Patients with atrial fibrillation after discharge from a multidisciplinary hospital: analysis of death risk and its causes based on 10-year follow-up data by M. M. Luk'yanov, T. A. Gomova, S. Yu. Martsevich, R. N. Shepel, A. G. Soplenkova, A. A. Smirnov, M. N. Valiakhmetov, E. V. Stepanova, A. A. Savishcheva, O. M. Drapkina

“…To evaluate the outcomes of 10-year follow-up of patients with atrial fibrillation (AF) after hospitalization in various departments of a multidisciplinary hospital and to determine the most significant prognostic factors associated with a high death risk.Material and methods. …”
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ARCHERY: a prospective observational study of artificial intelligence-based radiotherapy treatment planning for cervical, head and neck and prostate cancer – study protocol by Ajay Aggarwal, Hannah Simonds, Ruth Langley, Indranil Mallick, Peter Hoskin, Elizabeth Miles, Rozita Abdul Malik, Claire Murphy, Mahesh Parmar, Matthew Nankivell, Jeannette Parkes, Julie Torode, Issa Mohamad, Laurence Edward Court, Isabella Jacques, Mariana Kroiss, Sarbani Laskar, Yolande Lievens, Carol Roach, Barbara Vanderstraeten

“…A shortfall in specialised workforce has been identified as the most significant barrier to expanding radiotherapy capacity. …”
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Experience with long-term infliximab therapy in patients with ankylosing spondylitis by Oksana Alekseevna Rumyantseva, A G Bochkova, K Kh Kuzikyants, A V Levshakova, Sh F Erdes, E L Nasonov, Oksana Alekseyevna Rumyantseva, A G Bochkova, K Kh Kuzikyants, A V Levshakova, Sh F Erdes, E L Nasonov

“…The efficiency of the drug persists in most patients during its long-term regular therapy. …”
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Intranasal insulin for improving cognitive function in multiple sclerosis by Scott D. Newsome, Kathryn C. Fitzgerald, Abbey Hughes, Meghan Beier, Jacqueline Koshorek, Yujie Wang, Daniela Pimentel Maldonado, Thomas Shoemaker, Taimur Malik, Tarik Bayu, Pablo E. Ravenna, Ama Avornu, Elias S. Sotirchos, Meghan Romba, John Muschelli, Todd T. Brown, Peter A. Calabresi, Ellen M. Mowry

“…The cohort's mean age was 52.4 ​± ​9.7years, 62 ​% were female, and ∼60 ​% had relapsing-remitting MS. The most common side effects amongst treatment groups included headache, rhinorrhea, and dizziness. …”
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Surgical Management of Sacral Bone Tumors: A Retrospective Analysis of Outcomes, Complications, and Survival by Chiara Cini, Emanuela Asunis, Cristiana Griffoni, Gisberto Evangelisti, Giuseppe Tedesco, Riccardo Ghermandi, Marco Girolami, Valerio Pipola, Silvia Terzi, Giovanni Barbanti Brodano, Stefano Bandiera, Stefano Boriani, Alessandro Gasbarrini

“…Postoperative complications affected 60% of patients. The most common issues were surgical wound dehiscence with delayed healing (35%) and visceral changes affecting the bowel and urination (25%). …”
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RUSSIAN EXPERIENCE WITH USING MONOCLONAL ANTIBODIES TO B-LYMPHOCYTES (RITUXIMAB) IN SYSTEMIC VASCULITIDES ASSOCIATED WITH NEUTROPHIL CYTOPLASMIC ANTIBODIES (PRELIMINARY RESULTS OF... by T. V. Beketova, E. N. Aleksandrova, T. M. Novoselova, E. G. Sazhina, E. V. Nikolaeva, A. V. Smirnov, V. N. Sorotskaya, E. V. Zemerova, I. F. Nam, N. M. Nikitina, G. S. Arkhangelskaya, Z. R. Bagautdinova, I. N. Dashkov, S. Yu. Chernykh, O. V. Zhirnova, Yu. A. Lushpaeva, L. V. Masneva, I. P. Afanasieva, A. E. Arseniev, I. V. Kondratenko, I. B. Bashkova, S. I. Glukhova, E. L. Nasonov

