Physiologically‐based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population by Elizabeth J. Thompson, Angela Jeong, Victória E. Helfer, Valentina Shakhnovich, Andrea Edginton, Stephen J. Balevic, Laura P. James, David N. Collier, Ravinder Anand, Daniel Gonzalez, the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee

“…Weight‐tiered dosing resulted in the most (>90%) children with pantoprazole exposures in the reference range, regardless of obesity status or CYP2C19 phenotype, confirming results from previously published population PK models. …”
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Assessment of the relationship between organ donation attitudes and religious beliefs among postgraduate students by Umit Apak, Sami Akbulut, Sami Akbulut, Sami Akbulut, Zeynep Kucukakcali, Hasan Saritas

“…The Cronbach's alpha value of the ODAS scale was 0.841, indicating good internal consistency.ConclusionAlthough religious beliefs influenced major life decisions for most postgraduate students, they did not significantly alter attitudes toward organ donation, as measured by ODAS scores. …”
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Structural Diversity and in vitro Antiproliferative Activity of Purified Anthocyanins from Blackthorn and Chokeberry by Maria C. STANGA, Ioana STIRBU, Florica RANGA, Zoriţa M. DIACONEASA

“…Anthocyanins demonstrate promising anticancer potential, but most studies employ crude extracts containing multiple bioactive compounds that confound results interpretation. …”
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Dual-Toxin-Producing <i>Clostridium botulinum</i> Strain Isolated from a Foodborne Botulism Case in Korea: Genomic and Functional Insights by Eun-Sun Choi, Chi-Hwan Choi, Jun-Ho Jeon, So-Hyeon Kim, Hyun-Ju Song, Hwajung Yi, Gi-eun Rhie, Yoon-Seok Chung

“…<i>Clostridium botulinum</i> produces one of the most potent biological toxins and causes botulism, a rare but potentially fatal neuroparalytic disease. …”
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Expression of SIRPα-Fc by oncolytic virus enhances antitumor efficacy through tumor microenvironment reprogramming by Qingzhe Yang, Yongheng Shu, Yanwei Chen, Zhongbing Qi, Shichuan Hu, Yao Zhang, Yu Qin, Xianglin Xu, Jianchuan Hu, Anliang Huang, Ping Cheng

“…Among OVs, oncolytic adenoviruses (oAdVs) are the most widely studied due to their well-understood gene regulation, safety, and stability. …”
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Assessing the proficiency of large language models on funduscopic disease knowledge by Jun-Yi Wu, Yan-Mei Zeng, Xian-Zhe Qian, Qi Hong, Jin-Yu Hu, Hong Wei, Jie Zou, Cheng Chen, Xiao-Yu Wang, Xu Chen, Yi Shao

“…RESULTS: Among all the LLMs, ChatGPT-4 and PaLM2 exhibited the most substantial average correlation. Additionally, ChatGPT-4 achieved the highest average score and demonstrated the utmost confidence during the exam. …”
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Enhancing basal cell carcinoma classification in preoperative biopsies via transfer learning with weakly supervised graph transformers by Johan Björkman, Sigrid Lagerroth, Jan Siarov, Filmon Yacob, Noora Neittaanmäki

“…Abstract Background Basal cell carcinoma (BCC) is the most common skin cancer, placing a significant burden on healthcare systems globally. …”
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EXPLORING THE EFFECT OF CLIMATE CHANGE VIA PARITY-BASED PULSED TIMES OF COSINUSOIDAL WAVES IN SUSTAINABLY CONTROLLED MARINE BIOSYSTEMS by Ilias Elmouki, Amine Hamdache, Imane Abouelkheir, Fadwa El Kihal, Kanza Chouayakh, Abdelilah Jraifi, Aziz Darouichi

“…As we could not deny that most observations in this context may be collected at discrete times, we also explore those dynamics using the second system version and which takes the form of control difference equations despite the difficulty often met in their analysis, letting the literature focus on the continuous-time framework. …”
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Comparative efficacy assessment for various insulin regimens in patients with type 2 diabetes mellitus, ischaemic heart disease and frequent hypoglycemic events by Vladimir Ivanovich Kudinov, Maria Sergeevna Nichitenko, Anna Ivanovna Chesnikova, Natalya Vladimirovna Zolotareva

“…In patients with frequent hypoglycemic experience different types of arrhythmia and heart conduction abnormalities wereobserved in 75.9% of cases. Most patients had complex types of arrhythmic disorders (70.4%) with ventricular extrasystole being themost common one. …”
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Patient perception on risk of recurrence and decision-making in the management of HER2-positive early breast cancer: Insights from the ASKHER2 European survey by Matteo Lambertini, Christian Jackisch, Olivier Trédan, Maria Vidal, Mário Fontes-Sousa, Antonios Valachis, Rosanna D'Antona, Marcelo Ruz, Eugenia Krone, Miriam Brice, Erwan Berjonneau, Soraia Matos, Olivia Dialla, Laure Guéroult-Accolas

