Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer by Lidia Moyano‐Galceran, Elina A Pietilä, S Pauliina Turunen, Sara Corvigno, Elisabet Hjerpe, Daria Bulanova, Ulrika Joneborg, Twana Alkasalias, Yuichiro Miki, Masakazu Yashiro, Anastasiya Chernenko, Joonas Jukonen, Madhurendra Singh, Hanna Dahlstrand, Joseph W Carlson, Kaisa Lehti

“…In combination with platinum, RSK inhibitors effectively sensitized even the most platinum‐resistant EphA2high, GPRC5Ahigh cells to the therapy‐induced apoptosis. …”
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Anaplastic transformation of thyroid cancer in mesentery metastases presenting as intestinal perforation: a case report by Kiyotaka Hosoda, Kei Kusama, Naoe Yanagisawa, Taiichi Machida, Akihito Nishio, Shinji Nakata, Ichiro Ito, Masahide Watanabe, Harutsugu Sodeyama

“…Anaplastic transformation most commonly occurs in the thyroid itself or within regional lymph nodes. …”
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Inhibition of RPA32 and Cytotoxic Effects of the Carnivorous Plant <i>Sarracenia purpurea</i> Root Extract in Non-Small-Cell Lung Cancer Cells by Kuo-Ting Chang, Yu-Cheng Chen, Yi Lien, Yen-Hua Huang, Cheng-Yang Huang

“…Among these, the acetone-extracted root fraction (Sp-R-A) exhibited the most potent pro-apoptotic effects. The MTT assay demonstrated a dose-dependent cytotoxic effect on NSCLC cells, with IC₅₀ values of 33.74 μg/mL for H1975, 60.79 μg/mL for H838, and 66.52 μg/mL for A549. …”
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Preparation of recombinant SARS-CoV-2 nucleocapsid protein by A. S. Yakovleva, A. V. Kanshina, A. M. Timina

“…Recombinant protein used as an antigen is the most preferable because of its safety.Objective. …”
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Folha diagnótica para avaliação do estado nutricional do feijoeiro Diagnostic leaf for evaluation of the nutritional status of bean by Henrique A. de Souza, Amanda Hernandes, Liliane M. Romualdo, Danilo E. Rozane, William Natale, José C. Barbosa

“…A study with doses of lime and boron was conducted and correlations were made between two types of leaf (+1 and +3) of the bean with the contents of these elements in plants and production, aiming to establish the most appropriate leaf for diagnosis of nutritional status. …”
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Study on the evolution of the traditional Chinese Medicine syndromes of primary nephrotic syndrome treated with rituximab in children and the prognosis by Ai Yi-ying, Wu Rui-bo, Wen Zi-long, Xu Kai-si

“…At 30 days post-treatment， wind pathogen （16.9%） became the most common concurrent syndrome. By day 60， external wind （21.3%）， blood stasis （18.0%）， and damp-heat （16.9%） were the leading concurrent syndromes. …”
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Elevation of Inflammatory Cytokines and Proteins after Intra-Articular Ankle Fracture: A Cross-Sectional Study of 47 Ankle Fracture Patients by That Minh Pham, Lars Henrik Frich, Kate Lykke Lambertsen, Søren Overgaard, Hagen Schmal

“…Synovial concentrations of ACG, IL-12-p70, IFNγ, IL-4, and bFGF correlated with serum levels. While most of the examined synovial cytokines were unchanged after implant removal, IL-4 and IL-6 levels were upregulated. …”
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Convergent parallel mixed-methods study to understand the impact of decision-making for congenital cardiac surgery patients at a tertiary paediatric hospital: a study protocol by Patricia Trbovich, Mark Fan, Azadeh Assadi, Osami Honjo, Sonia Pinkney, Leyi Yin, Yasmin Zahiri, Mjaye Mazwi

“…Introduction Congenital heart disease (CHD) is the most common congenital condition, often necessitating complex heart surgeries that require careful planning by multidisciplinary teams. …”
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Risk factors and subclinical carotid atherosclerosis in rotating scheme conditions in the Arctic by N. P. Shurkevich, A. S. Vetoshkin, L. I. Gapon, A. A. Simonyan

“…Aim. To determine the most significant risk factors (RF) associated with subclinical carotid atherosclerosis (SKA) in people working rotating scheme (RS) in the Arctic, and the role of high blood pressure (BP) in the formation of the atherosclerotic process.Material and methods. …”
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Effects of 5-Methyl-2′-Deoxycytidine in G-Quadruplex Forming Aptamers d(G₃C)₄ and d[GCG₂(CG₃)₃C]: Investigating the Key Role... by Veronica Esposito, Daniela Benigno, Carla Aliberti, Camilla Esposito, Elisabetta Panza, Antonella Virgilio, Aldo Galeone

“…Furthermore, the resistance to nucleases and the antiproliferative activity of these <b>mC</b>-containing derivatives against HCT116 (human colorectal carcinoma) and T24 (human bladder carcinoma) cell lines have been evaluated. In most of the cases, STAT and STATB derivatives inhibit cell proliferation to different extents, although to a lesser degree than the unmodified parent sequences. …”
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Diagnostic delay in children with neurodevelopmental conditions attending a publicly funded developmental assessment service: findings from the Sydney Child Neurodevelopment Resear... by Adam J Guastella, Natalie Silove, Kelsie A Boulton, Natalie Ong, Marie-Antoinette Hodge, Ailsa Jewell

