Co‐designing a theory‐informed, multicomponent intervention to increase vaccine uptake with Congolese migrants: A qualitative, community‐based participatory research study (LISOLO... by Alison F. Crawshaw, Lusau M. Kitoko, Sarah L. Nkembi, Laura M. Lutumba, Caroline Hickey, Anna Deal, Jessica Carter, Felicity Knights, Tushna Vandrevala, Alice S. Forster, Sally Hargreaves

“…Fourteen barriers and 10 facilitators to COVID‐19 vaccination were identified; most barrier data related to four TDF domains (beliefs about consequences; emotion; social influences and environmental context and resources), and the behavioural diagnosis concluded interventions should target improving psychological capability, reflective and automatic motivations and social opportunities. …”
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Durvalumab and tremelimumab with or without stereotactic body radiation therapy in relapsed small cell lung cancer: a randomized phase II study by Chao Zhang, Shuhua Wang, Suresh Ramalingam, Sagar Lonial, Walter Curran, Edmund K Waller, Bassel Nazha, Taofeek K Owonikoko, Conor Steuer, Suchita Pakkala, Kristin Higgins, Zhengjia Chen, Gabriel Sica, Guojing Zhang, Mohammad S Hossain, Tyler Beardslee, Fadlo R Khuri

“…Pooled efficacy of D/T±SBRT in 15 Response evaluation criteria in solid tumors (RECIST) evaluable patients across both arms showed the best ORR in terms of partial response in 13.3%, stable disease in 26.6% and progressive disease in 60.0%; the overall median PFS and OS were 2.76 and 3.9 months. The most common adverse events were grade 1 fatigue (66%) and grade 1 elevated amylase (56%) in arm A, and grade 1 fatigue (56%) and pain (44%) in arm B. …”
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Clinical genome sequencing in patients with hereditary breast and ovarian cancer: Concept, implementation and benefits by Dennis Witt, Marc Sturm, Antje Stäbler, Benita Menden, Lisa Ruisinger, Kristin Bosse, Ines Gruber, Andreas Hartkopf, Silja Gauß, German Demidov, Nicolas Casadei, Elena Buena Atienza, Kira Mehnert, Janna Witt, Caspar Gross, Leon Schütz, Christopher Schroeder, Stephan Ossowski, Andreas Dufke, Tobias B. Haack, Olaf Riess, Ulrike Faust

“…Hereditary breast and ovarian cancer (HBOC) is one of the most frequent genetic cancer predisposition syndromes. …”
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The Hourglass Simulation: A Catalog for the Roman High-latitude Time-domain Core Community Survey by B. M. Rose, M. Vincenzi, R. Hounsell, H. Qu, L. Aldoroty, D. Scolnic, R. Kessler, P. Macias, D. Brout, M. Acevedo, R. C. Chen, S. Gomez, E. Peterson, D. Rubin, M. Sako, the Roman Supernova Project Infrastructure Team

“…This simulation, called the Hourglass simulation, uses the most up-to-date spectral energy distribution models and rate measurements for 10 extragalactic time-domain sources. …”
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Early discharge following transcatheter aortic valve implantation: a feasible goal during the learning curve? by Raquel Pimienta González, Alejandro Quijada Fumero, Marcos Farráis Villalba, Javier Lorenzo González, Ana Laynez Carnicero, Alejandro Iriarte Plasencia, Gabriela Noemí González Chiale, Cristina López Ferraz, Juan Manuel Llanos Gómez, Martín Caicoya Boto, Ángel López Castillo, Julio Salvador Hernández Afonso

“…Conclusions: The implementation of a standardized care protocol allows for early and safe discharge in most patients, even during the team’s learning cuve.…”
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Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens by Michael K. Fenwick, Phillip G. Pierce, Jan Abendroth, Kayleigh F. Barrett, Lynn K. Barrett, Kalinga Bowatte, Ryan Choi, Ian Chun, Deborah G. Conrady, Justin K. Craig, David M. Dranow, Bradley Hammerson, Tate Higgins, Donald D. Lorimer, Peer Lukat, Stephen J. Mayclin, Stephen Nakazawa Hewitt, Ying Po Peng, Ashwini Shanbhogue, Hayden Smutney, Matthew Z. Z. Stigliano, Logan M. Tillery, Hannah S. Udell, Ellen G. Wallace, Amy E. DeRocher, Isabelle Q. Phan, Bart L. Staker, Sandhya Subramanian, Wesley C. Van Voorhis, Wulf Blankenfeldt, Rolf Müller, Thomas E. Edwards, Peter J. Myler

“…Fifteen crystal structures of β-clamp orthologs were solved, most from Gram-negative bacteria, including eight cocrystal structures with griselimycin. …”
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Ovarian expression of functional MTTP and apoB for VLDL assembly and secretion in chickens by Yu-Hui Chen, Petnamnueng Dettipponpong, Mei-Ying Sin, Ling-Chu Chang, Chuen-Yu Cheng, San-Yuan Huang, Rosemary L. Walzem, Hsu-Chen Cheng, Shuen-Ei Chen