“…Care should be taken when combining RTM treatment with cytostatics (primarily with cyclophosphamide) because of the risk of secondary immunodeficiency and infectious adverse events (AE), which have been the most frequent serious AE (12%) in patients with ANCA-SV.…”
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Category semantic and global relation distillation for object detection by Yanpeng LIANG, Zhonggui MA, Zongjie WANG, Zhuo LI

“…Knowledge distillation stands out as it transfers knowledge from large teacher models to compact student models without modifying the network structure, enabling the student models to perform nearly as well as their larger counterparts. However, most distillation techniques have been optimized for image classification, not object detection, which involves simultaneously detecting and classifying multiple target objects within natural images. …”
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Association of <i>SLCO1B3</i> and <i>SLCO1B1</i> Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients by Rania Magadmi, Ahlam M. Alharthi, Lina A. Alqurashi, Ibtisam M. Jali, Zeina W. Sharawi, Maha H. Jamal, Yasser Bawazir, Mohammad Mustafa, Sami M. Bahlas, Basma T. Jamal, Hassan Daghasi, Abdulrahman S. Altowairqi, Dalal Sameer Al Shaer

“…<b>Background:</b> Methotrexate (MTX) remains the most commonly prescribed drug used to treat rheumatoid arthritis (RA). …”
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Management approaches for primary hepatic lymphoma: 10 year institutional experience with comprehensive literature review by Jennifer Ma, Remy Daou, Josiane Bou Eid, Beatrice Fregonese, Joe El-Khoury, N. Ari Wijetunga, Brandon S. Imber, Joachim Yahalom, Carla Hajj, Carla Hajj

“…Primary hepatic DLBCL appears to be treated mostly with chemotherapy with good disease control. …”
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CS07 | Endothelial dysfunction and impaired angiogenesis in Hermansky-Pudlak syndrome (HPS) type 1: studies with endothelial colony forming cells

“…Eleven genes have been identified as causative for HPS in humans. The most severe subtype of HPS is HPS-1, in which variants affect the HPS1 protein. …”
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T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles by Jacek Lubelski, Eline van Diest, Ator Ashoti, Christina Zotou, Hanneke Rijssemus, Raymond Schiffelers, Zhiyong Lei, Maurits Geerlings, Jaime Fernández Bimbo, Daniel E Murphy, Martijn J W Evers, Suneel A Narayanavari, Diana Pereira Vaz, Nadine Saber, Peter Mayrhofer

“…Strategies to generate CAR-T cells in vivo have emerged as a promising alternative that could bypass CAR-T manufacturing bottlenecks. Most current in vivo CAR-T approaches, while demonstrating encouraging preclinical efficacy, rely on transient messenger RNA (mRNA) delivery or viral vectors which both have limitations in terms of efficiency, durability, and scalability. …”
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Optimization of a portable ligand-free optical spectroscopy method for SARS-CoV-2 protein detection by Fatin Hamimi Mustafa, Nik Yusnoraini Yusof, Mawaddah Mohd Azlan, Fariza Hanim Suhailin, Chan Yean Yean, Nik Mohd Noor Nik Zuraina, Mohd Zulkifli Salleh, Hironaga Uchida, Irneza Ismail, Rosline Hassan, Raja Kamarulzaman Raja Ibrahim, Mohd Adzir Mahdi

“…In the optimization phase, transmittance spectral measurements were conducted on SARS-CoV-2 protein to determine the optimal wavelength within the ultraviolet–visible–near infrared range (200–1100 nm). The most effective fiber configuration was also evaluated using three combinations of transmitter–receiver fiber diameters: 600–400 μm, 600–100 μm, and 200–400 μm. …”
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መጽሐፈ ሐተታ ዘርዐ-ያዕቆብ አክሱማዊ? የዳዊት መዝሙር እንደማስረጃ by Nguse Kahsay

“…The analysis revealed that most of the Psalm verses appearing in the Hateta are also found in an Ethiopian book called Me’eraf. …”
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Carfilzomib, lenalidomide, dexamethasone, and cyclophosphamide (KRdc) as induction therapy for transplant-eligible, newly diagnosed multiple myeloma patients (Myeloma XI+): Interim... by Graham H Jackson, Charlotte Pawlyn, David A Cairns, Ruth M de Tute, Anna Hockaday, Corinne Collett, John R Jones, Bhuvan Kishore, Mamta Garg, Cathy D Williams, Kamaraj Karunanithi, Jindriska Lindsay, Alberto Rocci, John A Snowden, Matthew W Jenner, Gordon Cook, Nigel H Russell, Mark T Drayson, Walter M Gregory, Martin F Kaiser, Roger G Owen, Faith E Davies, Gareth J Morgan, UK NCRI Haemato-oncology Clinical Studies Group