“…Electronic data capture had high acceptability, with 88.2% of caregivers reporting a preference for electronic completion of questionnaires.Conclusions The study shows a substantial delay in diagnostic assessments that leaves most vulnerable children without an assessment by school age and highlights contributors to delays. …”
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Harnessing loblolly pine (Pinus taeda L.) for sustainable biofuels and bioenergy: A review of biomass feedstock potential, conversion technologies, and forest management in the US by Chioma Edwina Ogbuka, Pradip Saud, Marco Yáñez, Rajan Parajuli, Sagar Godar Chhetri, Matthew Pelkki

“…Loblolly pine (Pinus taeda L.), the most widely planted commercial species in the U.S., provides high-quality wood for the industry and lignocellulosic biomass for renewable energy. …”
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APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses by Cassi M. Friday, Isaiah O. Stephens, Cathryn T. Smith, Sangderk Lee, Diksha Satish, Nicholas A. Devanney, Sarah Cohen, Josh M. Morganti, Scott M. Gordon, Lance A. Johnson

“…To further explore these findings, primary microglia from E3 and E4 mice were exposed to exogenous lipids, LPS, and necroptotic N2A cells. Under most conditions, E4 microglia accumulated more LDs and secreted higher levels of proinflammatory cytokines (TNF, IL-1β, IL-10) compared to E3 microglia, although their LPS response was blunted. …”
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Estimation of the efficiency of <i>in vitro</i> anther culture method for obtaining haploid triticale plants (×<i>Triticosecale</i> wittmack) by V. N. Anikina, O. V. Khomyakova, T. I. Diyachuk, S. V. Zhilin, E. K. Barnashova, E. V. Kalashnikova, V. P. Kulikova

“…Anther culture is one of the most popular methods for obtaining haploid triticale plants. …”
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DNA Metabarcoding Illuminates Seasonal Dietary Pattern and Niche Partitioning by Three Sympatric Herbivores by Dandan Wang, Zhiming Cao, Yuqin Liu, Ruofei Li, Ruitao Wu, Wenguo Wu, Wuhua Liu, Xiaolong Hu, Yongtao Xu

“…ABSTRACT Diet composition is among the most critical dimensions of animal ecology, yet seasonal dietary diversity has rarely been investigated in sympatric herbivores. …”
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Negative effects of forest harvest on coastal tailed frog (Ascaphus truei) emerge after a decade‐long experiment by Aimee P. McIntyre, Reed Ojala‐Barbour, Jay E. Jones, Andrew J. Kroll, Eric M. Lund, Timothy Quinn, William J. Ehinger, Stephanie M. Estrella, Dave E. Schuett‐Hames, Marc P. Hayes

“…Headwater streams comprise most of the stream length in forested watersheds in the Pacific Northwest, the United States, including those that are globally important sources of wood biomass. …”
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Dynamics of the COVID-19 Epidemic Process and other Acute Respiratory Viral Infection in the Russian Far East (2019–2023) by A. A. Yakovlev, A. V. Shafigullin, A. F. Popov, M. Yu. Shchelkanov

“…Trends in the dynamics of the incidence of COVID-19, influenza and other acute respiratory infections in most administrative territories of the Far Eastern Federal District in the period 2019–2023, as well as in the region of the Far Eastern Federal District and the Russian Federation as a whole, do not have cardinal features. this indicates the predominant influence of a globally active factor on the epidemic processes of these infections. …”
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Sugar-Sweetened Beverage Consumption and Risk of Visceral Fat Accumulation Among University Students in Thailand by Phisit Pouyfung, Jaruneth Petchoo, Suwichak Chaisit

“…Results Sweetened tea, particularly freshly prepared iced milk tea, was most frequently consumed. High sugar consumption from SSB (≥ 24 g/day) was significantly associated with increased fat mass (16.9 ± 9.9 vs. 14.8 ± 7.8 kg, p = 0.021), BMI (22.6 ± 5.0 vs. 21.3 ± 4.2 kg/m², p = 0.007), and VFL > 9 (83.3% vs. 16.7%, p = 0.013). …”
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Years of Potential Life Lost for Children and Adults With Congenital Heart Defects: United States, 2007 to 2017 by Wendy N. Nembhard, Suman Maity, Emine Bircan, Maria D. Politis, Elijah H. Bolin, Jun Ying

“…Background Although most children with congenital heart defects (CHDs) live into adulthood, many have increased mortality risk across the lifespan. …”
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Enhanced in vitro and in vivo antifungal efficacy against Candida albicans of nanostructured lipid carrier loaded with benzyl isothiocyanate extracted from Carica papaya L. seeds by Zelin Zheng, Zijie Li, Mingqi Yu, Xinyi Ma, Jie Gao, Yan Wang, Jinyan Wu, Xiaodan Yu, Yinzheng Ma, Xiaowen He

“…Candida albicans is the most prominent conditional fungal pathogen, which can cause systemic candidiasis when an individual becomes immunocompromised. …”
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