Avaliação clínica da eficácia da combinação paracetamol e cafeína no tratamento da cefaléia tipo tensão Clinical evaluation of the efficacy of the acetaminophen and caffeine combin... by GETÚLIO DARÉ RABELLO, LUIS VICENTE FORTE, ANTONIO CEZAR RIBEIRO GALVÃO

“…<br>Tension type headache in both its forms, episodic and chronic, is the most common type of headache experienced by the population. …”
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In Situ Targeting RGD-Modified Cyclodextrin Inclusion Complex/Hydrogel Hybrid System for Enhanced Glioblastoma Therapy by Xiaofeng Yuan, Zhenhua Wang, Pengcheng Qiu, Zhenhua Tong, Bingwen Wang, Yingjian Sun, Xue Sun, Lu Sui, Haiqiang Jia, Jiajun Wang, Haifeng Tang, Weiliang Ye

“…<b>Background/Objectives</b>: Glioblastoma (GBM) remains the most aggressive primary brain tumor, characterized by high malignancy, recurrence rate, and dismal prognosis, thereby demanding innovative therapeutic strategies. …”
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The Influence of Reservoirs on Landslide Erosion by Fengjiao Tang, Shengwen Qi, Songfeng Guo, Yongchao Li, Xinyi Guo, Xiao Lu, Yu Zou, Xueliang Wang, Xie Hu, Lina Ma, Bowen Zheng, Zan Wang

“…We then analyzed reservoir-induced landslides worldwide and found that most reservoir bank slopes tend to stabilize after about five years of impoundment, eventually even becoming more stable than pre-impoundment, regardless of the location, scale, water fluctuations, and geoenvironment. …”
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Postcholecystectomy syndrome: the modern approach: resolution of Advisory council by V. T. Ivashkin, A. V. Okhlobystin, D. S. Bordin, E. Ya. Seleznyova, Yu. A. Kucheryavy, Ye. V. Bystrovskaya, O. C. Vasnev, M. F. Osipenko, G. H. Musayev, Yu. O. Shulpekova

“…At the same time at asymptomatic GSD the watchful waiting approach avoiding active treatment is considered to be the most expedient. Biliary sludge and microlithiasis including cases undiagnosed at routine investigation can be one of important factors for development of the PCS. …”
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The Immediate Effect of Protective Knee Brace application on the Ground Reaction Forces of People with Genu Valgum During Landing by M Barghamadi, K Shahbazioghli, E Piri, Kh Alapour, A Nosratihashi, H Allahverdidost

“…Purpose:Genu valgum is one of the most important lower limb abnormalities that puts athletes at risk of injury due to weight imbalance in the inner and outer parts of the knee. …”
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Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent by Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler

“…We observed the best performance when the model most closely reflected human infection or disease conditions. …”
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Glycemic response to SSBs and ASBs: the role of mixed meals and individual variability by Sejin Kim, YoonJu Song

“…At 120 min, the glucose dip was most pronounced for regular cola, whereas oral glucose load and muffin showed smaller reductions. …”
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Identifying leptospirosis hotspots in Selangor: uncovering climatic connections using remote sensing and developing a predictive model by Muhammad Akram Ab Kadir, Rosliza Abdul Manaf, Siti Aisah Mokhtar, Luthffi Idzhar Ismail

“…The feature importance score indicated river water level and rainfall contributes most to the model. Conclusions This GIS-based study identified a primarily sporadic occurrence of leptospirosis in Selangor with minimal spatial clustering. …”
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Type 2 diabetes risk prediction using glycemic control Metrics: A machine learning approach by Radwan Qasrawi, Suliman Thwib, Ghada Issa, Razan Abu Ghoush, Malak Amro

“…Glycemic load, age, BMI, waist-to-hip ratio, and self-reported health status were the most important risk indicators. Conclusion: This study showed the effectiveness of integrating machine learning with glycemic control metrics and lifestyle data for personalized T2DM prediction. …”
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Alectinib in combination with bevacizumab as first-line treatment in ALK-rearranged non-small cell lung cancer (ALEK-B): a single-arm, phase 2 trial by Oscar Arrieta, Luis Lara-Mejía, Eduardo Rios-Garcia, Enrique Caballé-Perez, Luis Cabrera-Miranda, Maritza Ramos-Ramírez, David Dávila-Dupont, Andrés F. Cardona, Graciela Cruz-Rico, Jordi Remon, Alexandra Garcilazo-Reyes, Rafael Rosell

“…Grade 3–4 adverse events occurred in 46.3% of patients, most commonly proteinuria and hepatotoxicity, with no fatal events reported. …”
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Impact of diet in shaping gut virome of grain-fed and grass-fed beef cattle revealed by a comparative metagenomic study by Yujie Zhang, Yen-Te Liao, Fang Liu, Robert W. Li, Vivian C. H. Wu

