Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy by Rob C Hoeben, Sjoerd H van der Burg, Thorbald van Hall, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Ruben L van den Oever, Jim Middelburg, Dana A M Mustafa, Nadine van Montfoort

“…Although tumor-infiltrating T cells were mostly reovirus-specific and not tumor-specific, they served as non-exhausted effector cells for the subsequently systemically administered CD3-bsAbs. …”
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Pengembangan Auto-AI Model Generatif Analisis Kompleksitas Waktu Algoritma Untuk Data Multi-Sensor IoT Pada Node-RED Menggunakan Extreme Learning Machine by Imam Cholissodin, Dahnial Syauqy, Dwi Ady Firmanda, Ibrahim Aji, Edy Rahman, Syazwandy Harahap, Fernando Septino

“…Abstract Initially, algorithms were only used for solving simple mathematical equations such as algebra, arithmetic, probability, and others that were mostly carried out manually and required quite a lot of time and effort as in the case of calculating the value of the time complexity of the algorithm with the formula model of T(n), both for non-recursive and recursive algorithms. …”
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Locally adapted guidelines: a scoping review by Dawid Pieper, Alexander Pachanov, Carolin Bahns, Robert Prill, Christian Kopkow, Eni Shehu, Adaptation Working Group-Guidelines International Network, Kyung-Eun Anna Choi

“…The number of sites (e.g. practices) ranged from 4 to 30. Reporting was mostly insufficient to understand how adaptation was performed. …”
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SELF-MONITORING DAN IMPULSIVE BUYING PRODUK KOSMETIK DI KALANGAN MAHASISWI: STUDI KORELASI by Milazia Putri, Intan Dewi Kumala, Risana Rachmatan, Arum Sulistyani

“…This is related to high self-monitoring, mostly due to the idea of always wanting to display a positive image of themselves, and to behave in accordance with the information received from their environment. …”
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Paradox of Low CA-125 in Patients with Decompensated Congestive Heart Failure by Raquel López-Vilella, Borja Guerrero Cervera, Víctor Donoso Trenado, Julia Martínez-Solé, Sara Huélamo Montoro, Valero Soriano Alfonso, Franco Appiani, Luis Martínez Dolz, Luis Almenar-Bonet

“…<b>Conclusions</b>: The proportion of patients with decompensated congestive HF and systemic congestion who present with a low CA-125 level is close to 25%. These patients are mostly women with a preserved ejection fraction and inspiratory collapse of the IVC of >50%. …”
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Validation of the Russian-language version of Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire by L. D. Vorobyova, T. V. Dubinina, A. O. Sablina, A. B. Demina, E. V. Ilinykh, K. V. Sakharova, I. A. Andrianova, T. V. Korotaeva, L. V. Ivanova

“…Тhe study included 100 patients with a definite diagnosis of AS according to the modified New York criteria of 1984. Patients were mostly men (58.5%), average age – 38.6±10 years, disease duration – 10.3±7.0 years, median disease activity by ASDAS-CRP – 2.32 [1.45; 2.94]. …”
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Experimental murine non-alcoholic steatohepatitis is associated with behavioural, cognitive, and peripheral neuronal dysfunction by V. A. Prikhodko, D. A. Orlyakhina, V. D. Petrova, V. E. Karev, D. Yu. Ivkin, S. M. Napalkova, S. V. Okovityi

“…Mice with NASH exhibited markers of elevated anxiety in the OF, EPM, and LDB tests (p &lt; 0.05, p &lt; 0.01), which were mostly specific to the very onset of liver disease (1 mo) as well as its later stages (6 mo). …”
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Term breech presentation—Intended cesarean section versus intended vaginal delivery—A systematic review and meta‐analysis by Julia Wängberg Nordborg, Therese Svanberg, Annika Strandell, Ylva Carlsson

