The Rebound Effect of the COVID-19 Pandemic on Clinically Significant Prostate Cancer Diagnosis by Antonio Fanelli, Ugo Giovanni Falagario, Marco Finati, Francesco Guzzi, Antonella Ninivaggi, Luca Montrone, Angelo Cormio, Oscar Selvaggio, Pasquale Annese, Gian Maria Busetto, Carlo Bettocchi, Francesca Sanguedolce, Luigi Cormio, Giuseppe Carrieri

“…The median number of biopsies performed in the pre-COVID, COVID and post-COVID period was 46 (43–56), 39 (27–43) and 46 (40–58), respectively (<i>p</i> = 0.02). The most significant decrease in the number of biopsies performed was observed during the peak of the pandemic, from March to May 2020. …”
Get full text

Correlation between mixed exposure to several heavy metals during early pregnancy and fetal low birth weight: Possible mediating effect of mitochondrial DNA copy number by Zhanyue Zheng, Tianao Sun, Minli Yang, Qitao Tan, Minglian Pan, Yingjie Zhou, Yongjie Ma, Yan Sun

“…Random forest analysis identified five metals—As, Se, Tl, Mn and Cd —as most strongly associated with the risk of preterm birth in LBW cases. …”
Get full text

Liver Cirrhosis as the Outcome of Non-Alcoholic Fatty Liver Disease Associated with PNPLA3 Gene RS738409 Polymorphism by I. G. Nikitin, A. S. Tikhomirova, T. A. Zhinzhilo, E. V. Vinnitskaya, Y. G. Sandler, V. A. Kislyakov, I. G. Fedorov

“…Relevance: Non-alcoholic fatty liver disease is the most common liver disease worldwide. Although the disease usually has a favorable, asymptomatic course, in some cases it can occur in the form of non-alcoholic steatohepatitis, and some patients may develop cirrhosis of the liver and hepatocellular carcinoma. …”
Get full text

Peculiarities of clinical and metabolic profile of patients with coronary artery disease associated with type 2 diabetes mellitus (retrospective analysis) by N. S. Mykhailovska, T. O. Kulynych, O. V. Shershnova, Ye. I. Bazun, I. S. Bocharnykova, V. E. Padafa, A. O. Kolesnykova, Yu. V. Hura

“…Coronary artery disease (CAD) is one of the most common reasons of disability and mortality. …”
Get full text

Dual IRE1 RNase functions dictate glioblastoma development by Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B Patterson, Olivier Pluquet, Claudio Hetz, Véronique Quillien, Aristotelis Chatziioannou, Eric Chevet

“…This concept is valid in glioblastoma multiform (GBM), the most lethal primary brain cancer with no effective treatment. …”
Get full text

Nonlinear Dynamics Induced by Optical Injection in Optical Frequency Combs Generated by Gain-Switching of Laser Diodes by Ana Quirce, Alejandro Rosado, Jaime Diez, Angel Valle, Antonio Perez-Serrano, Jose-Manuel G. Tijero, Luis Pesquera, Ignacio Esquivias

“…Different regions of locked combs with a tongue shape around detuning values given by multiples of <inline-formula><tex-math notation="LaTeX">$f_R$</tex-math></inline-formula> appear in the maps. P1 and P2 are the most widespread locked states for large values of the modulation amplitude. …”
Get full text

Feeding incremental amounts of the red seaweed Chondrus crispus: Effects on production performance, methane emissions, nutrient utilization, and ruminal and iodine metabolism in da... by D.C. Reyes, J.P. Sacramento, C.T.C. Quigley, B.S. Twining, A.B. Michaud, D. Emerson, B. Honisch, O. Keleher, M.A. Rahman, N.N. Price, A.F. Brito

“…Diets were fed as TMR, with the control treatment (0% C. crispus) consisting of (DM basis) 60% mixed-mostly grass baleage and 40% ground corn-soybean meal-based concentrate mash, with forage and grain (up to 2.1% each) replaced by 3% and 6% C. crispus in the remaining 2 diets. …”
Get full text

Effectiveness of Radiomics-Based Machine Learning Models in Differentiating Pancreatitis and Pancreatic Ductal Adenocarcinoma: Systematic Review and Meta-Analysis by Lechang Zhang, Dewei Li, Tong Su, Tong Xiao, Shulei Zhao

“…All studies adopted a case-control design, with 5 conducted across multiple centers. Most studies used CT as the primary imaging modality. …”
Get full text

Microbial Multidrug-Resistant Organism (MDRO) Mapping of Intensive Care Unit Infections by Ahmed Yassin, Ragaey Ahmad Eid, Mohammad Farouk Mohammad, Marwa O. Elgendy, Zeinab Mohammed, Mohamed E. A. Abdelrahim, Ahmed M. Abdel Hamied, Reem Binsuwaidan, Asmaa Saleh, Mona Hussein, Eman Hamdy Mohamed

“…MDROs accounted for 42% of infections. The most commonly detected MDRO was <i>Klebsiella</i> spp. (52%). …”
Get full text

Is the Existing Measles Vaccination Schedule in the Russian Federation Effective? by O. V. Tsvirkun, A. G. Gerasimova, N. V. Turaeva, N. T. Tikhonova, A. A. Melnikova, A. A. Vatolina

“…For more u For a more in-depth analysis, the years of the increase in the incidence of 2012, 2014, 2019, 2023 and 2024 were selected, when the patterns of involvement of this analyzed group in the epidemic process of measles were most pronounced. The Pearson coefficient was used to determine the correlation.Results and discussions. …”
Get full text

