Comparative Evaluation of Aortic Valve Replacement Methods in Patients Over 70 with Aortic Stenosis by V. V. Sokolov, M. V. Parkhomenko, A. I. Kovalyov, V. V. Vladimirov, O. L. Shiryayeva, N. M. Bikbova, V. K. Timerbayev

“…Background As life expectancy and quality of health improve, more and more people reach old age, and so does the number of heart diseases. One of the most urgent problems among elderly patients is degenerative stenosis of the aortic valve (AV). …”
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fMRI Insights into Visual Cortex Dysfunction as a Biomarker for Migraine with Aura by Damian Pikor, Natalia Banaszek-Hurla, Alicja Drelichowska, Mikołaj Hurla, Jolanta Dorszewska, Tomasz Wolak, Wojciech Kozubski

“…This review aims to synthesize current knowledge and analyse molecular and neurophysiological targets, providing a foundation for developing targeted therapies to modulate cortical excitability, restore neural network stability, and alleviate the burden of migraine with aura. The most important and impactful research in our field has been the focus of this review, which highlights important developments and their contributions to the knowledge and treatment of migraine with aura.…”
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Experience of using topical beta-blockers in combination therapy of rosacea by Inna V. Il`ina, Dana Z. Tlostanova, Svetlana A. Masjukova, Diana S. Urakova, Veronika V. Mordovtseva, Igor A. Volchek

“…However, the basic therapeutic goal underlying the formation of clinical manifestations of rosacea has not been determined, so most treatment methods do not give the desired result. …”
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A Claud Bernard Horner syndrome: The malignancy of cervical shwanoma by Achraf Amine Sbai, Saad Bouchlarhem, Drissia Benfadil, Azeddine Lachkar, Fahd El Ayoubi El Idrissi

“…Schwannomas are benign tumors that originate exclusively from Schwann cells, which form the myelin sheath of peripheral nerves. Schwannomas most commonly affect the vagus nerve, although other cranial nerves may also be involved. …”
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Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study by Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

“…ConclusionsThis is a prospective observational cohort study that intends to identify the metabolic disease risk factors, or combination of factors, that are most likely to cause adverse maternal and fetal health outcomes. …”
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A novel method utilizing a portable digital image-based colorimeter detector and a glutathione-functionalized gold nanoparticles (GSH-AuNPs) sensor for the highly selective and sen... by Eduwin Saputra, Zora Rispa Kase, Idham Ananta Timur, Aufaclav Zatu Kusuma Frisky, Naufal Dhaffa Akbar Wicaksono, Wisnu Aryo Jatmiko, Zulfa Munawwaroh, Alimin, Fajar Inggit Pambudi, Sri Juari Santosa

“…In comparison, the UV–Vis spectrophotometer as the detector has a LoD of 0.029 mM, and the Jaffe method has a LoD of 0.038 mM, making the proposed colorimetric method the most sensitive. The proposed colorimetric method demonstrates good selectivity for creatinine and has been successfully applied to detect creatinine in artificial urine with a recovery value of 99–103 %.…”
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Design of Ellipsoid and Spherical Combined Light Source for Uniform Flux and Color Mixing by Rui-Min Zeng, Ze-Tian Tang, Cheng-Xi Xia, Yang Wang, Shan Jin, Xin Ren, Li-Feng Bian, Zhao Ding, Chen Yang

“…Then Monte Carlo ray tracing simulation suggests that the most preferable output slot size is between 15% and 30% of the chamber radius when considering both uniformity and available test area. …”
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Retrospective cohort study on cumulative live birth rate of in vitro fertilization/intracytoplasmic sperm injection after multiple complete cycles in patients with diminished ovari... by Sisi Xi, Xiuli Yang, Jing Shang, Qing Xue

“…Abstract Background Diminished ovarian reserve refers to the decrease in the quantity and quality of oocytes in the ovary which may cause poor fertility outcomes even with the help of assisted reproductive techniques. Most patients will undergo multiple cycles of IVF treatments. …”
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Kinematic and morphological evaluation of frozen Friesian Holstein semen stored for 33, 30, 27, and 24 years by Ahmad Budi Purnawan, Rimayanti Rimayanti, Suherni Susilowati, Erma Safitri, Tatik Hernawati, Imam Mustofa, Zulfi Nur Amrina Rosyada, Adeyinka Oye Akintunde, Aswin Rafif Khairullah

“…Background: Fertility is determined by sperm motility, kinematics, and morphology. Motility is the most commonly used metric worldwide, aside from movement score and semen concentration, and is one of the semen quality indicators included in the Indonesian national standard (SNI 4869.1-2017) for frozen semen quality. …”
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Clinical Outcome and Molecular Profile in Patients with <i>DDX41</i> Mutation Hot-Spots by Nadia Toumeh, Yazan Jabban, Ahmad Nanaa, Rong He, David Viswanatha, Dragan Jevremovic, James M. Foran, Cecilia Y. Arana Yi, Antoine N. Saliba, Mehrdad Hefazi Torghabeh, William J. Hogan, Mithun V. Shah, Abhishek A. Mangaonkar, Mrinal M. Patnaik, Hassan B. Alkhateeb, Aref Al-Kali