“…The fear of disease recurrence, death, and treatment failure were identified as the most important concerns. Moreover, 30.4 % perceived they had clear communication with healthcare providers on risk of recurrence. …”
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Pathways linking health literacy to diabetes risk scores in a non-diabetic population in Ismailia, Egypt: a cross sectional study design by Mirella Youssef Tawfik, Rehab A. Mohamed, Noha M. Abu Bakr Elsaid

“…SEM revealed a weak but significant direct effect of HL on DR (β= − 0.05108, p < 0.001). The most substantial indirect effect was observed through PHB (β= − 0.93663, p < 0.001). …”
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Real‐World Treatment Patterns and Outcomes in Patients With Relapsed/Refractory Multiple Myeloma and 1–3 Prior Lines of Therapy: Optum Database by Binod Dhakal, Hermann Einsele, Jordan M. Schecter, William Deraedt, Nikoletta Lendvai, Ana Slaughter, Carolina Lonardi, Sandhya Nair, Nirosha Elsem Varghese, Jianming He, Akshay Kharat, Seina Lee, Patricia Cost, Ravi Potluri, Mythili Koneru, Nitin Patel, Erika Florendo, Paula Rodriguez‐Otero, Kwee Yong

“…Results A total of 1383 and 1597 patients with lenalidomide‐refractory disease were included from the Claims and EHR databases, respectively, with median ages of 72 and 68 years and mean Charlson Comorbidity Index scores of 4.0 and 3.1. The most common treatment combinations were daratumumab–pomalidomide–dexamethasone, daratumumab–bortezomib–dexamethasone, and pomalidomide–dexamethasone (~5% each). …”
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Influence of Livelihood Capital on Coastal Fishermen's Intentions for Livelihood Tourism Transformation: The Mediatory Role of Risk Cognition by Chen Yangle, Wang Tianyi, Tang Xiaoqian

“…Recent research has demonstrated that the transformation of livelihood tourism is one of the most promising strategies for rural tourism destinations. …”
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The Arab world at a crossroads: assessing future risks under changing climate by Rasha M. Abou Samra, R. R. Ali

“…Closed forests and croplands, particularly in Sudan, Syria, Iraq, Saudi Arabia, and Jordan, are expected to be most impacted, underscoring the need for adaptive conservation strategies. …”
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Circular RNAs: biology and clinical significance of breast cancer by Zhanwei Wang, Hao Deng, Yao Jin, Meng Luo, Jia Huang, Jing Wang, Kun Zhang, Li Wang, Jiaojiao Zhou

“…Breast cancer is among the most common malignant cancers diagnosed in women worldwide. …”
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Comparative evaluation of the accuracy and reliability of ChatGPT versions in providing information on Helicobacter pylori infection by Yi Ye, En-dian Zheng, Qiao-li Lan, Le-can Wu, Hao-yue Sun, Bei-bei Xu, Ying Wang, Miao-miao Teng

“…In terms of readability, ChatGPT-4 achieved the highest Flesch Reading Ease score of 24.88 (standard deviation 0.44), however, no statistically significant differences in readability were observed among the versions.ConclusionAll three versions of ChatGPT were effective in addressing Hp-related questions, with ChatGPT-4o delivering the most accurate information. These findings suggest that artificial intelligence-driven chat models hold significant potential in healthcare, facilitating improved patient awareness, self-management, and treatment compliance, as well as supporting physicians in making informed medical decisions by providing accurate information and personalized recommendations.…”
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Oxacillin-Supplemented Mueller-Hinton Agar for In Vitro Inhibition of Ambler Class C β-Lactamases in Enterobacterales by Edgar-Costin Chelaru, Andrei-Alexandru Muntean, Mădălina-Maria Muntean, Mihai-Octav Hogea, Costin-Ștefan Caracoti, Bogdan-Florin Ciomaga, Thierry Naas, Mircea Ioan Popa

“…AmpCs are found in many clinically relevant Enterobacterales, where they may compromise the effectiveness of most β-lactams, including carbapenems when associated with an impaired outer membrane. …”
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Microwave-assisted 1-decene oligomerization: In-depth analysis, kinetic insights, and thermodynamic perspectives with HY zeolite catalyst by Muhammad Nadeem Arshad, Muhammad Faisal Irfan, Malik Abdul Rub, Mohammad Asad, Khalid A. Alzahrani, Aman Ullah

“…Temperature and catalyst dose were identified as the most significant factors, while time had a statistically insignificant effect. …”
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COMPARATIVE ANALYSIS OF MONOCORTICAL AND BICORTICAL METHODS OF INSTALLING MINI-IMPLANTS by O.Yu. Rivis, V.S. Melnyk, M.V. Rivis, K.V. Zombor

“…Results of the study. One of the most important factors leading to the success of the use of a mini-implant is its stability in the process of orthodontic treatment. …”
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Investigation of the influence of the processing method before drying on the organoleptic characteristics, the amount of weight loss and microbiological parameters of zucchini chip... by T. V. Pershakova, T. V. Yakovleva, Yu. N. Chernyavskaya, D. V. Kotvitskaya, A. A. Tyagushcheva

“…Drying is one of the most popular ways to preserve plant materials by reducing humidity and preventing microbiological contamination and it is a promising direction in the food industry. …”
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