In vitro Study of Fungus-Like Organisms Peronospora ficariae and Wilsoniana bliti as Potential Inhalant Allergens by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…Additionally, these fungi can pose a health hazard to humans, as they are significant sources of allergens. The most prominent allergenic fungi include Alternaria, Aspergillus, Cladosporium, Penicillium, and Fusarium. …”
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Freehand ventricular catheter placement in ventriculoperitoneal shunt surgery is associated with higher rates of proximal catheter failure compared to image guidance by Nikhil Sharma, Jeffery R. Head, Regan M. Shanahan, Shovan Bhatia, Michael R. Kann, Sydney Scanlon, Amogh Vellore, Michael Raver, Hussam Abou-Al-Shaar, Nicolas M. Kass, Fritz Steuer, Lucille Cheng, Stephen P. Canton, Arka N. Mallela, Peter C. Gerszten, Edward G. Andrews

“…Results: Sixty patients met inclusion criteria, with a mean age of 54.1 ± 15.9 years. Most VCs were placed with the freehand technique (n = 40, 66.7 %), with all revisions (100 %) placed using freehand technique. …”
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Antibacterial and Anti-Adherence Efficacy of Silver Nanoparticles Against Endodontic Biofilms: An In Vitro and Ex Vivo Study by Mariana Goretti Pérez-Sáenz, Rita Elizabeth Martínez-Martínez, Erasto Armando Zaragoza-Contreras, Rubén Abraham Domínguez-Pérez, Simón Yobanny Reyes-López, Alejandro Donohue-Cornejo, Juan Carlos Cuevas-González, Karla Lizette Tovar-Carrillo, Erika de Lourdes Silva-Benítez, José Luis Ayala-Herrera, León Francisco Espinosa-Cristóbal

“…<b>Background/Objectives:</b> Root canal infections represent a serious challenge to the success of endodontic treatment. The most commonly used antimicrobial irrigants, such as sodium hypochlorite (NaOCl), have certain limitations, while endodontic biofilms pose a significant microbiological complexity in the endodontic field. …”
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Effects of dietary Vitamin A on growth performance, antioxidant and immune capacity of mandarin fish (Siniperca chuatsi) by Xiaolu Yan, Lingcheng Pan, Min Zhao, Junkang Ma, Fubao Wang, Xuliang Zhai, Yang Xue, Haiping Liu, Yongjun Chen, Yuanfa He, Hongqin Li, Li Luo

“…A quadratic regression analysis established the most effective vitamin A dosage to be between 9255.6 and 9280.0 IU/kg, as determined by WGR and FCR.…”
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Assessment of CD20 Marker as a Prognostic Predictor for Patients with Classical Hodgkin Lymphoma by Atarji E, Daous YM, Barefah A, Alahwal H, Albaity B, Hakami NY, Alkhatabi H, Qadah T

“…Statistical significance was set at p &lt; 0.05.Results: Of 52 CHL patients, 11 (21.2%) showed CD20-positive Hodgkin Reed-Sternberg (HRS) cells. Most parameters showed no significant differences between the CD20-positive and CD20-negative groups, except for serum albumin level (p = 0.042). …”
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The current status and prospects of gut microbiota combined with PD-1/PD-L1 inhibitors in the treatment of colorectal cancer: a review by Min Deng, Xiaoyu Li, Huiming Wu, Dingwen Xue, Yize Wang, Renkai Guo, Yipeng Cui, Chenfei Jin, Fei luo, Huiyu Li

“…Conclusion The treatment regimen combining gut microbiota with PD-1/PD-L1 inhibitors has shown promising therapeutic prospects in both animal studies and clinical research, although most clinical trials are data remain limited. Future studies should focus on: (1) gene-edited probiotic strains with targeted modifications; (2) the synergistic effects of multiple probiotics; and (3) conducting high-quality, multicenter clinical trials.…”
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Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway by Zhibin Liu, Ke Huang, Hai Huang, Eungyung Kim, Hyeonjin Kim, Chae Yeon Kim, Dong Joon Kim, Sang In Lee, Sangsik Kim, Do Yoon Kim, Kangdong Liu, Zae Young Ryoo, Mee-Hyun Lee, Lei Ma, Myoung Ok Kim

