Low serum uric acid levels and levodopa-induced dyskinesia in Parkinson's disease by Nayron Medeiros Soares, Gabriela Magalhães Pereira, Ana Carolina Leonardi Dutra, Nathalie Ribeiro Artigas, Júlia Schneider Krimberg, Bruno Elkfury Monticelli, Artur Francisco Schumacher-Schuh, Rosa Maria Martins de Almeida, Carlos Roberto de Mello Rieder

“…Background Levodopa is the most used and effective medication for motor symptoms of Parkinson disease (PD), its long-term use is associated with the appearance of levodopa-induced dyskinesia (LID). …”
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Risk assessment of Retithrips syriacus for the EU by EFSA Panel on Plant Health (PLH), Claude Bragard, Paola Baptista, Elisavet Chatzivassiliou, Francesco Di Serio, Paolo Gonthier, Josep Anton Jaques Miret, Annemarie Fejer Justesen, Alan MacLeod, Christer Sven Magnusson, Panagiotis Milonas, Juan A. Navas‐Cortes, Stephen Parnell, Roel Potting, Philippe Lucien Reignault, Emilio Stefani, Hans‐Hermann Thulke, Wopke van derWerf, Jonathan Yuen, Lucia Zappalà, Élison Fabrício Bezerra Lima, David Makowski, Matteo Crotta, Alex Gobbi, Dejana Golic, Andrea Maiorano, Olaf Mosbach‐Schulz, Eugenio Rossi, Anastasia Terzidou, Antonio Vicent Civera

“…The estimated number of founder population per year is mostly driven by the import of cut roses and plants for planting. …”
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Improving Explainability and Integrability of Medical AI to Promote Health Care Professional Acceptance and Use: Mixed Systematic Review by Yushu Liu, Chenxi Liu, Jianing Zheng, Chang Xu, Dan Wang

“…The majority (18/22, 82%) originated from high-income countries, and most (17/22, 77%) adopted qualitative methodologies, with the remainder (5/22, 23%) using quantitative or mixed method approaches. …”
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[SPA] "UTOPÍA" COMO CONSTRUCTO SOCIOCULTURAL: ENTRE REALIDAD Y FICCIÓN // "UTOPIA" AS A SOCIOCULTURAL CONSTRUCT: BETWEEN FACT AND FICTION by Paniótova Taissia S.

“…On the other hand, fiction allows us to formulate the most cherished and boldest dreams as truths that are possible in the historical perspective. …”
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TULIP: The UK Life Induction Programme by Aman Sharma, Harjinder Kainth

“…Almost half believed that these challenges prolonged their adaptation to the NHS, potentially hindering their professional development. Most IMGs expressed a strong interest in participating in a structured induction program, with many even stating they would be willing to pay for such a resource, especially if it offered Continuing Professional Development points. …”
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Treatments for rotator cuff calcific tendinitis: a systematic review and network meta-analysis of randomized-controlled trials by Yuming Yao, Guang Yang, Shide Jiang, Bingzhou Ji, Hongfu Jin, Peiyuan Tang, Hengzhen Li, Bangbao Lu, Yusheng Li

“…For pain relief, radial shock wave therapy (RSWT) + PT (ranked 1st) was most effective. In surgical treatments, arthroscopic bursectomy debridement of rotator cuff (ABD) + arthroscopic subacromial decompression (ASD) showed similar effects to ABD alone for functional improvement (SMD: −0.01, 95% CI: −0.54 to 0.57) and pain relief (SMD: −0.02, 95% CI: −0.51 to 0.43), with no significant differences observed. …”
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Development of model for identifying homologous recombination deficiency (HRD) status of ovarian cancer with deep learning on whole slide images by Ke Zhang, Youhui Qiu, Songwei Feng, Han Yin, Qi Liu, Yuxin Zhu, Haoyu Cui, Xiaoying Wei, Guoqing Wang, Xiangxue Wang, Yang Shen

“…The AUC of the Ensemble Model was 0.769 (Precision = 0.800, Recall = 0.727, F1-score = 0.762) in the study. The most discriminative features between HRD and HRP comprised S_mean_dln_obtuse_ratio, S_mean_dln_acute_ratio and mean_Graph_T-S_Betweenness_normed. …”
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Administrative Procedural Law in Russia: Status, Problems and Prospects by V. E. Sevryugin

“…Within the framework of this study, appropriate legal tools are proposed for resolving the most important tasks today in the field of administrative procedural legal relations. …”
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Comparative genomic insights into adaptation, selection signatures, and population dynamics in indigenous Indian sheep and foreign breeds by Malarmathi Muthusamy, Oludayo Michael Akinsola, Oludayo Michael Akinsola, Pritam Pal, Chitra Ramasamy, Saravanan Ramasamy, Abdulraheem Arome Musa, Aranganoor Kannan Thiruvenkadan

“…Historical effective population sizes showed sharp declines in most breeds, especially those under recent selection. …”
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Immunogenic cell death biomarkers for sepsis diagnosis and mechanism via integrated bioinformatics by Guansheng Li, Xiaoxing Tian, Enyao Wei, Feng Zhang, Huang Liu

“…GSVA identified the top three activated pathways as β-alanine metabolism, citrate cycle/TCA cycle, and glyoxylate and dicarboxylate metabolism, while the most inhibited pathways included glycosphingolipid biosynthesis (lacto and neolacto series), α-linolenic acid metabolism, and linoleic acid metabolism. …”
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Assessing morphological changes in the choroid plexus between standing and supine positions using a rotatable MRI system by Yulin Wang, Shiying Ke, Jiaxin Li, Jie Zeng, Jichang Zhang, Shengyang Niu, Chendie Yao, Jianjun Zheng, Thomas Meersmann, Guangqing Liu, Haosheng Zhu, Li Zhao, Chengbo Wang

