New Insights into the Anticancer Effects and Toxicogenomic Safety of Two β-Lapachone Derivatives by José Rivaldo De Lima, Alexandre José Da Silva Góes, Elizabeth Fernanda De Oliveira Borba, Meykson Alexandre da Silva, Rodrigo Ribeiro Alves Caiana, Maria do Desterro Rodrigues, Mariza Severina De Lima Silva, Cristiano Aparecido Chagas, Blandine Baratte, Thomas Robert, Stéphane Bach, Isabelle Ourliac-Garnier, Pascal Marchand, Teresinha Gonçalves Da Silva

“…<b>Methods</b>: The cytotoxic effects of BV3 and BV5 were assessed in cancer cell lines and a non-cancerous cell line. The compounds were most effective against HeLa (human cervical adenocarcinoma) cells. …”
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Case Report: Improved hearing in a rare, adult IDH2-mutant brainstem astrocytoma successfully treated with radiation and temozolomide by Takuya Okada, Manabu Natsumeda, Manabu Natsumeda, Hidemoto Fujiwara, Nayuta Higa, Toshiaki Akahane, Yuki Watabe, Kaoru Tomikawa, Kyoka Nishita, Yoshihiro Tsukamoto, Shinsuke Ohshima, Arata Horii, Akihide Tanimoto, Ryosuke Hanaya, Hiroshi Shimizu, Akiyoshi Kakita, Makoto Oishi

“…Left hearing improved from 87.5 dB to 8.3dB by 6-frequency pure tone audiogram (PTA) and 90% speech discrimination at 35 dB after concomitant TMZ and radiation treatment, followed by 12 cycles of adjuvant TMZ treatment. 2HG also decreased to 0.186 mM on MRS after treatment determining treatment strategy.DiscussionStudies have shown that as high as 31% of adult brainstem gliomas are IDH mutant, with most of these mutations being non-canonical IDH1/2 mutations. …”
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Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma by Ming Zhang, Yang Yang, Hong Zhang, Jun Liu, Zhigang Li, Li Zhu, Zhichao Liu, Yan Shen, Jinchen Shao, Yifeng Sun, Xiaolong Fu, Xiaoyue Cai, Hongxuan Li, Hezhong Chen, Bentong Yu, Renquan Zhang

“…Safety was assessed in the modified intention-to-treat population that was treated with at least one dose of camrelizumab.Results From November 20, 2019 to December 22, 2020, 60 patients were enrolled. 55 (91.7%) patients completed the full two-cycle treatment successfully. 51 patients underwent surgery and R0 resection was achieved in 50 (98.0%) patients. pCR (ypT0N0) was identified in 20 (39.2%) patients and 5 (9.8%) patients had complete response of the primary tumor but residual disease in lymph nodes alone (ypT0N+). 58 patients (96.7%) had any-grade treatment-related adverse events (TRAEs), with the most common being leukocytopenia (86.7%). 34 patients (56.7%) had adverse events of grade 3 or worse, and one patient (1.7%) occurred a grade 5 adverse event. …”
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Prevalence and Correlates of Behavioural Risk Factors for Non‐Communicable Diseases Among Allied Health Undergraduate Students in Ghana: A Cross‐Sectional Study by Margaret Atuahene, Frank Quarshie, Francis Kwaku Nyasem, Daniel Eshun, Philip Narteh Gorleku, Pamela Achiaa Addai, Maurice Ofoe Gorleku, Martin Owusu Asante, Joseph Otchere, Prince Aubin

“…ABSTRACT Background and Aim Non‐communicable diseases (NCDs) are noninfectious diseases mostly marked by complex aetiology with different risk factors. …”
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Transient colonization by Priestia megaterium B1L5 alters the structure of the rhizosphere microbiome towards potential plant beneficial bacterial groups in apple plantlets by Fatma M. Mahmoud, Holger Edelmann, Yang Si, Lea Endrejat, Karin Pritsch, Caroline Gutjahr, Armin Ehrenreich, Traud Winkelmann, Jana Barbro Winkler, Jörg‑Peter Schnitzler, Michael Schloter

“…In contrast, fungal communities remained largely unaffected by inoculation. Most bacterial and fungal shifts observed in the rhizosphere of inoculated plantlets at 33 dpi did not exhibit similar patterns in uninoculated controls over time, indicating that these shifts were largely driven by the inoculum rather than by plant development or natural microbial succession. …”
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The GIEMS-MethaneCentric database: a dynamic and comprehensive global product of methane-emitting aquatic areas by J. Bernard, J. Bernard, C. Prigent, C. Prigent, C. Jimenez, C. Jimenez, E. Fluet-Chouinard, B. Lehner, E. Salmon, P. Ciais, Z. Zhang, S. Peng, M. Saunois

