Improved in-situ direct shear test of rock mass structural plane and its application to stability analysis of bedding slope by Zhiming Wang, Changguang Qi, Zhichao Zhang, Rufa Huang, Chaoxu Guo, Lijin Dong, Rongyue Zheng

“…Previous tests of shear strength parameters for rock mass structural planes have mostly focused on laboratory experiments, which inevitably suffer from sample disturbance, boundary effects, size effects, and grading scale error. …”
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The seed transcriptome of Rafflesia reveals horizontal gene transfer and convergent evolution: Implications for conserving the world's largest flower by Jeanmaire Molina, Adhityo Wicaksono, Todd P. Michael, Su‐Hwan Kwak, Ronniel D. Pedales, Zoé Joly‐Lopez, Semar Petrus, Allen Mamerto, Brian Tomek, Sumaya Ahmed, Venkatasivasankar Maddu, Kristina Yakubova, Danilo Tandang, Joseph W. Morin, So‐Yon Park, Hyun‐Oh Lee, William McLaughlin, Kyle Wallick, James Adams, Ari Novy, Susan Pell, Michael D. Purugganan

“…To date, ex situ propagation of Rafflesia by seed has been mostly unsuccessful. Our research is a bold step forward in understanding the fundamentals of Rafflesia seed biology that will inform the continued propagation and seed‐banking efforts concerning this recalcitrant plant. …”
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Is rotavirus aetiology in young children with acute diarrhoea associated with sociodemographic and clinical factors, including rotavirus vaccination status? A secondary cross-secti... by Jie Liu, Christopher R Sudfeld, Per Ashorn, Queen Dube, Tahmeed Ahmed, Pratibha Dhingra, Usha Dhingra, Arup Dutta, Sunil Sazawal, Karim Manji, Rodrick Kisenge, Mohamed Bakari, Rajiv Bahl, Jonathon L Simon, Naor Bar-Zeev, Christopher Duggan, Ayesha De Costa, Nigel Cunliffe, Sadia Shakoor, Mohammod Jobayer Chisti, Farah Naz Qamar, Desiree Witte, Patricia B Pavlinac, Doreen Rwigi, Judd L Walson, Samba O Sow, Shahida Qureshi, Eric Houpt, James Platts-mills, Chifundo Ndamala, Sarah Somji, Abraham Samma, Fadima Cheick Haidara, Karen L Kotloff, Emily L Deichsel, Benson Singa, Mohammad Tahir Yousafzai, Muhammad Waliur Rahman, Irin Parvin, Anil Kumar Sharma, Vijay Kumar Jaiswal, Churchil Nyabinda, Christine McGrath, Maurine Anyango, Kevin Mwangi Kariuki, Stephanie N Tornberg-Belanger, Flanon Coulibaly, Jasnehta Permala-Booth, Dramane Malle, Latif Ndeketa, Rozina Thobani, Jan Mohammed, Cecylia Msemwa, Md Farhad Kabir

“…Introduction One of the leading causes of global child mortality continues to be diarrhoea where rotavirus contributed to about 24% of deaths among all diarrhoeal deaths, mostly in low-income and middle-income countries. …”
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Reconstruction of Holocene and Last Interglacial vegetation dynamics and wildfire activity in southern Siberia by J. Margerum, J. Homann, S. Umbo, G. Nehrke, T. Hoffmann, A. Vaks, A. Kononov, A. Kononov, A. Osintsev, A. Giesche, A. Mason, F. A. Lechleitner, G. M. Henderson, O. Kwiecien, S. F. M. Breitenbach

“…While our understanding of the drivers behind wildfires and their environmental impact is growing, it is mostly limited to the observational period. Here we focus on the boreal forests of southern Siberia and exploit a U–Th-dated stalagmite from Botovskaya Cave, located in the upper Lena region of southern Siberia, to document wildfire activity and vegetation dynamics during parts of two warm periods: the Last Interglacial (LIG; specifically part of the Last Interglacial maximum between 124.1 and 118.8 ka) and the Holocene (10–0 ka). …”
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Impact of germline BRCA1/2 status on outcomes for patients with HR+/HER2- metastatic breast cancer treated with CDK4/6 inhibitors: a systematic review and meta-analysis by Michele Bottosso, Christian Zurlo, Federica Miglietta, Anna Chiara Cattelan, Daniela Iannaccone, Maria Vittoria Dieci, Gaia Griguolo, Fabio Girardi, Valentina Guarneri