“…Abstract Background In the United States beef industry, grain-feeding and grass-feeding are the two most common types of cattle feeding. Different feeding methods are likely to affect gut microbiota compositions and subsequently change microbial adaptation and cattle metabolism. …”
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A novel global MPPT method based on sooty tern optimization for photovoltaic systems under complex partial shading by Mohammed Taha Kaaitan, Rashid Ali Fayadh, Zuhair S. AL-sagar, Salam J. Yaqoob, Mohit Bajaj, Mebratu Sintie Geremew

“…Specifically, under the most challenging PSC scenario (Pattern 4), the proposed method achieved a tracking efficiency of 99.94%, with an average power output of 1676 W and a response time of 0.5 s, outperforming PSO (97.1%, 1630 W), GWO (94.2%, 1580 W), and P&O (56.5%, 950 W). …”
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Estimation of Tomato Quality During Storage by Means of Image Analysis, Instrumental Analytical Methods, and Statistical Approaches by Paris Christodoulou, Eftichia Kritsi, Georgia Ladika, Panagiota Tsafou, Kostantinos Tsiantas, Thalia Tsiaka, Panagiotis Zoumpoulakis, Dionisis Cavouras, Vassilia J. Sinanoglou

“…Additionally, water activity, moisture content, total soluble solids, texture, and color were evaluated. Most physicochemical changes occurred between days 14 and 17, without major impact on overall fruit quality. …”
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Facilitators in treatment pathways for depression or anxiety among adults in Nepal: a qualitative study by Nagendra P. Luitel, Bishnu Lamichhane, Kavita Sah, Baidahee Basnet, Poonam Sainju, Kamal Gautam, Brandon A. Kohrt, Mark J. D. Jordans

“…Traditional healers were the most popular choice for initial visits, followed by private clinics and government hospitals. …”
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RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM GENES POLYMORPHISM AND RELATION WITH VASOPRESSORS IN ESSENTIAL HYPERTENSION AMONG DAGESTAN INHABITANTS by M. Z. Saidov, S. N. Mammaev, S. N. Abdullaev, T. B. Arapkhanova, G. R. Izraylova

“…Serum levels of ET 1-21 and ACE were significantly higher or had tendency to increase, but AT II and AS decreased in both cases, comparing to the controls (р&lt;0,05, р&lt;0,01). Most number of significant direct correlations was found in polymorphisms of the genes AGT, AGTR1 and ADRB2 and level of serum ET 1-21.Conclusion. …”
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Integrated network pharmacology, transcriptomics, and experimental validation to explore the mechanism of Qihuang Jianpi Zishen granules against Sjögren’s syndrome by Haikun Wang, Zichuang Ma, Na Wu, Xin Wang, Xinmeng Yang

“…In vitro experiments showed that QJZG, at a concentration of 4 mg/mL, exerted the most pronounced effects on human salivary gland (HSG) cells. …”
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A chimeric antigen receptor tailored to integrate complementary activation signals potentiates the antitumor activity of NK cells by Eunbi Yi, Eunbi Lee, Hyo Jin Park, Hyeon Ho Lee, So Hyeon Yun, Hun Sik Kim

“…Accordingly, an NK-CAR incorporating DAP10, 2B4, and CD3ζ signaling domains coupled to CD8α H and CD28 TM domains was identified as the most promising candidate to improve CAR-mediated cytotoxicity. …”
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Investigation on the thermal performance of MgO-filled basalt Fiber/PLA composites for high-temperature industrial applications by Thandavamoorthy Raja, Yuvarajan Devarajan, Jayanta Kumar Nath, Swapnil M Parikh, Krishna Kumar Shukla, Sunil Kumar M, Lokesh Verma

“…Notably, the L3 formulation (3 % MgO) exhibited the most significant enhancements, with a tensile strength of 154.94 MPa (7.79 %), flexural strength of 159.21 MPa (8 %), impact strength of 32.45 kJ/m² (28 %), and Shore D hardness of 132 (13,6 %), highlighting its mechanical superiority. …”
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Assessment of polyvinylpyrrolidone vinyl acetate effect on quercetin properties in binary solid dispersion prepared by hot melt extrussion by A. A. Danilova, K. A. Gusev, N. O. Arkhipova, L. G. Danilov, E. V. Vishnyakov, D. N. Maimistov, E. V. Flisyuk

“…At the same time, the complete release of quercetin from 1 % SDS was achieved in 40 minutes in the hydrochloric acid and citrate buffer, and also quercetin dissolution of 90 % in 60 minute was observed in phosphate buffer.Conclusion. 1 % quercetin SDS based on PVP/VA appears to be the most promising for solid dosage forms development.…”
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Increased infection risk in patients on preventive CGRP-targeting therapies– a meta-analysis and clinical effect assessment by Marcin Straburzyński, Daria Kopyt, Karol Marschollek, Bartłomiej Błaszczyk, Ewa Kuca-Warnawin, Weronika Kurowska, Błażej Misiak, Kuan-Po Peng, Marta Waliszewska-Prosół, Arne May

“…However, it is unlikely to affect most migraine patients considering relatively high NNH, low effect size and few infectious SAEs reported so far. …”
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