“…The certainty of evidence was moderate or low because the study designs were mostly retrospective cohort studies. The only randomized trial showed reduced risk of perinatal mortality for planned cesarean section, risk ratio (RR) 0.27 (95% confidence interval [CI] 0.08–0.97, 2078 women, low certainty of evidence), stillbirths excluded. …”
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Global Rice Paddy Inventory (GRPI): A High‐Resolution Inventory of Methane Emissions From Rice Agriculture Based on Landsat Satellite Inundation Data by Zichong Chen, Haipeng Lin, Nicholas Balasus, Andy Hardy, James D. East, Yuzhong Zhang, Benjamin R. K. Runkle, Sarah E. Hancock, Charles A. Taylor, Xinming Du, Bjoern Ole Sander, Daniel J. Jacob

“…Abstract Rice agriculture is a major source of atmospheric methane, but current emission inventories are highly uncertain, mostly due to poor rice‐specific inundation data. …”
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Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and... by Michael E. Herce, Caitlin Cassidy, Alexandra Munson, Jessie K. Edwards, Sarah E. Rutstein, Mitch Matoga, Chimwemwe Kumwenda, Katherine R. Simon, Joep J. van Oosterhout, Carrie M. Cox, Funny Kamanga, Wiza Kumwenda, Sam Phiri, Ethel Rambiki, Agness Thawani, Jacqueline Huwa, Bridget Malewezi, Tisu Mvalo, Agatha Bula, Lameck Chinula, Irving Hoffman, Madeleine A. Squibb, Rose K. Nyirenda, Friday Saidi, Mina C. Hosseinipour, Maganizo B. Chagomerana

“…In Malawi, the current standard of care (SOC) involves mostly passive approaches to pediatric HIV diagnosis, relying on mothers presenting to health facilities with their infants. …”
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Typology of out-of-home eaters: a description of sociodemographic, lifestyle, nutritional and environmental characteristics in the NutriNet-Santé cohort by Emma Meyer, Benjamin Allès, Justine Berlivet, Sandrine Péneau, Alice Bellicha, Mathilde Touvier, Brigitte Langevin, Philippe Pointereau, Denis Lairon, Serge Hercberg, Emmanuelle Kesse-Guyot, Julia Baudry

“…Frequent weekday and weekend eaters, with the highest OOH consumption, had the lowest dietary quality and the highest diet-related environmental impacts and consisted mostly of younger women with higher socioeconomic status. …”
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Perioperative the BTLA inhibitor (tifcemalimab) combined with toripalimab and chemotherapy for resectable locally advanced thoracic esophageal squamous cell carcinoma trial (BT-NIC... by Chengzhi Ding, Yahao Zhang, Tian Xia, Jiwei Li, Wenjian Yao, Quan Zhang, Zhijun Han, Jianjun Wang, Zhikun Cao, Jinlong Hu, Li Wei

“…BackgroundThe treatment of cancer has brought about a paradigm shift with the introduction of immune checkpoint blockade (ICB) therapy, which is mostly dependent on inhibiting PD-1/PD-L1 and CTLA-4. …”
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Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI by Omar Baritello, Simon H. Sündermann, Kristian Espinosa‐Garnica, Jörg Kempfert, Markus Jähnert, Nick L. Beetz, Dominik Geisel, Jasmin Gaugel, Julia Rominger, Ursula Müller‐Werdan, Catrin Herpich, Kristina Norman, Alexandra Chadt, Hadi Al‐Hasani, Heinz Völler, Annett Salzwedel, Heike Vogel

“…ABSTRACT Background Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). …”
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Statin-induced risk of diabetes does not reduce cardiovascular benefits in primary prevention: a 6-year propensity-score matched study in a large population by Maria Lembo, Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Stanislovas S. Jankauskas, Paola Gallo, Roberto Piccinocchi, Carmine Morisco, Gaetano Piccinocchi, Luca Bardi, Stefano Cristiano, Giovanni Esposito, Giuseppe Giugliano, Fahimeh Varzideh, Maria Virginia Manzi, Bruno Trimarco, Gaetano Santulli