“…Results: Of 1339 potentially eligible records, 14 studies were included, covering a population of 618 gBRCAm patients. Studies were mostly retrospective, with moderate-to-high risk of bias according to ROBINS-E algorithm. …”
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Identification of bioaccessible and neuroprotective peptides from fermented casein hydrolysate by Ruirui Li, Shufang Shan, Yujie Xu, Jingyuan Xiong, Guo Cheng

“…However, known neuroprotective peptides are mostly prepared by enzymatic hydrolysis, and physicochemical screening of food-derived functional peptides typically overlooks the interference of biotransport after ingestion. …”
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Feasible and Rapid Screening of <i>IDH1/2</i> and <i>FLT3-TKD2</i> Mutations by High-Resolution Melting for Patients with Acute Myeloid Leukemia by José Vicente Gil, Sandra de las Heras, Alberto Miralles, Claudia Sargas, Marta Llop, Rebeca Rodríguez-Veiga, Laura Torres-Miñana, Blanca Boluda, Isabel Cano-Ferri, Evelyn Acuña-Cruz, Irene Navarro, Pilar Lloret-Madrid, Pau Montesinos, Eva Barragán

“…No false positives were observed, and false negatives were detected in less than 1% of cases, mostly in <i>FLT3</i>-TKD2, all occurring below the established limit of detection. …”
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The Activity of Influenza Viruses during 2017-2018 Season in Russia and Countries of the Northern Hemisphere: Conflict by the B-virus Vaccine Component by D. K. Lvov, E. I. Burtseva, E. A. Mukasheva, L. V. Kolobukhina, S. V. Trushakova, N. V. Breslav, E. L. Feodoritova, L. N. Merkulova, K. G. Krasnoslobotsev, E. O. Morozova, I. T. Fedyakina, A. V. Aristova, R. V. Vartanian, L. B. Kisteneva, A. G. Prilipov, S. V. Alkhovsky, A. G. Rosatkevich, I. S. Kruzhkova, A. L. Belyaev, E. V. Axselrod, M. V. Bazarova, S. V. Smetanina

“…The number of hospitalizations and lethal outcomes was lower and mostly was found in patients of 65 years and older. …”
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Evaluación del riesgo de ruptura de aneurismas de aorta abdominal personalizados mediante factores biomecánicos/Patient-specific abdominal aortic aneurysms rupture risk assessment... by Ariel Zúñiga‐Reyes, Leorlen Rojas‐Mazaira, Guillermo Vilalta‐Alonso, María Elena Montesinos‐Otero, Jayme Pinto‐Ortiz, Melchor Rodríguez‐Madrigal, Carlos Vaquero

“…<br />______________________________________________________________________________<br /><br /><strong>Abstract</strong><br /><br />Abdominal Aortic Aneurysm is a localized, progressive and permanent dilation of the infra-renal aorta.AAA has increasingly been recognized as an important health problem in the last decades. The AAA rupture is mostly associated with fatal consequences. The lack of more reliable criteria for rupture riskassessing, results in a problem in the clinical management of the disease. …”
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Real-world treatment patterns for patients with non-infectious uveitis in Japan: a descriptive study using a large-scale claims database (J-CAT study) by Sentaro Kusuhara, Koh-Hei Sonoda, Toshikatsu Kaburaki, Tachie Fujita, Saki Katayama, Misako Makishima, Takao Nakamura, Mariko Nio, Takashi Omoto, Yukari Matsuo-Tezuka, Tomoki Yoshizaki, Kensuke Sasaki, Kairi Ri, Keiko Sato, Hiroshi Goto

“…Results The majority of patients (68.7%; 37,869/55,091) were treated with corticosteroid eye drops only for mild NIU; 19.0% (10,449/55,091) were given other treatments for moderate-to-severe NIU, mostly oral corticosteroids (7,473/10,449) and posterior sub-Tenon’s corticosteroid injections (1,636/10,449). …”
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On-farm welfare assessment of semi-extensively managed sheep using Animal Welfare Indicators (AWIN) protocol by S. Koçak, Z. Bozkurt, Ö. G. Hacan, K. Çelikeloğlu, M. Tekerli, M. Demirtaş, S. Çinkaya, M. Erdoğan

“…Major body lesions were rare (major lesions were mostly found on the udder at 0.65 % and least on the legs at 0.00 %), while lameness (1.3 %) and hoof overgrowth (6.27 %) were at relatively low levels. …”
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Genetic evaluation of different graded Holstein Friesian × Local (HF × L) crossbred breeding bulls of Bangladesh by Md. Forhad Ahmed Hridoy, Sadia Afrin Siddiqua, Doo Ho Lee, Yeong Kuk Kim, Md. Shane Khoda, Monira Akter Mou, Abul Kashem Fazlul Haque Bhuiyan, Seung Hwan Lee, Mohammad Shamsul Alam Bhuiyan

