EFFECTIVENESS AND SAFETY OF FAVIPIRAVIR INFUSION IN PATIENTS HOSPITALIZED WITH COVID-19 by L. A. Balykova, K. Ya. Zaslavskaya, V. F. Pavelkina, N. A. Pyataev, N. M. Selezneva, N. V. Kirichenko, A. Yu. Ivanova, G. V. Rodoman, K. B. Kolontarev, K. S. Skrupsky, E. N. Simakina, O. A. Mubarakshina, A. V. Taganov, D. Yu. Pushkar

“…The versatility and resistance to mutations of RNA-dependent RNA polymerase make it possible to consider it as the main target for combating the most common RNA viruses that cause ARVI, that determines the need  further studies of favipiravir to expand the range of its indications.…”
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Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathway in HaCaT cells by Ji-Ye Han, Ji-Ye Han, Do-Won Lim, Do-Won Lim, Osoung Kwon, Osoung Kwon, Yun Jung Lee, Yun Jung Lee, Hye Yung Choi, Hyun-Ju Jung, Hyun-Ju Jung, Soohyang Noh, Mansoo Cho, Sung Suk Kang, Young-Mi Lee, Young-Mi Lee, Young-Mi Lee

“…Among the cannabinoids identified in HCIE, CBDA and CBD were the most abundant, collectively accounting for approximately 28% of the total extract. …”
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Novel sonographic reference charts for early pregnancy based on known gestational age by Julia Häusler, M.D., Alexander M Quaas, M.D., Ph.D., Manuel Fischer, Ph.D., Andreas Schötzau, M.Sc., Fiona Pugin, Ph.D., Christian De Geyter, M.D., Ursula Gobrecht-Keller, M.D., Beatrice Mosimann, M.D., Gwendolin Manegold-Brauer, M.D.

“…Objective: To study pregnancy dating, we developed growth charts using data from pregnancies with known gestational age. The most widely used growth charts for ultrasonographic early pregnancy variables were developed decades ago and are based on dating by the last menstrual period. …”
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Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genes by Run-Sen Liang, Jin-Qi Su, Xiang-Qi Wu, Qi Wang, Yong-Mei Cai, Hong-Yong Su, Ji-Xin Tang, Cui-Wei Yao

“…Compelling statistical evidence indicates that TUBB represents the most promising pharmacological target for the treatment of CKD. …”
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Construction and evaluation of a height prediction model for children with growth disorders treated with recombinant human growth hormone by Feng Zhu, Anle Wu, Lingling Chen, Ya Xia, Xiaoju Luo, Jieqian Zhu, Lina Huang, Yu Zhang

“…Chronological age, BA-CA, HSDS, and BSDS were the most influential variables. The decision tree identified HSDS ≥ -0.72 as the primary split point. …”
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Peptide-mimetics derived from leucyl-tRNA synthetase are potential agents for the therapy of mt-tRNA related diseases by Annalinda Pisano, Sara Belloli, Sara Belloli, Maria Gemma Pignataro, Paolo Rainone, Paolo Rainone, Silvia Valtorta, Silvia Valtorta, Angela Coliva, Valeria de Turris, Luciana Mosca, Patrizio Di Micco, Rosa Maria Moresco, Rosa Maria Moresco, Giulia d’Amati, Veronica Morea

“…Additionally, as anticipated, the PMTs had significantly higher plasma stability than the parent peptide. The most promising PMT was radiolabelled with Cu-64 and used in in vivo biodistribution and tolerability studies. …”
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Risk predictors of severe adverse maternal outcomes in pre-eclampsia: a systematic review and meta-analysis protocol by Anish Keepanasseril, Farid Foroutan, Rohan D’Souza, Lindsay Hales, Kara Nerenberg, Isabelle Malhamé, Harika Dasari, Meriem Hammache, Bérengère Deveaux-Cattino, Sophia Bourgeois, Sonia M. Grandi, Stella S. Daskalopoulou