“…Minimal residual disease negativity (cutoff 4 × 10-5 bone marrow leucocytes) was achieved in 55% of patients tested in the KRdc group at the end of induction, increasing to 75% of those tested after ASCT. The most common adverse events were haematological, with a low incidence of cardiac events. …”
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To the fauna of gastrointestinal nematodes of sheep in the European part of Russia by I. A. Pimenov, D. N. Kuznetsov, I. M. Odoevskaya, A. D. Afanasyev, A. I. Varlamova, I. A. Arkhipov

“…Thus, T. colubriformis and T. circumcincta were the most frequently found nematodes in sheep in all of the four studied regions, and these two species also showed the highest rates of infection. …”
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Emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China by Ximei Kong, Jian Wang, Gaopeng Lei, Yang Yang, Weifeng Huang, Yun Leng, Yanfang Miao, Ming Li, Qiwu Yuan, Yuanyuan Zhao, Xin Xu, Haojiang Zuo, Lvbo Tian

“…ST11 (S. Enteritidis) was the most prevalent, while S. Kentucky comprised 3.27% (5/153) of isolates, significantly higher than the national average (0.33%, P < 0.05). …”
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Subcutaneous axillary primary epithelioid hemangioendothelioma: report of a rare case by Takayoshi Niwa, Takaaki Konishi, Asako Sasahara, Ayaka Sato, Arisa Morizono, Mayumi Harada, Kotoe Nishioka, Osamu Fukuoka, Naohiro Makise, Yuki Saito, Mizuo Ando, Takako Yoshimoto, Takeshi Shikama, Satoshi Yamashita, Masahiko Tanabe, Yasuyuki Seto

“…Abstract Background Epithelioid hemangioendothelioma (EHE) is a rare and slow-growing malignant vascular neoplasm composed of epithelioid endothelial cells within a distinctive myxohyaline stroma. It most commonly involves somatic soft tissue, lungs, liver and bone. …”
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Diagnostic value of left atrial compliance in determining heart failure with preserved ejection fraction by Nikita E. Shirokov, Elena I. Yaroslavskaya, Dmitry V. Krinochkin, Mikhail D. Kosterin, Natalya A. Musikhina

“…Statistically significant differences between Groups I and II and Groups I and III were detected for most echocardiographic parameters. No significant differences were found between Groups II and III, except for the following parameters: E/e’ (11.2 [9.8; 12.6] vs. 9.3 [7.7; 10.9], respectively, p<0.001), LASr (21.4 [19.8; 24.5] % vs. 27.6 [24.6; 29.8] %, p < 0.001) and LA compliance (2.0 [1.6; 2.4] vs. 3.0 [2.4; 3.7], p<0.001). …”
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<i>PD-L1</i> and <i>PD-L2</i> gene expression in human glioblastoma cells resistant to chemo- and radiotherapy by A. A. Pinevich, N. L. Vartanyan, L. N. Kiseleva, I. I. Bode, I. Yu. Krutetskaya, A. V. Kartashev, V. E. Makarov, T. E. Poneza, I. V. Smirnov, M. P. Samoilovich

“…In T2 glioblastoma cells, and especially in T98G cells, a significant increase in expression of these genes was found, most pronounced for PD-L2 gene. This increase in expression may indicate an enhanced malignancy of resistant T2 and T98G cells. …”
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Single-cell and spatial atlas of glioblastoma heterogeneity: characterizing the PCLAF+ subtype and YEATS4’s oncogenic role by Siqi Ma, Yuwei Sun, Shaowei Zheng, Yilong Fu, Liangyu Wang, Dun Liu, Henan Jiao, Xuqiang Zhu, Xueyuan Li, Dongming Yan, Di Chen, Zi Ye

“…BackgroundGlioblastoma (GBM) was considered the most aggressive type of primary brain tumor, marked by poor clinical outcomes and a high tendency to relapse. …”
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