“…Genetic correlations among the considered traits were found to be mostly weak. Among the top 20%, breeding bulls belonged to 75%HF × 25%L and 62.5%HF × 37.5%L crossbred groups. …”
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Clinical and Laboratory Correlates of Acute Respiratory Failure in Patients with COVID-19 Depending on the Values of Transcutaneous Saturation by O. V. Voennov, V. I. Zagrekov, А. А. Ezhevskaya, Zh. B. Prusakova, O. N. Gunderchuk, V. А. Skorodumov

“…The revealed changes are mostly consistent with generally accepted ideas about the relationship between values of transcutaneous saturation and blood gas composition and parameters of blood ABB in the case of ARF. …”
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Regular use of non-steroidal anti-inflammatory drugs can effectively control pain and global health in patients with moderate activity of rheumatoid arthritis by A. E. Karateev, E. Yu. Pogozheva, V. N. Amirdzhanova, E. S. Filatova, V. A. Nesterenko

“…All patients received DMARDs, mostly methotrexate 15 to 25 mg weekly, 8.2% biological agents, 18.6% glucocorticoids. …”
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Improving the time-efficiency of initial mental health assessment (triaging) using an online assessment tool followed by a clinical interview via phone: a randomised controlled tri... by Irosh Fernando, Rahul Gupta, Kate Simpson, Stuart Szwec, Mariko Carey, Agatha Conrad, Todd Heard, Lisa Lampe

“…Out of 184 referrals allocated to the intervention arm, the assessment was completed in 125, but only 81 were included in the analysis, mostly due to failure of clinicians to follow the protocol (completing the assessment without using self-reported data, likely due to inexperience with the novel process). …”
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Pengambilan Data secara Bergerak pada Automatic Meter Reading Bertopologi Mesh by Fandisya Rahman, Achmad Basuki, Ismiarta Aknuranda

“…The data gathering process mostly performed by officers who periodically visit each customers' house. …”
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Assessing water and energy fluxes in a regional hydrosystem: case study of the Seine basin by Kilic, Deniz, Rivière, Agnès, Gallois, Nicolas, Ducharne, Agnès, Wang, Shuaitao, Peylin, Philippe, Flipo, Nicolas

“…It also simulates temperature evolution in each aquifer and evaluates that river thermal regulation mostly relies by order of importance on short wave radiations (109.3 W${\cdot }$m$^{-2}$), groundwater fluxes (48.1 W${\cdot }$m$^{-2}$) and surface runoff (22.7 W${\cdot }$m$^{-2}$).…”
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The Ability of Bacteriophages to Reduce Biofilms Produced by <i>Pseudomonas aeruginosa</i> Isolated from Corneal Infections by Kuma Diriba Urgeya, Dinesh Subedi, Naresh Kumar, Mark Willcox

“…It is a major cause of ocular infections, mostly linked to contact lens wear. <i>P. aeruginosa</i> often produces biofilm during infections, and these are also associated with antibiotic resistance. …”
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CHANGES OF ACTIVITY INDEX AND TOTAL SEVERITY INDEX IN PATIENTS WITH SYSTEMIC SCLEROSIS AND INTERSTITIAL LUNG DISEASE OVER A 5-YEAR FOLLOW-UP PERIOD by O. B. Ovsyannikova, L. P. Ananyeva, V. N. Lesnyak, O. A. Koneva, M. N. Starovoitova, O. V. Desinova

“…Assessment of SS activity and severity is hindered as it is very difficult to differentiate fibrous and inflammatory changes that are mostly interrelated and have a similar picture.Objective: to estimate activity index (AI) and total severity index (TSI) for the follow-up of SS patients with different variants of ILD. …”
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The fundamental importance of the ban on turning for the worse for the criminal procedure system by K. D. Vanyan, N. N. Lysov, M. T. Tashilin, A. S. Shuisky, I. R. Gilmanov, V. V. Kosterin

“…This problem is relevant to the science of criminal procedure.The purpose of the study is to analyze critically the practice of returning of a criminal case back to the prosecutor in order to correct mistakes made at the pre-trial stages of the proceedings according to the new concept of justice independence and the absence of an accusatory bias in the court functioning.The methodological basis of the study is a set of scientific techniques, focused mostly on the dialectical approach, which made it possible to determine the essential characteristics of the prohibition to turn the criminal proceedings in Russia for the worse. …”
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