Mental disorders in antiphospholipid syndrome patients: association with clinical and immunological manifestations of the disease by А. В. Borisova, Т. А. Lisitsyna, D. Yu. Veltishchev, Т. М. Reshetnyak, О. F. Seravina, О. В. Kovalevskaya, F. А. Cheldieva, А. А. Abramkin, А. Е. Zeltyn, Е. L. Nasonov

“…Cognitive impairment (CI), mostly mild and moderate, was found in the vast majority of patients with APS (102 (95.3%)). …”
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Influence of urokinase gene-knockout in C57BL/6-PlautmI. IBugThisPlau6FDhu/GFDhu mice on growth factors in malignant melanoma by E. M. Frantsiyants, I. V. Kaplieva, I. V. Neskubina, V. A. Bandovkina, L. K. Trepitaki, E. I. Surikova, N. D. Cheryarina, L. A. Nemashkalova, N. S. Lesovaya

“…Levels of VEGFA, VEGFC, sVEGFR1, sVEGFR3, IGF1, IGF2, TGFβ1 and FGF21 were determined by ELISA in the skin, tumor and perifocal tissues isolated on the 21st day of the tumor growth.Results. uPA gene-knockout inhibited the growth (mostly in females) and metastasis (predominantly in males) of melanoma in mice. …”
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Tumor gene expression signatures associated with outcome in large B−cell lymphoma treated with CD19-directed CAR T−cell therapy (axicabtagene ciloleucel) by Yuan Tian, Justin Budka, Frederick L. Locke, Jason R. Westin, Christina To, Gayatri Tiwari, Daqin Mao, Davide Bedognetti, Rhine R. Shen, Jorge Andrade, Simone Filosto

“…Herein, we leveraged the ZUMA-7 phase III randomized trial of relapsed/refractory large B-cell lymphoma (LBCL) patients treated with axicabtagene ciloleucel (axi-cel; CD19-targeting CAR T cells) to discover tumor gene expression signatures (GES) associated with outcome.MethodsWith tumor transcriptomics from 134 axi-cel patients, we employed multivariate penalized Cox models analyzing event-free survival (EFS), progression-free survival (PFS), and duration of response (DOR).Results and DiscussionWe identified two novel GES, a six-gene/transcript signature (6-GES; CD19, CD45RA, CCL22, KLRK1, SOX11, SIGLEC5) correlated with improved outcome after axi-cel (HR: 0.27, 95% CI: 0.16–0.44 for EFS), representing lymphomas with abundant target antigen (CD19) expression, adhesion molecules, and relatively low immune infiltration mostly composed of cytotoxic lymphocytes (T and NK cells) and DCs, and secondly, a 17-gene/transcript signature (17-GES; CD45RO, BCL2, IL-18R1, TNFSF4 [OX40L], KLRB1 [CD161], KIR3DL2, ITGB8, DUSP5, GPC4, PSMB5, RPS6KB1, SERPINA9, NBN,GLUD1, ESR1, ARID1A, and SLC16A1) correlated with disease progression after axi-cel (HR: 6.12, 95% CI: 3.57–10.50 for EFS), consistent with high immune inflammation and escape mechanisms, such as the upregulation of genes involved in repair of damaged DNA or chromatin remodeling, inhibition of apoptosis, and a metabolically restrictive environment. …”
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Mapping of the Literal Regressive and Geospatial–Temporal Distribution of Solar Energy on a Short-Scale Measurement in Mozambique Using Machine Learning Techniques by Fernando Venâncio Mucomole, Carlos Augusto Santos Silva, Lourenço Lázaro Magaia

“…The statistical findings show a high degree of solar energy incidence, with increments <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mfenced separators="|"><mrow><mo>∆</mo><msubsup><mrow><mi>K</mi></mrow><mrow><mi>t</mi></mrow><mrow><mo>*</mo></mrow></msubsup></mrow></mfenced></mrow></semantics></math></inline-formula> in the average order of −0.05 and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mi>K</mi></mrow><mrow><mi>t</mi></mrow><mrow><mo>*</mo></mrow></msubsup></mrow></semantics></math></inline-formula> mostly ranging between 0.4 and 0.9. In 2012 and 2014, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mi>K</mi></mrow><mrow><mi>t</mi></mrow><mrow><mo>*</mo></mrow></msubsup></mrow></semantics></math></inline-formula> was 0.8956 and 0.6986, respectively, because clear days had a higher incident flux and intermediate days have a higher frequency of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mo>∆</mo><mi>K</mi></mrow><mrow><mi>t</mi></mrow><mrow><mo>*</mo></mrow></msubsup></mrow></semantics></math></inline-formula> on clear days and a higher occurrence density. …”
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Preoperative level of sex hormones as a predictor (prognostic factor) of the morphological characteristics of testicular malignancies by R. F. Kholbobozoda, A. A. Kostin, N. V. Vorobyev, A. O. Tolkachev, A. A. Krasheninnikov, I. A. Taraki, A. D. Kaprin

