Single-cell transcriptome sequencing reveals the sphingolipid metabolism pathway plays an important role in leaf senescence in tobacco by Quan Sun, Bing Hou, Xinghui Liu, Langlang Zhang, Pingan Chang, Huimin Pang, Xiaohong He, Zexiang Huang, Jili Zhang, Guoxia Liu, Daping Gong, Mingli Chen

“…Enrichment analysis indicated that the differentially expressed genes in various cells were mainly related to chlorophyll synthesis and photosynthesis. Interestingly, most genes tended to show downregulated expression during senescence, whereas genes in the sphingolipid metabolism pathway were significantly upregulated in the senescent samples. …”
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Patient reported outcomes in the FDA approved drugs for systemic rheumatic diseases (2013–2024) by Yan Xie, Yang Liu, Yunhe Qin, Geng Yin, Xiaoyuan Chen, Qibing Xie

“…PROs served as multiple types of endpoints in most trials. All 58 reviewed trials utilized PROs as secondary or exploratory endpoints. …”
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The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology by Ahmad A. Abulaban, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Mustafa M. Shokr, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha

“…While the pathogenesis of MS involves complex interactions between peripheral immune cells and CNS glia, astrocytes—the most abundant glial cells—play a dual role in disease progression. …”
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Breast cancer screening and prevention in the UAE: a cross-sectional study of risk awareness and provider engagement by Maram O. Abbas, Semira Beshir, Rizah Anwar Assadi, Maimouna Anis, Hana Yahya, Naiba Khusrau, Haneen Badreldin Ali, Hanan Al-Helo, Tallal Younis

“…Women aged 40–69 were significantly more likely to pursue preventive measures and screening practices, undergo BC risk assessments, and receive screening recommendations from healthcare providers. However, most participants reported rarely or never undergoing mammography (68%), clinical breast exams (68%), or breast self-exams (56%). …”
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A fast composition-stability machine learning model for screening MAX phases and guiding discovery of Ti2SnN by Zhiyao Lu, Yun Fan, Zhaoxu Sun, Xiaodong He, Chuchu Yang, Hang Yin, Jinze Zhang, Guangping Song, Yongting Zheng, Yuelei Bai

“…Additionally, with the help of the ML model, the mean number of valence electrons and the valence electron deviation are the two most critical factors influencing stability. Additionally, one of these predicted MAX phases, Ti₂SnN, was experimentally synthesized through Lewis acid substitution reactions at 750 °C, with interesting A-site deintercalation and self-extrusion. …”
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Weight changes among antiretroviral therapy-naïve people living with human immunodeficiency virus in Lagos, Nigeria by Oluwatosin Olaseni Odubela, Oluwatosin Olaseni Odubela, Nasheeta Peer, Nasheeta Peer, Nkiruka Nnonyelum Odunukwe, Adesola Zaidat Musa, Babatunde Lawal Salako, Babatunde Lawal Salako, Andre Pascal Kengne, Andre Pascal Kengne

“…Logistic regressions were applied to identify variables associated with weight changes with statistical significance set at p < 0.05.ResultsA total of 6,737 study participants had their weights available at both visits. Most study participants were females (67.2%), employed (83.3%), married (57.1%), and had normal range body mass index (53.5%). …”
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Unexpected stability in faunal population abundances following an estuary‐wide collapse of oysters by Gabrielle D. Love, Zachary A. Siders, David A. Gandy, William E. Pine III, Shirley Baker, Edward V. Camp

“…The surprising paucity of faunal decline following oyster loss may be due to the use of alternative habitat types, exceptionally lagged faunal responses, or, perhaps most compelling, a disconnect between preferred and required habitats. …”
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Changes in Sperm Glutathione and Glutathione Redox States Correlate to Poor Sperm Qualitative Measures by Caroline G. Ploeger, Kate Hansen, Ammon Bayles, Adriana Burger, Jason Hansen, Timothy Jenkins

“…The glutathione (GSH) and glutathione disulfide (GSSG) molecular couple reflect cellular redox environments and are thus reflective of oxidative stress in most cells. Shifting GSH/GSSG redox states to abnormal, more oxidizing conditions can disrupt normal cellular activities. …”
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Screening of Aflatoxin B1-Degrading Strains and Functional Mining of Key Enzyme Genes in Pseudomonas promysalinigenes CT1-8 by Zhaofu CHEN, Zhilin WANG, Jing LIU, Shijuan YAN, Junjin DENG

“…【Objective】Aflatoxin B1 (AFB1), one of the most toxic natural carcinogens known, poses severe threats to human health and food safety. …”
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PERIOPERATIVE NUTRITIONAL SUPPORT IN GASTRIC CANCER PATIENTS UNDERGOING RADICAL SURGERY by A. L. Potapov, A. D. Dorozhkin, S. V. Gamayunov, V. Yu. Skoropad, I. P. Kostjuk, D. D. Kudryavtsev, S. A. Ivanov, A. D. Kaprin