“…In terms of wetland extent, all wetlands and peatlands in GIEMS-MC and WAD2M show similar results, with a mean annual maximum of 7.7 Mkm<span class="inline-formula">²</span> for GIEMS-MC and 6.8 Mkm<span class="inline-formula">²</span> for WAD2M, with similar spatial patterns in most regions. The GIEMS-MC seamless time series represents a significant advance in wetland representation for methane modelling, although limitations remain in the accurate identification of rice, coastal, and peatland areas. …”
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Association of proBNPage with all-cause and cardiovascular mortality among US adults: an analysis of data from the National Health and Nutrition Examination Survey by Yan Wang, Yan Li, Xiaoyu Zhang, Jiang He, Fang Wu, Jing Ren, Jun Tao, Chen Su, Wenhao Xia, Zhe Zhou, Yijia Shao

“…These findings were confirmed in most subgroups. A non-linear relationship was observed between proBNPage and all-cause and cardiovascular mortality with an inflection point.Conclusions A non-linear positive relationship was observed between proBNPage and clinical outcomes. …”
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Association between physical activity and executive function of Chinese adolescents aged 13–18 by Yuan Liu, Xiaojian Yin, Yi Sun, Feng Zhang, Feng Zhang, Cunjian Bi, Yaru Guo, Yaru Guo, Pengwei Sun, Pengwei Sun, Hong Jun, Hong Jun, Yanyan Hu, Yanyan Hu, He Liu, He Liu

“…Optimal EF improvement was observed at 59.02–60.88 min/day of MVPA, suggesting this range may be most beneficial for adolescents’ executive function.…”
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Combination chemotherapy and hormone therapy in patients with hormone receptor positive and HER2 negative metastatic breast cancer by Kripa Bajaj, Sushmita Rath, Deep Vora, Pallavi Parab, Seema Gulia, Swapnil Rane, Tanuja Shet, Jaya Ghosh, Palak Popat, Prabhat Bhargava, Anbarasan Sekar, Anuradha Mehta, Yogesh Kembhavi, Dinesh Jethwa, Rajiv Sarin, Tabassum Wadasadawala, Shalaka Joshi, Rajendra Badwe, Sudeep Gupta

“…. ≥ 2, PFS 14.9 vs. 6.0 months, HR 0.32, 95% CI 0.23–0.44, p < 0.001; OS 36.2 vs. 11.0 months, HR 0.29, 95% CI 0.20–0.42, p < 0.001) and duration of most recent endocrine therapy (> 12 vs. ≤ 12 months, PFS 11.7 vs. 6.9 months, HR 0.32, 95% CI 0.23–0.44, p = 0.023; OS 21.9 vs. 15.0 months, HR 0.70, 95% CI 0.49–0.99, p = 0.047) were significantly associated with survival. …”
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Sex differences in the impact of social determinants of health on substance use disorder treatment outcomes by C. Leonardo Jimenez Chavez, MacKenzie R. Peltier, Sherry A. McKee

“…For men, lack of prior treatment for SUD was the most consistent predictor for substance use at discharge and treatment dropout. …”
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Functional goals and outcomes of rehabilitation within palliative care: a multicentre prospective cohort study by Matthew Maddocks, Lucy Fettes, Naomi Takemura, Joanne Bayly, Helena Talbot-Rice, Karen Turner, Rebecca Tiberini, Richard Harding, Fliss E.M. Murtagh, Richard J. Siegert, Irene J. Higginson, Stephen A. Ashford, Lynne Turner-Stokes

“…Goals had a median (range) timeframe of 28 (1-196) days and spanned 13/30 ICF domains; most frequently mobility, general tasks and demands, mental functions, community, social and civic life, and self-care. …”
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Emergency and critical care services in Somalia: a cross-sectional nationwide hospital assessment using the WHO Hospital Emergency Unit assessment tool by Haron Ndwiga Njiru, Pryanka Relan, Sk Md Mamunur Rahman Malik, Azad Abdullah, Mukhtar Shube, Ali Haji Adam Abubakar, Ibrahim Nur, Abdinasir Yusuf Osman, Paul Sonenthal, Shada Rouhani, Bernard Olayo, Naoko Ohno, Ireneaus Sebit Sindani, Ali Abdirahman Osman, Md Shajib Hossain, Ndithia James, Monther Alabesat, Mohamed Derow

“…User fees, lack of equipment and the absence of staff availability around the clock were identified as the most common barriers to emergency and critical care readiness. …”
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Predictive value of serum myeloperoxidase (MPO) concentration combined with triglyceride-glucose index (TyG) for major adverse cardiaovascular events (MACE) in patients with corona... by Adila Wulamu, Xiao-Lei Li, Munawaer Keremu, Shu-Ying Ding, Aibibanmu Aizezi, Yan-Peng Li, Gulihuma Abudukeranmu, Fen Liu, Xia li, Xiao-Mei Li, Yi-Tong Ma, Dilare Adi, Adila Azhati

“…The area under the receiver operating characteristic (ROC) curve (AUC) was utilized to identify the most valuable predictor. Kaplan-Meier curve analysis was employed to examine the relationship between the predictor and prognosis. …”
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Paracoccidioidomicose do sistema nervoso central: análise de 13 casos Central nervous system paracoccidioidomycosis: analysis os 13 cases by Walter J. Fagundes-Pereyra, Gervásio Teles Cardoso Carvalho, Alfredo de Miranda Góes, Francisco das Chagas Lima e Silva, Atos Alves de Sousa

