PgtE protease enables virulent Salmonella to evade C3-mediated serum and neutrophil killing by Michael H. Lee, Araceli Perez-Lopez, Leigh A. Knodler, Grace Nguyen, Gregory T. Walker, Judith Behnsen, Steven Silva, Jean Celli, Melissa A. Tamin, Michael H. Liang, Karine Melchior, Felix A. Argueta, Sean-Paul Nuccio, Manuela Raffatellu

“…However, these activities have mostly been observed with mutant, avirulent strains with a truncated O-antigen that renders bacteria sensitive to complement killing. …”
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Case Report: jaundice in the young: the complexity of rare diseases beyond cholangiopathies by Simone Guglielmo, Simone Guglielmo, Francesca Pasin, Marta Biolo, Claudia Mescoli, Stefania Vio, Luca Fabris, Luca Fabris, Luca Fabris, Paolo Simioni, Paolo Simioni

“…One year later, the patient developed gastrointestinal symptoms, mostly abdominal pain and diarrhea, which led to the endoscopic diagnosis of Crohn’s disease. …”
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Lisocabtagene maraleucel for R/R LBCL in patients not intended for HSCT: final results of the phase 2 PILOT study by Alison Sehgal, Daanish Hoda, Peter A. Riedell, Nilanjan Ghosh, Mehdi Hamadani, Gerhard C. Hildebrandt, John E. Godwin, Patrick M. Reagan, Nina D. Wagner-Johnston, James Essell, Rajneesh Nath, Scott R. Solomon, Rebecca Champion, Edward Licitra, Suzanne Fanning, Neel K. Gupta, Victor A. Chow, Brenda Yuan, Zhi Yang, Ken Ogasawara, Jerill Thorpe, Leo I. Gordon

“…Thirty patients in the leukapheresis set (n = 74) died, mostly of disease progression (n = 24). In this population with high incidence of high-grade B-cell lymphoma, primary-refractory disease, advanced age, and comorbidities, liso-cel demonstrated durable efficacy and a favorable safety profile, consistent with previous reports. …”
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Quantitative study of the impact of land use change on groundwater level in the Songnen Plain, China by Zhong Lu, Jinliang Zhang, Dengming Yan, Chaoqun Li, Guoping Lei, Zhiqiang Dong, Quanlai Ma

“…In recent years, there have been significant oscillations in groundwater levels, mostly attributed to changes in the underlying surface. …”
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Sulfur-mediated transformation, export and mineral complexation of organic and inorganic C, N, P and Si in dryland soils by Xin Gao, Jie Zhang, Khan M. G. Mostofa, Wang Zheng, Cong-Qiang Liu, Nicola Senesi, Giorgio S. Senesi, Davide Vione, Jie Yuan, Yu Liu, Mohammad Mohinuzzaman, Longlong Li, Si-Liang Li

“…In forested and agricultural soils, the humic substances (HS) components in LS forms were subjected to a substantial degradation, whereas HSCS components remained mostly unaffected, implying their occurrence in organo-mineral protection. …”
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WINFOCUS worldwide survey on central venous catheter insertion and position confirmation practices (CVC-ICON study) by Francesco Corradi, Giada Cucciolini, Guido Tavazzi, Adrian Wong, Cosmin Balan, Lawrence A. Melniker, Arif Hussain, Julina Md Noor, Jacob John Bailey, Anselmo A. Abdo Cuza, Alberto Goffi, Gabriele Via

“…Over half (51.3%) had over six years of experience and placed over 200 CVC, mostly using ultrasound guidance (70% of cases). The internal jugular vein (IJV) was the preferred insertion site (74%). …”
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Protocol on establishing a prospective enhanced surveillance of vaccine preventable diseases in residential aged care facilities in Central Queensland, Australia: an observational... by Mohammad Rashidul Hashan, Robert Booy, Michael Kirk, Gulam Khandaker, Gwenda Chapman, Jacina Walker, Sonya Jayne Davidson, Jill Auriac, Nicolas Smoll, Delwar Akbar

