Exploration of virulence and immune evasion functions of the candidate vaccine antigen SpyAD in the globally disseminated M1T1 group A Streptococcus strain by Alexandra Stream, Samira Dahesh, Lamar Thomas, Nina J. Gao, Elisabet Bjånes, Kalisa Kang, Truman Koh, Neeraj Kapoor, Victor Nizet

“…Here, we investigate the contribution of SpyAD in establishing and maintaining infection in M1T1 GAS, a persistent and globally disseminated strain that is the most frequently isolated serotype in both invasive and noninvasive infections. …”
Get full text

Risk analysis of tooth extraction in hypertensive patients under ECG monitoring: a single-center retrospective study by Yifan Yang, Wenying Wang, Ying Ji, Xiangliang Xu, Chengge Liu, Jingyi Li

“…Additionally, ROC curves were used to determine the optimal cutoff points for linear variables, thereby developing the most effective predictive model. Results A total of 8.01% of patients required temporary intraoperative antihypertensive medication for blood pressure control, while 37.20% exhibited transient intraoperative ECG abnormalities. …”
Get full text

Valorization of Edible Oil Industry By-Products Through Optimizing the Protein Recovery from Sunflower Press Cake via Different Novel Extraction Methods by Christoforos Vasileiou, Maria Dimoula, Christina Drosou, Eleni Kavetsou, Chrysanthos Stergiopoulos, Eleni Gogou, Christos Boukouvalas, Magdalini Krokida

“…The amino acid profiling confirmed SPC as a valuable protein source, with glutamic acid, arginine, and aspartic acid being the most abundant. These results highlight the potential of UMAE and PLE as efficient strategies for valorizing edible oil industry by-products into high-quality protein ingredients for food and biotechnological applications.…”
Get full text

Marcação imunoistoquímica da expressão astrocitária de proteína glial fibrilar ácida e de vimentina no sistema nervoso central de cães com cinomose Immunohistochemical staining of... by Heloísa Orsini, Eduardo Fernandes Bondan, Melissa Sanchez, Maria Anete Lallo, Paulo César Maiorka, Maria Lúcia Zaidan Dagli, Dominguita Luthers Graça

“…It was possible to notice, on most of the sections from sick animals, degenerative lesions that indicate demyelination. …”
Get full text

Statistical models for predicting the number of under-five mortality in Nepal. by Madhav Kumar Bhusal, Shankar Prasad Khanal

“…The zero-inflated negative binomial regression (ZINBR) model was fitted as the most plausible model to analyze the number of under-five mortality by its covariates after assessing the different count models including the Poisson regression (PR) model, negative binomial regression (NBR) model, zero-inflated negative binomial regression (ZINBR) model, and hurdle negative binomial regression (HNBR) model.…”
Get full text

A hybrid model for refining gross primary productivity estimation by integrating multiple environmental factors by Zhilong Li, Ziti Jiao, Zheyou Tan, Chenxia Wang, Jing Guo, Sizhe Chen, Ge Gao, Fangwen Yang, Xin Dong

“…Environmental factors lead mainly to the uncertainty of gross primary productivity estimation in most light use efficiency (LUE, ε) models since the simple physical formulas are inadequate to fully express the overall constraint of diverse environmental factors on the maximum ε (εmax). …”
Get full text

Increased risks of Maternal Mental Health Conditions Following the COVID-19 Pandemic by Anita Zhou, Allison Zetterman, Megan Ott, Colman Freel, Kayla Adams, Andrea Rodriguez-Dasta, Rebekah Rapoza, Rebecca Drakowski, Sarah Sweeney, Alyssa Freeman, Matthew VanOrmer, Melissa Thoene, Elizabeth Lyden, Charmayne R. Adams, Gurudutt Pendyala, Corrine Hanson, Ashley J. Blount, Ann Anderson-Berry

