Clinical picture of ankylosing spondylitis in HLA-B27 positive and negative patients by Sh. F. Erdes, K. V. Sakharova

“…In the Russia’s AS patient population there are associations with HLA-B27, characteristic for most ethnic groups (e. g., earlier onset of the disease) and associations not found in all ethnic groups (e. g., a more severe course, a higher incidence of arthritis and enthesitis). …”
Get full text

Pathomorphological changes of the placenta in coronavirus disease (COVID 19) by T. V. Savchuk, S. H. Gychka, I. V. Leshchenko

“…These changes lead to the development of fibrosis in the wall of arterioles and intervillous space. The most significant structural changes in the placenta, leading to placental insufficiency, were observed in group 2 – at the time of infection in the period from 23–33 weeks of pregnancy. …”
Get full text

MACHINE LEARNING TECHNIQUES FOR RETINOPATHY DETECTION IN DIABETIC PATIENTS by Ajay Kushwaha, Ahankari Sachin Suresh, Chennoju Phanindra, Anil Kumar Sahu, Devanand Bhonsle, Yamini Chouhan

“…The suggested method analyzes high-resolution retinal pictures using deep learning methods, most especially Convolutional Neural Networks (CNNs). …”
Get full text

Resveratrol-derived MDM2 inhibitors: Synthesis, characterization, and biological evaluation against MDM2 and HCT-116 cells by Oraibi Amjad Ibrahim, Dawood Ashour H., Debbabi Nawres, Almukram Ali Majeed Ali, Almaary Khalid S., Dabiellil Fakhreldeen, Chekir-Ghedira Leila, Kilani-Jaziri Soumaya

“…MDM2-p53 inhibitory activity confirmed AMJ3 as the most potent inhibitor (IC50: 0.24 ± 0.02 µM), followed by AMJ5 (IC50: 0.48 ± 0.04 µM), both surpassing Nutlin (IC50: 0.39 ± 0.03 µM). …”
Get full text

Management of disease-modifying therapies in multiple sclerosis and comorbid rheumatoid arthritis by Franz Felix Konen, Torsten Witte, Diana Ernst, David Hagin, Konstantin Fritz Jendretzky, Nora Möhn, Sandra Nay, Lea Grote-Levi, Kurt-Wolfram Sühs, Luisa Klotz, Steffen Pfeuffer, Refik Pul, Christoph Kleinschnitz, Marc Pawlitzki, Sven G. Meuth, Thomas Skripuletz

“…Conclusion Among approved DMT for MS and RA, teriflunomide and anti-CD20 therapies are the most suitable options for moderately or highly active MS with comorbid RA. …”
Get full text

Interventions to Counter Health Misinformation Among Older People: Protocol for a Scoping Review by Maryline Vivion, Valérie Reid, Valérie Trottier, Frédéric Bergeron, Isabelle Savard, Emilie Dionne, André Tourigny

“…A previous review identified pedagogical approaches most commonly adopted in interventions aiming to improve the digital literacy of older adults but did not specifically address digital health literacy. …”
Get full text

Russian Randomized Trial to Select Optimal Antibiotic Prophylaxis in Radical Cystectomy: Initial Results of MACS-TRIAL (NCT05392634) by A. K. Nosov, M. V. Berkut, E. M. Mamizhev, T. Yu. Galunova, D. I. Rumyantseva, D. P. Semeyko, S. A. Reva, S. Yu. Konyashkina

“…At the same time, the incidence of infectious complications in a number of studies reaches 33%, which in most cases causes repeated hospitalizations and disrupts the Enhanced Recovery After Surgery (ERAS) guidelines. …”
Get full text

X-RAY MORPHOLOGICAL SEMIOTICS OF NON-TUBERCULOUS MYCOBACTERIAL PULMONARY DISEASE by R. B. Amansakhedov, L. N. Lepekha, L. I. Dmitrieva, I. Yu. Andrievskaya, A. T. Sigaev, N. N. Makar’yants, V. V. Romanov, A. E. Ergeshov

“…Thus, the CT typical signs of NTMPD are the asymmetric location of its foci with an endobronchial extension, peribronchovascular localization of foci; the presence of a CT tree-in-bud sign; and the slight involvement of the pulmonary pleurae in the process. 99mTs-technetril radionuclide study has established that the most active inflammatory process is located in the lung and the tracer accumulates in the pathologically altered lymph nodes.…”
Get full text

CHANGE OF ACTIVITY, FUNCTIONAL CLASS, AND SPINAL MOBILITY IN ANKYLOSING SPONDYLOSIS DURING THERAPY WITH DIFFERENT PHARMACOLOGICAL AGENTS by M. Ivanova, R. Stoilov, S. G. Radenska-Lopovok, I. Manolova

“…TNF-α inhibitors are the most effective agent to suppress disease activity and to improve functional status in AS.…”
Get full text

Strategies for resilience: Mitigating the effects of climate change on hunger and mental health by Kelechi Chinemerem Mezieobi, Esther Ugo Alum, Chukwuoyims Kevin Egwu, Daniel Ejim Uti, Benedict Nnachi Alum, Christine Ainebyoona, Daniel Omuna

“…Objectives: Climate change is one of the most significant threats to global public health in the 21st century, affecting ecosystems, food systems, and psychological well-being. …”
Get full text