Differences between valve types in anatomic changes of the aortic root after surgical aortic valve replacementCentral MessagePerspective by Ai Kawamura, MD, PhD, Kazuo Shimamura, MD, PhD, Daisuke Yoshioka, MD, PhD, Yusuke Misumi, MD, PhD, Kizuku Yamashita, MD, PhD, Koichi Maeda, MD, PhD, Takuji Kawamura, MD, PhD, Masashi Kawamura, MD, PhD, Yutaka Matsuhiro, MD, Shumpei Kosugi, MD, Daisuke Nakamura, MD, Isamu Mizote, MD, PhD, Yasushi Sakata, MD, PhD, Shigeru Miyagawa, MD, PhD

“…The valve-to-coronary distance and valve-to-aorta distance (VTA) were adequate in most patients. The only difference between the groups was in the left VTA. …”
Get full text

Optimasi Weight AHP Menggunakan Genetic Algorithm untuk Rekomendasi Platform Media Sosial Sebagai Sarana Promosi Digital by Risqy Siwi Pradini, Mochammad Anshori, M. Syauqi Haris

“…One of the main challenges faced by marketers for digital promotion is how to choose the most appropriate social media platforms to achieve optimal promotional goals. …”
Get full text

Emergence, Spread of Antimicrobial-Resistant Bacteria and Phylogenetic Relationships in Coastal Ecosystems—Gastropod <i>Phorcus lineatus</i> as a Bioindicator by Dércia Santos, Ana Rita Pinto, Rita Barata, Conceição Fernandes, Hugo Guedes, Gonçalo Almeida, Edna Cabecinha, Sandra M. Monteiro, Simone Varandas, Maria José Saavedra

“…Among the isolates, phylogroups A and B2 were the most prevalent, followed by phylogroup B1. The isolates of phylogroup A showed a higher prevalence of antimicrobial resistance. …”
Get full text

Complete Blood Count-Derived Biomarkers’ Association with Risk of PD-1 or PD-1/CTLA-4 Inhibitor-Induced Hypothyroidism in Patients with Solid Tumors by Ketevan Lomidze, Nino Kikodze, Marine Gordeladze, Nino Charkviani, Tinatin Chikovani

“…Background: A novel and highly effective strategy for tumor immunotherapy involves enhancing host immune responses against tumors through the blockade of checkpoint molecules. The most common toxicities associated with checkpoint blockade therapies include autoimmune damage to various organs. …”
Get full text

Dietary Lagenaria siceraria fruit improves growth, gene expression, histology, and immune-antioxidant defense to overcome the Fusarium solani challenge in Litopenaeus vannamei by Moaheda E.H. Eissa, Ehab El-Haroun, Hanan Mohammed Rashwan, Zulhisyam Abdul Kari, Roshmon Thomas Mathew, Dalal Sulaiman Alshaya, Najah M. Albaqami, Layla A. Almutairi, Sultan Mohammed Areshi, Mada M. AL-Qurashi, Yasmin M. Abd El-Aziz, El-Sayed Hemdan Eissa, Afaf N. Abdel Rahman

“…Dietary LS enrichment improved growth and feed efficiency variables as well as fish survival. The most favorable outcomes were in the LS10 diet. The ash content and amylase activity were enhanced by LS supplementation. …”
Get full text

Mapping the landscape of carbon trading & carbon offset research: A global and Indonesian perspective by Arief Heru Kuncoro, Afri Dwijatmiko, Noer’aida, Vetri Nurliyanti, Agus Sugiyono, Widhiatmaka, Andri Subandriya, Nurry Widya Hesty, Cuk Supriyadi Ali Nandar, Irhan Febijanto, La Ode Muhammad Abdul Wahid, Paul Butarbutar

“…These findings underscore the need for further, more in-depth research to identify the most effective carbon trading mechanisms specific to Indonesia’s unique context. …”
Get full text

Real-World Assessment of the Association Between PCSK9i Adherence and LDL Reduction and Variability in a Chinese Clinical Practice by Ye X, Zhang S, Zhong X, Li M, Liu M, Zhuang X, Liao X

“…For every 0.1-unit increase in PDC, the LDL-C standard deviation decreased by 0.042 units, indicating improved lipid stability with higher adherence.Conclusion: The adherence to PCSK9i presented as a skewed distribution, most people only received one injection, which did not reach the ideal adherence goal. …”
Get full text

The Contribution of the Hotel Industry on Youth Empowerment in Mbarara City: A Case Study of Hotel Triangle Mbarara City. by Owomuhangi, Emmanuel

“…It was found out that in a view that most hotels provide sufficient pay for the youth employees, only 13% agreed which proved that it was not the case.…”
Get full text

Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosis: a systematic review and economic evaluation by Steven J Edwards, Benjamin G Farrar, Kate Ennis, Nicole Downes, Victoria Wakefield, Isaac Mackenzie, Archie Walters, Tracey Jhita

“…CF affects organ systems throughout the body, including the digestive system and lungs. Most people with CF experience progressive lung function loss over their lifetime, and lung disease is the primary cause of death for people with CF. …”
Get full text

An “EVs-in-ECM” mimicking system orchestrates transcription and translation of RUNX1 for in-situ cartilage regeneration by Qi Cheng, Qianping Guo, Xiaoyu Zhang, Yuanchen Zhu, Chengyuan Liu, Huan Wang, Caihong Zhu, Li Ni, Bin Li, Huilin Yang

“…The self-repair ability of articular cartilage is limited, which is one of the most difficult diseases to treat clinically. Kartogenin (KGN) induces chondrogenesis by regulating RUNX1 mRNA translation and the small molecule compound TD-198946 (TD) promotes chondrogenic differentiation of mesenchymal stem cells (MSCs) through increasing the transcription of RUNX1 mRNA. …”
Get full text