“…Testicular cancer (TC) mostly affect young men of reproductive age. Several studies have shown correlation between the level of sex hormones in testicular cancer and serum tumor markers. …”
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An integrated approach for very high cardiovascular risk patients. Intermediate results by E. I. Usova, M. V. Ionov, A. S. Alieva, N. G. Avdonina, N. V. Orbeladze, А. A. Khodyreva, A. N. Yakovlev, N. E. Zvartau

“…Both high-density lipoprotein cholesterol (-0,48 mmol/l, p=0,348), office and home BP remained mostly unchanged. The proportion of patients with target office BP levels was almost the same (χ2=3,06, p=0,08). …”
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A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case-control study. by Silvana Debernardi, Harrison O'Brien, Asma S Algahmdi, Nuria Malats, Grant D Stewart, Marija Plješa-Ercegovac, Eithne Costello, William Greenhalf, Amina Saad, Rhiannon Roberts, Alexander Ney, Stephen P Pereira, Hemant M Kocher, Stephen Duffy, Oleg Blyuss, Tatjana Crnogorac-Jurcevic

“…Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally advanced or metastatic disease, as there are no useful biomarkers for detection in its early stages, when surgery can be curative. …”
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The Development and Implementation of a Simulated Patient Resource for Teaching and Assessment in Optometry Low Vision Rehabilitation by Karas M, Lucas N, Ryan B

“…Even though feedback suggested that the method is mostly acceptable to both assessors and students, we have concluded that having access to a readily available pool of real patients is the more credible option for teaching and assessing this accredited level of low vision practice. …”
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Impact on physical function of the +AGIL Barcelona program in community-dwelling older adults with cognitive impairment: an interventional cohort study by Cristina Arnal, L Monica Pérez, Luís Soto, Álvaro Casas Herrero, Joan Ars, Sonia Baró, Francisco Díaz, Araceli Abilla, M Belén Enfedaque, Matteo Cesari, Marco Inzitari

“…Results 194 participants were included (82 with CI, based on previous diagnosis or the Mini-COG screening tool), 68% women, mean age 81.6 (SD = 5.8) yo. Participants were mostly independent in Activities of Daily Living (mean Barthel = 92.4, SD = 11.1). …”
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PLANNING IN ARTIFICIAL INTELLIGENCE AND ROBOTICS (PAIR) by Editorial, Foreword

“…These papers have been mostly written by undergraduate students, and it is my great pleasure to see how they put their results into a form of research papers. …”
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Study of NO₂ and HCHO vertical profile measurement based on fast synchronous multi-axis differential optical absorption spectroscopy (FS MAX-DOAS) by J. Xu, J. Xu, A. Li, Z. Hu, H. Zhang, H. Zhang, M. Qin

“…Compared with the differential slant column densities (dSCDs) at each elevation angle measured by the MAX-DOAS system, the Pearson correlation coefficient of NO<span class="inline-formula">₂</span> reached 0.9, while for HCHO it ranged mostly between 0.76 and 0.85. The results of the slant column concentration inversion indicate that the root mean square (rms) of the FS MAX-DOAS spectrum inversion can consistently be lower than that of MAX-DOAS over an extended period. …”
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Growth characteristics of tusks of elephants in Kruger National Park by Ian Whyte, Anthony Hall-Martin

“…The incidence of tusklessness and of single-tusked animals of each sex in the population was low, and the evidence suggests that the lack of tusks was mostly the result of accidental injury, not genetic inheritance. …”
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Analisis Penggunaan Media Pembelajaran Inovatif pada Pembelajaran Awal Pengenalan Angka Terhadap Anak Penderita Autisme by Stevania Bere, Herman Tolle, Fitra Abdurrachman Bachtiar

“…Early learning for autistic children that is carried out mostly still uses books as learning aids and is not in digital form. …”
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Genetic Analysis of Prenatal Renal Abnormalities in 17q12 Microdeletion Syndrome by Yongmei Shen, Yaqi Li, Xiaomin Zhao, Lei Zhang, Liying Yao, Jiasong Cao, Qimei Lin, Hefei Wang, Maolin Nie, Rongxin Wei, Ying Chang, Yang Pan, Jue Li