Birth-Related Subdural Hemorrhage in Asymptomatic Newborns: Magnetic Resonance Imaging Prevalence and Evolution of Intracranial and Intraspinal Localization by Davide Turilli, Leandra Piscopo, Alberto Dessì, Claudia Pinna, Liala Mirella Fattacciu, Emma Solinas, Ilaria Conti, Stefania Tamburrini, Giacomo Sica, Michele Klain, Salvatore Masala, Mariano Scaglione

“…<b>Results</b>: About the analysis of the SDH locations in the 32 patients, the most common location was the cerebellum (31/32, 96.9%), followed by parietal and occipital lobes (19/32, 59.4%; 18/32, 56.2%, respectively), falx cerebri (11/32, 34.4%), tentorium cerebelli (10/32, 31.2%), temporal lobes (6/32, 18.7%), and finally cervical and dorsal spine in the same patients (4/32, 12.5%). …”
Get full text

The relevance of creating a new combined ophthalmic drug with anti-inflammatory and antibacterial effects by L. I. Kucherenko, D. V. Okolzin

“…It was found that with a wide range of available drugs, their therapeutic effect often remains insufficient in complex eye injuries, especially those received during combat operations. Most of available drugs are aimed at treating standard inflammatory processes or certain types of infections, while complex combat injuries require greater pharmacological action and diverse therapy. …”
Get full text

Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients by Beata Shiratori, Susan Leano, Chie Nakajima, Haorile Chagan-Yasutan, Toshiro Niki, Yugo Ashino, Yasuhiko Suzuki, Elisabeth Telan, Toshio Hattori

“…Tuberculosis (TB) is the second most common cause of death from infectious diseases and results in high socioeconomic losses to many countries. …”
Get full text

The Fundamentals of Health Research training for community health workers: a mixed-methods study by Nicole Wolfe, Andrea Diaz, Brian Do-Golden, Esther Karpilow, Mayra Rubio-Diaz, Michele D. Kipke, Michele D. Kipke, Michele D. Kipke

“…The program was evaluated using a mixed-methods approach, including pre- and post-training surveys, satisfaction surveys, and 3- and 12-month follow-ups.ResultsBetween March and September 2023, 128 CHW/Ps completed the training; 103 (80.5%) completed the 12-month follow-up. Most participants identified as Latino/Hispanic (93%) and female (96%). …”
Get full text

Association between metabolic score of visceral fat and all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a follow-up study based... by Guoqing Huang, Ping-Ping Zhang, Tieqiao Wang, Shixue Bao, Yushan Mao

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, seriously threatening the public health. …”
Get full text

A scoping review of nausea, vomiting and retching measurement methods in children with cancer by Celeste LY. Ewig, Wai Yin Yung, Hobart Ho Man Ng, Cho Lee Wong, Alex Wing Kwan Leung, Chi-kong Li, Yin Ting Cheung

“…In the assessment of NVR, structured surveys were the most commonly used instrument for NVR assessment (75%) and the use of patient diaries (50%). …”
Get full text

Hydration behaviors, knowledge, and attitudes among Chinese recreational marathon runners: a cross-sectional study by Jingyi Zhang, Yan Chen, Xueyuan Zhao, Xiangxin Li, Wei Wen, Wenqiang Wu, Menghui Zou, Junqiang Qiu, Junqiang Qiu

“…Participants primarily obtained hydration knowledge from friends/family (54.9%) and social media (45.6%). Most participants (93.7%) acknowledged water’s health benefits and were willing (92.2%) to improve hydration habits to enhance athletic performance (p &lt; 0.001 for all). …”
Get full text

Association between the triglyceride-glucose index (TyG Index) and risk of colorectal cancer: a systematic review and meta-analysis by Hala Fathi EmamElkhir Omer, Mohamed Alghazali, Mohamed Y. Ibrahim, Nadeen Mohamed Yousif Abdalla, Ashraf Hassan Mohamed Hassan, Eram Asim Seidahmed Yousif, Aseel E. B. Abdhameed, Yaser Waheeb Slaiman Naser, Nawras Mustafa Elashai Hamad, Malaz A. I. Abdalla, Mohamed Osman Mohamed Idres, Ali Abdelhaleem Omar Ahmed, Yasir Ahmed Mohammed Elhadi, Sagad O.O. Mohamed

“…Abstract Background Colorectal cancer (CRC) is one of the most common malignancies worldwide, with increasing evidence linking metabolic dysregulation, such as insulin resistance and chronic inflammation, to its development and progression. …”
Get full text

LncRNA Gm35585 transcriptionally activates the peroxidase EHHADH against diet-induced fatty liver by Ming Jin, Qian Lu, Ninglin Xia, Xue Fan, Ziling Zhang, Xiaofei Huang, Li Sun, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu

“…Abstract Metabolic-dysfunction-associated steatotic liver disease is one of the most common chronic liver diseases worldwide and has no approved treatment thus far. …”
Get full text

Role of preoperative magnetic resonance imaging on the surgical outcomes of radical prostatectomy: Does preoperative tumor recognition reduce the positive surgical margin in a spec... by Thitipat Hansomwong, Pat Saksirisampant, Sudhir Isharwal, Pubordee Aussavavirojekul, Varat Woranisarakul, Siros Jitpraphai, Sunai Leewansangtong, Tawatchai Taweemonkongsap, Sittiporn Srinualnad

“…Results: In total, 322 (30.1%) patients underwent MRI before RP. PSM most frequently occurred at the apex (33.2%), followed by posterior (13.5%), bladder neck (12.7%), anterior (10.7%), posterolateral (9.9%), and lateral (2.3%) positions. …”
Get full text