Host-specific vascular endothelial cell responses to Angiostrongylus vasorum: a comparative in vitro study in red foxes (Vulpes vulpes) and domestic dogs by Belinda Eisenhut, Aline Wittwer, Manuela Schnyder, Andreas W. Oehm, Andreas W. Oehm

“…L1 antigen stimulation caused the most substantial differences between species: IL-6 was upregulated more in dogs (4.7-fold) than foxes (1.2-fold). …”
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Early intravenous beta-blockers injection in patients with acute STEMI: the results of the Russian registry REGION-IM by T. S. Sukhinina, M. A. Terenicheva, R. G. Gulyan, R. M. Shakhnovich, O. V. Stukalova, O. A. Saygina, I. S. Yavelov, D. V. Pevsner

“…The majority of patients (61.5%, n=56) were transferred to oral administration of BB on the first day, another 33% of patients (n=30) — the next day, 4.4% (n=4) received only intravenous BB, one (1.1%) information is missing due to the transfer to another hospital. The most common relative and absolute contraindications to the appointment of BB — acute heart failure (AHF), including Killip II, and systolic blood pressure less than 120 mmHg. …”
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Isoenergetic reduction of dietary macronutrients affects body composition, physical activity, and post-prandial hormone responses in lean and obese cats fed to maintain body weight by Hannah Godfrey, Érico de Mello Ribeiro, Shoshana Verton-Shaw, Anna Kate Shoveller, Darcia Kostiuk, Janelle Kelly, Jennifer Saunders Blades, Adronie Verbrugghe

“…Serum ghrelin was lower at 6-h post-prandial (PDiet*Time = 0.0030) and serum PYY was greater at 1-h post-prandial (PDiet*Time = 0.0086) for LC.DiscussionOverall, the LP, LF, and LC diets were not associated with differences in most parameters, supporting that cats are metabolically flexible if nutrient requirements are met. …”
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High-entropy RuO2 catalyst with dual-site oxide path for durable acidic oxygen evolution reaction by Fangren Qian, Dengfeng Cao, Shuangming Chen, Yalong Yuan, Kai Chen, Peter Joseph Chimtali, Hengjie Liu, Wei Jiang, Beibei Sheng, Luocai Yi, Jiabao Huang, Chengsi Hu, Huxu Lei, Xiaojun Wu, Zhenhai Wen, Qingjun Chen, Li Song

“…This OPM-type catalyst delivers ~1500 h of stable operation at 1 A cm− 2 and 50 °C, demonstrating superior durability versus most reported RuO2-based catalysts. This work provides fundamental insights for designing highly stable proton exchange membrane water electrolysis.…”
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Exosomal tsRNA-Gly-5-0007 may be used as a diagnostic marker for colorectal cancer by Zhe Zhang, Guanghao Li, Lei Li, Wenxiao Jiang, Shiwen Wang, Na Zhou, Xuan Zhao, Fanfeng Lin, Jie Zhang, Li Xie

“…Abstract Colorectal cancer is one of the common malignant tumors nowadays, with the highest mortality rate among cancers, and most patients have metastasis when diagnosed. Exosomes contain bioactive molecules such as RNA, which can participate in signal transduction between cells. tRF is a new type of non-coding small RNA, which plays an important role in the progression of cancer. …”
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Analisis Perbandingan Pengalaman Pengguna pada Aplikasi Investasi dengan Menggunakan UX Curve (Studi pada Bibit dan Ajaib) by Griscipta Yosefanita, Buce Trias Hanggara, Retno Indah Rokhmawati

“…There is a movement in the curve's direction, which is supported by reasons derived from respondents' positive and negative experiences. The reasons that most respondents conveyed for the two investment applications were the reasons contained in the utility aspect of the pragmatic category. …”
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Classifying Patient Complaints Using Artificial Intelligence–Powered Large Language Models: Cross-Sectional Study by Sky Wei Chee Koh, Eunice Rui Ning Wong, John Chong Min Tan, Stephanie C C van der Lubbe, Jun Cong Goh, Ethan Sheng Yong Ching, Ian Wen Yih Chia, Si Hui Low, Ping Young Ang, Queenie Quek, Mehul Motani, Jose M Valderas