“…In situ hybridization analysis found that ApoB transcripts are most abundant in thecal layers, whereas immunohistochemistry showed that MTTP predominates in the granulosa layers. …”
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A foundational triage system for improving accuracy in moderate acuity level emergency classifications by Tuo Liu, Yang Gu, Hongyi Chen, Yan Zhang, Leqi Zheng, Xuanqi Huang, Yanjun Xu, Cai Wen, Mansheng Chen, Jiaqi Lin, Dongguo Huang, Feixia Chen, Yulan Zhong, Hui Chen, Yanfeng Guo, Mei Lu, Guangwei Zhang, Hao Wu, Changdong Wang, Xiaotu Xi, Li Li, Tao Yu

“…Results Here we show that on the most difficult level for human to distinguish (moderate acuity level), our KUTS substantially outperforms the previous shallow single-modal methods, deep single-modal methods and deep multi-modal methods on AUC score, by an average of 0.19, 0.35, and 0.13 (from 0.76, 0.60, 0.82 to 0.95), respectively. …”
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Prenatal diagnosis, ultrasound findings and pregnancy outcome of 7q11.23 deletion and duplication syndromes: what are the fetal features? by Xiaojin Luo, Hongyan Niu, Fei Zhou, Xiaohang Chen, Yuanyuan Pei, Weiqiang Liu, Fengxiang Wei

“…Cardiovascular abnormalities and intrauterine growth restriction are the most common clinical manifestations observed in prenatal 7q11.23 deletion syndrome. …”
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Subsets of follicular lymphoma 3B have divergent outcomes: results from the prospective multicenter MER and LEO cohorts by Patrizia Mondello, Brianna Negaard, Andrew L. Feldman, Brian K. Link, Carla Casulo, Dai Chihara, David Russler-Germain, Jason Romancik, Caitlin Gribbin, Sara Haddadi, Eric Mou, Ivana N. Micallef, Patrick B. Johnston, Joseph Novak, Yucai Wang, Rebecca L. King, Anne J. Novak, Thomas M. Habermann, Peter Martin, Brad Kahl, Grzegorz S. Nowakowski, Loretta J. Nastoupil, James R. Cerhan, Christopher R. Flowers, Izidore S. Lossos, Richard W. Burack, Matthew J. Maurer, Stephen M. Ansell

“…Our data suggest that most FL3B have a good outcome, while a subset has an aggressive behavior.…”
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Polysomnography validation of SANSA to detect obstructive sleep apnea by Cathy Goldstein, Hamid Ghanbari, Surina Sharma, Nancy Collop, Andrew Namen, Douglas B. Kirsch, Michael Drucker, Rami Khayat, Mark Pollock, Brennan Torstrick, Colleen Walsh, Emily Herreshoff, David S. Frankel, Ilene M. Rosen

“…Performance of participating site PSG scores were also evaluated against consensus PSG scores for comparison.ResultsSANSA demonstrated excellent agreement with PSG for most performance parameters. AHI correlation was 0.91 (95% CI: 0.89, 0.93) using Rule 1B and 0.90 (95% CI: 0.87, 0.92) using Rule 1A. …”
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Original drugs approved by the Food and Drug Administration (Center for Drug Evaluation and Research) in 2024 by D. V. Kurkin, N. A. Osadchenko, A. R. Makarova, D. A. Galkina, D. A. Bakulin, O. V. Shatalova, A. V. Strygin, V. I. Petrov, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, A. V. Zaborovsky, D. V. Yunina, K. N. Koryanova, E. I. Morkovin, M. A. Dzhavakhyan, V. I. Zvereva, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…The search for new rational combinations of antibiotics remains relevant. Most of the original drug market is still made up of small molecules, among which there are medicines — ligands of new targets and oligonucleotide sequences.…”
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IgG glycosylation profiling of systemic lupus erythematosus using lectin microarray by Shangzhu Zhang, Xiaofeng Zeng, Qian Wang, Jiuliang Zhao, Xinping Tian, Mengtao Li, Yan Zhao, Dong Xu, Chaojun Hu, Yang Wu, Minhui Wang