“…Abstract The choroid plexus (ChP) is crucial for most cerebrospinal fluid (CSF) secretion. However, few studies have explored the morphology of ChP in a natural upright posture. …”
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Immunohistochemical analysis of IDH1, ATRX, p53, and Ki-67 in glioblastoma and diffuse infiltrative glioma: Therapeutic and prognostic correlation by Hasbay Bermal, Kayaselçuk Fazilet, Süner Halil İbrahim, Tufan Kadir

“…Background/Aim. The most common molecular alterations in high-grade astrocytoma include mutation of the isocitrate dehydrogenase (IDH) gene, loss of 1p19q, and p53 mutation. …”
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Occupational exposure to heavy metals and its association with DNA oxidative stress among urban green space workers by Pourya Ahmadi Jalaldehi, Hossein Abbaslou, Seyed Jamaleddin Shahtaheri, Ziba Veisi Malekshahi, Nasim Farahmand Derav, Kamal Azam, Monireh Khadem

“…Findings revealed that cobalt and cadmium exhibit the most significant influence on changes in oxidative stress, as indicated by the dependent variable 8-OHDG. …”
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Incidence of deep venous thrombosis following medial opening-wedge high tibial osteotomy for varus knee osteoarthritis: a retrospective study by Shian Zhang, Chenni Ji, Song Liu, Wenxue Tong, Ling Qin, Yanbin Zhu

“…The incidence rates for isolated calf muscle vein thrombosis (ICMVT), deep calf vein thrombosis (DCVT), and proximal DVT was 10.7%, 1.9% and 0.5%, respectively. Most laboratory indexes demonstrated non-significant (P > 0.05) or poor (AUC < 0.70) predictive performance, except for AT III and FDP (p = 0.022, 0.033, respectively). …”
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A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy by Zixu Liu, Zixu Liu, Zixu Liu, Yuchen Mao, Shukai Wang, Haoyu Zheng, Kangping Yang, Liang Yang, Peng Huang, Peng Huang

“…Furthermore, gene frequency analysis in this study revealed the most abundant gene, APOE, and SIRT1-7 proteins.ConclusionThe combination of aging therapies with tumor immunotherapies is currently in its preliminary stages. …”
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Targeted sequencing analysis pipeline for species identification of human pathogenic fungi using long-read nanopore sequencing by Nattapong Langsiri, Navaporn Worasilchai, Laszlo Irinyi, Piroon Jenjaroenpun, Thidathip Wongsurawat, Janet Jennifer Luangsa-ard, Wieland Meyer, Ariya Chindamporn

“…The nanopore-based technology is now one of the most promising long-read sequencing technologies on the market as it has the potential to sequence the full-length ITS region in a single read. …”
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ANALYSIS OF POLYMORPHISMS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND RELATION TO VASOPRESSORS IN ESSENTIAL SYSTEMIC HYPERTENSION WITH THE LEFT VENTRICLE HYPERTROPHY IN DAGESTAN RE... by M. Z. Saidov, S. N. Mammaev, A. A. Abdullaev, T. B. Arapkhanova, G. R. Israilova

“…In Dagestan  population, in EAH with and with no LVH, most significant are  genotypes  AA,  AC and  CC  of  polymorphism  A1166C gene   AGTR1,  and genotypes Arg/Arg, Arg/Gly, Gly/Gly and alleles Arg and Gly polymorphism Arg16Gly gene ADRB2. …”
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Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial. by Paul T Edlefsen, Morgane Rolland, Tomer Hertz, Sodsai Tovanabutra, Andrew J Gartland, Allan C deCamp, Craig A Magaret, Hasan Ahmed, Raphael Gottardo, Michal Juraska, Connor McCoy, Brendan B Larsen, Eric Sanders-Buell, Chris Carrico, Sergey Menis, Gustavo H Kijak, Meera Bose, RV144 Sequencing Team, Miguel A Arroyo, Robert J O'Connell, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Supachai Rerks-Ngarm, Merlin L Robb, Tatsiana Kirys, Ivelin S Georgiev, Peter D Kwong, Konrad Scheffler, Sergei L Kosakovsky Pond, Jonathan M Carlson, Nelson L Michael, William R Schief, James I Mullins, Jerome H Kim, Peter B Gilbert

“…Since signature sites were not preferentially restricted to the vaccine immunogens and because most of the associations were insignificant following correction for multiple testing, we predict that few of the genetic differences are strongly linked to the RV144 vaccine-induced immune pressure. …”
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Immunogenicity of adjuvanted recombinant zoster vaccine in patients with rheumatoid arthritis treated with upadacitinib: 60-week results from a randomised controlled trial substudy by Kevin L Winthrop, Michael Chen, Eduardo Mysler, Anthony L Cunningham, Xianwei Bu, Conrado Garcia, Sara K Penn, Alvin F Wells, Irina Fish, Justin Klaff, Yanxi Liu

“…One patient developed herpes zoster 4 months after the second RZV dose.Conclusions Most patients receiving upadacitinib 15 mg QD with background methotrexate achieved satisfactory humoral and CMI responses 4 weeks after the second RZV vaccination (week 16).…”
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Machine learning based identification of anoikis related gene classification patterns and immunoinfiltration characteristics in diabetic nephropathy by Jing Zhang, Lulu Cheng, Shan Jiang, Duosheng Zhu

“…In addition, seven key genes, including PDK4, S100A8, HTRA1, CHI3L1, WT1, CDKN1B, and EGF, were screened by machine learning algorithm. Most of these genes exhibited low expression in renal tissue of DN patients and positive correlation with neutrophils, and their expressions were verified in an external dataset cell model. …”
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