“…While numerous studies have explored potential risk markers, there is still no consensus on the most reliable factors and models to use in clinical practice. …”
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Complete genome sequence, metabolic profiling and functional studies reveal Ligilactobacillus salivarius LS-ARS2 is a promising biofilm-forming probiotic with significant antioxida... by Sinjini Patra, Biswaranjan Pradhan, Anasuya Roychowdhury

“…Anti-Salmonella effect of LS-ARS2 is prominent (p < 0.0001). Most interestingly, LS-ARS2-CFS inhibits MRSA-biofilm (p < 0.0001), again rare among LS strains.ConclusionLS-ARS2 is a novel, fast-growing, biofilm-forming probiotic with significant antioxidant, antibacterial, and anti-biofilm potentials, suggesting the promising applications of LS-ARS2 for combating pathogenic biofilms and improving gut-health. …”
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Evaluating statistical methods to predict indoor black carbon in an urban birth cohort by Sherry WeMott, Grace Kuiper, Sheena E. Martenies, Matthew D. Koslovsky, William B. Allshouse, John L. Adgate, Anne P. Starling, Dana Dabelea, Sheryl Magzamen

“…Most air pollution epidemiology studies rely on outdoor exposure data from various sources, such as reference monitors, low-cost monitors, models, or Earth observations. …”
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Differences Between the 8th and 9th Editions of the TNM Staging System in Predicting Mortality in Non-Small Cell Lung Cancer Patients Staged with EBUS by Ezgi Demirdöğen, Orkun Eray Terzi, Özge Aydın Güçlü, Ahmet Ursavaş, Mehmet Karadağ

“…<b>Results:</b> In this retrospective study, a total of 90 patients were included. Most of the patients were male (84.4%), and the mean age of the study group was 64.0 ± 9.6; deceased patients were older (<i>p</i> = 0.024). …”
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Elevated adipokines and myokines are associated with fatigue in long COVID patients by Nina R. G. Visconti, Nazareth N. Rocha, Nazareth N. Rocha, Gabriela S. Nascimento, Caio V. B. Menário, Johnatas D. Silva, Camila M. Martins, Celso Caruso-Neves, Fernanda F. Cruz, Patricia R. M. Rocco, Fernanda C. Q. Mello, José R. Lapa-e-Silva

“…BackgroundPersistent fatigue is one of the most common and debilitating symptoms experienced by patients recovering from COVID-19, contributing significantly to the burden of “long COVID” or post-COVID-19syndrome. …”
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Increase in urine albumin-to-creatinine ratio as one of the earliest markers of renal damage in patients with hypertension and type 2 diabetes mellitus by S.M. Koval, L.A. Rieznik, T.G. Starchenko, D.K. Miloslavsky

“…A moderate increase in urine ACR is diagnosed not only in most hypertensive patients with T2DM with a decrease in eGFR to G3a category (89 % of cases), but also in 55 % of individuals with a slight decrease in eGFR (G2 category), as well as in 25 % of patients with normal or high eGFR. …”
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Delivering an Electronic Health Record Based Educational Intervention Promoting Peri-Operative Non-Pharmacological Pain Care as Part of a Randomized Controlled Trial: Mixed Method... by Sarah A Minteer, Cindy Tofthagen, Kathy Sheffield, Susanne Cutshall, Susan Launder, Jane Hein, Mary McGough, Christy M Audeh, Jon C Tilburt, Andrea L Cheville

“…We disseminated educational materials directly to patients via the EHR patient portal and prompted patients to select the techniques they were most interested in using, which auto-populated the EHR so that their care team could view their preferences. …”
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Antibacterial Effects of 59 Chinese Medicines Against Pathogens from Micropterus salmoides in vitro by Meizhen SU, Caijuan LI, Xianhua OUYANG, Aiying LEI, Guixiang TONG, Shuiping WEN, Wei LIAO, Fuyan CHEN