“…The burden of vaccine preventable diseases (VPDs) among RACFs residents is mostly unknown and there is a lack of quality data from population-based prospective VPD surveillance in RACFs. …”
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A Hydroacoustic Assessment of the Density, Size, and Biomass of Fish in a Freshwater Reservoir After Non-Classical Biomanipulation by Aihuan Guo, Qingping Lian, Pengcheng Sheng, Aiju Zhang, Julin Yuan, Kohji Iida

“…The catch composition revealed silver carp (<i>Hypophthalmichthys molitrix</i>) and bighead carp (<i>Aristichthys nobilis</i>) to be dominant species, mostly comprising young individuals. Stock enhancement plays a critical role in reshaping the fishery population structure in a reservoir. …”
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Factors associated with antibiotic use in children hospitalized for acute viral gastroenteritis and the relation to rotavirus vaccination by Muna Omar, Eias Kassem, Emilia Anis, Roula Abu-Jabal, Basher Mwassi, Lester Shulman, Dani Cohen, Khitam Muhsen

“…Of those, 253 (18.1% [95% CI 16.1–20.2]) had unnecessary antibiotic treatment, mostly penicillin 46.6%, ceftriaxone 34.0% and azithromycin 21.7%. …”
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Improvement in Functional Outcome from 6 to 12 Months After Moderate and Severe Traumatic Brain Injury Is Frequent, But May Not Be Detected With the Glasgow Outcome Scale Extended by Rabea Iris Pantelatos, Jonas Stenberg, Turid Follestad, Oddrun Sandrød, Cathrine Elisabeth Einarsen, Anne Vik, Toril Skandsen

“…Importantly, change, mostly improvement, in GOSE score between 6 and 12 months was frequent and argues against the use of 6 months outcome as a time end-point in research. …”
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Experiences, perceptions and attitudes on providing advice on physical activity to patients with chronic ischaemic heart disease: a qualitative study in general practitioners in Ge... by Norbert Donner-Banzhoff, Rik Crutzen, Sabrina Kastaun, Verena Leve, Stefan Wilm, Alicia Prinz, Sabrina Hoppe

“…GPs were involved throughout the entire research process, for example, in multi-professional analysis groups.Results Although GPs are mostly aware of the health benefits of PA for patients with IHD, PA advice is not routinely provided. …”
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Impact of CD3 expression on outcome in pediatric anaplastic large cell lymphoma by Ahmed Salah, Hanafy Hafez, Hanafy Hafez, Samah Semary, Samah Semary, Eman Naguib Khorshed, Eman Naguib Khorshed, Sonia Soliman, Sonia Soliman, Iman Zaky, Iman Zaky, Shahenda M. Shahin, Leslie Lehmann, Alaa ElHaddad, Alaa ElHaddad

“…The literature is conflicting on whether CD3 expression affects prognosis, and it has been analyzed mostly in the relapse setting. The purpose of this study was to determine the effect of CD3 expression on survival and its relation to the other prognostic variables in newly diagnosed patients with pediatric ALCL treated at a single large pediatric oncology center.MethodsA retrospective study was done on 89 newly diagnosed pediatric ALCL patients (under 18 years old) treated at Children’s Cancer Hospital Egypt (CCHE-57357) from July 2007 to December 2019. …”
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Green Extract from Pre-Harvest Tobacco Waste as a Non-Conventional Source of Anti-Aging Ingredients for Cosmetic Applications by Mariana Leal, María A. Moreno, María E. Orqueda, Mario Simirgiotis, María I. Isla, Iris C. Zampini

“…The xanthine oxidase and lipoxygenase activities were mostly inhibited by CU extracts with IC₅₀ values of 63.50 and 8.0 μg GAE/mL, respectively. …”
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Genome-wide identification and analysis of the WRKY gene family in Sainfoin (Onobrychis viciifolia) and their response to drought, salt, and alkali stress by Wenxiang Li, Yinuo Yan, Yanxia Liang, Shiyao Yue, Yaling Liu, Feng Yuan, Mengrong Xu, Dengxia Yi, Jun Li, Yan Zhao, Lili Nan, Wenbo Jiang

