Applying bioinformatic analysis for prognostic assessment of the <i>HS3ST6</i> missense mutations clinical significance in the development of hereditary angioedema by N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. R. Denisova, N. S. Podchernyaeva, A. A. Totolian

“…The mutation NC_000016.9:g.1962132G&gt;A (p.A163V) is most likely to be involved in pathogenesis of HAE by indirect disruption of heparan sulfate O-sulfation directly within the protein. …”
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Freeze-Dried Probiotic Fermented Camel Milk Enriched with Ajwa Date Pulp: Evaluation of Functional Properties, Probiotic Viability, and In Vitro Antidiabetic and Anticancer Activit... by Sally S. Sakr, Hassan Barakat

“…Cytotoxicity against Caco-2 cells was most potent in non-ADP samples (IC₅₀: 82.22 μg mL⁻¹ for FCM), suggesting ADP and <i>L. rhamnosus</i> may reduce antiproliferative effects due to proteolytic activity. …”
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Characteristics and Influence Mechanism of Cultural and Creative Enterprise Migration from the Amenity Perspective: A Case Study of Guangzhou by Liao Huihui, Wei Cheng, Luo Peng, Shen Jing

“…However, there is still relatively little research on amenities in China, and most of it focuses on national and regional scales, emphasizing conceptual interpretation, indicator construction, and evaluation. …”
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Insights into wind-driven heavy metal pollution and human health risk assessment in a typical lead-zinc mining area of northern China by Zun-zhuang Ke, Xue Han, Ran Zhou, Yi-fei Zhang, Guan-nan Liu, Chang-qing Zhang, Zhao Liu, Xiao-sai Li, Wen-bo Li

“…The results of contamination factor (CF), pollution load index (PLI) and geo-accumulation index (Igeo) indicated that heavy metals in most soils exhibited non-polluted level or slight pollution level, though localized severe contamination by As, Cd, Pb, and Zn was observed. …”
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A viral circular RNA in Kaposi’s sarcoma-associated herpesvirus modulates viral and host gene expression during latent and lytic replication by Soleil Torres, Vaibhav Jain, Daniel Stribling, Lauren A. Gay, Muhammed Naeem, Melody Baddoo, Erik K. Flemington, Scott A. Tibbetts, Rolf Renne

“…Results: RT-PCR of Δcirc-vIRF4-infected iSLK cells demonstrated no expression of wild-type (WT) isoforms, but PCR cloning showed that alternative backsplice sites were used to express novel vIRF4 circRNAs, where the most prominent isoform was a 1,020 nt isoform. RNA-seq analyses comparing WT- and Δcirc-vIRF4-infected iSLK cells demonstrated significant differential expression of both host and viral genes during both phases of the viral life cycle. …”
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Layer-by-Layer Multifractal Scanning of Optically Anisotropic Architectonics of Blood Plasma Films: Fundamental and Applied Aspects by Alexander Ushenko, Natalia Pavlyukovich, Oksana Khukhlina, Olexander Pavlyukovich, Mykhaylo Gorsky, Iryna Soltys, Alexander Dubolazov, Yurii Ushenko, Olexander Salega, Ivan Mikirin, Jun Zheng, Zhebo Chen, Lin Bin

“…The experimental data derived from laser layer-by-layer Jones-matrix theziography were quantitatively analyzed using two complementary approaches: statistical analysis (central moments of the 1st to 4th orders) and multifractal analysis (spectra of fractal dimension distributions). As a result, the most sensitive markers—namely asymmetry and kurtosis—were identified, highlighting changes in the statistical and scale self-similar structures of the theziograms of linear and circular birefringence in blood plasma facies. …”
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Spatial variability of soil properties in red soil and its implications for site-specific fertilizer management by Fang-fang SONG, Ming-gang XU, Ying-hua DUAN, Ze-jiang CAI, Shi-lin WEN, Xian-ni CHEN, Wei-qi SHI, Gilles COLINET