“…Of these, the diameters of inhibition circles of G. chinensis and S. aromaticum against A. hydrophila were 21.20 mm and 26.19 mm, respectively, with MICs of 7.81 mg/mL and MBCs of 15.63 mg/mL; the inhibition circle of G. chinensis against E. tarda reached 30.33 mm in diameter, with MICs of 3.91 mg/mL and MBCs of 7.81 mg/mL, respectively; the two pathogens were highly sensitive to M. officinalis, P. vulgaris, A. argyi, and V. yedoensis with diameters ranging from 15.84 mm to 19.47 mm respectively. The most pronounced bacteriostatic effect on A. hydrophila was recorded with C. sappan+G.chinensis and S. aromaticum+T. chebula exhibiting MIC and MBC of 3.91 mg/mL. …”
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Sarcopenia, Muscle Mass and Protein Intake in Adults Older Than 65 Years After Earlier Bariatric Surgery by Gabriël Eksteen, Tim Vanuytsel, Roman Vangoitsenhoven, Ann Mertens, Matthias Lannoo, Ellen De Leus, Bart Van der Schueren, Christophe Matthys

“…Protein intake tended to be higher in BAR than in CON (1.36 ± 0.36 g/kg FFM/day vs. 1.25 ± 0.27, p = 0.09). Most participants did not meet optimal protein intake recommendations after BMS nor for older adults in general. …”
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Comparative analysis of the effectiveness of BPG, AGU, AVIF and HEIF compression methods for medical images corrupted by noise of two types by Viktoriia Naumenko, Volodymyr Lukin, Vitalii Naumenko, Nadiia Kozhemiakina, Mykyta Solodovnyk

“…The goal of this study is to compare encoders regarding optimal image compression parameters and select the most suitable metric to determine the optimal operation point. …”
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Predictors of long-term outcome of patients with schizophrenia in Africa: systematic review and meta-analysis by Mulualem Kelebie, Setegn Fentahun, Gebresilassie Tadesse, Girum Nakie, Girmaw medfu, Birtukan Fasil, Gidey Rtbey, Mulu Muche, Melese Gobezie, Abenet Alazar, Mamaru Melkam, Getasew Kibralew

“…Abstract Background One of the most compelling areas of schizophrenia research involves the investigation of its longitudinal course and clinical outcomes. …”
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Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models by Colleen S. Curran, Xizhong Cui, Yan Li, Tom Gamble, Junfeng Sun, Samuel Minkove, Alicia A. Livinski, Peter Q. Eichacker, Parizad Torabi-Parizi

“…Fifty-six studies met inclusion criteria, with 24 published after 2019. Most studies employed mouse (n = 40 studies) or rat (n = 12) models and administered either a bacterial toxin (n = 28) or bacterial (n = 19) challenge. …”
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Athletes’ access to, attitudes towards and experiences of help-seeking for mental health: a scoping review by Kirsty R Brown, Mary L Quinton, Grace Tidmarsh, Jennifer Cumming

“…This comprised of 87 primary research articles, 13 interventions and 4 systematic reviews. Most of the primary articles and interventions were published in the USA (50%). 49.4% of the primary articles used quantitative methods, 34.5% used qualitative methods and 16.1% used mixed methods. …”
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Clinical efficacy of exercise therapy for lumbar disc herniation: a systematic review and meta-analysis of randomized controlled trials by Shaojie Du, Shaojie Du, Zeyu Cui, Zeyu Cui, Shurui Peng, Shurui Peng, Jieyu Wu, Jieyu Wu, Jinhai Xu, Jinhai Xu, Wen Mo, Wen Mo, Jie Ye, Jie Ye

“…The incidence of LDH in young people aged 18–35 years has shown a significant upward trend. LDH is one of the most common causes of back pain, affecting approximately 1–3% of the global population, and it is mainly concentrated in people aged 30–50 years. …”
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