinib (n = 16, 30.2%) and erlotinib (n = 8, 15.1%). …”
Get full text

HIV–HPV Co-Infection and Identification of Novel High-Risk HPV Among Women at Two Hospital Centers in Cotonou, Republic of Benin by Clémence D. Gouton, Ifeoluwa O. Bejide, Oludayo O. Ope-ewe, Marius Adjagba, Simon Azonbakin, Gaonyadiwe Muzanywa, Florence T. Akinyi, Arnaud Agbanlinsou, Yanique Goussanou, Onikepe Folarin, Anatole Laleye, Christian T. Happi, Chinedu A. Ugwu

“…Fifteen HR-HPV genotypes were identified, with HPV 45 most prevalent in WLWHIV and HPV 16 in WWHIV. Notably, HR-HPV 67, 70, and 82 were detected for the first time in Benin. …”
Get full text

Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy by Fang Lu, Si Chen, Honglei Guo, Qing Li, Lin Wu, Ying Pan, Yangfan Wu, Hua Shu, Simeng Liu, Bo Zhang, Huijuan Mao, Changying Xing, Hongwei Liang, Suyan Duan, Yanggang Yuan

“…However, the immunopathogenic mechanisms underlying B cell involvement in PMN remain elusive.MethodsWe employed single-cell RNA sequencing on peripheral blood mononuclear cell samples (PBMC) obtained from 6 patients with PMN and 3 healthy controls (NC) to explore the transformation of B cells and their interaction with immune cells.ResultsCompared with NC, the most significant alterations were in plasma cells and regulatory B (Breg) cells in PMN patients. …”
Get full text

Early Adoption and Utilization of Perfluorohexyloctane for Dry Eye Disease in the United States by Shen Lee B, Pizzicato L, Langford E, Shi L, Divino V, Alexander A, Nair AA

“…Over the 90-day follow-up, most (72.0%) PFHO patients refilled the prescription for their index therapy compared to 37.4% of CsA patients. …”
Get full text

Epidemiological characteristics and management of Gram-negative bacteraemia in different immunocompromised hosts: Observational single-center study. by Alice Toschi, Renato Pascale, Dino Gibertoni, Riccardo Pasquali, Andrea Grechi, Irene Grassi, Marta Malosso, Ludovica Mangione, Cecilia Bonazzetti, Beatrice Tazza, Matteo Rinaldi, Armando Amicucci, Caterina Campoli, Zeno Pasquini, Simone Ambretti, Pier Giorgio Cojutti, Francesca Bonifazi, Pierluigi Viale, Maddalena Giannella

“…Urinary tract infection was the most common source of BSI in nm-IC (nm-IC: 50.1%, HM:15%; SOT: 33.3%; mSC: 25.9%, p < 0.001), intra-abdominal infection was the more frequent source among SOT and mSC (SOT:42.3%; mSC: 49.3%, nm-IC: 27.8%, HM:29%; p < 0.001). …”
Get full text

ODE TO JOY: BEETHOVEN’S NINTH SYMPHONY IN CINEMATOGRAPHIC INTERPRETATIONS / «К РАДОСТИ»: ДЕВЯТАЯ СИМФОНИЯ Л. БЕТХОВЕНА В КИНЕМАТОГРАФИЧЕСКИХ ИНТЕРПРЕТАЦИЯХ... by KONONENKO NATALIA G. / КОНОНЕНКО Н.Г.

“…The motif known as the “Freudenmelodie” (“the melody of joy”) holds a prominent place among the most popular classical musical topoi in cinema. Its multilayered semantics has contributed to an extensive history of extramusical associations with Beethoven’s opus. …”
Get full text