“…Esophageal squamous cell carcinoma (ESCC), one of the most frequent malignant tumors of the digestive system, is marked by a poor prognosis and high mortality rate. …”
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A bottom-up approach to find lead compounds in expansive chemical spaces by Álvaro Serrano-Morrás, Andrea Bertran-Mostazo, Marina Miñarro-Lleonar, Arnau Comajuncosa-Creus, Adrià Cabello, Carme Labranya, Carmen Escudero, Tian V. Tian, Inna Khutorianska, Dmytro S. Radchenko, Yurii S. Moroz, Lucas Defelipe, David Ruiz-Carrillo, Maria Garcia-Alai, Robert Schmidt, Matthias Rarey, Patrick Aloy, Carles Galdeano, Jordi Juárez-Jiménez, Xavier Barril

“…To address this challenge, we have conceived an innovative strategy that explores the chemical universe from the bottom up, performing a systematic search on the fragment space (exploration phase), to then mine the most promising areas of on-demand collections (exploitation phase). …”
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Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status by Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Francesca Tinti, Enea Bonci, Antonello Giovannetti, Claudio Casella, Adolfo Marco Perrotta, Domenico Bagordo, Manuel Murciano, Alessandro Galani, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange

“…Cystic fibrosis (CF) is one of the most frequent genetic diseases. The discovery and implementation of new therapies prolonged the survival of CF patients in the last years. …”
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0.01% atropine combined with carteolol hydrochloride can inhibit the scleral remodeling in guinea pigs with form-deprivation myopia by Qin Xiang, Jing Yang, Qing Liu, Jing Fang, Xin Li, Xinyu Fu, Xu Gao, Zhou Fu

“…Abstract Myopia is the most widespread refractive error caused by an increase in the axial length (AL) of the eyeball, and is also a major risk factor for other blinding eye diseases, seriously endangering human health and quality of life. …”
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G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo by Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

“…Abstract Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. …”
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The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation by Christoph Fickentscher, Iryna Magorivska, Christina Janko, Mona Biermann, Rostyslav Bilyy, Cecilia Nalli, Angela Tincani, Veronica Medeghini, Antonella Meini, Falk Nimmerjahn, Georg Schett, Luis E. Muñoz, Laura Andreoli, Martin Herrmann

“…It is likely that the most important pathogenic factor of the anti-β2GP1-IgG is related to the different glycosylation observed in healthy and diseased individuals. …”
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Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota by Xingduo Liu, Chaoqun Sun, Yuqiong Dai, Feifei Duan, Tianzhen He, Menglu Zhen, Enxi Liang, Shuting Zhang, Yun Xia, Nianchun Hu, Ruoting Zhan, Ruoting Zhan, Dong Deng, Sijun Liu

“…Gut microbiota composition, diversity, and function were then analyzed by 16S rRNA sequencing.ResultsThe results of Behavioral experiment indicate that Danggui Shaoyao San and its disassembled prescriptions can ameliorate spatial memory deficits (Morris water maze), enhance recognition memory (novel object recognition), and reduce anxiety-like behaviors (open field test), with the DSS group demonstrating the most pronounced effects. In addition, through 16S sequencing analysis we predicted DSS and its disassembled prescriptions reduced harmful bacteria (Firmicutes, Akkermansia) while increasing beneficial bacteria (Bacteroidetes, Bifidobacterium, Lactobacillus). …”
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Soft Power of Higher Education as a Global Leadership Factor by N. L. Antonova, A. D. Sushchenko, N. G. Popova