“…Chromosome test results were mostly normal in patients with other renal abnormalities, such as kidney dysplasia, horseshoe kidneys, hydronephrosis, kidney deficiency, and ectopic kidneys. …”
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DEPENDENCE OF CHANGES IN THE HYGIENIC CONDITION OF THE ORAL CAVITY AND PERIODONTIUM IN CHILDREN WITH MALIGNANT TUMORS ON THE DURATION OF POLYCHEMYTHERAPY AND QUANTITIES OF CYTOSTAT... by Yu.V. Popelo

“…On external examination, only 2 children of the first (10,0%) and 1 of the second group (5%) had a red normal-coloured lip border, while the rest had exfoliation, cracks, and angular cheilitis. The oral mucosa mostly looked pale and pasty, except for 7 people of the second group (35,0%), who had manifestations of erythema. …”
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Safety of creatine supplementation: Analysis of Adverse Events reported in clinical trials and adverse event reports by Sarah E. Johnson, Drew E. Gonzalez, Kelly Hines, Adriana Gil, Diego A. Bonilla, Richard B. Kreider

“…Similar findings were seen when looking at other databases’ products associated with AERs.Conclusions The mention of Cr in worldwide AERs is rare (0.00072%), mostly associated with co-ingestion of other nutrients and/or drugs, and in some cases report symptoms Cr studies never observed in any clinical trial or unrelated to the known effects of Cr supplementation. …”
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Levels of interleukin-6 in tears before and after excimer laser treatment by Resan Mirko, Stanojević Ivan, Petković-Ćurčin Aleksandra, Pajić Bojan, Vojvodić Danilo

“…Interleukin-6 (IL-6) is mostly known as a proinflammatory cytokine. However, it also has regenerative and anti-inflammatory effects. …”
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Ethylene during controlled atmosphere transport of fruits and flowers: concentrations, causes and consequences by Leo Lukasse, Marcel Staal, Rob Schouten, Taylor Person, Fátima Pereira da Silva

“…In 16 commercial long-distance transports of avocados, bananas, strawberries and cut roses, ethylene mostly ranged between 0.02 and 3.2 μl l-1, with the highest concentration usually occurring during the first days of transport. …”
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STATISTICAL DATA AND ANALYSIS OF LITERATURE SOURCES ON PATHOPHYSIOLOGICAL MECHANISMS OF THE CROSSTALK BETWEEN ACUTE KIDNEY AND LIVER INJURY IN PRETERM NEWBORNS DURING THE EARLY NEO... by О. Оболонська, Л. Вакуленко

“…ALF manifestations were mostly detected on day 5 and accounted for 79.3% of infants with AKI, 3 times more frequent in its severe course (p<0.05) and 4.2 times more frequent than in those without AKI signs (p<0.05). …”
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Prenatal detection of congenital heart defects using the deep learning-based image and video analysis: protocol for Clinical Artificial Intelligence in Fetal Echocardiography (CAIF... by Aris Papageorghiou, Aris T Papageorghiou, David Black, Lawrence Impey, Rachel Craik, Alison Noble, Rahul Ahuja, Christina Aye, Christos Ioannou, Beverly Tsai-Goodman, Kevin Roman, Anupama Nair, Jessica Farmer, J Alison Noble, Makrina Savvidou, Bernadette Brent, Julene Carvalho, Olga Patey, Netzahualcoyotl Hernandez-Cruz, Elena D’Alberti, Bojana Salovic, Theophilus Adu-Bredu, Ilaria Bo, Angelo Cavallaro, FabricioDa SivaCosta, Emma Eccleston, Joanne Everingham, CristianeDe FreitasPaganoti, Eleni Fotaki, Tyrrell Hatch, Joanna Kellett, Karina Lopes, Sally Mahler, Risa Miyazaki Sankar, Divyanshu Mishra, Jennifer Norville, Olivia Nunn, Lola Oshodi, Stavros Polyviou, Lorjah Rajah, Daifenir Rodriguezde LaCruz, Katja Shipp, Bethany Shobbrook, Sophie Tooth, Dimuthu Weerasuriya, Qianye Yang, Yingyu Yang

“…Currently, CHD detection based on AI models is not accurate enough for practical clinical use, in part due to the lack of ultrasound data available for machine learning as CHDs are rare and heterogeneous, the retrospective nature of published studies, the lack of multicentre and multidisciplinary collaboration, and utilisation of mostly standard planes still images of the fetal heart for AI models. …”
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