“…LLM classifications were assessed for accuracy and consistency with human coding using accuracy and F1 ResultsThe majority of complaints fell under the HCAT (GP) domain of management (1079/1816, 59.4%), specifically relating to institutional processes (830/1816, 45.7%). Most complaints were of medium severity (994/1816, 54.7%), occurred within the practice (627/1816, 34.5%), and resulted in minimal harm (75.4%). …”
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“A FACE FROM THE SCREEN”. WHEREIN LIES THE SECRET OF THE POPULARITY OF THE TALK SHOW “vDud”? / «ЛИЦО С ЭКРАНА». В ЧЕМ СЕКРЕТ ПОПУЛЯРНОСТИ ТОК-ШОУ «вДудь»?... by PODOSOKORSKY NIKOLAY NIKOLAYEVICH / ПОДОСОКОРСКИЙ НИКОЛАЙ НИКОЛАЕВИЧ

“…The article analyzes one of the most successful talk shows of the Russian segment of YouTube of the last two years — “vDud,” hosted by the 31-year-old sport journalist and previous editor-in-chief of the website Sports.ru, and presently the assistant of its general director Yuri Dud. …”
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Enhancing Spinal Metastasis Detection and Feature Evaluation on Computed Tomography Scans Using Deep‐Learning Systems by Zhiyu Wang, Guangyu Yao, Shengyuan Xu, Yifeng Gu, Yujie Chang, Jing Sun, Jingyi Guo, Shiqi Peng, Bolin Lai, Xiaoyun Zhang, Chunbin Wang, Haiying Jiang, Surong Chen, Yanfeng Wang, Ya Zhang, Yuehua Li, Hui Zhao

“…Additionally, resident physicians show a more significant improvement in sensitivity and specificity compared with attending or chief physicians in spinal metastasis detection and most feature evaluation (p < 0.01). In a cohort test study, resident oncologists assisted by the DLS achieve significantly higher sensitivity and specificity compared with those without assistance (all p < 0.01), except for the sensitivity of vertebral body collapse evaluation (p > 0.01). …”
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Efficacy of Pneumococcal Polysaccharide Conjugate Vaccine (13-valent, Adsorbed) in Patients with Systemic Juvenile Idiopathic Arthritis Treated with Genetically Engineered Biologic... by Ekaterina I. Alexeeva, Dariya D. Vankova, Tatyana M. Dvoryakovskaya, Ksenia B. Isaeva, Rina V. Denisova, Anna V. Mamutova, Aleksandra M. Chomakhidze, Tatyana V. Radygina, Irina V. Zubkova, Natalia E. Tkachenko, Anna N. Fetisova, Olga L. Lomakina, Yanina O. Orlova, Mariya K. Kurdup, Marina S. Gautier, Elizaveta A. Krekhova, Meyri S. Shingarova, Olga P. Galkina

“…PCV-13 vaccination allows to achieve protective antibodies level in most of the patients with SJIA in children population regardless of the disease stage and the history of GEBD administration.…”
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Comparative pharmacogenetic study of disulfiram or cyanamide efficacy for alcohol dependence: the key role of dopamine neurotransmission gene polymorphisms by A. O. Kibitov, K. V. Rybakova, V. M. Brodyansky, V. A. Berntsev, E. P. Skurat, E. M. Krupitsky

“…The actual direction of increasing the efficacy of alcohol dependence (AD) treatment is the search for opportunities for individualization of therapy using pharmacogenetic markers to stratify patients in order to select the most optimal therapeutic tactics. Aims. To test an associations of possible pharmacogenetic markers with indicators of the efficacy of disulfiram and cyanamide to stabilize remission in patients with AD. …”
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Aplikasi Sistem Temu Kembali Angket Mahasiswa Menggunakan Metode Generalized Vector Space Model by Suprianto Suprianto, Abdul Fadlil, Sunardi Sunardi

“…The application created can display and sort documents that are most similar to keywords. Applications are built with the Generalized Vector Space Model (GVSM) method as a basis for solving existing problems. …”
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Clinical and Molecular Spectrum of Glutamate Dehydrogenase Gene Defects in 26 Chinese Congenital Hyperinsulinemia Patients by Chang Su, Xue-Jun Liang, Wen-Jing Li, Di Wu, Min Liu, Bing-Yan Cao, Jia-Jia Chen, Miao Qin, Xi Meng, Chun-Xiu Gong

“…Phenotypic heterogeneity of GDH-HI patients was observed within the Chinese cohort in the present study. The fact that most patients had a GLUD1 p. S445L mutation implies that this site could be a hotspot in Chinese patients. …”
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Phylogenetic analysis of a 2024 Sheeppox virus isolate from the Almaty region of Kazakhstan and investigation of its pathogenicity in merino sheep by Moldir Azanbekova, Muratbay Mambetaliyev, Aisulu Valiyeva, Nurlan Kozhabergenov, Nurbek Aldayarov, Sanat Kilibayev, Bekbolat Usserbayev, Moldir Tuyskanova, Balziya Kadyrova, Balzhan Myrzakhmetova, Lespek Kutumbetov, Olga Chervyakova, Sergazy Nurabayev, Maxat Berdikulov, Aslan Kerimbayev, Aralbek Rsaliyev, Yergali Abduraimov, Kuandyk Zhugunissov