“…The maps produced by selecting the best predictive variables showed that SOM, TN, and CEC had moderate levels in most parts of the study area. This study highlights the importance of site-specific agricultural management and suggests guidelines for appropriate land management decisions.…”
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SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications by Yoko Kobayashi Takahashi, Kenshiro Tabata, Shimpei Baba, Eri Takeshita, Noriko Sumitomo, Yuko Shimizu‐Motohashi, Takashi Saito, Eiji Nakagawa, Atsushi Ishii, Shinichi Hirose, Mitsuhiro Kato, Naomichi Matsumoto, Hirofumi Komaki, Ken Inoue

“…Plain Language Summary Dravet syndrome is a severe epilepsy that usually begins in infancy and is linked to changes in a gene called SCN1A. Most cases are caused by gene changes that reduce function, but in some cases, the gene may become overactive. …”
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UNDERSTANDING EDUCATORS’ EXPERIENCE AND ATTITUDE TO GAMIFIED LEARNING APPLICATIONS by Anastasiia V. Tokarieva, Inna V. Сhyzhykova

“…The results obtained can be summarised as follows: 1) gamified learning applications (GLAs) are becoming a part of an instructional toolkit of the Ukrainian educationalists; 2) the most popular GLAs used by educators from Ukraine are interactive quizzes, educational games and gamified learning systems; 3) the majority of the respondents see educational role as the main purpose of GLAs. …”
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Characterization of emerging H3N3 avian influenza viruses in poultry in China by Cheng Yan, Jianzhong Shi, Pengfei Cui, Yuan Chen, Congcong Wang, Yan Wang, Jiahao Miao, Yaping Zhang, Huihui Kong, Xianying Zeng, Guobin Tian, Chengjun Li, Yasuo Suzuki, Guohua Deng, Hualan Chen

“…Seventeen viruses were tested in mice and most replicated efficiently but were not lethal. …”
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Maternal and Perinatal Outcome of Maternal Obesity at RSCM in 2014–2019 by Junita Indarti, Sulaeman Andrianto Susilo, Purnomo Hyawicaksono, Jimmy Sakti Nanda Berguna, Galuh Anindya Tyagitha, Muhammad Ikhsan

“…In this study, obese patients had a mean age of 31.23 years, mean gravida 2, parity 1, and abortion 0. Most of these patients used an intrauterine device (IUD) for family planning (74.8%). …”
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Machine learning approach effectively discriminates between Parkinson’s disease and progressive supranuclear palsy: Multi-level indices of rs-fMRI by Weiling Cheng, Xiao Liang, Wei Zeng, Jiali Guo, Zhibiao Yin, Jiankun Dai, Daojun Hong, Fuqing Zhou, Fangjun Li, Xin Fang

“…Subsequently, different validation templates were employed to assess the classification results and investigate the relationship between the most significant features and clinical assessment scales. …”
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METABOLIC SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY WITH THE NEW RADIOPHARMACEUTICAL ⁹⁹ᵐTc-1-thio-D-glucose IN THE DIAGNOSIS AND MONITORING OF THE PRIMARY BREAST LYMPHOMA (CASE RE... by Ye. A. Dudnikova, V. I. Chernov, A. V. Muravleva, T. L. Kravchuk, R. V. Zelchan, A. A. Medvedeva, O. D. Bragina, Ye. L. Simolina, N. O. Popova, V. V. Vysockaja, N. M. Lukina, V. A. Shatalova, O. V. Shpileva, A. V. Goldberg, V. Ye. Goldberg

“…Diffuse large B-cell lymphoma is the most common histological type occurring usually as a unilateral palpable tumor in middle-aged women. …”
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CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway by Lv H, Zhang B, Weng X, Li Y, Deng C, Wang R, Shi L, Yin Y