“…Transcriptome analysis revealed that highly expressed genes under drought, salt, and alkali stress mostly belonged to groups I, III, IId, IIa, and IIb. …”
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Exploring mental health professionals’ emotional responses with individuals diagnosed with antisocial personality disorder or psychopathy: a scoping review by Gabriele Lo Buglio, Leonardo Zaninotto, Renan Göksal, Uyangakhishig Bayasgalan, Alice Barsanti, Brad D. Booth, Brad D. Booth, Nicola Carone, Anmar Mighri, Alessandro Miola, Alessandro Miola, Laura Muzi, Vittorio Lingiardi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Tommaso Boldrini, Tommaso Boldrini

“…PubMed, Web of Science, and EBSCO/PsycINFO were searched for studies published from 01/01/1990 to 06/12/2023, including clinicians providing clinical care to individuals with antisocial or psychopathy traits or disorders assessed via standardized and validated tools and focusing on their cognitive, emotional and behavioral responses, with no restriction regarding context/location and study design (protocol: https://osf.io/eaquj).ResultsTwelve studies were included, mostly from Europe, mainly focusing on clinicians working with individuals with ASPD. …”
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Identifying Causative Agents of a Paretic Syndrome in Waterbirds in Southern Portugal by María V. Mena Casero, Andrew D. Turner, Begoña Ben-Gigirey, Ryan P. Alexander, Karl J. Dean, Robert G. Hatfield, Benjamin H. Maskrey, Christelle Mazuet, Kobey Karamendin, Rafael Mateo

“…In the Iberian Peninsula, a paretic clinical picture without known etiology affecting mostly gulls has been reported during the last few decades. …”
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Multimodal deep learning for predicting neoadjuvant treatment outcomes in breast cancer: a systematic review by Eriseld Krasniqi, Lorena Filomeno, Teresa Arcuri, Gianluigi Ferretti, Simona Gasparro, Alberto Fulvi, Arianna Roselli, Loretta D’Onofrio, Laura Pizzuti, Maddalena Barba, Marcello Maugeri-Saccà, Claudio Botti, Franco Graziano, Ilaria Puccica, Sonia Cappelli, Fabio Pelle, Flavia Cavicchi, Amedeo Villanucci, Ida Paris, Fabio Calabrò, Sandra Rea, Maurizio Costantini, Letizia Perracchio, Giuseppe Sanguineti, Silvia Takanen, Laura Marucci, Laura Greco, Rami Kayal, Luca Moscetti, Elisa Marchesini, Nicola Calonaci, Giovanni Blandino, Giulio Caravagna, Patrizia Vici

“…Results Fifty-one studies, mostly retrospective (90.2%, median cohort 281), were included. …”
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West Nile Virus Outbreak in Israel 2024 Compared with Previous Seasons: A Retrospective Study by Guy Katzenellenbogen, Michal Canetti, Ili Margalit, Yonatan Shusterman, Alon Simchovitz-Gesher, Lior Naveh, Nadav Baharav, Miki Goldenfeld, Ana Belkin, Marina Brod, Anat Wieder-Finesod, Eyal Leshem, Erez Magiel, Itzchak Levy, Yaniv Lustig, Victoria Indenbaum, Nicola Maggio, Shahar Dekel, Bella Mechnik, Yovel Peretz, Noam Barda, Amir Tafesh, Dafna Yahav, Gili Regev-Yochay

“…The majority (109/134, 81%) had neuroinvasive disease, mostly encephalitis. In 2024, patients were older, with a lower functional state, and a higher proportion were severely immunocompromised. …”
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Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…Spike density, falling number and thousand kernel weight were positively and significantly altered by biochar amendment, whilst the remaining parameters mostly differed between cultivars only. By contrast, biochar application did not alleviate nitrogen reduction in grains and straw in both cultivars neither increase grain protein content, although it remained sufficient for pasta making under all treatment combinations. …”
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Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database by Alexandre O. Gérard, Diane Merino, Nouha Ben Othman, Alexandre Destere, Delphine Viard, Elliot Ewig, Fanny Rocher, Antoine Sicard, Milou-Daniel Drici

“…However, the European Medicines Agency (EMA) Summary of Product Characteristics (SmPC) includes a broad range of adverse drug reactions (ADRs), mostly identified in small clinical trials with cyclosporine as a control, in patients exposed to other immunosuppressants. …”
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