“…PCR detected viral DNA by day 5 post-infection in most tissues. Necropsy revealed typical pathological sheeppox lesions in the lungs, spleen, lymph nodes, and skin. …”
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Prognostic role of epidermal growth factor receptors’ expression in patients with i-ii stage of non-small cell lung cancer by A.P. Kolesnik, A.I. Shevchenko, V.A. Tumansky, A.V. Evseev, M.A. Shishkin

“…Molecular markers’ use for prognostic groups’ selection is one of the ways to solve the problem of individualized treatment. The most significant among great number of prognostic markers is the group of growth factor receptors [11]. …”
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On the Treatment of Acute Poisoning With Paracetamol by A. Yu. Simonova, M. M. Potskhveriya, M. V. Belova, K. K. Ilyashenko, V. V. Kulabuhov, N. Y. Stolbova, A. E. Klyuev

“…BACKGROUND Currently, despite the optimization of diagnostic methods in order to predict the development of liver damage, improvement of treatment protocols, paracetamol poisoning is a serious problem in medicine, being the most common cause of acute liver failure worldwide.AIM OF STUDY To determine the indications for the use of acetylcysteine in paracetamol poisoning and evaluate the effectiveness of the 21-hour protocol for its administration.MATERIAL AND METHODS We examined 20 patients with acute paracetamol poisoning (15 women and 5 men), the median age was 21.5 (19.8–32.3) years. …”
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SIU-ICUD: Germline Genetic Susceptibility to Prostate Cancer: Utility and Clinical Implementation by James T. Kearns, Annabelle Ashworth, Elena Castro, Rosalind A. Eeles, Liesel M. FitzGerald, Peter J. Hulick, Stacy Loeb, Christian P. Pavlovich, Timothy R. Rebbeck, Susan T. Vadaparampil, Zhuqing Shi, Huy Tran, Jun Wei, Jianfeng Xu, Brian T. Helfand

“…<b>Background/Objectives:</b> Prostate cancer is the most common cancer among men globally and a leading cause of cancer-related death. …”
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Associations of polymorphisms in the gene promoters of cytokines and matrix metalloproteinases with bone mineral density in postmenopausal type 2 diabetic women by Olga N. Fazullina, Vadim V. Klimontov, Vladimir I. Konenkov, Alla V. Shevchenko, Viktor F. Prokoviev, Yakov A. Tsepilov

“…The СС genotype in position -1562 of MMP9, CC genotype in position -863 of TNFA, GG genotype in position -308 of TNFA, and AA genotype in position -1082 of IL10 were the most prevalent variants in these combinations. Conclusions. …”
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CRISPR/dCas-mediated counter-silencing: reprogramming dCas proteins into antagonists of xenogeneic silencers by Johanna Wiechert, Biel Badia Roigé, Doris Dohmen-Olma, Hindra, Xiafei Zhang, Roberto G. Stella, Marie A. Elliot, Julia Frunzke

“…Systematic in vivo reporter studies with dCas9 and dCas12a and various guide RNAs revealed effective counter-silencing of different CgpS target promoters in response to guide RNA/dCas DNA binding, independent of promoter sequence modifications. The most prominent CRISPRcosi effect was observed when targeting the CgpS nucleation site, an effect that was also seen in S. venezuelae when targeting a known Lsr2 nucleation site within the chloramphenicol biosynthesis gene cluster. …”
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Assessment of Long-Read Sequencing-Based Congenital Adrenal Hyperplasia Genotyping Assay for Newborns in Fujian, China by Xudong Wang, Xingxiu Lu, Faming Zheng, Kun Lin, Minjuan Liao, Yi Dong, Tiantian Chen, Ying He, Mei Lu, Jing Chen, Yanfang Li, Yulin Zhou

“…The c.293-13C>G variant (31.19%) was the most prevalent in Fujian. Additionally, 647 neonates with suspected positive results were genotyped, and 41 were identified as carriers, with carrier frequencies of 1:18 for <i>CYP21A2</i>, 1:162 for <i>HSD3B2</i>, and 1:324 for <i>CYP17A1</i> in Xiamen. …”
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