“…Receiver operating characteristic (ROC) analysis evaluated the diagnostic value of these glycosylation changes in SLE and its subgroups, including neuropsychiatric SLE (NPSLE), lupus nephritis (LN), pulmonary arterial hypertension, immune thrombocytopaenia and SLE without major organ involvement (WMOI).Results Compared to DC and HC groups, the IgG glycan level of Galβ3GalNAc (binding Jacalin (11.3%) and Maclura pomifera lectin (14.4%)) was significantly increased, whereas most IgG glycan levels were significantly decreased, including core fucose, high mannose, GlcNAc, GalNAc and Galβ4GlcNAc in the SLE group (all p<0.05).The IgG glycan levels were elevated in GalNAc and galactose patterns in the NPSLE group compared to the WMOI group, as well as higher Galβ3GalNAc and galactose patterns in NPSLE and LN compared to HCs.Moreover, ROC curve analysis showed PNA levels might have moderate potential for discriminating SLE from pSS.Conclusions Patients with SLE show disease-specific alterations in serum IgG glycosylation, and aberrant Galβ3GalNAc, galactose and GalNAc glycosylation may have diagnostic value for SLE and NPSLE. …”
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ROLE OF STREPTOCOCCUS PNEUMONIAE IN THE STRUCTURE OF BACTERIAL INFECTIONS IN THE CHILDREN HOSPITALIZED TO INPATIENT HOSPITALS IN MOSCOW IN 2011–2012 by A. A. Baranov, L. S. Namazova-Baranova, N. A. Mayanskiy, T. V. Kulichenko, T. A. Polunina, A. V. Lazareva, N. M. Alyabyeva, L. K. Katosova, O. A. Ponomarenko, I. E. Koltunov, A. M. Ivanenko, E. A. Degtyaryova, N. V. Kondratenko, A. A. Korsunsky, K. V. Konstantinov, D. A. Tulupov, M. A. Lazareva

“…Nasopharyngeal pneumococcal carriage analysis revealed the prevalent serotypes — 19F, 14, 23F, 3, 6A and B; they were present in 3/4 of all cases; 19F was the most frequent (> 20%). Diversity of the S. pneumoniae serotypes detected in middle ear liquid was less significant — 17 serotypes (in comparison with 24 serotypes in nasopharynx). …”
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Cellulosomal hemicellulases: Indispensable players for ensuring effective lignocellulose bioconversion by Min Xiao, Ya-Jun Liu, Edward A. Bayer, Akihiko Kosugi, Qiu Cui, Yingang Feng

“…Hemicelluloses, the second most abundant polysaccharides in plant cell walls, hold valuable application potential but can also induce inhibitory effects on cellulose hydrolysis, thus highlighting the indispensable roles of hemicellulases within the cellulosome complex. …”
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BLH3 Regulates the ABA Pathway and Lignin Synthesis Under Salt Stress in <i>Lilium pumilum</i> by Wenhao Wan, Lingshu Zhang, Xingyu Liu, Huitao Cui, Miaoxin Shi, Hao Sun, Wei Yang, Xinran Wang, Fengshan Yang, Shumei Jin

“…RT-qPCR analysis revealed that <i>LpBLH3</i> is most highly expressed in the leaves of <i>L. pumilum</i>. …”
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Effect of Resistance Training on Hepatic Bile Acid, beta-Klotho Protein and Expression of Farnesoid X Receptor, Fibroblast Growth Factor 15 and Fibroblast Growth Factor Receptor 4... by Mehri Gholipour, Najme Rezaeian, Mohammad Karimi, Sadegh Cheragh-Birjandi

“…Despite the recommendations for patients with NAFLD to participate in regular exercise, the type, intensity and duration of exercise that is most beneficial for these patients is not clearly determined yet. …”
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Blood type susceptibility to SARS-CoV-2 at a tertiary hospital in Accra, Ghana by Prince N. Odoom, Olayinka S. Okoh, Yaa Y. Asare, Clara O. Mac-Arthur, Judith D. Azumah, Albert Mensah, Akua K. Yalley, Kwamena W. Sagoe, Nicholas I. Nii-Trebi

“…The total SARS-CoV-2 seropositivity was 61.4% (157/277). Most of the participants (245/277, 88.4%) were unvaccinated. …”
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Differences in the management of heart failure with preserved ejection fraction among physicians from Europe, the Middle East and North Africa: an international survey by Omar Ahmad, Nathan Mewton, Dania Mohty, Najmeddine Echahidi, Clara Saldarriaga, Anastasia Shchendrygina, Sydney Goldfeder de Gracia, Mohamed H Omer, Mosaad Alhussain, Suleiman M Kharabsheh, Fakhr Ayoubi, Kamal Alghalayni, Jehad Alburaiki, Bahaa Fadel, Feras Bader, Hadi Skouri, Mohamad Hamade, Marta Załęska-Kocięcka, Federica Guidetti

“…Pharmacotherapy preferences showed both regional similarities and differences, with SGLT2 inhibitors being the most preferred drug of choice universally. In contrast, there was a higher ranking of mineralocorticoid receptor antagonists in Europe (p=0.007) and greater reported use of angiotensin receptor-neprilysin inhibitors in MENA (p=0.03).Conclusion This large international survey offers a descriptive mapping of HFpEF care practices across Europe and MENA, revealing overall guideline alignment but also regional differences in diagnostic test use and pharmacotherapy preferences. …”
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Tracking Clinical Competency Growth: A Longitudinal Study of Medical Students in a Multidisciplinary Emergency Department Internship Program by Sung TC, Shih HI, Kawaguchi T, Chi CH, Hsu HC

“…Generalized Estimating Equations (GEE) modeling assessed performance trends and inter-cohort differences between 2018 and 2019.Results: Significant improvements were observed across all competencies, with the most notable gains in history taking, clinical judgment, communication, prescription, and documentation. …”
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