“…<b>Background/Objectives:</b> <i>DDX41</i>, DEAD-box RNA helicase 41 gene located on chromosome 5q25.3, is one of the most mutated genes in patients with germline predisposition to myeloid neoplasms. …”
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Changes in Systemic Hemodynamics in Orthostasis in Patients With Long-Term Impairment of Consciousness by Viktor N. Dorogovtsev, Artem E. Skvortsov, Elena A. Yudina

“…A severe traumatic brain injury was the most frequent cause of long-term disorders of consciousness (53.3%), other causes were associated with severe disorders of cerebral circulation (13.4%) and following consequences: rupture of cerebral aneurysms (10%), or post-hypoxic brain damage (10%), or removal of brain tumors (13.3%). …”
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Investigating Awareness of Pesticide Exposure as a Risk Factor for Parkinson’s Disease and Uptake of Exposure-Mitigating Behaviour in Farming Communities in Ireland by Lucy M. Collins, Éilis J. O’Reilly, Joan Omosefe Osayande, Fionnuala Wilson, Jolie Morisho, Rebekah Bevans, Rachel Roberts, Bereniece Riedewald, Louise M. Collins, Gerard W. O’Keeffe, Aideen M. Sullivan

“…Only 69% of those with pesticide contact reported using PPE, with gloves (57%) and masks (50%) most commonly used. Only 22% were aware of an association between PD and pesticides, and awareness did not increase PPE use. …”
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Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4 by Qing Luo, Li Zhang, Yue Hao, Chunwei Xu, Xiaojia Wang, Zhen Jia, Xiandong Xie, Zhihong Huang, Xiaomin Gao, Yu Chen, Xue Zhu, Jing Fang, Ke Wang, Yongxiang Yin

“…Abstract Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC), characterized by limited treatment options and poor clinical outcomes. …”
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Five-Year Analysis of Microbial Keratitis Incidence, Isolates, and In Vitro Antimicrobial Sensitivity in the South West of England: An Epidemiological Study by Poonam Sharma, Chimwemwe Chipeta, Kieran O’Kane, Alexander Whiteman, Bryher Francis, Richard Thornton, Indy Sian, Charlotte Buscombe, Jennifer Court, Nathaniel Knox-Cartwright, Harry Roberts

“…<i>Pseudomonas aeruginosa</i> was the most frequent isolate (69 cases, 19.3%). In vitro sensitivity to fluoroquinolones was 94.4% for Gram-positive and 98.6% for Gram-negative bacteria. …”
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Machine learning based reduced-order models to predict spatiotemporal dynamics of soil carbon and biomass yield of different bioenergy crops by Sagar Gautam, Umakant Mishra, Corinne D. Scown

“…., with gains of 29 % and 10 %, respectively. The most significant increases for sorghum are expected at higher latitudes. …”
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Exploring the prognostic role and expression patterns of FAM3A family genes in kidney renal clear cell carcinoma by Shoaib Muhammad, Pengyu Yan, Huifang Wang, Ahmad Mahmood, Syed Shah Zaman Haider Naqvi, Muhammad Zaeem, Chun Liu

“…Abstract Kidney renal clear cell carcinoma (KIRC) is the most common subtype of kidney cancer, characterized by complex molecular alterations. …”
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The Emerging Black Hole Mass Function in the High-redshift Universe by Junehyoung Jeon, Boyuan Liu, Anthony J. Taylor, Vasily Kokorev, John Chisholm, Dale D. Kocevski, Steven L. Finkelstein, Volker Bromm

“…Observations with the James Webb Space Telescope (JWST) have identified an abundant population of supermassive black holes (SMBHs) already in place during the first few hundred million years of cosmic history. Most of them appear overmassive relative to the stellar mass in their host systems, challenging models of early black hole seeding and growth. …”
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CYTOIMMUNOGRAM OF THE SKIN: A NEW METHOD FOR OBJECTIVE EVALUATION OF THE SKIN CELL SUBPOPULATION PROFILE by S. V. Goltsov, E. N. Goltsova, Yu. G. Sukhovey, E. G. Kostolomova, V. Yu. Pauls

“…The results of a single case analysis showed the following findings for this skin sample: 1) a subpopulation of keratinocytes is actively represented, most of them activated, which indicates a moderate proliferative activity of the basal layer of the epidermis; 2) there are B-lymphocytes, which normally are residents of the circulating blood and lymph, since they have a positive taxis to the high endothelial venulas located mainly in the lymph nodes. …”
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Salvage Pulmonary Resection After Immune Checkpoint or Tyrosine Kinase Inhibitor Therapy for Initially Unresectable Non-Small-Cell Lung Cancer: A Systematic Review by Vasile Gaborean, Catalin Vladut Ionut Feier, Razvan Constantin Vonica, Alaviana Monique Faur, Vladut Iosif Rus, Calin Muntean

“…Lobectomy (63%) and segmentectomy (21%) were most frequent. Video-assisted/robotic approaches were achieved in 48%. …”
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Acute-onset Concomitant Esotropia in Children: A Comparison of Clinical Features and Treatment Outcomes by Ying Wang, Jingjing Jiang, Li Li

“…Conclusion: In our study, type II was the most common clinical classification for ACE. Favorable outcomes could be achieved with both BTX-A injection and surgery. …”
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