“…Previous research indicates that women pregnant during COVID-19 were at a greater risk of developing mental health conditions and being exposed to stressors. While most of the research in the field focuses solely on maternal mental health or interactions between stressors and maternal mental health, little research has been done comparing maternal mental health, demographic variables, and socioeconomic variables across pre-, during-, and post-COVID-19 time periods. …”
Get full text

Burden of Exacerbations in Patients Newly Initiating an Inhaled Regimen for COPD: A Claims Analysis by Sethi S, Wan ES, Tejwani V, Lamprey C, Aggarwal K, Dixon A, Pan Y, Siddharthan T

“…The average number of moderate/severe exacerbations per patient and the proportion of patients with inpatient, emergency department (ED), office, and outpatient visits within 12 months post-index were also assessed.Results: Of the 137,691 included patients, 51.5% were female and 74.6% were White, with a mean (standard deviation [SD]) age of 70.9 (9.49) years and a mean (SD) Elixhauser Comorbidity Index of 5.67 (3.29). Most (48.3%) patients were initiated on long-acting beta-agonists/inhaled corticosteroids (LABA/ICS). …”
Get full text

Probiotic Characterization, Safety and Whole Genome Association Analysis of Lacticaseibacillus rhamnosus Z23 by Yuxing HE, Gaowa BAI, Jinghe YU, Wei LIU, Xiaofeng YANG, Mingchao LIU, Wuyundalai

“…Lacticaseibacillus rhamnosus is one of the most researched and commercially utilized strains in recent years due to its excellent probiotic properties. …”
Get full text

Efficacy and Safety of Lumasiran in Patients With Primary Hyperoxaluria Type 1: Results from a Phase III Clinical Trial by Jeffrey M. Saland, John C. Lieske, Jaap W. Groothoff, Yaacov Frishberg, Hadas Shasha-Lavsky, Daniella Magen, Shabbir H. Moochhala, Eva Simkova, Martin Coenen, Wesley Hayes, Julien Hogan, Anne-Laure Sellier-Leclerc, Richard Willey, John M. Gansner, Sally-Anne Hulton

“…Medullary nephrocalcinosis generally remained stable or improved; approximately one-third of patients (both groups) improved to complete resolution. The most common lumasiran-related adverse events (AEs) were mild, transient injection-site reactions. …”
Get full text

Impact of host factors and invasive meningococci on bacterial adhesion, proliferation, primary nasal epithelial barrier function, and immune response by Daan W. Arends, Debbie van Rooijen, Esther van Woudenbergh, Janine Wolf, Milou Ohm, Marien I. de Jonge, Gerco den Hartog

“…We assessed transepithelial electrical resistance (TEER), bacterial binding and growth, and the epithelial cytokine response. Most donor-strain combinations induced a TEER drop, with higher bacterial loads generally associated with lower TEER, indicative of a more permeable epithelial barrier. …”
Get full text

Comparative study of lung cancer care and survival outcomes across the Nordic countries by Ghida Khalife, Juho Waris, Uffe Bødtger, Johan Isaksson, Kirill Neumann, Hrönn Harðardóttir, Heidi Andersén, Antti Jekunen, Maria Lovén, Tuula Vasankari, Susanna Nurmi-Rantala, Paulus Torkki

“…The survey results were then analyzed, and a follow-up Nordic LC expert workshop was held to identify the most relevant factors potentially influencing LC survival outcomes. …”
Get full text

Disseminated cutaneous blastomycosis acquired in Mexico: A case report and literature review by Mina Kang, Penelope J. Teoh, Rachel Southern-Thomas, Peter Rae, Christopher B. Bunker, Sarah Logan, Neil Stone

“…It is an endemic mycosis that causes a spectrum of disease, most often pulmonary and cutaneous. It is rarely diagnosed in the United Kingdom (UK) where it is non-endemic. …”
Get full text

CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma by Rosanna Mezzapelle, Francesco De Marchis, Chiara Passera, Manuela Leo, Francesca Brambilla, Federica Colombo, Maura Casalgrandi, Alessandro Preti, Samuel Zambrano, Patrizia Castellani, Riccardo Ertassi, Marco Silingardi, Francesca Caprioglio, Veronica Basso, Renzo Boldorini, Angelo Carretta, Francesca Sanvito, Ottavio Rena, Anna Rubartelli, Lina Sabatino, Anna Mondino, Massimo P Crippa, Vittorio Colantuoni, Marco E Bianchi

“…While releasing T‐cell brakes has received most attention, tumor recognition by T cells is a pre‐requisite. …”
Get full text

Phytochemical Screening and Biological Activities of <i>Lippia multiflora</i> Moldenke by Dorcas Tlhapi, Ntsoaki Malebo, Idah Tichaidza Manduna, Monizi Mawunu, Ramakwala Christinah Chokwe

“…According to several studies, these secondary metabolites have been reported and proven to be the most abundant for antioxidant potential. The identified flavonoids (catechin, quercitrin, and (−)-epigallocatechin) and phenolic compound (6-gingerol) can significantly contribute to the antioxidant properties of different plant parts of <i>L. multiflora</i>. …”
Get full text

Effects of non-HDL-C and statin therapy on mortality in ARDS: a retrospective cohort study by Haiming Hu, Haiming Hu, Haiming Hu, Jin Wei, Lijuan Zhao, Lijuan Zhao, Yixing Zhu, Yixing Zhu, Yixing Zhu, Geer Zhou, Geer Zhou, Geer Zhou, Anqi Zhao, Anqi Zhao, Anqi Zhao, De Chang, De Chang

“…These findings indicate that non-HDL-C might be a useful marker for identifying ARDS patients who may benefit most from statin therapy.…”
Get full text

Impact of relative estradiol changes during ovarian stimulation on blastocyst formation and live birth in assisted reproductive technology by Wenjie Huang, Liuyan Wei, Juan Tang, Liuying Nong, Ni Tang, Qiuyue Wen, Zuxing Qin, Lixiang Xu, Jingjing Li, Li Fan

“…The primary outcomes were blastocyst formation rate, clinical pregnancy rate, and live birth rate, while secondary outcomes included miscarriage rate and ectopic pregnancy rate. Most cycles (96.5%) demonstrated an increase in E2 levels during COS. …”
Get full text

Thrombogenesis-related characteristics of platelets and platelet indices in pregnant COVID-19 women by N. V. Spiridonova, T. A. Gritsenko, E. F. Khurtova

“…Thrombosis emerging in COVID-19 represents one of its most common complications. The period of pregnancy is accompanied by elevated susceptibility to infectious diseases and increased risk of thrombosis.Aim: to assess time-dependent change in platelet count and platelet indices in general clinical blood test in pregnant COVID-19 women related to illness onset and developed thrombosis.Materials and Methods. …”
Get full text

Caracterización morfológica de 29 introducciones de Physalis peruviana L. de la colección de trabajo de la Universidad Nacional de Colombia Sede Palmira Morphological characterizat... by Carlos Eduardo Madriñán Palomino, Jaime Eduardo Muñoz Flórez, Herney Darío Vásquez Amariles, Nancy Barrera Marín

“…. &#40;gooseberry&#41; Solanaceae family, is one of the most important to export for Colombia because its nutritional and medicinal properties. …”
Get full text

A 7 day Multiwavelength Flare Campaign on AU Mic. II. Electron Densities and Kinetic Energies from High-frequency Radio Flares by Isaiah I. Tristan, Rachel A. Osten, Yuta Notsu, Adam F. Kowalski, Alexander Brown, Graeme L. White, Carol A. Grady, Todd J. Henry, Eliot Halley Vrijmoet

“…M dwarfs are the most common type of star in the solar neighborhood, and many exhibit frequent and highly energetic flares. …”
Get full text