“…Abstract Background The long-term risk of cardiovascular (CV) events in individuals who develop new-onset type 2 diabetes (T2D) after having received statin therapy in primary prevention is mostly unknown. Methods We designed a population-based cohort study in individuals without T2D and atherosclerotic CV disease (ASCVD), divided in two groups according to the presence of statin therapy. …”
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Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous mycobacteria by Céline Boidin-Wichlacz, Marc Maresca, Isabelle Correia, Olivier Lequin, Vanessa Point, Magali Casanova, Alexis Reinbold, Olga Iranzo, Sharon A. Huws, Priscille Brodin, Linda B. Oyama, Aurélie Tasiemski, Stéphane Canaan, Jean-François Cavalier

“…Membrane permeabilization and monolayer lipid insertion assays suggested that these peptides mostly act by insertion into the mycobacterial membrane resulting in a rapid membranolytic effect. …”
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Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its Fren... by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…In contrast, SRP strains were detected in 98 of the samples, mostly from the southern part of the river, at population densities that did not exceed 3 ´ 104 bacteria L-1. …”
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Adjunctive IgM-enriched immunoglobulin therapy with a personalised dose based on serum IgM-titres versus standard dose in the treatment of septic shock: a randomised controlled tri... by Giacomo Grasselli, Patrizia Murino, Emanuela Biagioni, Martina Tosi, Giorgio Berlot, Giacomo Castiglione, Alberto Corona, Maria Giovanna De Cristofaro, Abele Donati, Paolo Feltracco, Francesco Forfori, Fiorentino Fragranza, Ornella Piazza, Livio Tullo

“…Immunoglobulin preparations enriched with the IgM component have largely been used in sepsis, mostly at standard dosages (250 mg/kg per day), regardless of clinical severity and without any dose adjustment based on immunoglobulin serum titres or other biomarkers. …”
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A worldwide event-based debris flow barrier dam dataset from 1800 to 2023 by H. Cheng, H. Cheng, K. Hu, K. Hu, S. Liu, S. Liu, X. Zhang, X. Zhang, H. Li, H. Li, Q. Zhang, Q. Zhang, L. Ning, L. Ning, M. R. Gouli, M. R. Gouli, P. Li, P. Li, A. Yang, A. Yang, P. Zhao, P. Zhao, J. Liu, J. Liu, L. Wei, L. Wei

“…The understanding of debris flow barrier dams (DFBDs) is poor, mostly due to existing studies focusing on individual events and a lack of summarization of multiple DFBD events. …”
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CRISPR/Cas9-mediated knockout of SLC15A4 gene involved in the immune response in bovine rumen epithelial cells by Mao-cheng JIANG, Zi-xuan HU, Ke-xin WANG, Tian-yu YANG, Miao LIN, Kang ZHAN, Guo-qi ZHAO

“…Meanwhile, the down-regulated genes were mostly enriched in the nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. …”
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Integrating anamnestic and lifestyle data with sphingolipid levels for risk-based prostate cancer screening by Caterina Peraldo-Neia, Paola Ostano, Melissa Savioli, Maurizia Mello-Grand, Ilaria Gregnanin, Francesca Guana, Francesca Crivelli, Francesco Montagnani, Michele Dei-Cas, Rita Paroni, Antonella Sinopoli, Francesco Ferranti, Nicolò Testino, Marco Oderda, Andrea Zitella, Chiara Fiameni, Amedeo Gagliardi, Alessio Naccarati, Luca Clivio, Paolo Gontero, Stefano Zaramella, Giovanna Chiorino

“…Univariable logistic regression was applied to identify ananmestic and lifestyle variables mostly associated with PCa. Penalized logistic regression models predictive of PCa or ISUP > 1 PCa were built both using the 814 subjects with complete information for such variables, applying a 10-fold cross validation approach, and dividing the dataset into a training (n = 445: 132 PCa, 313 non-PCa) and a test (n = 369: 147 PCa, 222 non-PCa) set. …”
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