“…There were eleven men and two women. The most frequent symptoms were motor deficits (53.8%), cognitive disturbance (53.8%), weight loss (46.1%), headaches (46.1%) and seizures (46.1%). …”
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Introduction by Jerzy F. Latka

“…Paper and its derivatives can also be used to build permanent lightweight shelters, suitable for transport by water, land or air, to be used in the most endangered and poorest parts of the world, such as certain countries in Africa, Asia and South America. …”
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Preconception, prenatal and early childhood exposure to green space and risk of neurodevelopmental delays: a national cohort study among Medicaid enrollees by Hayon Michelle Choi, Krista F. Huybrechts, Sonia Hernandez-Diaz, Xinye Qiu, Michael Leung, Peter James, Matthew Shupler, Wanyu Huang, Yaguang Wei, Antonella Zanobetti, Christopher J McDougle, Joel Schwartz, Brent Coull, Marc Weisskopf, Stefania Papatheodorou

“…Findings: The study found protective associations between green space exposure and most neurodevelopmental disorders. The strongest associations were seen for preconception exposure and intellectual disability (HR 0.66 [95 % CI: 0.48–0.95]), pregnancy exposure and ASD (HR 0.83 [95 % CI: 0.73–0.95]), and postnatal exposure for learning difficulties (HR 0.81 [95 % CI: 0.68–0.97]) per interquartile range (IQR = 0.12) increase in NDVI. …”
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Spatial and socioeconomic patterns of COVID-19 in transition zones between municipalities in eastern Amazonia by Dinar Duarte Vasconcelos, Dinar Duarte Vasconcelos, Dinar Duarte Vasconcelos, Dinar Duarte Vasconcelos, Hermes Fonsêca de Medeiros, Hermes Fonsêca de Medeiros, Hermes Fonsêca de Medeiros, José Antonio Herrera, José Antonio Herrera, José Antonio Herrera, Lucas de Oliveira Lima, Lucas de Oliveira Lima, Lucas de Oliveira Lima, Pedro Fernando da Costa Vasconcelos, Pedro Fernando da Costa Vasconcelos, Pedro Fernando da Costa Vasconcelos, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma

“…We recommend further studies in the transition zones, considering the municipalities of Floresta do Araguaia, Mãe do Rio, and Redenção for mortality, Barcarena, Capitão Poço, and Redenção for hospitalization, and Cumaru do Norte and Pau D’Arco for fatality, in order to understand the health dynamics of each territory. The most affected areas are located near the border with the state of Amazonas. …”
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Green synthesis, biomedical effects, and future trends of Ag/ZnO bimetallic nanoparticles: An update by Zhang Shengai, Chen Jia, Ma Yiwei, Zhao Qinghua, Jing Bo, Yu Mingli, Yang Na, Yang Aili, Shen Qingqing, Wang Yuyan, Yang Haiyan, Zhao Chunhai

“…Among these methods, biosynthesis, particularly plant-based synthesis, has emerged as the most effective and sustainable strategy. Plant-derived Ag/ZnO bimetallic nanoparticles exhibit exceptional characteristics and performance, making them highly effective for biomedical, antibacterial, therapeutic, and environmental applications. …”
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Comparison of treatment patterns, efficacy and safety between generic and branded atorvastatin users in China: a multicenter, retrospective propensity score-matched cohort study by Xiaoxuan Xing, Zhizhou Wang, Ke Wang, Yiming Hua, Xiaoxi Li, Kejia Le, Wenbing Ma, Yingyun Guan, Aiping Deng, Xiong Yun, Hongfu Cai, Yongning Lyu, Guoying Xiong, Min Yang, Siyang Wang, Chaojun Xue, Jing Zhang, Qiushi Guo, Song Hu, Jing Li, Xianzhe Dong, Lan Zhang

“…Both groups exhibited a comparable incidence of most adverse events. Less fasting plasma glucose increase and fewer new-onset diabetes were observed in the generic group (0.01 mmol/L [IQR 0–0.58] vs 0.16 mmol/L [IQR 0–0.73]; P = 0.009; 664/28640 [2.3%] vs 1244/28640 [4.3%]; P < 0.001). …”
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Extended Trochanteric Osteotomy Increases the Risk of Tapered Splined Stem Subsidence in Revision Total Hip Arthroplasty by Josef E. Jolissaint, MD, Samuel Rodriguez, MD, Leonardo Albertini Sanchez, BA, Travis R. Weiner, BS, Elizabeth B. Gausden, MD, MPH, Jason L. Blevins, MD, Peter Sculco, MD, Jose Rodriguez, MD, FAOA

“…In the United States, tapered splined titanium stems (TSTSs) are the most frequently used femoral stem design in revision total hip arthroplasty. …”
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