“…In the era of information and knowledge, one of the most effective tools for this task is soft power of education. …”
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Examination of Factors Affecting the Development of Osteoporosis in Children with Duchenne Muscular Dystrophy by Yiğithan Güzin, Safa Mete Dağdaş, Özlem Ateş, Özkan Alataş, Ayşe Özbay Yıldız, Bakiye Tunçay, Pınar Gençpınar, Figen Baydan, Hakan Birinci, Bumin Nuri Dündar, Nihal Olgaç Dündar

“…Objective: Duchenne muscular dystrophy (DMD), which is primarily treated with glucocorticoids, is the most common genetic progressive neuromuscular disease in children, which can lead to osteoporosis and fractures. …”
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Cognitive Assessments in Randomized Controlled Trials of Acute or Secondary Prevention Stroke Treatments 2011 to 2024: A Scoping Review by Sajeevan Sujanthan, Jesse Buchman, Aaron Herlick, Damyen Henderson‐Lee Wah, William Betzner, Alisia Southwell, Theresa Aves, Pugaliya Puveendrakumaran, Idris Fatakdawala, Vanessa Norouzi, Teruko Kishibe, Michael D. Hill, Raed A. Joundi, Ryan T. Muir, Bijoy K. Menon, Jennifer S. Rabin, Katie N. Dainty, Morgan Barense, Krista L. Lanctôt, Aravind Ganesh, Richard H. Swartz

“…The Mini‐Mental State Examination (22/43 studies, 52%) and Montreal Cognitive Assessment (18/43 studies, 42%) were used in the most RCTs. There were 66 distinct cognitive tasks used, with greatest diversity in memory tasks (19), executive tasks (11) and global screens (11). …”
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Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients by Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Jesús Alonso Gándara-Mireles, Jesús Alonso Gándara-Mireles, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Oscar Kevin Sánchez García, Andrea Mariela Ruano Toledo, Amy Kateleen Aldana de la Cruz, Ismael Lares-Asseff, Ismael Lares-Asseff, Leslie Patrón-Romero, Horacio Almanza-Reyes, Randall Lou-Meda

“…The CYP3A5 *3/*3 genotype was most prevalent (66.7%), followed by *1/*3 (26.7%) and *1/*1 (6.7%). …”
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Large Language Model–Assisted Risk-of-Bias Assessment in Randomized Controlled Trials Using the Revised Risk-of-Bias Tool: Usability Study by Jiajie Huang, Honghao Lai, Weilong Zhao, Danni Xia, Chunyang Bai, Mingyao Sun, Jianing Liu, Jiayi Liu, Bei Pan, Jinhui Tian, Long Ge

“…At the signaling question level, LLMs achieved 83.2% average accuracy (95% CI 77.5-88.9), with accuracy exceeding 70% for most questions except 2.4 (assignment), 2.5 (assignment), 3.3, and 3.4. …”
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An Integrative Machine Learning Model for Predicting Early Safety Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation by Abilkhair Kurmanaliyev, Kristina Sutiene, Rima Braukylienė, Ali Aldujeli, Martynas Jurenas, Rugile Kregzdyte, Laurynas Braukyla, Rassul Zhumagaliyev, Serik Aitaliyev, Nurlan Zhanabayev, Rauan Botabayeva, Yerlan Orazymbetov, Ramunas Unikas

“…<i>Results</i>: The random forest model identified left femoral artery diameter and aortic valve calcification volume as the most influential predictors of early safety outcomes. …”
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Molecular diagnostics for perioperative microbial identification in periprosthetic joint infection: A scoping review and proposal of a diagnostic flow chart by Pier Francesco Indelli, Trifon Totlis, Bruno Lovreković, Michael Engl, Bruno Violante, Pawel Skowronek, Guillaume Demey, Stefano Ghirardelli, Chiara Maci, Antonella Castagna, Laura Schianchi, Chiara Tassan Din, James Harty, Goksel Dikmen, Christian Schaller, Marko Ostojić

“…Abstract Purpose Periprosthetic joint infections (PJI) are among the most feared complications of joint reconstruction. …”
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