“…Haishu Lv,1 Beibei Zhang,1 Xi Weng,1 Youjia Li,2 Chaoxian Deng,1 Rui Wang,2 Lei Shi,3 Yuanqin Yin1 1Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China; 2Department of Pathology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China; 3Department of Ophthalmology, The Affiliated Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Lei Shi, The Affiliated Shenjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China, Email shiny713@126.com Yuanqin Yin, Department of Tumor Biotherapy and Cancer Research, the First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China, Email doustar88@126.comBackground: Breast cancer has become one of the most prevalent malignant neoplasms among women, poses a significant threat to public health. …”
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Estimating the impact of maternal anemia on low-birth-weight in Sub-Saharan African countries: propensity score matching analysis by Bezawit Melak Fente, Angwach Abrham Asnake, Yohannes Mekuria Negussie, Zufan Alamrie Asmare, Hiwot Altaye Asebe, Beminate Lemma Seifu, Mamaru Melkam, Meklit Melaku Bezie

“…The initiative to conduct this study is that most of the time mothers suffer from anemia and at the same time they deliver low birth weight children. …”
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Current debates, developments and challenges regarding torture, enforced disappearances and human rights by Pau Perez-Sales, Bernard Duhaime, Juan Méndez

“…ED is a composite human rights violation that involves two kinds of victims: first, the direct victim, who suffered the violence of abduction, the anguish of being held defenceless in an unknown place and who, in most cases, suffered physical or psychological torture, and, on the other hand, the relatives of the disappeared[3]. …”
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Evaluation of the immunoprotective potential of recombinant EtMIF as a subunit vaccine candidate against Eimeria tenella infection in chickens by Rui Bai, Rui Bai, Hui Wang, Hui Wang, Jiale Guo, Yang Pei, Yongbin Li, Yongbin Li, Shuying Zhu, Shuying Zhu, Chenyang Lv, Jianhui Li, Xiaozhen Cui, Xiaoling Lv

“…IntroductionEimeria tenella is recognized as the most pathogenic species of chicken coccidia. Infection with E. tenella results in digestive disorders and hemorrhagic diarrhea in chickens. …”
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Recovery and long-term health outcomes of SARS-CoV-2 infection in a prospective cohort in an urban setting, Kenya by Isaac Kisiangani, Ângela Jornada Ben, Elke Wynberg, Welcome Wami, Samuel Iddi, Idah Kinya, Anna Vassall, Catherine Kyobutungi, Abdhalah Ziraba, John Njeru, Olive Mugenda, Marion Wangui Kiguoya, Mutambuki Kimondo, Geoffrey Githua, Menno D. de Jong, Shukri F. Mohamed, Gershim Asiki, Constance Schultsz

“…Fatigue (40.2%), pain (36.8%), sore throat (36.8%), headaches (36.4%), and loss of strength (31.6%) were most common. Median time to recovery was longer for severe/critical cases than mild/moderate (234 vs 206 days, p = 0.016). …”
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Physiological and Transcriptomic Mechanisms Underlying Vitamin C-Mediated Cold Stress Tolerance in Grafted Cucumber by Panpan Yu, Junkai Wang, Xuyang Zhang, Zhenglong Weng, Kaisen Huo, Qiuxia Yi, Chenxi Wu, Sunjeet Kumar, Hao Gao, Lin Fu, Yanli Chen, Guopeng Zhu

“…Results showed that 150 mg L⁻¹ Vc treatment was most impactive, significantly reducing the cold damage index while increasing the root-to-shoot ratio, root vitality, chlorophyll content, and activities of antioxidant enzymes (SOD, POD, CAT). …”
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Exploring novel of 1,2,4-triazolo[4,3-a]quinoxaline sulfonamide regioisomers as anti-diabetic and anti-Alzheimer agents with in-silico molecular docking simulation by Moustafa S. Abusaif, Ahmed M. Sh El-Sharief, Yehia A. Mohamed, Yousry A. Ammar, Mostafa A. Ismail, Wael M. Aboulthana, Mohamed S. A. El-Gaby, Ahmed Ragab

“…The N-allyl-[1,2,4]triazolo[4,3-a]quinoxalin-1-amine derivative 10a demonstrated the most significant inhibitory activity, with percentages of 64.70 ± 0.02% and 75.36 ± 0.01% against α-amylase and α-glucosidase, respectively, in comparison to acarbose (IP = 67.33 ± 0.01% and 57.79 ± 0.01%). …”
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