“…Nutritional support before surgery is recommended for most patients with gastric cancer. In all cases, priority should be given to nutrients that support immunity. …”
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High-throughput robotic isolation of human iPS cell clones reveals frequent homozygous induction of identical genetic manipulations by CRISPR-Cas9 by Gou Takahashi, Minato Maeda, Kayoko Shinozaki, Gakuro Harada, Saburo Ito, Yuichiro Miyaoka

“…Abstract Background Genome editing in human iPS cells is a powerful approach in regenerative medicine. CRISPR-Cas9 is the most common genome editing tool, but it often induces byproduct insertions and deletions in addition to the desired edits. …”
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The efficacy and safety of pharmacological treatment of desquamative gingivitis: a systematic review by Dhanushka Leuke Bandara, Kodikara Mudiyanselage Chathurika Padmakumari, Yovanthi Anurangi Jayasinghe, Prasangi Madubhashini Peiris, Chamilka Asanthi Bandaranayake, Liyana Arachchige Aruni Pradeepika, Rasika Manori Jayasinghe, Ruwan Duminda Jayasinghe, Kehinde Kazeem Kanmodi

“…Clobetasol (53.33%) and tacrolimus (26.67%) were the most frequently studied agents, both demonstrating significant reductions in pain and lesion severity. …”
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Enhancing agricultural sustainability: Optimizing crop planting structures and spatial layouts within the water-land-energy-economy-environment-food nexus by Haowei Wu, Zhihui Li, Xiangzheng Deng, Zhe Zhao

“…Hegang-Jixi area in the northeast of the BSRNC was identified as the key area with the most intense crop planting transfer among different scenarios. …”
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A network analysis of timing and conditions present at time of death for periviable infants (22+0–23+6 weeks) admitted to neonatal intensive care after receiving survival-focused c... by J. Peterson, J. Peterson, D. M. Smith, E. D. Johnstone, E. D. Johnstone, K. Harvey, A. Mahaveer, A. Mahaveer

“…Professionals currently lack adequate prognostic tools to accurately predict pre-birth which infants will survive.MethodsThis study utilises an anonymised dataset from the North West Neonatal Network to delineate time of death profiles for periviable infants admitted to neonatal intensive care units (NICU) and explores the demographics, timing and diagnoses recorded at the time of the death.ResultsThe data show that most periviable infants who died following admission to NICU died within the first seven days after birth [24 infants born at 22 weeks (65%) and 55 infants born at 23 weeks (52%)]. …”
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New record of Anopheles superpictus (Diptera: Culicidae) in central Italy (Tuscany): resting adults and evidence of natural breeding sites by Ilaria Bernardini, Francesco Severini, Michela Menegon, Claudia Mangiapelo, Riccardo Bianchi, Gioia Bongiorno, Marco Di Luca, Daniela Boccolini

“…Anopheles superpictus was the most abundant species recorded (n = 512; 46%), peaking in August and found in sympatry with An. labranchiae, the main historical malaria vector in Maremma Plain. …”
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Immunological factor development of external genital endometriosis by M. A. Levkovich, N. V. Ermolova, I. I. Krukier, T. N. Pogorelova, L. V. Kravchenko

“…Currently, endometriosis is recognized as one of the most common diseases associated with infertility. …”
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Predicting Water Distribution and Optimizing Irrigation Management in Turfgrass Rootzones Using HYDRUS-2D by Jan Cordel, Ruediger Anlauf, Wolfgang Prämaßing, Gabriele Broll

“…Sensitivity analysis revealed that soil hydraulic property shape factor (<i>n</i>) was most sensitive, followed by factor θ_s^w (water content at saturation for the wetting water retention curve). …”
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Effective Facial Expression Recognition System Using Artificial Intelligence Technique by Imad S. Yousif, Tarik A. Rashid, Ahmed S. Shamsaldin, Sabat A. Abdulhameed, Abdulhady Abas Abdullah

“… Facial expressions are the most basic non-verbal method people use to communicate feelings, intentions and reactions without words. …”
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The Anatomical Relationship Between the Hyoid Bone and the Carotid Arteries by Nektaria Karangeli, George Triantafyllou, Panagiotis Papadopoulos-Manolarakis, George Tsakotos, Katerina Vassiou, Marianna Vlychou, Panagiotis Papanagiotou, Maria Piagkou

“…Type 6 (ECA positioned laterally to the GH) was the most prevalent carotid–hyoid configuration (18.5%). …”
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Universal amplification and sequencing of foot-and-mouth disease virus complete genomes using nanopore technology by Andrew E. Shaw, Kebaneilwe Lebani, Lina González Gordon, Ugonna E. Ihearahu, Jemma Wadsworth, Hayley M. Hicks, Noemi Polo, Graham Freimanis, Dennis Muhanguzi, Chandana Tennakoon, Richard J. Orton, Nick J. Knowles, Antonello Di Nardo, Ryan A. Waters, Barend MdeC Bronsvoort, Donald P. King

“…Nanopore sequencing is an affordable and accessible form of high-throughput sequencing (HTS) technology. However, most published methods for FMDV only sequence genomic fragments or focus upon specific lineages. …”
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